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[Editors' Choice] Polyglutamine makes the switch
In worms, a regulator of noncoding RNA directly catalyzes formation of toxic protein aggregates in the presence of polyglutamine. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 28, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] Shaping the gut microbiome from the pancreas
The intracellular Ca2+ channel Orai1 in pancreatic acinar cells helps to suppress inflammation-associated bacterial strains in the gut. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 28, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] Antidepressants protect bones from metastatic prostate cancer
Monoamine oxidase A-targeted antidepressants inhibit a tumor-stroma loop and could delay the metastatic outgrowth of prostate cancer. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 28, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Research Article] Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production
Stress depletes STAT3 in the mitochondria, and restoration of this STAT3 pool suppresses stress-induced ROS production. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 28, 2017 Category: Science Authors: Jeremy A. Meier, Moonjung Hyun, Marc Cantwell, Ali Raza, Claudia Mertens, Vidisha Raje, Jennifer Sisler, Erin Tracy, Sylvia Torres-Odio, Suzana Gispert, Peter E. Shaw, Heinz Baumann, Dipankar Bandyopadhyay, Kazuaki Takabe, Andrew C. Larner Source Type: news

[Research Article] Caveolin-1-mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype
Internalization and degradation of a vitamin C transporter trigger activation of microglia. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 28, 2017 Category: Science Authors: Camila C. Portugal, Renato Socodato, Teresa Canedo, C á tia M. Silva, T â nia Martins, Vivian S. M. Coreixas, Erick C. Loiola, Burkhard Gess, Dominik R ö hr, Ana R. Santiago, Peter Young, Richard D. Minshall, Roberto Paes-de-Carvalho, Ant ó nio F. Amb Source Type: news

[Research Article] Sphingosine 1-phosphate signaling through its receptor S1P5 promotes chromosome segregation and mitotic progression
Targeting the signaling lipid S1P might suppress tumor growth by slowing mitosis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 27, 2017 Category: Science Authors: Guillaume Andrieu, Adeline Ledoux, Sophie Branka, Magalie Bocquet, Julia Gilhodes, Thierry Walzer, Kousuke Kasahara, Masaki Inagaki, Roger A. Sabbadini, Olivier Cuvillier, Anastassia Hatzoglou Source Type: news

[Editors' Choice] New connections: Getting the good without the bad, opiate edition
Researchers identify strategies to limit the adverse effects and liabilities of opioid receptor-targeting drugs. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 21, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] Autophagy and vitamin D
Vitamin D receptor represses basal autophagy in breast tissue, which is derepressed by vitamin D, slowing cancer progression. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 21, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Research Resource] Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression
Common changes in signaling pathway-associated gene expression may explain why chronic pain or stress can lead to depression. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 21, 2017 Category: Science Authors: Giannina Descalzi, Vasiliki Mitsi, Immanuel Purushothaman, Sevasti Gaspari, Kleopatra Avrampou, Yong-Hwee Eddie Loh, Li Shen, Venetia Zachariou Source Type: news

[Research Article] Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking
An inflammation-associated kinase also stimulates glucose uptake through plasma membrane translocation of GLUT4 in response to insulin. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 21, 2017 Category: Science Authors: Maeran Uhm, Merlijn Bazuine, Peng Zhao, Shian-Huey Chiang, Tingting Xiong, Sheelarani Karunanithi, Louise Chang, Alan R. Saltiel Source Type: news

[Editors' Choice] An insulin-like message from mother
Nematodes experiencing osmotic stress signal to the germline to prepare their offspring. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] Hypothermia-induced neuroprotection
A reticulon contributes to the neuroprotective effects of hypothermia. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] sTREM2 and neuroinflammation
The soluble form of the innate immune receptor TREM2 promotes microglial survival and inflammatory responses in the brain. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Podcast] Science Signaling Podcast for 14 March 2017: The Cancer Moonshot
Signaling research can contribute to the Cancer Moonshot in many ways. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2017 Category: Science Authors: Michael B. Yaffe and Annalisa M. VanHook Source Type: news

[Review] Degrons in cancer
Understanding protein degradation signals and systems reveals targets for cancer therapy. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2017 Category: Science Authors: B á lint M é sz á ros, Manjeet Kumar, Toby J. Gibson, Bora Uyar, Zsuzsanna Doszt á nyi Source Type: news

[Review] Endoplasmic reticulum proteostasis in glioblastoma-From molecular mechanisms to therapeutic perspectives
Combined therapies targeting the unfolded protein stress response might be a way to treat glioblastomas. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2017 Category: Science Authors: Joanna Obacz, Tony Avril, Pierre-Jean Le Reste, Hery Urra, V �ronique Quillien, Claudio Hetz, Eric Chevet Source Type: news

[Review] Molecular mechanisms and therapeutic targets in pediatric brain tumors
Molecular signatures hint at new opportunities for targeted and selective therapies for children with brain tumors. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2017 Category: Science Authors: Kun-Wei Liu, Kristian W. Pajtler, Barbara C. Worst, Stefan M. Pfister, Robert J. Wechsler-Reya Source Type: news

[Research Article] PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer
Prostate-specific membrane antigen is both a diagnostic marker and an indicator for personalized therapeutic intervention for cancer patients. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2017 Category: Science Authors: Leslie Ann Caromile, Kristina Dortche, M. Mamunur Rahman, Christina L. Grant, Christopher Stoddard, Fernando A. Ferrer, Linda H. Shapiro Source Type: news

[Research Article] Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes
Systematic tissue antigen analysis reveals the stepwise changes in protein activity that drive melanoma. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2017 Category: Science Authors: Christian Ostalecki, Jung-Hyun Lee, Jochen Dindorf, Lena Collenburg, Stephan Schierer, Beate Simon, Stefan Schliep, Elisabeth Kremmer, Gerold Schuler, Andreas S. Baur Source Type: news

[Editorial Guide] Focus Issue: Cancer-Beyond tumor genetics to protein landscapes
Changes in the protein landscape of both the tumor and surrounding cells hold the keys to effectively treating cancer. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 12, 2017 Category: Science Authors: Leslie K. Ferrarelli and Nancy R. Gough Source Type: news

[Editors' Choice] Of nerves and stomach cancer
Blocking a feed-forward cholinergic loop between gastric neurons and the mucosal epithelium may inhibit proliferation in tumor-associated stem cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 7, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] UV radiation induces a gene's dual functionality
A protein and noncoding RNA encoded by the same gene have opposing roles in the response to UV radiation-induced damage. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 7, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Research Resource] Identifying protein kinase-specific effectors of the osmostress response in yeast
Phosphoproteomics identifies direct and indirect targets of the kinase Hog1 during the yeast osmostress response. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 7, 2017 Category: Science Authors: Natalie Romanov, David Maria Hollenstein, Marion Janschitz, Gustav Ammerer, Dorothea Anrather, Wolfgang Reiter Source Type: news

[Research Article] RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKa
The signal to move or proliferate diverges at RAF1. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 7, 2017 Category: Science Authors: Andrea Varga, Karin Ehrenreiter, Bertram Aschenbrenner, Pawel Kocieniewski, Marek Kochanczyk, Tomasz Lipniacki, Manuela Baccarini Source Type: news

[Research Article] Dosage-dependent regulation of VAV2 expression by Steroidogenic Factor-1 drives adrenocortical carcinoma cell invasion
Inhibiting the guanine nucleotide exchange factor VAV2 may prevent metastatic progression of adrenocortical carcinoma. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 7, 2017 Category: Science Authors: Carmen Ruggiero, Mabrouka Doghman-Bouguerra, Silviu Sbiera, Iuliu Sbiera, Maddy Parsons, Bruno Ragazzon, Aur é lie Morin, Estelle Robidel, Judith Favier, J é r ô me Bertherat, Martin Fassnacht, Enzo Lalli Source Type: news

[Research Article] Cytoskeletal adaptivity regulates T cell receptor signaling
A stiffer cytoskeleton limits the responsiveness of na ï ve T cells; a flexible cytoskeleton enables easy activation of effector T cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 2, 2017 Category: Science Authors: Timothy J. Thauland, Kenneth H. Hu, Marc A. Bruce, Manish J. Butte Source Type: news

[Editors' Choice] Ferroptosis-like cell death in plants
Heat stress induces a form of cell death in plants that is morphologically and biochemically similar to ferroptosis in animal cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] Hypoxia-induced plasticity in cancer cell migration
Hypoxia stimulates cancer cells to switch from collective migration to amoeboid migration. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Podcast] Science Signaling Podcast for 28 February 2017: Balancing autophagy in the stressed heart
The protein DDiT4L protects the heart from pathological hypertrophy by stimulating autophagy (Simonson et al. in 28 February 2017 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2017 Category: Science Authors: Saumya Das and Annalisa M. VanHook Source Type: news

[Review] Target acquired: Selective autophagy in cardiometabolic disease
Boosting the autophagic degradation of dysfunctional organelles could be used to treat various cardiometabolic diseases. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2017 Category: Science Authors: Trent D. Evans, Ismail Sergin, Xiangyu Zhang, Babak Razani Source Type: news

[Review] Mitochondrial homeostasis in adipose tissue remodeling
Degradation of mitochondria through autophagy determines adipocyte identity and function. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2017 Category: Science Authors: Svetlana Altshuler-Keylin and Shingo Kajimura Source Type: news

[Review] Retrograde signaling from autophagy modulates stress responses
Autophagy-related proteins regulate the activity of transcription factors that mediate stress-induced changes in gene expression. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2017 Category: Science Authors: Hans-Uwe Simon, Robert Friis, Stephen W. G. Tait, Kevin M. Ryan Source Type: news

[Research Article] DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress
The mTORC1 inhibitor DDiT4L prevents the increase in heart size caused by stress. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2017 Category: Science Authors: Bridget Simonson, Vinita Subramanya, Mun Chun Chan, Aifeng Zhang, Hannabeth Franchino, Filomena Ottaviano, Manoj K. Mishra, Ashley C. Knight, Danielle Hunt, Ionita Ghiran, Tejvir S. Khurana, Maria I. Kontaridis, Anthony Rosenzweig, Saumya Das Source Type: news

[Editorial Guide] Focus Issue: Autophagy as hero and villain
Context dictates whether autophagic responses to stress are beneficial or detrimental. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 26, 2017 Category: Science Authors: Wei Wong Source Type: news

[Editors' Choice] Microbiome-dependent recombination shapes the host antibody repertoire
Secreted IgD concentration depends on the presence of microbiota. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 21, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] New connections: New targets for fighting hepatic steatosis
Insight into the signaling pathways that regulate de novo lipogenesis may lead to new treatments for hepatic steatosis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 21, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Research Article] Pentraxin-3 is a PI3K signaling target that promotes stem cell-like traits in basal-like breast cancers
PI3K-stimulated induction of pentraxin-3 links innate immune signaling with the growth of basal-like breast cancer. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 21, 2017 Category: Science Authors: Cl é mence Thomas, Whitney Henry, Benjamin G. Cuiffo, Anthony Y. Collmann, Elisabetta Marangoni, Vanessa Benhamo, Manoj K. Bhasin, Cheng Fan, Laetitia Fuhrmann, Albert S. Baldwin, Charles Perou, Anne Vincent-Salomon, Alex Toker, Antoine E. Karnoub Source Type: news

[Research Article] Transcriptional activation of lipogenesis by insulin requires phosphorylation of MED17 by CK2
Phosphorylation of MED17 by distinct kinases enables nutrient-dependent transcriptional activation of lipogenesis by insulin. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 21, 2017 Category: Science Authors: Jose A. Viscarra, Yuhui Wang, Il-Hwa Hong, Hei Sook Sul Source Type: news

[Research Article] Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties
ST034307 is a selective AC1 inhibitor with analgesic activity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 21, 2017 Category: Science Authors: Tarsis F. Brust, Doungkamol Alongkronrusmee, Monica Soto-Velasquez, Tanya A. Baldwin, Zhishi Ye, Mingji Dai, Carmen W. Dessauer, Richard M. van Rijn, Val J. Watts Source Type: news

[Research Article] The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo
A molecule from red berries blocks the activity of a proinflammatory cytokine and alleviates inflammation in mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 21, 2017 Category: Science Authors: Caini Liu, Liang Zhu, Koichi Fukuda, Suidong Ouyang, Xing Chen, Chenhui Wang, Cun-jin Zhang, Bradley Martin, Chunfang Gu, Luke Qin, Suguna Rachakonda, Mark Aronica, Jun Qin, Xiaoxia Li Source Type: news

[Editorial Guide] Sources of variation: Animal microbiota
Researchers need to consider experimental design from the microbiota point of view. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 15, 2017 Category: Science Authors: Alexandra A. Mushegian Source Type: news

[Editors' Choice] Pseudophosphatase as E3 ubiquitin ligase inhibitor
The pseudophosphatase STYX prevents the substrate recognition subunit FBXW7 from binding the catalytic E3 ubiquitin ligase complex. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 15, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] When silencing mRNA, position matters
The mechanism of posttranscriptional silencing by an RNA-binding protein depends on the position of the protein-binding sequence in the mRNA. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 15, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] Tamoxifen as an immunotherapy
Antiestrogen drugs may treat some estrogen receptor-negative tumors by limiting the proliferation and activity of suppressive immune cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 15, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Research Resource] A high-throughput, image-based screen to identify kinases involved in brown adipocyte development
Multiple kinases are potential targets to enhance the development and function of brown fat. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 15, 2017 Category: Science Authors: Aliki Perdikari, Elisabeth Kulenkampff, Carla Rudigier, Heike Neubauer, Gerd Luippold, Norbert Redemann, Christian Wolfrum Source Type: news

[Research Article] Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
Acetylation ofMDM2 promotes its oncogenic function by blocking its self-ubiquitination while enhancing its ubiquitination of the tumor suppressor p53. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 15, 2017 Category: Science Authors: Naoe T. Nihira, Kohei Ogura, Kouhei Shimizu, Brian J. North, Jinfang Zhang, Daming Gao, Hiroyuki Inuzuka, Wenyi Wei Source Type: news

[Research Article] The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection
Targeting a microRNA that inhibits type I interferon production may be a strategy to treat Japanese encephalitis virus infection. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 9, 2017 Category: Science Authors: Bibhabasu Hazra, Kanhaiya Lal Kumawat, Anirban Basu Source Type: news

[Editors' Choice] New connections: Protein trafficking for strong bones and teeth
Distinct mechanisms of dysregulated protein secretion result in weak bones or teeth. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 7, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] Tumors direct vessels to feed growth
Blood vessels go from blocking growth factor signaling with IGFBP7 to sending the growth factor IGF1 in response to tumor-released FGF4. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 7, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

[Editors' Choice] Recovering rRNA processing after heat shock
NF- κ B repressing factor controls localization and activation of an rRNA processing protein in heat stress response. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 7, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news