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Total 1318364 results found since Jan 2013.

Risk of self-harm after the diagnosis of psychiatric disorders in Hong Kong, 2000–10: a nested case-control study
This study aimed to investigate the risk of self-harm following diagnosis of different psychiatric disorders in an Asian population, through a review of inpatient records retrieved from the Hong Kong Clinical Data Analysis and Reporting System (CDARS).MethodsFor this nested case-control study, the inpatient data of people admitted for any reason to Hong Kong public hospitals, between Jan 1, 2000, and Dec 31, 2010, were extracted from CDARS. Cases were people aged 10 years or older who had been admitted to inpatient care with a first-listed record of psychiatric disorder during the study period. The seven psychiatric disord...
Source: The Lancet Psychiatry - January 21, 2020 Category: Psychiatry Source Type: research

Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells.
In conclusion, the addition of PPIs to the treatment regimen of breast cancer appears to be a promising strategy to potentiate the efficacy of chemotherapy and may suppress cancer metastasis. PMID: 31955147 [PubMed - in process]
Source: Acta Pharmaceutica - January 21, 2020 Category: Drugs & Pharmacology Authors: Ihraiz WG, Ahram M, Bardaweel SK Tags: Acta Pharm Source Type: research

Effects of new generation triptans - frovatriptan and almotriptan - on hemodynamic parameters in intact male and female rats.
Abstract The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats. We used a non-invasive "tail-cuff" method to measure the arterial blood pressure. Female and...
Source: Acta Pharmaceutica - January 21, 2020 Category: Drugs & Pharmacology Authors: Saracheva K, Hrischev P, Vasileva L, Topolov M, Nikolova J, Getova D Tags: Acta Pharm Source Type: research

Biopharmaceutical classification of desloratadine - not all drugs are classified the easy way.
Abstract The biopharmaceutical classification of drugs was designed as a basis for bio-waivers - a mechanism with the double ethical benefit of delivering new drug formulations to the market with less human testing and lower cost. However, many drugs defy simple classification because in vitro permeability and stability assessment can be challenging as shown in this study for desloratadine. Literature shows that desloratadine is highly soluble, while data on luminal stability and permeability are circumstantial. Combined with borderline bioavailability and not really known fraction of absorbed dose, desloratadine ...
Source: Acta Pharmaceutica - January 21, 2020 Category: Drugs & Pharmacology Authors: Berginc K, Sibinovska N, Žakelj S, Trontelj J, Legen I Tags: Acta Pharm Source Type: research

Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors.
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries. Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay. All new compounds underwent justification for their target structures via microanalytical and spectral data. SAR studies were performed. Biological results revealed that the most potent compounds were 4-(cyclopent-1-en-3-ylamino)-5-(2-(4-iod...
Source: Acta Pharmaceutica - January 21, 2020 Category: Drugs & Pharmacology Authors: Zaher NH, Mostafa MI, Altaher AY Tags: Acta Pharm Source Type: research

Qualitative and Quantitative Assessment of Technical Skills in Percutaneous Coronary Intervention: In Vivo Porcine Studies
Conclusion: The objective, effective, and comprehensive assessment of technical skills can be provided by qualitatively and quantitatively analyzing interventionalists’ natural behaviors in PCI. Sig- ificance: This paper suggests a novel approach for the technical skill assessment and the promising results demonstrate the great importance and effectiveness of the proposed method for promoting the development of objective assessment techniques.
Source: IEEE Transactions on Biomedical Engineering - January 21, 2020 Category: Biomedical Engineering Source Type: research

Portable Device for Optical Quantification of Hemozoin in Diluted Blood Samples
Conclusion: This paper features an autonomous, portable, 1-min analysis time, and low-cost per test device, without the need for samples, centrifugation, allowing the use of whole blood. Significance: The presented device is a step ahead for meeting the growing clinical demands for reliable, rapid, portable, and quantitative malaria diagnosis.
Source: IEEE Transactions on Biomedical Engineering - January 21, 2020 Category: Biomedical Engineering Source Type: research

Pose Estimation of Periacetabular Osteotomy Fragments With Intraoperative X-Ray Navigation
Conclusion: The proposed pipeline is capable of accurately reporting femoral head coverage within a range clinically identified for long-term joint survivability. Significance: Human interpretation of fragment pose is challenging and usually restricted to rotation about a single anatomical axis. The proposed pipeline provides an intraoperative estimate of rigid pose with respect to all anatomical axes, is compatible with minimally invasive incisions, and has no dependence on external fiducials.
Source: IEEE Transactions on Biomedical Engineering - January 21, 2020 Category: Biomedical Engineering Source Type: research

Investigation of Injection Depth for Subretinal Delivery of Exogenous Glutamate to Restore Vision via Biomimetic Chemical Neuromodulation
Chemical neuromodulation of the retina using native neurotransmitters to biomimetically activate target retinal neurons through chemical synapses is a promising biomimetic alternative to electrical stimulation for restoring vision in blindness caused by photoreceptor degenerative diseases. Recent research has shown that subretinal chemical stimulation could be advantageous for treating photoreceptor degenerative diseases but many of the parameters for achieving efficacious chemical neuromodulation are yet to be explored. In this paper, we investigated how the depth at which neurotransmitter is injected subretinally affects...
Source: IEEE Transactions on Biomedical Engineering - January 21, 2020 Category: Biomedical Engineering Source Type: research

Hyperdimensional Computing With Local Binary Patterns: One-Shot Learning of Seizure Onset and Identification of Ictogenic Brain Regions Using Short-Time iEEG Recordings
Conclusion and significance: Our algorithm provides: 1) a unified method for both learning and classification tasks with end-to-end binary operations; 2) one-shot learning from seizure examples; 3) linear computational scalability for increasing number of electrodes; and 4) generation of transparent codes that enables post-translational support for clinical decision making. Our source code and anonymized iEEG dataset are freely available at http://ieeg-swez.ethz.ch.
Source: IEEE Transactions on Biomedical Engineering - January 21, 2020 Category: Biomedical Engineering Source Type: research

Dynamics and Distant Effects of Frontal/Temporal Epileptogenic Focus Using Functional Connectivity Maps
Conclusion: Epileptic activity originating in the temporal or frontal areas is seen to affect these areas in both hemispheres. Significance: The results obtained express the dynamics of focal epilepsy in context to both the epileptogenic zone and the affected distant areas of the brain.
Source: IEEE Transactions on Biomedical Engineering - January 21, 2020 Category: Biomedical Engineering Source Type: research

Automated Diagnosis of Neonatal Encephalopathy on aEEG Using Deep Neural Networks
Publication date: Available online 20 January 2020Source: NeurocomputingAuthor(s): Jingling Wang, Rong Ju, Yuanyuan Chen, Guijun Liu, Zhang YiAbstractAmplitude-integrated electroencephalography, called aEEG clinically, is an effective approach for monitoring neonatal cerebral function. Early aEEG screening is necessary to diagnose neonatal encephalopathy. The electroencephalography (EEG) signal contains lots of information about infant neurological status and prognosis. Traditional computer-aided diagnosis methods pay more attention to process EEG signal data, while doctors referring more to aEEG screening images in clinic...
Source: Neurocomputing - January 21, 2020 Category: Neuroscience Source Type: research

Biosynthesis and half-life of MBX-2168-triphosphate in herpes virus-infected cells
Publication date: Available online 20 January 2020Source: Antiviral ResearchAuthor(s): Hannah E. Sauer, Marie L. Nguyen, John D. Williams, Terry L. Bowlin, Brian G. GentryAbstractThe third generation of methylenecyclopropane nucleoside analogs (MCPNAs) elicit an anti-viral effect against all three sub-classes of herpes viruses without inducing cytotoxicity in vitro. It has been previously established that the mechanism of action of MCPNAs is similar to that of ganciclovir (GCV) or acyclovir (ACV). However, the activation of MBX-2168, a third generation MCPNA, involves additional and unique enzymatic steps and this process ...
Source: Antiviral Therapy - January 21, 2020 Category: Virology Source Type: research

Sense of coherence and hypertensive target organ damage.
CONCLUSIONS: The findings of this study suggest, that the sense of coherence may not be strongly associated with good somatic health. They may also contribute to the discussion about diagnostic usefulness of the SOC-29 method as a single tool. We believe that the level of sense of coherence should be taken into consideration in further studies on the development of hypertensive TOD. PMID: 31955183 [PubMed - in process]
Source: Psychiatria Polska - January 21, 2020 Category: Psychiatry Tags: Psychiatr Pol Source Type: research

Properties of melanin from Lachnum YM156 and its hepatoprotective effect in Cd-exposure mice
Publication date: Available online 20 January 2020Source: Process BiochemistryAuthor(s): Liuqing Yang, Yaling He, Jinglei Li, Xiaoming Gao, Tingting Chen, Ming YeAbstractNatural melanin was extracted from Lachnum YM156 (LIM). LIM had better thermostability and light resistance, and its solubility was relatively high under alkaline conditions. Simultaneously, we examined its hepatoprotective effect in Cd-exposure mice. Cd-exposure resulted in decreasing weight growth rate, raised liver index, elevated serum levels of alanine aminotransferase (ALT) and aspartate aminotransaminase (AST), and increased Cd accumulation in liver...
Source: Process Biochemistry - January 21, 2020 Category: Biochemistry Source Type: research

Rust for Cheminformatics
ConclusionRust is a fast, safe language for systems development. In its current state, Rust offers the technical ingredients needed to eventually support a robust cheminformatics platform. A handful of tentative efforts using Rust in computational chemistry have appeared, but no project demonstrating the suitability of Rust for cheminformatics exists. This article takes a small step in that direction. Future articles will explore the idea further.
Source: Depth-First - January 21, 2020 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

Evaluation of comprehensive care for older adults in primary care services
CONCLUSIONS The evaluated services had incipient implementation of comprehensive care for older adults. The evaluation framework can contribute to processes to improve the quality of primary health care.RESUMO OBJETIVO Avaliar o desempenho da aten ção integral ao idoso em serviços de atenção primária do Sistema Único de Saúde no estado de São Paulo, Brasi lMÉTODOS Um total de 157 serviços de atenção primária de cinco regiões de saúde do centro-oeste paulista respondeu, de outubro a dezembro de 2014, o instrumento pré-validad o Questionário de Avaliação e Monitoramento de Serviços de Atenção Básica 2...
Source: Revista de Saude Publica - January 21, 2020 Category: International Medicine & Public Health Source Type: research

Prenatal care in the Brazilian public health services
CONCLUSION Improvements in the quality of prenatal care, appropriate coordination and comprehensive care at the time of birth have a potential to reduce prematurity rates and, consequently, infant morbidity and mortality rates in the country.RESUMO OBJETIVO Verificar desigualdades regionais no acesso e na qualidade da aten ção ao pré-natal e ao parto nos serviços públicos de saúde no Brasil e a sua associação com a saúde perinatal. MÉTODOS Nascer no Brasil foi uma pesquisa nacional de base hospitalar realizada entre 2011 e 2012, que incluiu 19.117 mulheres com pagamento público do parto. Diferenças region ais n...
Source: Revista de Saude Publica - January 21, 2020 Category: International Medicine & Public Health Source Type: research

Assessment of Primary Health Care for rural workers exposed to pesticides
CONCLUSIONS Despite the high coverage of the Family Health Strategy, occupational risk and its consequences have not been detected by health services, which do not seem oriented to primary care, even lacking their essential attributes. There is a need for immediate and effective adaptation of public policies regarding the health of rural workers, with adequate training of teams and review of the portfolio of PHC services offered.ABSTRACT OBJETIVO Avaliar os atributos da aten ção primária à saúde (APS) na assistência à saúde de trabalhadores rurais; analisar condições sociodemográficas, histórico de intoxicaçã...
Source: Revista de Saude Publica - January 21, 2020 Category: International Medicine & Public Health Source Type: research

Basically all As but still bottom half of class ranking?
I'm an M2. 14/16 of my graded classes were As, the other two solid Bs. I randomly fell to third quartile recently. 15/16 of my classes I was overall anywhere from average to well above average since we know averages for each test. Idk how one slightly below average class brought me down so far. Is this something appropriate to bring up to administration for a possible error? Is there other stuff that goes into calculating class rank? What's the point of class rank if everyone apparently... Basically all As but still bottom half of class ranking?
Source: Student Doctor Network - January 21, 2020 Category: Universities & Medical Training Authors: smh343 Tags: Medical Students - MD Source Type: forums

2020 NANS Rumors, Gossip, and Innuendo...Post it all here...
From every indication of the text storm between reps, this year's NANS is the one **NOT** to miss. It's going to be the duck's nuts!
Source: Student Doctor Network - January 21, 2020 Category: Universities & Medical Training Authors: drusso Tags: Pain Medicine Source Type: forums

UMPT Class of 2023 Acceptance
Hey Everyone, I came across last years thread for acceptances and update info and I haven't been able to find one for this year so I thought I would go ahead and make it. Feel free to post any updates you have regarding UM's acceptances, interviews, or waitlist information. I interviewed Oct 25 and I haven't heard back yet. Looking forward to any updates you all can provide!
Source: Student Doctor Network - January 21, 2020 Category: Universities & Medical Training Authors: EazyE23 Tags: Physical Therapy Source Type: forums

New Schools
With all these new schools and class sizes expanding, will there be enough residency spots for everyone. There will probably be a lot more coming up too.
Source: Student Doctor Network - January 21, 2020 Category: Universities & Medical Training Authors: smooooooothjazz365 Tags: Medical Students - DO Source Type: forums

CT Perfusion as a Selection Tool for Mechanical Thrombectomy, a Single-Centre Study
Conclusions: Mechanical thrombectomy for anterior circulation strokes based on CTP did not result in a significant functional outcome improvement. The duration of the thrombectomy procedure was the sole time-interval related to improved functional outcome. Published on 2020-01-20 12:01:10
Source: Journal of the Belgian Society of Radiology - January 21, 2020 Category: Radiology Source Type: research

A Multi-Method Investigation of the Personality Correlates of Digital Aggression
Publication date: Available online 20 January 2020Source: Journal of Research in PersonalityAuthor(s): M. Kim, SL. Clark, MB. Donnellan, SA. BurtAbstractDigital aggression (DA) refers to the use of computer-mediated technologies to harm others. A handful of previous studies have provided mixed results regarding the personality correlates of DA. We clarified these findings by analyzing the associations between three measures of DA (behavioral, Twitter, and self-report) and the Big Five traits using data from 1167 undergraduate participants. Big Five personality trait measures predicted all three DA measures, but results var...
Source: Journal of Research in Personality - January 21, 2020 Category: Psychiatry & Psychology Source Type: research

Stay or Go Decisions
What if you’re currently tolerating a situation you don’t want, but you’re unclear about where to go next? What if your current job, relationship, or lifestyle is a mismatch for you, but you feel hesitant to leave it behind? Imagine being stuck on an island, but you don’t like it there. It’s too small. The weather is often bad. And it smells like rotting fish. And suppose that when you climb to the tallest point on this island and look around, all you can see is the vastness of the sea in every direction. What do you do? Well, you have two options. You can stay or you can leave. If you stay you’ll s...
Source: Steve Pavlina's Personal Development Blog - January 21, 2020 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Lifestyle Source Type: blogs

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Nineteen nurses from the same NICU unit at a Nebraska hospital all gave birth to babies of their own during 2019.
Source: CNN.com - Health - January 21, 2020 Category: Consumer Health News Source Type: news

Therapeutic Strategies for Corneal Wound Angiogenesis
AbstractPurpose of ReviewCorneal diseases are a major cause of blindness worldwide, resulting from corneal scarring and neovascularization. There is an unmet need for developing effective therapies to prevent and/or treat corneal neovascularization.Recent FindingsTopical steroid medication, cautery, argon and yellow dye laser, and fine needle diathermy have all been advocated with varying degrees of success. Vascular endothelial growth factor family of proteins play a pivotal role in corneal neovascularization, and current therapies are aimed at disrupting the various steps in this pathway. Advancement in cell-based therap...
Source: Current Pathobiology Reports - January 21, 2020 Category: Laboratory Medicine Source Type: research

Sensors, Vol. 20, Pages 577: The Coefficient of Variation of Step Time Can Overestimate Gait Abnormality: Test-Retest Reliability of Gait-Related Parameters Obtained with a Tri-Axial Accelerometer in Healthy Subjects
aki Ogasawara The aim of this study was to investigate whether variation in gait-related parameters among healthy participants could help detect gait abnormalities. In total, 36 participants (21 men, 15 women; mean age, 35.7 ± 9.9 years) performed a 10-m walk six times while wearing a tri-axial accelerometer fixed at the L3 level. A second walk was performed ≥1 month after the first (mean interval, 49.6 ± 7.6 days). From each 10-m data set, the following nine gait-related parameters were automatically calculated: assessment time, number of steps, stride time, cadence, ground for...
Source: Sensors - January 21, 2020 Category: Biotechnology Authors: Shunrou Fujiwara Shinpei Sato Atsushi Sugawara Yasumasa Nishikawa Takahiro Koji Yukihide Nishimura Kuniaki Ogasawara Tags: Technical Note Source Type: research

Fluoxetine effects on behavior and adult hippocampal neurogenesis in female C57BL/6J mice across the estrous cycle
ConclusionsTaken together, these data are the first to illustrate the effects of fluoxetine on behavior and adult hippocampal neurogenesis across all four phases of the murine estrous cycle.
Source: Psychopharmacology - January 21, 2020 Category: Psychiatry Source Type: research

Teaching Tongue Lateralization as a Component of Chewing Instruction
This study evaluated the efficacy of a treatment package which included tongue lateralization as part of chewing instruction. Participants consisted of three children who consumed only pureed food and had no history of chewing. Using the outcome measures,tongue lateralization andchewing, we demonstrated improvements in these outcomes for each of the three children. Prior to the end of treatment, all three transitioned to table food and continued to consume table food in follow-up. In addition to measuring changes in observed outcomes, three speech pathologists not involved with the intervention independently rated video cl...
Source: Journal of Developmental and Physical Disabilities - January 21, 2020 Category: Disability Source Type: research

Key Transitions in the Evolution of Rapid and Slow Growing Mycobacteria Identified by Comparative Genomics
Mycobacteria have been classified into rapid and slow growing phenotypes, but the genetic factors that underlie these growth rate differences are not well understood. We compared the genomes of 157 mycobacterial species, representing all major branches of the mycobacterial phylogenetic tree to identify genes and operons enriched among rapid and slow growing mycobacteria. Overlaying growth phenotype on a phylogenetic tree based on 304 core genes suggested that ancestral mycobacteria had a rapid growth phenotype with a single major evolutionary separation into rapid and slow growing sub-genera. We identified 293 genes enrich...
Source: Frontiers in Microbiology - January 21, 2020 Category: Microbiology Source Type: research

Prediction of Neighbor-Dependent Microbial Interactions From Limited Population Data
Modulation of interspecies interactions by the presence of neighbor species is a key ecological factor that governs dynamics and function of microbial communities, yet the development of theoretical frameworks explicit for understanding context-dependent interactions are still nascent. In a recent study, we proposed a novel rule-based inference method termed the Minimal Interspecies Interaction Adjustment (MIIA) that predicts the reorganization of interaction networks in response to the addition of new species such that the modulation in interaction coefficients caused by additional members is minimal. While the theoretica...
Source: Frontiers in Microbiology - January 21, 2020 Category: Microbiology Source Type: research

The first record on Giardia muris from mice in Turkey
AbstractGiardia muris has been reported from both laboratory and wild rodents in worldwide. During routine care, soft consistency was observed in feces of Swiss albino mice. MotileGiardia spp. trophozoites were observed microscopically on all fecal preparations after stained with Lugol ’s iodine solution. The trophozoites were broadly ovoid in a form with a pointed end. They possess two large nuclei and an adhesive disk whose length overlapped one-half of the trophozoite body length. The caudal flagella are unequal. β giardin (bg) gene region of isolates was successfully amplified and sequenced. According to sequence an...
Source: Journal of Parasitic Diseases - January 21, 2020 Category: Parasitology Source Type: research

Assessment of Spoilage Bacterial Communities in Food Wrap and Modified Atmospheres-Packed Minced Pork Meat Samples by 16S rDNA Metagenetic Analysis
Although several studies have focused on the dynamics of bacterial food community, little is known about the variability of batch production and microbial changes that occur during storage. The aim of the study was to characterize the microbial spoilage community of minced pork meat samples, among different food production and storage, using both 16S rRNA gene sequencing and classical microbiology. Three batches of samples were obtained from four local Belgian facilities (A–D) and stored until shelf life under food wrap (FW) and modified atmosphere packaging (MAP, CO2 30%/O2 70%), at constant and dynamic temperature. Ana...
Source: Frontiers in Microbiology - January 21, 2020 Category: Microbiology Source Type: research

Transcriptome Sequencing of Listeria monocytogenes Reveals Major Gene Expression Changes in Response to Lactic Acid Stress Exposure but a Less Pronounced Response to Oxidative Stress
In this study, we examine the chromosomal and plasmid transcriptomes of two different L. monocytogenes strains, 6179 [belonging to sequence type (ST) 121] and R479a (ST8), in response to 30 min exposure to oxidative (0.01% hydrogen peroxide) and acid (1% lactic acid, pH 3.4) stress. The exposure to oxidative stress resulted in 102 and 9 differentially expressed (DE) genes in the chromosomal transcriptomes of 6179 and R479a, respectively. In contrast, 2280 and 2151 DE genes were observed in the respective chromosomal transcriptomes of 6179 and R479a in response to lactic acid stress. During lactic acid stress, we observed u...
Source: Frontiers in Microbiology - January 21, 2020 Category: Microbiology Source Type: research

Flow Cytometry Combined With Single Cell Sorting to Study Heterogeneous Germination of Bacillus Spores Under High Pressure
This study validated FCM as a powerful technique to investigate the heterogeneous behavior of spores under HP, and provided a pipeline using FACS for isolation of different sub-populations and subsequent characterization to understand their physiological states.
Source: Frontiers in Microbiology - January 21, 2020 Category: Microbiology Source Type: research

Effectiveness of Transitional Interventions in Improving Patient Outcomes and Service Use After Discharge From Psychiatric Inpatient Care: A Systematic Review and Meta-Analysis
Conclusions: We observed that transitional interventions with bridging components were no more effective in reducing readmission than treatment as usual; however, these results are based on limited evidence. Therefore, additional high-quality research is required to conclude the effectiveness of transitional interventions. Nevertheless, transitional interventions with bridging components are preferred by service users and could be an alternative to strategies regularly employed.
Source: Frontiers in Psychiatry - January 21, 2020 Category: Psychiatry Source Type: research

Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice
ConclusionLong-term Cr deficiency in GAMT–/– mice reduces mitochondrial volume without affecting respiratory function, most likely due to impaired biogenesis. This is associated with hemodynamic changes without evidence of heart failure, which may represent an acceptable functional compromise in return for reduced energy demand in aging mice.
Source: Frontiers in Physiology - January 21, 2020 Category: Physiology Source Type: research

EANS Basic Brain Course (ABC): combining simulation to cadaver lab for a new concept of neurosurgical training
ConclusionsIt is possible that this combined concept of training on technical and non-technical skills, using emerging technologies along with pedagogic techniques and cadaver dissection, may become the state-of-the-art for European Neurosurgical training programs in the next future.
Source: Acta Neurochirurgica - January 21, 2020 Category: Neurosurgery Source Type: research

Quality of life effects of pain from para-lumbar- and lower extremity entrapment syndrome and carpal tunnel syndrome and comparison of the effectiveness of surgery
ConclusionThe detrimental QOL effects are stronger in patients with para-lumbar- or lower extremity entrapment syndrome than in patients with carpal tunnel syndrome.
Source: Acta Neurochirurgica - January 21, 2020 Category: Neurosurgery Source Type: research

Cross-sectional study of the educational background and trauma knowledge of trainees in the “China trauma care training” program
ConclusionsThe level of trauma knowledge of trauma care providers was associated with their department, professional position and previous participation in related academic conferences. Trauma care experience and participation in academic lectures and training program including CTCT may effectively improve individuals ’ level of trauma knowledge.
Source: Military Medical Research - January 21, 2020 Category: International Medicine & Public Health Source Type: research

Increased Hepcidin Levels During a Period of High Training Load Do Not Alter Iron Status in Male Elite Junior Rowers
The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1). Circulating levels of hepcidin and the iron storage protein ferritin are elevated during the recovery period after acute endurance exercise, which can be interpreted as an acute phase reaction to intense exercise with far-reaching consequences for iron metabolism and homeostasis. Since absolute and functional iron deficiency (ID) potentially lead to a loss of performance and well-being, it is surprising that the cumulative effects of training stress on hepcidin levels and its ...
Source: Frontiers in Physiology - January 21, 2020 Category: Physiology Source Type: research

Knockdown of SLC38 Transporter Ortholog – CG13743 Reveals a Metabolic Relevance in Drosophila
Solute Carrier (SLC) is a cluster of families of membrane bound transporters, of which many members lack defined substrate profile, and many more are poorly characterized. Many play a vital role in regulating metabolic systems, protein synthesis, and post translational modifications. SLC38 is one of the families of SLCs, which are also known as sodium-coupled neutral amino acid transporters (SNATs). In mice, it has 11 members (SNAT1-11) but in Drosophila there are two homologs for the SLC38 family; CG13743 and CG30394. Here, we show characteristics of Drosophila CG13743 which closely resembles SLC38A11 in humans. SLC38A11 ...
Source: Frontiers in Physiology - January 21, 2020 Category: Physiology Source Type: research

Geometry of the Carotid Artery and Its Association With Pathologic Changes in a Chinese Population
ConclusionGeometry of the carotid artery and position relative to cervical spine might be associated with ECM and YAP protein expression, which could contribute to carotid artery stenosis.
Source: Frontiers in Physiology - January 21, 2020 Category: Physiology Source Type: research

Energetics Equivalent of the Cardiac Force-Length End-Systolic Zone: Implications for Contractility and Economy of Contraction
We have recently demonstrated the existence of a region on the cardiac mechanics stress-length plane, which we have designated “The cardiac end-systolic zone.” The zone is defined as the area on the pressure-volume (or stress-length) plane within which all stress-length contraction profiles reach their end-systolic points. It is enclosed by three boundaries: the isometric end-systolic relation, the work-loop (shortening) end-systolic relation, and the zero-active stress isotonic end-systolic relation. The existence of this zone reflects the contraction-mode dependence of the cardiac end-systolic force-length relations,...
Source: Frontiers in Physiology - January 21, 2020 Category: Physiology Source Type: research

Sex and gender interactions on the use and impact of recreational cannabis - Greaves L, Hemsing N.
Cannabis is the second most frequently used substance in the world and regulated or legalized for recreational use in Canada and fourteen US states and territories. As with all substances, a wide range of sex and gender related factors have an influence on...
Source: SafetyLit - January 20, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Site-specific probabilistic seismic hazard analysis for the western area of Naples, Italy - Ebrahimian H, Jalayer F, Forte G, Convertito V, Licata V, d ’Onofrio A, Santo A, Silvestri F, Manfredi G.
Probabilistic seismic hazard analysis (PSHA) encompasses quantitative estimation of seismic hazard at a site by considering all plausible earthquake scenarios. The outcome of a PSHA is often reported as the mean rate of exceeding a specific ground motion i...
Source: SafetyLit - January 20, 2020 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

The significance of considering multiple angles of seismic incidence for estimating engineering demand parameters - Skoulidou D, Rom ão X.
The accurate determination of demand during the seismic analysis of buildings requires that all factors having a significant contribution must be accounted for. The present study examines the effect of the angle of seismic incidence of earthquake ground mo...
Source: SafetyLit - January 20, 2020 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

Suicide among cancer patients: adolescents and young adult (AYA) versus all-age patients - Zhou H, Xian W, Zhang Y, Yang Y, Fang W, Liu J, Shen J, Zhang Z, Hong S, Huang Y, Zhang L.
BACKGROUND: Many researchers have studied suicide risk factors of patients with one specific cancer. But there is no comprehensive study to compare suicide issues between adolescents and young adult (AYA) group and all-age groups in a pan-cancer view. ...
Source: SafetyLit - January 15, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news