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Total 1753436 results found since Jan 2013.

An automated synthesis of 177Lu-EDTMP as an efficient bone-seeking therapeutic radiopharmaceutical
CONCLUSIONS: These findings demonstrated that the 177Lu-EDTMP radiopharmaceutical could be used safely to achieve considerable therapeutic efficacy, in metastatic bone pain palliation together with the safe clinical application and low radiation exposure during preparation.PMID:34337731 | DOI:10.26355/eurrev_202107_26396
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: U Elboga B Kilbas E Sahin Y B Cay ırlı K Eryilmaz T Begec H E Bakar G Mercanoglu Y Z Celen Source Type: research

Use of Deep-Learning Genomics to Discriminate Healthy Individuals from Those with Alzheimer's Disease or Mild Cognitive Impairment
CONCLUSION: The DLG model can achieve higher accuracy and sensitivity when applied to progression of AD. More importantly, we discovered several novel genetic biomarkers of AD progression, including rs6311 and rs6313 in HTR2A, rs1354269 in NAV2, and rs690705 in RFC3. The roles of these novel loci in AD should be explored in future research.PMID:34336000 | PMC:PMC8298161 | DOI:10.1155/2021/3359103
Source: Behavioural Neurology - August 2, 2021 Category: Neurology Authors: Lanlan Li Yeying Yang Qi Zhang Jiao Wang Jiehui Jiang Alzheimer's Disease Neuroimaging Initiative Source Type: research

A new and reliable landmark in parotid surgery: tragomastoid groove (Akil Groove)
CONCLUSIONS: The tragomastoid groove was defined for the first time in the literature as a reliable landmark for identifying the facial nerve truncus easily during parotid surgery.PMID:34337727 | DOI:10.26355/eurrev_202107_26391
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: F Akil V Kinis U Yilmaz M Akdag S F Toprak M Ayral H Durak Source Type: research

Efficacy of intravenous perioperative parecoxib administration in the surgical fixation of unstable ankle fracture: a prospective, double-blinded, randomized, placebo-controlled trial
CONCLUSIONS: Although the perioperative administration of parecoxib did not provide significantly better postoperative pain control or reduce the opioid requirement relative to placebo, its use led to a shorter hospital stay.PMID:34337726 | DOI:10.26355/eurrev_202107_26390
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: C Angthong S Manuwong V Singh P Rajbhandari A Veljkovic Source Type: research

Efficacy and effect of intracameral adrenaline infusion on pulse rate and blood pressure during phacoemulsification in patients with dark irides
CONCLUSIONS: In comparison with the use of preoperative topical mydriatics alone, adding intracameral adrenaline to the irrigation fluid maintains better pupillary dilatation throughout Phacoemulsification surgery, thereby providing better clinical outcomes in dark irides, even in those with IFIS. Its use has no incremental effect on either blood pressure or pulse rate.PMID:34337725 | DOI:10.26355/eurrev_202101_26389
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: K M Alabdulwahhab Source Type: research

PCSK9 and inflammatory biomarkers in the early post kidney transplantation period
CONCLUSIONS: PCSK9 levels were increased post-KTx independently from renal function and inflammatory biomarkers, in both living and deceased-donor recipients.PMID:34337724 | DOI:10.26355/eurrev_202107_26388
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: C Melexopoulou S Marinaki E Oikonomou M J Bonios P Theofilis A Miliou G Siasos D Tousoulis J N Boletis Source Type: research

A novel modification of frozen elephant trunk technique: unique protocol from one institution
CONCLUSIONS: Our modification of FET technique was feasible, effective, and safe, with good postoperative outcomes.PMID:34337721 | DOI:10.26355/eurrev_202107_26384
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: D H S Phung T S Nguyen H-L Vo N T Vu N T Duong V L Pham Q H Doan H U Nguyen Source Type: research

Meta-analysis of the effects of furosemide combined with hydration therapy on contrast-induced acute kidney injury after coronary intervention
CONCLUSIONS: Furosemide combined with hydration therapy has no significant effect on the incidence of CI-AKI in patients after coronary intervention but can reduce the incidence of MACEs and mortality, thereby providing clinical benefits.PMID:34337720 | DOI:10.26355/eurrev_202107_26383
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: M-J Hu E-F Luo C-C Tang L Wang Q-G Zhang J-B Gong Source Type: research

Lipidomic analysis of meibomian glands from type-1 diabetes mouse model and preliminary studies of potential mechanism
In this study, we found that the amount of lipids in the meibomian acini in STZ-induced type 1 diabetic mice decreased, and the lipid droplets became larger and irregular. In all, 31 lipid subclasses were identified in the mouse MGs, which contained 1378 lipid species in total through lipidomics analysis based on LC-MS/MS. Diabetes caused a significant increase in the content of ceramides (Cer) in the MGs but a significant decrease in the ration of sphingomyelin to ceramides (SM/Cer). The quantity of meibocytes in diabetic mice was dramatically decreased, and the proliferation activity was alleviated, which may be associat...
Source: Experimental Eye Research - August 2, 2021 Category: Opthalmology Authors: Huifeng Wang Qingjun Zhou Luqin Wan Menglong Guo Chen Chen Junfa Xue Lingling Yang Lixin Xie Source Type: research

Iguratimod attenuates general disease activity and improves lung function in rheumatoid arthritis-associated interstitial lung disease patients
CONCLUSIONS: Iguratimod attenuates general inflammation, disease activity, and improves lung function in RA-ILD patients.PMID:34337716 | DOI:10.26355/eurrev_202107_26379
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: P Shu S-Q Shao X-N Cai D-M Zhou H Ma L Lu H-Q Yin S-L Yin Source Type: research

Timing of pancreatic enzyme replacement therapy (PERT) in cystic fibrosis
CONCLUSIONS: We were unable to determine whether one dosing schedule for PERT is better than another since we identified no eligible RCTs. While the introduction of PERT to people with CF can improve their nutritional status, there are a limited number of studies which address this review question, and none met our eligibility criteria. Since malnutrition and adverse gastrointestinal symptoms remain a common feature in CF, the assessment of the relative performance of dosing schedules may provide evidence to improve outcomes in people with CF who are pancreatic insufficient. Further research is needed to fully evaluate the...
Source: Cochrane Database of Systematic Reviews - August 2, 2021 Category: General Medicine Authors: Christabella Ng Giles Major Alan R Smyth Source Type: research

Implementation of a  standardized clinical test kit for diagnostics of periprosthetic infections in the clinical routine
DISCUSSION: In a prospective study it was shown, that the implementation of the standardized test kit lead to a guideline based PJI diagnostic in all cases and thus to a significantly increase of the diagnostic quality. There is currently no single test that reliably excludes or proves an infection. The alpha-defensin laboratory ELISA test showed the best test accuracy, whereby the consideration of test combinations is obligatory and at the same time safe.PMID:34338839 | DOI:10.1007/s00113-021-01016-4
Source: Der Unfallchirurg - August 2, 2021 Category: Orthopaedics Authors: Y Gramlich M Kremer C Br üning J Breuer L Hofmann A Klug R Hoffmann Source Type: research

Incidence rates and employment trends in schizophrenia spectrum disorders, bipolar affective disorders and recurrent depression in the years 2000-2013: a Danish nationwide register-based study
CONCLUSION: This study of three severe mental illness subgroups shows significant increasing incidence rates and decreasing employment rates both before and after the diagnosis between 2000 and 2013, highlighting the importance of timely and correct volume of the psychiatric treatment and vocational rehabilitation programs.PMID:34339349 | DOI:10.1080/08039488.2021.1952304
Source: Nordic Journal of Psychiatry - August 2, 2021 Category: Psychiatry Authors: Thomas Nordahl Christensen Iben Gammelg ård Wallstrøm Lene Falgaard Eplov Thomas Munk Laursen Merete Nordentoft Source Type: research

Rhino-orbital mucormycosis following COVID-19 in previously non-diabetic, immunocompetent patients
CONCLUSIONS: Those involved in the care of COVID-19 patients should be aware about the possibility of recent-onset DM, even in patients without a history of corticosteroid therapy. Rarely, recent-onset DM following COVID-19 may present as rhino-orbital mucormycosis, which requires aggressive surgical and medical intervention.PMID:34338124 | DOI:10.1080/01676830.2021.1960382
Source: Orbit - August 2, 2021 Category: Opthalmology Authors: Akshay Gopinathan Nair Namrata G Adulkar Lynn D'Cunha Priyanka R Rao Renuka A Bradoo Maneesh M Bapaye Abhishek Kothari Tarjani V Dave Chhaya A Shinde Source Type: research

Anterior approach ptosis surgery: comparison of absorbable polyglactin sutures and non-absorbable polyester sutures. Does Vicryl stand the test of time?
CONCLUSION: The use of non-absorbable Ethibond sutures to advance the levator aponeurosis onto the tarsal plate in primary ptosis surgery is associated with improved long-term success and reduced need for secondary surgery.PMID:34334084 | DOI:10.1080/01676830.2021.1958873
Source: Orbit - August 2, 2021 Category: Opthalmology Authors: Gemma S L Manasseh Samantha V Hunt Helen Garrott Rebecca L Ford Richard Caesar Richard A Harrad Source Type: research

Amelanotic melanocytoma of the cervicomedullary junction
Clin Neuropathol. 2021 Aug 2. doi: 10.5414/NP301411. Online ahead of print.ABSTRACTA 64-year-old female with a 1-year history of gait difficulties and right-sided dysesthesias was found to have an intra-axial left-sided exophytic cervicomedullary enhancing mass. Microscopic, immunohistochemical, and ultrastructural findings demonstrated an amelanotic melanocytic neoplasm. Next-generation sequencing with a targeted exomic oncopanel identified a variant of functional significance in the GNA11 gene, thus confirming the diagnosis of a primary amelanotic melanocytoma. The crucial distinction from a melanoma was possible by corr...
Source: Clinical Neuropathology - August 2, 2021 Category: Pathology Authors: Bradley Chaharyn Stephen Yip John A Maguire Source Type: research

A Facile Method for the Quantification of Urinary Uracil Concentration by a Uracil-Specific Fluorescence Derivatization Reaction
Chem Pharm Bull (Tokyo). 2021;69(8):768-772. doi: 10.1248/cpb.c21-00221.ABSTRACTA facile and reliable fluorescence method for the quantification of urinary uracil concentration is proposed herein. The assay utilizes a specific fluorescence (FL) derivatization reaction for uracil using 3-methylbenzamidoxime as a fluorogenic reagent. Although the presence of urine inhibited the FL reaction, 10 µL of urine was sufficient for the detection of urinary uracil. The uracil derivative was successfully separated from other fluorescent impurities using simple reversed-phase LC with FL detection. Urinary uracil concentrations from 16...
Source: Chemical and Pharmaceutical Bulletin - August 2, 2021 Category: Drugs & Pharmacology Authors: Takayuki Shibata Ryosuke Shimamura Yuji Yamamoto Hiroki Sakurai Junya Fujita Asako Yamayoshi Toshimitsu Nemoto Tsutomu Kabashima Source Type: research

Investigation of the Real-World Situation and Risk Factors Associated with Olanzapine Prescribed to Diabetes Patients by Using a Japanese Claims Database
Biol Pharm Bull. 2021;44(8):1151-1155. doi: 10.1248/bpb.b21-00170.ABSTRACTOlanzapine is effective for schizophrenia management; however, it is contraindicated in diabetes patients. In addition, olanzapine is useful for treating nausea and vomiting, such as in the case of chemotherapy-induced nausea and vomiting (CINV). Therefore, we hypothesized that the contraindicated prescription of olanzapine likely occurs among cancer patients with diabetes, especially by non-psychiatric physicians. Hence, we conducted a nationwide survey to elucidate the situation of such contraindicated prescriptions and the associated risk factors....
Source: Biological and Pharmaceutical Bulletin - August 2, 2021 Category: Drugs & Pharmacology Authors: Shinsuke Yamashita Shungo Imai Kenji Momo Hitoshi Kashiwagi Yuki Sato Mitsuru Sugawara Yoh Takekuma Source Type: research

Androgen-Dependent Differences in the Amounts of CYP mRNAs in the Pig Kidney
Biol Pharm Bull. 2021;44(8):1120-1128. doi: 10.1248/bpb.b21-00333.ABSTRACTWe previously reported androgen-dependent sex and breed differences in the amounts of mRNAs of CYP isoforms in the pig liver. To clarify whether there are such sex and breed differences in the kidney, we examined the amounts of several CYP mRNAs in the kidney using both sexes of 5-month-old Landrace, Meishan and/or their crossbred F1 (LM and ML) pigs. Significant sex differences in the amounts of several CYP mRNAs were found: male < female for CYP2A19 and CYP3A29; and male > female for CYP4A24/25 in all the breeds. Sex differences in the amount...
Source: Biological and Pharmaceutical Bulletin - August 2, 2021 Category: Drugs & Pharmacology Authors: Misaki Kojima Masakuni Degawa Source Type: research

Differences in Pharmaceutical Intervention Triggers for the Optimization of Medication by Patient Age: A University Hospital Study
In this study, the impact of medication review by pharmacists on medication optimization and avoidance of adverse drug events (ADE) was investigated, as well as differences in the triggers for pharmaceutical intervention to allow for optimization of medication by patient age. Data for this study were collected from reports recorded between April 2013 and March 2019 for patients admitted to the Hiroshima University Hospital. In response to pharmacists' proposals, prescriptions were modified in 18932 cases, comprising 17% of the total 111479 patients during hospitalization. The frequency of such intervention was higher in el...
Source: Biological and Pharmaceutical Bulletin - August 2, 2021 Category: Drugs & Pharmacology Authors: Yuuka Shibata Hideki Itoh Hiroaki Matsuo Kazue Nakajima Source Type: research

Transformative dynamism in pharmaceutical and biomedical research: Complexity of integration of innovative R & amp; D hubs
Conclusion: To achieve a fully functional innovative R & D hub, a "know-how" approach with the systems thinking mindset within all the parties is of paramount necessity. The healthier the order of the whole working system is, the more effective will be the encompassed entitles and players. However, systems should have several checkpoints to enhance clarity and evade discrepancy and divergence. Since the medication is a highly trusted and needed public enterprise, the drug discovery and development paradigm should be practiced at the highest speed with maximum transparency and accountability.PMID:34336611 | PMC:PMC83140...
Source: BioImpacts - August 2, 2021 Category: Research Authors: Yadollah Omidi Hossein Omidian Source Type: research

Thrombotic potential during pediatric acute lymphoblastic leukemia induction: Role of cell-free DNA
CONCLUSION: We conclude that childhood ALL is associated with a prothrombotic milieu at the time of diagnosis that continues during induction chemotherapy, and cfDNA contributes to increased thrombogenic potential.PMID:34337307 | PMC:PMC8312738 | DOI:10.1002/rth2.12557
Source: Thrombosis and Haemostasis - August 2, 2021 Category: Hematology Authors: Rahul Kumar Parmeshwar B Katare Steven R Lentz Arunkumar J Modi Anjali A Sharathkumar Sanjana Dayal Source Type: research

Establishing the promising role of novel combination of triple therapeutics delivery using polymeric nanoparticles for Triple negative breast cancer therapy
Conclusion: The current investigation focuses on designing a multifunctional drug delivery platform for concurrent delivery of either PAC or PARP inhibitor (olaparib) and FOXM1 siRNA in chitosan-coated poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) with the ability to emerge as a front runner therapeutic for TNBC therapy.PMID:34336608 | PMC:PMC8314031 | DOI:10.34172/bi.2021.27
Source: BioImpacts - August 2, 2021 Category: Research Authors: Ranjita Misra Bamadeb Patra Sudha Varadharaj Rama Shanker Verma Source Type: research

Characterization of isolated compounds from < em > Morus < /em > spp. and their biological activity as anticancer molecules
Conclusion: The study generated interesting results in terms of health benefits of Morus species by documenting their antioxidant and anticancer activities, thereby validating the folk claims of therapeutic benefits of mulberry.PMID:34336607 | PMC:PMC8314033 | DOI:10.34172/bi.2021.09
Source: BioImpacts - August 2, 2021 Category: Research Authors: Aditya Rao Rao Shimoga Janakirama Suma Mathad Shivayogi Jamuna Kolkar Satyanarayana Ramesh Chapeyil Kumaran Source Type: research

Association Between TLR4 Gene Polymorphisms and Risk of Preeclampsia: Systematic Review and Meta-Analysis
CONCLUSIONS TLR4 rs4986790 and rs4986791 polymorphisms may not be implicated in PE susceptibility, primarily in a White population. More high-quality studies of genetic associations with PE are warranted.PMID:34334784 | DOI:10.12659/MSM.930438
Source: Medical Science Monitor - August 2, 2021 Category: Research Authors: Manni Sun Hui Jiang Tao Meng Peiyan Liu Haiying Chen Source Type: research

Potential of Olive oil and its phenolic compounds as therapeutic intervention against colorectal cancer: A comprehensive review
Br J Nutr. 2021 Aug 2:1-50. doi: 10.1017/S0007114521002919. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the major causes of death across the world and incidence rate of CRC increasing alarmingly each passing year. Diet, genomic anomalies, inflammation and deregulated signaling pathways are among the major causes of CRC. Because of numerous side effects of CRC therapies available now, researchers all over the world looking for alternative treatment/preventive strategy with lesser/no side effects. Olive oil which is part of Mediterranean diet contains numerous phenolic compounds that fight against free ra...
Source: The British Journal of Nutrition - August 2, 2021 Category: Nutrition Authors: Arindam Sain Sakshi Sahu Debdut Naskar Source Type: research

Diabetes-related quality of life in six European countries measured with the DOQ-30
CONCLUSION: Descriptive and clinical characteristics were weakly associated with perceived obstacles. However, the residential country plays an essential role in the decline of the QoL of PWDs. Education of both PWDs and healthcare professionals (HCPs) plays an essential role in countering the fear of insulin.PMID:34338125 | DOI:10.1080/13814788.2021.1954615
Source: European Journal of General Practice - August 2, 2021 Category: Primary Care Authors: Liina Pilv Etienne I J J Vermeire Anneli R ätsep Alain Moreau Davorina Petek Hakan Yaman Marje Oona Ruth Kalda Source Type: research

Task shifting in primary care to tackle healthcare worker shortages: An umbrella review
CONCLUSION: Evidence suggests that allied healthcare workers such as pharmacists and nurses can potentially undertake substantially expanded roles to support physicians in primary care in response to the changing health service demand. Tasks include providing care to patients, independent prescribing, counselling and education, with comparable quality of care.PMID:34334095 | DOI:10.1080/13814788.2021.1954616
Source: European Journal of General Practice - August 2, 2021 Category: Primary Care Authors: Siew Lian Leong Siew Li Teoh Weng Hong Fun Shaun Wen Huey Lee Source Type: research

Effects of tourniquet inflation on peri- and postoperative cefuroxime concentrations in bone and tissue
Acta Orthop. 2021 Aug 2:1-7. doi: 10.1080/17453674.2021.1942620. Online ahead of print.ABSTRACTBackground and purpose - Tourniquet is widely used in orthopedic surgery to reduce intraoperative bleeding and improve visualization. We evaluated the effect of tourniquet application on peri- and postoperative cefuroxime concentrations in subcutaneous tissue, skeletal muscle, calcaneal cancellous bone, and plasma. The primary endpoint was the time for which the free cefuroxime concentration was maintained above the clinical breakpoint minimal inhibitory concentration (T > MIC) for Staphylococcus aureus (4 µg/mL).Patients and...
Source: Acta Orthopaedica - August 2, 2021 Category: Orthopaedics Authors: Pelle Hanberg Mats Bue Jesper Kabel Andrea Ren é Jørgensen Christian Jessen Kjeld S øballe Maiken Stilling Source Type: research

Risk-benefit analysis of 9-valent HPV vaccination for adolescent boys from an individual perspective
Jpn J Infect Dis. 2021 Jul 30. doi: 10.7883/yoken.JJID.2021.367. Online ahead of print.ABSTRACTJapan recently approved quadrivalent human papillomavirus (HPV) vaccine for males, but 9-valent vaccine is only approved for females. Given the low female vaccination rate due to a concern of adverse events in Japan, quantifying the risk and benefit of the HPV vaccination for male may help the decision making to vaccinate adolescent boys in Japan. Using quality-adjusted life years, the risk-benefit ratio for an adolescent boy to get the 9-valent HPV vaccination was calculated. The male HPV vaccination reduced the QALY gain due to...
Source: Japanese Journal of Infectious Diseases - August 2, 2021 Category: Infectious Diseases Authors: Taito Kitano Source Type: research

Molecular epidemiology of Microsporum canis isolated from Japanese cats, dogs and pet owners by multilocus microsatellite typing fragment analysis
Jpn J Infect Dis. 2021 Jul 30. doi: 10.7883/yoken.JJID.2020.809. Online ahead of print.ABSTRACTMultilocus microsatellite typing (MLMT) was performed on 93 strains of Microsporum canis isolated between 2012 and 2017 from 75 cats, eight dogs and 10 pet owners. These strains were derived from two major reservoirs: commercial breeding facilities and pet shops (PS), and stray cats and pet cats that went outdoors and came in contact with stray cats (Outdoor). Six microsatellite markers were used for genotyping. These 93 strains included 22 genotypes, 11 previously detected in Japan and 11 new genotypes. Strains belonging to the ...
Source: Japanese Journal of Infectious Diseases - August 2, 2021 Category: Infectious Diseases Authors: Shigeo Yamada Kazushi Anzawa Takashi Mochizuki Source Type: research

Wastewater-Based Epidemiology of Enteric Viruses and Surveillance of Acute Gastrointestinal Illness Outbreaks in a Resource-Limited Region
This study applied the principles of wastewater-based epidemiology for the preventive identification of potential outbreaks of acute viral gastroenteritis and hepatitis A by analyzing the presence of human enteric viruses in influents of small municipal wastewater treatment plants (WWTPs) handling domestic sewage, together with public health reports of acute diarrheal and hepatitis A disease in Costa Rica during 2013. Raw wastewater samples were collected during four seasonal periods with different rainfall levels. The presence of five human enteric viruses (rotavirus A, norovirus GI, norovirus GII, enterovirus, and hepati...
Source: Am J Trop Med Hyg - August 2, 2021 Category: Infectious Diseases Authors: Luz Chac ón Eric Morales Carmen Valiente Liliana Reyes Kenia Barrantes Source Type: research

The new unbounded number line estimation task: A systematic literature review
Acta Psychol (Amst). 2021 Jul 30;219:103366. doi: 10.1016/j.actpsy.2021.103366. Online ahead of print.ABSTRACTIn 2011, Cohen and Blanc-Goldhammer introduced a new unbounded version of the number line estimation task which they argued to overcome limitations of its 'traditional' bounded counterpart. In line with this proposition, there is increasing evidence that the unbounded number line estimation task may indeed reflect a purer measure of the underlying representation of number magnitude. However, only few studies used this task version yet. In the present literature review, we aimed at evaluating all studies employing t...
Source: Acta Psychologica - August 2, 2021 Category: Psychiatry & Psychology Authors: Regina Miriam Reinert Korbinian Moeller Source Type: research

Examination of Analytical Method for Mothproofing Agents to Revise the Official Methods Based on "Act on the Control of Household Products Containing Harmful Substances"
Yakugaku Zasshi. 2021;141(8):1031-1040. doi: 10.1248/yakushi.21-00058.ABSTRACTIn Japan, the use of mothproofing agents [dieldrin and 4,6-dichloro-7-(2,4,5-trichlorophenoxy)-2-trifluoromethylbenzimidazole; DTTB] in textiles is regulated by the Act on the Control of Household Products Containing Harmful Substances. Since official analytical methods for these agents have been in place for approximately 40 years, we developed an improved method in a previous study. In the present study, we validated this method. Accordingly, six laboratories analyzed the sample prepared at 3 μg/g (1/10 of the regulation value) and 30 μg/g (t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2021 Category: Drugs & Pharmacology Authors: Iwaki Nishi Hitoshi Uemura Tomoko Ooshima Naeko Sugaya Kaori Innami Kayo Tabata Tsuyoshi Kawakami Source Type: research

Clinical Usefulness of Nested Reverse-Transcription Polymerase Chain Reaction for the Diagnosis of Severe Fever with Thrombocytopenia Syndrome
Am J Trop Med Hyg. 2021 Aug 2:tpmd210183. doi: 10.4269/ajtmh.21-0183. Online ahead of print.ABSTRACTSevere fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV) is an emerging tick-borne infectious disease. Few studies have assessed the clinical usefulness of nested reverse-transcription polymerase chain reaction (RT-PCR) for diagnosing SFTS. We performed conventional RT-PCR targeting the M segment, nested RT-PCR targeting M and S segments, and real-time RT-PCR targeting the S segment of SFTSV for four patients with suspected SFTS. Although conventional RT-PCR results for the first two patients were neg...
Source: Am J Trop Med Hyg - August 2, 2021 Category: Infectious Diseases Authors: Choon Mee Kim Dong-Min Kim Na-Ra Yun Source Type: research

Pharmaceutical Intervention According to Strict Management System Can Normalize Decreased Serum Calcium Level by Denosumab and Prevent Its Aggravation
In conclusion, pharmaceutical interventions according to our management system benefit safe denosumab treatment, especially in severe hypocalcemia prevention.PMID:34334547 | DOI:10.1248/yakushi.21-00055
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 2, 2021 Category: Drugs & Pharmacology Authors: Yoshitaka Saito Kazuki Uchiyama Tatsuhiko Sakamoto Kojiro Yamazaki Kosei Kubota Yoh Takekuma Yoshito Komatsu Mitsuru Sugawara Source Type: research

Chikungunya Fever in Southern Thailand, 2018
Am J Trop Med Hyg. 2021 Aug 2:tpmd210436. doi: 10.4269/ajtmh.21-0436. Online ahead of print.ABSTRACTInfection by the mosquito-borne chikungunya virus (CHIKV) causes acute febrile illness and debilitating arthralgia. Outbreaks are sometimes not recognized because of its clinical resemblance to the more common dengue fever ubiquitous in tropical countries. An upsurge of dengue-like illness was reported in Satun province located in southern Thailand during the rainy season in 2018. We investigated probable outbreak of CHIKV disease. We collected serum samples from 127 patients and tested for CHIKV infection based on nucleic a...
Source: Am J Trop Med Hyg - August 2, 2021 Category: Infectious Diseases Authors: Natthaphon Nanakorn Theerakamol Pengsakul Kannika Bunrod Suwich Thammapalo Pathomporn Prikchoo Sompong Vongpunsawad Yong Poovorawan Source Type: research

Clinical Features of Acute Chikungunya Virus Infection in Children and Adults during an Outbreak in the Maldives
We describe the genotype and polymorphism of Maldives chikungunya virus using phylogenetic analysis. All isolates were consistent with the East Central South African genotype of the Indian Ocean lineage, with a specific E1-K211E mutation. In addition, we explored the clinical and laboratory manifestations of acute chikungunya in children and adults, of which severe infection was found in some children, whereas arthritis primarily occurred in adults. Arthritides in adults occurred irrespective of underlying comorbidities and were associated with the degree of viremia.PMID:34339379 | DOI:10.4269/ajtmh.21-0189
Source: Am J Trop Med Hyg - August 2, 2021 Category: Infectious Diseases Authors: Hisham Ahmed Imad Juthamas Phadungsombat Emi E Nakayama Keita Suzuki Ahmed Mifthah Ibrahim Aminath Afaa Aminath Azeema Aminath Nazfa Aminath Yazfa Anoosha Ahmed Athifa Saeed Azna Waheed Fathimath Shareef Mohamed Moinul Islam Shausha Mohamed Anees Sana Sal Source Type: research

Prediction and cost-effectiveness comparison of amblyopia screening methods at ages 3-4  years
CONCLUSIONS: In a previous unscreened population, aged 3-4 years, screening programs using either UCVA or PO alone, should reconsider doing both tests simultaneously, since, for a high level of sensitivity, using simultaneously UCVA + PO is more cost-effective, per screened, and treated amblyopia. Concerns relating higher time-consuming exams for the combination of UCVA + PO should be surpassed, since costs per treated child drop considerably. When children benefit from good primary-care routine examinations since birth, no benefit was found for using CT in a screening setting. SR showed little benefit.PMID:34337976 | DOI:...
Source: European Journal of Ophthalmology - August 2, 2021 Category: Opthalmology Authors: Sandra Viegas Guimaraes Paula Alexandra Veiga Patr ício Soares Costa Eduardo Duarte Silva Source Type: research

Modified Crohn's disease exclusion diet is equally effective as exclusive enteral nutrition: Real-world data
CONCLUSION: Treatment with CDED + PEN (with prior 1-2 weeks of EEN) has comparable efficacy to EEN therapy alone in inducing remission in children with CD, and it leads to better weight gain. Further studies are needed to confirm these results.PMID:34339527 | DOI:10.1002/ncp.10752
Source: Nutrition in Clinical Practice - August 2, 2021 Category: Nutrition Authors: Tena Niseteo Sara Sila Ivana Trivi ć Zrinjka Mi šak Sanja Kola ček Iva Hojsak Source Type: research

Evaluation of nutrition status of very preterm infants in neonatal intensive care units using different growth indicators
CONCLUSIONS: Indicator III, change in weight z-score from birth to discharge (adjusted for birth weight z-score, gestational age, and time to regain birth weight), appears to be the most accurate for evaluating the quality of nutrition in the NICU.PMID:34339517 | DOI:10.1002/ncp.10741
Source: Nutrition in Clinical Practice - August 2, 2021 Category: Nutrition Authors: Na Wang Jia Zhang Zhangbin Yu Bin Tang Lin Zhang Yujie Yin Zengqin Wang Shuangshuang Li Shanyu Jiang Weiwei Hou Yan Gao Huaiyan Wang Xiaoqing Chen Xiaoyi Deng Yi Lu Lingling Zhu Lin Bo Shuping Han Source Type: research

Isolation and Characterization of Urease-Producing Soil Bacteria
Int J Microbiol. 2021 Jul 9;2021:8888641. doi: 10.1155/2021/8888641. eCollection 2021.ABSTRACTUrease is an enzyme produced by ureolytic microorganisms which hydrolyzes urea into ammonia and carbon dioxide. Microbial urease has wide applications in biotechnology, agriculture, medicine, construction, and geotechnical engineering. Urease-producing microbes can be isolated from different ecosystems such as soil, oceans, and various geological formations. The aim of this study was to isolate and characterize rapid urease-producing bacteria from Ethiopian soils. Using qualitative urease activity assay, twenty urease-producing ba...
Source: International Journal of Microbiology - August 2, 2021 Category: Microbiology Authors: Eshetu Mekonnen Ameha Kebede Asefa Nigussie Gessese Kebede Mesfin Tafesse Source Type: research

Asymptomatic Bacteriuria among Pregnant Women in Addis Ababa, Ethiopia: Prevalence, Causal Agents, and Their Antimicrobial Susceptibility
This study aimed to estimate the prevalence of ASBU and potential risk factors among pregnant women attending antenatal care centers in Addis Ababa. It also aimed to identify causal bacterial pathogens and to assess their antimicrobial susceptibility. A health facility-based cross-sectional study was conducted from March to June 2019. Urine samples from a total of 281 pregnant women with no symptoms of urinary tract infection were tested for ASBU. Women whose urine samples carried greater than or equal to 105 colony-forming units (CFU) of bacteria per milliliter of urine when grown on plate count agar were considered posit...
Source: International Journal of Microbiology - August 2, 2021 Category: Microbiology Authors: Ketema Bizuwork Haile Alemayehu Girmay Medhin Wondwossen Amogne Tadesse Eguale Source Type: research

Spectrum mutations of PRF1, UNC13D, STX11, and STXBP2 genes in Vietnamese patients with hemophagocytic lymphohistiocytosis
CONCLUSION: Vietnamese patients with HLH showed a distinct genetic variant spectrum, in which UNC13D is the predominant genetic lesion associated with HLH.PMID:34339548 | DOI:10.1111/ijlh.13674
Source: International Journal of Laboratory Hematology - August 2, 2021 Category: Hematology Authors: Phan Thi Xinh Ho Quoc Chuong Truong Pham Hong Diem Tuan Minh Nguyen Nguyen Dinh Van Nguyen Hoang Mai Anh Huynh Nghia Hoang Anh Vu Source Type: research

Prognostic and clinicopathological significance of TMEFF2, SMOC-2, and SOX17 expression in endometrial carcinoma
In conclusion, we demonstrated that both TMEFF2 and SMOC-2 were highly expressed in EC and were associated with a shortened survival rate, dismal outcome, and poor prognosis in EC patients. While SOX17 expression was related to a favorable outcome and its down-regulation was associated with dismal EC patient's survival.PMID:34339705 | DOI:10.1016/j.yexmp.2021.104670
Source: Experimental and Molecular Pathology - August 2, 2021 Category: Pathology Authors: Mohamed Ali Alabiad Ola A Harb Nabila Hefzi Rham Z Ahmed Gamal Osman Amany Mohamed Shalaby Amr Abd-Almohsen Alnemr Yasser S Saraya Source Type: research

Reliability of the Theory of Mind Task Battery (ToM TB) to assess social cognition in post-stroke patients
Top Stroke Rehabil. 2021 Aug 1:1-8. doi: 10.1080/10749357.2021.1948155. Online ahead of print.ABSTRACTTheory of mind is the ability to understand, and infer thoughts or mental states to others. This is a central domain of social cognition that can be impaired after brain injury, resulting in changes in social skills and implications for rehabilitation.The aim of this investigation was to analyze the reliability of the Theory of Mind Task Battery (ToM TB) in post-stroke patients.This is a cross-sectional prospective study with psychometric characteristics, involving 38 patients diagnosed with ischemic or hemorrhagic stroke ...
Source: Topics in Stroke Rehabilitation - August 2, 2021 Category: Neurology Authors: Nayara Karina Ferreira Pereira Gabriele Natane de Medeiros Cirne F ábio Ricardo de Oliveira Galvão Maria Eloiza Costa Wellington Dos Santos Lima J únior Enio Walker Azevedo Cacho Marcos Hortes N Chagas Roberta de Oliveira Cacho Source Type: research

Harvesting cancellous bone or composite corticocancellous bone grafts from the posterior iliac crest
Oper Orthop Traumatol. 2021 Aug 2. doi: 10.1007/s00064-021-00724-9. Online ahead of print.ABSTRACTOBJECTIVE: Harvesting bone-either cancellous bone or composite corticocancellous bone grafts-from the iliac crest is an efficient method for filling or bridging bony defects commonly encountered in comminuted epimetaphyseal fractures (e.g., tibial head fractures), in nonunions or during reconstructive measures as in arthrodesis of major joints or spondylodesis, bone defects due to tumor resection or following eradication of chronic infection.INDICATIONS: All bone defects with a maximum size of 4-5 cm.CONTRAINDICATIONS: Rejecti...
Source: Operative Orthopadie und Traumatologie - August 2, 2021 Category: Orthopaedics Authors: Steffi S I Falk Thomas Mittlmeier Source Type: research

High-performance sonographical multimodal imaging of non cystic thyroid lesions: Chances of the preoperative diagnostics in relation to histopathology
CONCLUSION: Using modern multimodal imaging offers new possibilities for the differentiation between benign and malignant thyroid lesions. It is a very important diagnostic tool in addition to the B-Mode TIRADS classification and eases the decision between TIRADS 3, 4 and 5. However, additional multicenter studies are required for more detailed evaluations.PMID:34334387 | DOI:10.3233/CH-219101
Source: Clinical Hemorheology and Microcirculation - August 2, 2021 Category: Hematology Authors: M Brandenstein I Wiesinger F Jung C Stroszczynski E M Jung Source Type: research

Liver stiffness measured with two-dimensional shear wave elastography comparable to histopathology falls dominantly on the severe liver fibrosis
CONCLUSION: 2D-SWE using a specific diagnostic ultrasound system is effective for the assessment of severe liver fibrosis and cirrhosis, but is limited in diagnosing mild liver fibrosis.PMID:34334386 | DOI:10.3233/CH-211223
Source: Clinical Hemorheology and Microcirculation - August 2, 2021 Category: Hematology Authors: Ya Li Size Wu Source Type: research

Liraglutide improves pancreatic islet β cell apoptosis in rats with type 2 diabetes mellitus by inhibiting the IKKε/NF-κB pathway
CONCLUSIONS: Liraglutide improves pancreatic islet β cell apoptosis in rats with type 2 diabetes mellitus by inhibiting the IKKε/NF-κB pathway.PMID:34337733 | DOI:10.26355/eurrev_202107_26395
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: Y-T Liu T He H-Q Li P Jiang Source Type: research