Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00494J, PaperYu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Hui Xu, Rui Guo, Yuanting Li, Jing Jia, Xiaoming Qi, Xiaoling Gao Imbalances of amino acids and the purinergic system show significant hypothalamic metabolic perturbations, which are closely associated with mechanisms of depression. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - November 13, 2017 Category: Molecular Biology Authors: Yu Wu Source Type: research
Correction: Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.M. Tomin, S. Tomic To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - November 13, 2017 Category: Molecular Biology Authors: M. Tomin Source Type: research
Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00391A, PaperLakshmi Prabhu, Lan Chen, Han Wei, Ozlem Demir, Ahmad Safa, Lifan Zeng, Rommie E. Amaro, Bert H. O'Neil, Zhon-Yin Zhang, Tao Lu The proposed workflow of the drug development pipeline with adapted AlphaLISA HTS-based screening to discover inhibitors of epigenetic targets like PRMT5 with possible significance in disease treatment. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - November 3, 2017 Category: Molecular Biology Authors: Lakshmi Prabhu Source Type: research
Pharmacology of predatory and defensive venom peptides in cone snails
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00511C, Review ArticleJutty Rajan Prashanth, Sebastien Dutertre, Richard James Lewis Cone snails use distinct venoms for defence and prey capture. The pharmacology of these neurotoxic peptides have been extensively studied for pharmacological probes, venom evolution mechanisms and potential therapeutics. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - November 1, 2017 Category: Molecular Biology Authors: Jutty Rajan Prashanth Source Type: research
Staphylococcus aureus Extracellular Vesicles (EVs): Surface-Binding Antagonists of Biofilm Formation
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00365J, PaperSteven A Soper, Robert James Mitchell, Sujin Lee, Hansol Im The prevalence of Staphylococcus aureus worldwide as a nosocomial infectious agent is recognized but the reason behind the spread of this bacterium has remained elusive. Here, we hypothesized that the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 30, 2017 Category: Molecular Biology Authors: Steven A Soper Source Type: research
Model system based proteomics to understand the host response during bacterial infections
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00372B, Review ArticleArumugam Kamaladevi, Shanmugam Marudhupandiyan, Krishnaswamy Balamurugan An overall schematic representation of model animals and proteomics techniques used to understand the host response during bacterial infections. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 30, 2017 Category: Molecular Biology Authors: Arumugam Kamaladevi Source Type: research
Mechanism of the formation of the RecA-ssDNA nucleoprotein filament structure: A coarse-grained approach
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00486A, PaperGoutam Mukherjee, Arumay Pal, Yaakov Levy In eukaryotes, RecA protein catalyzes the repair and strand exchange of double-stranded DNA. RecA binds to single-stranded DNA (ssDNA) and forms a presynaptic complex in which the protein polymerizes around... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 27, 2017 Category: Molecular Biology Authors: Goutam Mukherjee Source Type: research
Conformational heterogeneity in tails of DNA-binding proteins is augmented by proline containing repeats
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00412E, PaperHarshavardhan Khare, Debayan Dey, Chilakapati Madhu, Dillip Senapati, S Ragothama, Govindaraju T, suryanarayanarao ramakumar Cationic terminal extension or tail is a common feature of many DNA-binding proteins. We show that a particular type of tails rich in proline, alanine and lysine belong to the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 26, 2017 Category: Molecular Biology Authors: Harshavardhan Khare Source Type: research
Development of AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00391A, PaperLakshmi Prabhu, Lan Chen, Han Wei, Ozlem Demir, Ahmad Safa, Li-Fan Zeng, Rommie Amaro, Bert Howard O'Neil, Zhong-Yin Zhang, Tao Lu The protein arginine methyltransferase (PRMT) family of enzymes comprises nine family members in mammals. They catalyze arginine methylation, either monomethylation or symmetric/asymmetric dimethylation of histone and non-histone proteins. PRMT methylation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 25, 2017 Category: Molecular Biology Authors: Lakshmi Prabhu Source Type: research
Imbalance in Amino Acid and Purine Metabolisms at Hypothalamus in Inflammation Associated Depression by GC-MS
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00494J, PaperYu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Hui Xu, Rui Guo, Yuanting Li, Jing Jia, Xiaoming Qi, Xiaoling Gao The hypothalamic dysfunction was the key in depression, with increasing evidences highlighted the abnormality of neuroinflammation and imbalance in neurotransmitter and purinergic system in pathophysiology of depression. Little is however... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 25, 2017 Category: Molecular Biology Authors: Yu Wu Source Type: research
Host immune evasion strategies of malaria blood stage parasite
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00502D, Review ArticleXue Yan Yam, Peter Rainer Preiser Host immune evasion is a key strategy for the continual survival of many microbial pathogens including Apicomplexan protozoan: Plasmodium spp., the causative agent of Malaria. The malaria parasite has evolved... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 23, 2017 Category: Molecular Biology Authors: Xue Yan Yam Source Type: research
An interaction network approach to study the correlation between Endocrine Disrupting Chemicals and Breast Cancer
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00489C, PaperAndrea Polo, Chiara Nittoli, Anna Crispo, Teresa Langastro, Stefania Cocco, Lorella Severino, Michelino De Laurentiis, Gennaro Ciliberto, Maurizio Montella, Alfredo Budillon, Susan Costantini Endocrine disrupting chemicals (EDCs) are natural or synthetic exogenous substances affecting human health. Although present at low concentrations in the environment, they can cause a broad range of negative effects... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 20, 2017 Category: Molecular Biology Authors: Andrea Polo Source Type: research
Model system based proteomics to understand host response during bacterial infections
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00372B, Review ArticleArumugam Kamaladevi, Shanmugam Marudhupandiyan, Krishnaswamy Balamurugan Infectious diseases caused by bacterial pathogens pose a major concern on public health and, thus, a great deal of attention has been given to provide insightful knowledge on host-pathogen interactions.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 19, 2017 Category: Molecular Biology Authors: Arumugam Kamaladevi Source Type: research
The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00498B, PaperKelly Karch, Marie-France Langelier, John M Pascal, Benjamin A. Garcia ADP-ribosylation is a protein post-translational modification catalyzed by ADP-ribose transferases (ARTs). ART activity is critical in mediating many cellular processes, and is required for DNA damage repair. All five histone... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 16, 2017 Category: Molecular Biology Authors: Kelly Karch Source Type: research
Protein-protein interaction networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00434F, Review ArticleMarianna Caterino, Margherita Ruoppolo, Annalisa Mandola, Michele Costanzo, Stefania Orru, Esther Imperlini Proteins interacting with each VDAC isoform highlight the distinct functional roles of these porins in physiological and pathological conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 13, 2017 Category: Molecular Biology Authors: Marianna Caterino Source Type: research
