Complement activation in wasp venom-induced acute kidney injury
In this study, a complement-depleted mouse model was used to investigate the role of complement in wasp venom-induced AKI. Mice were randomly categorized into control, cobra venom factor (CVF), AKI, and CVF + AKI groups. Compared to the AKI group, the CVF + AKI group showed improved pathological changes in kidneys and reduced blood urea nitrogen (BUN) levels. The expression levels of renal complement 3 (C3), complement 5 (C5), complement 1q (C1q), factor B (FB), mannose-binding lectin (MBL), and C5b-9 in AKI group were upregulated compared with the control group. Conversely, the renal tissue expression levels of C3, C5, C1...
Source: Renal Failure - April 21, 2024 Category: Urology & Nephrology Authors: Rui Cheng Liang Xu Jianhua Gong Fanglin Yu Ying Lv Hai Yuan Fengqi Hu Source Type: research
Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study
CONCLUSION: HFR treatment effectively eliminates uremic toxins from the bloodstream of patients undergoing MHD, especially protein-bound toxins and large middle-molecule toxins. Additionally, it retains essential physiological compounds like albumin and branched-chain amino acids, underscoring its commendable safety profile.PMID:38632963 | PMC:PMC11028005 | DOI:10.1080/0886022X.2024.2338929 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Renhua Lu Yan Fang Wangshu Wu Xiaojun Zeng Tingting Liu Yue Qian Yuanyuan Xie Yijun Zhou Leyi Gu Source Type: research
Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group
CONCLUSION: CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.PMID:38637275 | PMC:PMC11028022 | DOI:10.1080/0886022X.2024.2341787 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Aysegul Oruc Abdullah Sumnu Ayd ın Turkmen Taner Basturk Egemen Cebeci Kenan Turgutalp Hakk ı Cetinkaya M üge Uzerk Kibar Nurhan Seyahi Erhan Tatar Metin Ergul Ülver Derici Mehmet Deniz Ayl ı Musa P ınar Bet ül Bakar R ümeyza Kazancıoglu Abd ülm Source Type: research
Prognostic value of neutrophil-to-lymphocyte ratio dynamics in patients with septic acute kidney injury: a cohort study
CONCLUSIONS: High ΔNLR is independently associated with increased risk of patient mortality and adverse outcomes. ΔNLR might be utilized to facilitate risk stratification and optimize septic AKI management.PMID:38637281 | PMC:PMC11028010 | DOI:10.1080/0886022X.2024.2343818 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Wei Wei Caihong Liu Guojiao Song Letian Yang Jian Li Bo Wang Ting Yin Yingying Yang Liang Ma Ling Zhang Ping Fu Yuliang Zhao Source Type: research
Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study
CONCLUSION: HFR treatment effectively eliminates uremic toxins from the bloodstream of patients undergoing MHD, especially protein-bound toxins and large middle-molecule toxins. Additionally, it retains essential physiological compounds like albumin and branched-chain amino acids, underscoring its commendable safety profile.PMID:38632963 | DOI:10.1080/0886022X.2024.2338929 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Renhua Lu Yan Fang Wangshu Wu Xiaojun Zeng Tingting Liu Yue Qian Yuanyuan Xie Yijun Zhou Leyi Gu Source Type: research
Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group
CONCLUSION: CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.PMID:38637275 | DOI:10.1080/0886022X.2024.2341787 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Aysegul Oruc Abdullah Sumnu Ayd ın Turkmen Taner Basturk Egemen Cebeci Kenan Turgutalp Hakk ı Cetinkaya M üge Uzerk Kibar Nurhan Seyahi Erhan Tatar Metin Ergul Ülver Derici Mehmet Deniz Ayl ı Musa P ınar Bet ül Bakar R ümeyza Kazancıoglu Abd ülm Source Type: research
Prognostic value of neutrophil-to-lymphocyte ratio dynamics in patients with septic acute kidney injury: a cohort study
CONCLUSIONS: High ΔNLR is independently associated with increased risk of patient mortality and adverse outcomes. ΔNLR might be utilized to facilitate risk stratification and optimize septic AKI management.PMID:38637281 | DOI:10.1080/0886022X.2024.2343818 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Wei Wei Caihong Liu Guojiao Song Letian Yang Jian Li Bo Wang Ting Yin Yingying Yang Liang Ma Ling Zhang Ping Fu Yuliang Zhao Source Type: research
Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy
This study aimed to identify the optimal cross-talk genes, potential pathways, and mutual immune-infiltrating microenvironments between IBD and IgAN to elucidate the linkage between patients with IBD and IgAN. The IgAN and IBD datasets were obtained from the Gene Expression Omnibus (GEO). Three algorithms, CIBERSORTx, ssGSEA, and xCell, were used to evaluate the similarities in the infiltrating microenvironment between the two diseases. Weighted gene co-expression network analysis (WGCNA) was implemented in the IBD dataset to identify the major immune infiltration modules, and the Boruta algorithm, RFE algorithm, and LASSO...
Source: Renal Failure - April 17, 2024 Category: Urology & Nephrology Authors: Qianqian Yan Zihao Zhao Dongwei Liu Jia Li Shaokang Pan Jiayu Duan Zhangsuo Liu Source Type: research
Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy
This study aimed to identify the optimal cross-talk genes, potential pathways, and mutual immune-infiltrating microenvironments between IBD and IgAN to elucidate the linkage between patients with IBD and IgAN. The IgAN and IBD datasets were obtained from the Gene Expression Omnibus (GEO). Three algorithms, CIBERSORTx, ssGSEA, and xCell, were used to evaluate the similarities in the infiltrating microenvironment between the two diseases. Weighted gene co-expression network analysis (WGCNA) was implemented in the IBD dataset to identify the major immune infiltration modules, and the Boruta algorithm, RFE algorithm, and LASSO...
Source: Renal Failure - April 17, 2024 Category: Urology & Nephrology Authors: Qianqian Yan Zihao Zhao Dongwei Liu Jia Li Shaokang Pan Jiayu Duan Zhangsuo Liu Source Type: research
Shen Shuai II recipe improves renal hypoxia to attenuate renal injury in 5/6 renal ablation/infarction rats and effect evaluation using blood oxygenation level-dependent functional magnetic resonance imaging
Conclusion: The degree of renal oxygenation reduction is correlated with the severity of renal injury in CKD. SSR can improve renal hypoxia to attenuate renal injury in 5/6 (A/I) rats of CKD.PMID:38622926 | DOI:10.1080/0886022X.2024.2338565 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Yizeng Xu Fang Lu Meng Wang Lingchen Wang Chaoyang Ye Shuohui Yang Chen Wang Source Type: research
The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy
CONCLUSION: HMGB2 expression is greater in IgAN patients than in healthy controls; it promotes APRIL expression by interacting with HMGA1, thereby inducing Gd-IgA1 overexpression and leading to IgAN.PMID:38622929 | DOI:10.1080/0886022X.2024.2338931 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Huijuan Tian Yaling Zhai Shuaigang Sun Wenhui Zhang Zhanzheng Zhao Source Type: research
COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies
CONCLUSION: In conclusion, the limited number of published controlled studies revealed no statistically significant association between COVID-19 infection and biopsy-proven rejection among KTRs. However, the broader analysis of non-controlled studies showed a variable rejection incidence with a pooled rejection rate of 11.8%. There is insufficient high-quality data to explore the association of COVID-19 infection and rejection.PMID:38627208 | DOI:10.1080/0886022X.2024.2336126 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Ahmed Daoud Karim Soliman Maria Aurora Posadas Salas Genta Uehara Sakshi Vaishnav Wisit Cheungpasitporn Michael J Casey Source Type: research
Mechanism of dexmedetomidine protection against cisplatin induced acute kidney injury in rats
CONCLUSION: Dex protected rats from CP-induced AKI, and the mechanism may be related to NLRP-3/Caspase-1-mediated pyroptosis.PMID:38627212 | DOI:10.1080/0886022X.2024.2337287 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Zeng-Lu Zheng Jun-Wei Ma Yi Luo Gui-Jin Liang Shi-Jie Lei Ke-Jin Yan Hai-Bing Meng Xiu-Juan Liu Source Type: research
Shen Shuai II recipe improves renal hypoxia to attenuate renal injury in 5/6 renal ablation/infarction rats and effect evaluation using blood oxygenation level-dependent functional magnetic resonance imaging
Conclusion: The degree of renal oxygenation reduction is correlated with the severity of renal injury in CKD. SSR can improve renal hypoxia to attenuate renal injury in 5/6 (A/I) rats of CKD.PMID:38622926 | DOI:10.1080/0886022X.2024.2338565 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Yizeng Xu Fang Lu Meng Wang Lingchen Wang Chaoyang Ye Shuohui Yang Chen Wang Source Type: research
The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy
CONCLUSION: HMGB2 expression is greater in IgAN patients than in healthy controls; it promotes APRIL expression by interacting with HMGA1, thereby inducing Gd-IgA1 overexpression and leading to IgAN.PMID:38622929 | DOI:10.1080/0886022X.2024.2338931 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Huijuan Tian Yaling Zhai Shuaigang Sun Wenhui Zhang Zhanzheng Zhao Source Type: research
