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Neurodevelopmental disorder –associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase | Science Signaling
Loss of kinase function in TAOK1 impairs autoregulation of its interaction with the plasma membrane. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - January 3, 2023 Category: Science Source Type: news

Serine-threonine phosphoregulation by PknB and Stp contributes to quiescence and antibiotic tolerance in Staphylococcus aureus | Science Signaling
Acid-induced antibiotic tolerance in S.  aureus depends on serine-threonine phosphorylation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - January 3, 2023 Category: Science Source Type: news

Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies | Science Signaling
The channel PANX-1 initiates or collaborates in enabling chemotherapy-induced lytic cell death. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 20, 2022 Category: Science Source Type: news

Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses | Science Signaling
Degradation of HDAC10 during viral infection releases a brake on the induction of the type I interferon response. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 20, 2022 Category: Science Source Type: news

Keeping brown fat brown | Science Signaling
The multilocular phenotype of brown adipose tissue is determined by an ER –lipid droplet anchoring protein. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 20, 2022 Category: Science Source Type: news

Stress signaling boosts interferon-induced gene transcription in macrophages | Science Signaling
Stress-induced p38 activity enhances the positive and negative effects of macrophage interferon responses. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 13, 2022 Category: Science Source Type: news

Rewiring the logic board of IFN signaling | Science Signaling
Integrated cell stress and interferon signaling enable enhanced and customized immune responses (Boccuni et  al., in 13 December 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 13, 2022 Category: Science Source Type: news

Hitching a ride in macrophages | Science Signaling
Toxoplasma gondii infection confers a migratory phenotype upon macrophages. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 13, 2022 Category: Science Source Type: news

Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension | Science Signaling
TSC2 limits mechanosensitive and cell growth signaling that drives pulmonary hypertension. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 6, 2022 Category: Science Source Type: news

Synaptic activity –dependent changes in the hippocampal palmitoylome | Science Signaling
The dynamics of palmitoylation of synaptic and nonsynaptic proteins supports neuronal plasticity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 6, 2022 Category: Science Source Type: news

Gut bugs on drugs | Science Signaling
Targeting the effects of cocaine on the gut microbiome may be a way to treat addiction. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 6, 2022 Category: Science Source Type: news

VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney | Science Signaling
The lipid kinase VPS34 limits nutrient loss but enables viral entry in renal proximal tubule cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 29, 2022 Category: Science Source Type: news

Quantal leaps in understanding Ca2+ signaling: A “Taylored” approach | Science Signaling
The organizers of a symposium honoring the contributions of Colin Taylor to calcium signaling research summarize the presentations. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 29, 2022 Category: Science Source Type: news

CMTM4 makes IL-17 signaling more complex | Science Signaling
A transmembrane protein promotes the plasma membrane localization and signaling mediated by an IL-17 receptor subunit. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 29, 2022 Category: Science Source Type: news

Characterization of TGF- β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth | Science Signaling
A human skin model reveals requirements for distinct TGF- β signaling pathways in epidermal development and homeostasis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 22, 2022 Category: Science Source Type: news