Optimum Risk Assessment for Stroke in Atrial Fibrillation: Should We Hold the Status Quo or Consider Magnitude Synergism and Left Atrial Appendage Anatomy?
Optimum Risk Assessment for Stroke in Atrial Fibrillation: Should We Hold the Status Quo or Consider Magnitude Synergism and Left Atrial Appendage Anatomy?
Thromboembolic stroke and systemic embolism are generally agreed to be the major morbidity/mortality concerns for patients with AF. However, the risk of thromboembolism (TE) is not the same for all AF patients. While ECG rhythm strips of patients with AF are generally indistinguishable, it has long been known that ...
Optimum Risk Assessment for Stroke in Atrial Fibrillation: Should We Hold the Status Quo or Consider Magnitude Synergism and Left Atrial Ap...
Source: Radcliffe Cardiology - April 16, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
A Rare Case of Tuberculous Constrictive Pericarditis Due to Disseminated Tuberculosis with Response to Anti-tuberculosis Chemotherapy and Steroids in a Developed City State
Tuberculosis (TB) is a rare cause of constrictive pericarditis in the developed world, accounting for<5% of all cases.1 In countries where TB is endemic, tuberculous pericarditis is the most common manifestation of TB in the cardiovascular system and pericardial constriction can still occur in up...
A Rare Case of Tuberculous Constrictive Pericarditis Due to Disseminated Tuberculosis with Response to Anti-tuberculosis Chemotherapy and Steroids in a Developed City State
Tuberculosis (TB) is a rare cause of constrictive pericarditis in the developed world, accounting for<5% of all cases.1 ...
Source: Radcliffe Cardiology - April 10, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Implementing a Polypill Approach in Heart Failure: A Survey Study
A critical challenge in the management of patients with heart failure with reduced ejection fraction (HFrEF) includes suboptimal use and dose uptitration of prognostically significant guideline-directed medical therapy (GDMT), as demonstrated in various registries, such as ASIAN-HF and CHAMP-HF.1,2 It is likely that failure to achieve recommended dosing is partly attributable to the length of time require...
Implementing a Polypill Approach in Heart Failure: A Survey Study
A critical challenge in the management of patients with heart failure with reduced ejection fraction (HFrEF) includes subo...
Source: Radcliffe Cardiology - April 8, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
The Use of Quantitative Flow Ratio for Decisions and Outcomes in Percutaneous Coronary Intervention Study
Functional evaluation is crucial for diagnosing undetermined coronary artery stenosis in stable coronary artery disease.1 –3 Fractional flow reserve (FFR) is the gold standard for assessing the physiological severity of coronary stenosis.4 Several trials have revealed a reverse correlation between post-interventional FFR and the risk of adverse events.5,6 Many studie...
The Use of Quantitative Flow Ratio for Decisions and Outcomes in Percutaneous Coronary Intervention Study
Functional evaluation is crucial for diagnosing undetermined coronary artery stenosis in stable coronary artery disease...
Source: Radcliffe Cardiology - April 8, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Value of Extended Arrhythmia Screening in Adult Congenital Heart Disease Patients
Over the past decades, the life expectancy of children born with congenital heart disease (CHD) has improved considerably.1,2 Hence, the population of adult CHD (ACHD) patients is growing.3 Many ACHD patients are affected lifelong by cardiac symptoms, reduced quality of life and cardiac events.2 Clinical arrhythmias are important regarding morbidity and mortality in patients with ACHD.4 –6 ...
Value of Extended Arrhythmia Screening in Adult Congenital Heart Disease Patients
Over the past decades, the life expectancy of children born with congenital heart disease (CHD) has improved considerab...
Source: Radcliffe Cardiology - April 8, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Dual-pathway Inhibition with Low-dose Aspirin and Rivaroxaban versus Aspirin Monotherapy in Patients with Coronary Artery Disease and Peripheral Artery Disease: Systematic Literature Review and Meta-analysis
Platelet activation and aggregation play a pivotal role in the complex pathophysiological process of atherosclerotic disease, resulting in the formation of an occlusive thrombus.1 Furthermore, platelets modulate the various endothelial and inflammatory processes tha...
Dual-pathway Inhibition with Low-dose Aspirin and Rivaroxaban versus Aspirin Monotherapy in Patients with Coronary Artery Disease and Peripheral Artery Disease: Systematic Literature Review and Meta-analysis
Platelet activation and aggregation play a pivotal role in the complex pathophysiological process of atherosclerotic disea...
Source: Radcliffe Cardiology - April 4, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
The Therapy and Management of Heart Failure with Preserved Ejection Fraction: New Insights on Treatment
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome affecting approximately 3 million people in the US and up to 32 million people worldwide. Patients with HFpEF are hospitalised approximately 1.4 times per year and have a mortality rate of approximately 15% per year.1HFpEF is mainly characterised by the presence of diastolic dys...
The Therapy and Management of Heart Failure with Preserved Ejection Fraction: New Insights on Treatment
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome affecting approximately 3 million pe...
Source: Radcliffe Cardiology - April 3, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Drug-induced AF: Arrhythmogenic Mechanisms and Management Strategies
AF is the most common sustained cardiac arrhythmia, affecting millions of people globally.1 It is associated with an increased risk of various adverse health outcomes, such as heart failure, stroke, dementia and other conditions, placing a substantial burden on healthcare systems worldwide.2Despite significant advances in the development of drugs and interventional procedures for the treatment of AF, t...
Drug-induced AF: Arrhythmogenic Mechanisms and Management Strategies
AF is the most common sustained cardiac arrhythmia, affecting millions of people globally.1 It is associated with an incre...
Source: Radcliffe Cardiology - April 3, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Safety and Efficacy of Percutaneous Pulmonary Valve Implantation: The Singapore Experience
Right ventricular outflow tract (RVOT) dysfunction in the adult congenital heart disease (ACHD) population frequently requires repeated surgical interventions throughout the patients ’ lives, with significant associated morbidity.1 Percutaneous pulmonary valve implantation (PPVI) was developed as an alternative to open heart surgery, and was first performed by Bonhoeffer et al. in ...
Safety and Efficacy of Percutaneous Pulmonary Valve Implantation: The Singapore Experience
Right ventricular outflow tract (RVOT) dysfunction in the adult congenital heart disease (ACHD) population frequently r...
Source: Radcliffe Cardiology - April 1, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Cardiac Amyloidosis: Everywhere, but Nowhere
In the past decade, there has been increasing interest surrounding cardiac amyloidosis (CA), partly due to the availability of effective therapies for transthyretin CA (ATTR-CA).1,2 Unfortunately, such progress has been largely limited to developed countries, with little to no progress seen in countries like Malaysia. In fact, clinical pathways in the initial evaluation and management of CA remain sparse in Malaysia, although...
Cardiac Amyloidosis: Everywhere, but Nowhere
In the past decade, there has been increasing interest surrounding cardiac amyloidosis (CA), partly due to the availabilit...
Source: Radcliffe Cardiology - April 1, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
In Cardiogenic Shock, Age is Not Just a Number
Cardiogenic shock (CS) is a heterogenous disease process with varied clinical presentation, aetiology and severity. Owing to such heterogeneity, it is difficult to prognosticate patients in CS at their initial clinical encounter. While the Society of Cardiovascular Angiography and Interventions (SCAI) stages of CS have been validated as a prognostic tool, they rely on several biomarkers and invasive haemodynamic variables t...
In Cardiogenic Shock, Age is Not Just a Number
Cardiogenic shock (CS) is a heterogenous disease process with varied clinical presentation, aetiology and severity. Owing ...
Source: Radcliffe Cardiology - March 29, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
RotaTripsy Risk and Rewards: Findings from a Registry of Patients Undergoing Combined Rotational Atherectomy and Intravascular Lithotripsy
Pathological deposition of calcium in the intimal and medial layers of the arterial wall is associated with old age, chronic kidney disease and diabetes among conventional cardiovascular risk factors, and represents a therapeutic challenge for interventional cardiologists worldwide.1Patients with coronary artery calcification (CAC) are le... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - March 15, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Secondary Mitral Regurgitation: Diagnosis and Management
Mitral regurgitation (MR) is the most common type of valve disease in developed nations and affects more than 2 million people in the US.1 It is seen in approximately one-third of patients with chronic heart failure, and contributes to the progression of disease and a worsening prognosis.2 In patients aged ≥50 years, yearly mortality rates for moderate to severe MR range from 3% to 6%.3MR can be caused by an abnormalit... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - March 15, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Remarkable Reviewers in 2023
Henry Oldenburg, the first secretary of the Royal Society, introduced the concept of peer review for assessing submissions to the eminent journal Philosophical Transactions of the Royal Society in 1660. Since then, the quality and impact of articles published in scientific journals are heavily dependent on knowledgeable and truly committed reviewers. Arrhythmia& Electrophysiology Review is determined to obtain outstanding reviews for every s... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - March 11, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
What Cannot be Missed: Important Publications on Electrophysiology in 2023
A list of the most important articles on arrhythmia published in 2023.Healey JS, Lopes RD, Granger CB, et al. Apixaban for stroke prevention in subclinical atrial fibrillation. N Engl J Med 2024;390:107 –17.Crossref | PubmedKirchhof P, Toennis T, Goette A, et al. Anticoagulation with edoxaban in patients with atrial high-rate episodes. N Engl J Med 2023;389:1167–79. Crossref | PubmedSohns C, Fox H, Mar... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - March 11, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
