Postepy higieny i medycyny doswiadczalnej 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Postepy Hig Med Dosw 2017; 71:797-810 "The role of vitamin D in the development of autoimmune diseases"
Witamina D, poza istotn ą rol ą w utrzymaniu homeostazy wapnia i metabolizmie kostnym, odgrywa wa ż n ą rol ę w funkcjonowaniu uk ł adu odporno ś ciowego. Niedob ó r witaminy D wi ą ż e si ę z wieloma niekorzystnymi dla zdrowia skutkami, w ł ą czaj ą c w to m.in. os ł abienie odporno ś ci, czego skutkiem jest zwi ę kszona podatno ś ć na zaka ż enia wirusowe, bakteryjne oraz grzybicze. W artykule opisano podstawy metabolizmu witaminy D oraz jej rol ę fizjologiczn ą , ze szczeg ó lnym uwzgl ę dnieniem wp ł ywu na kom ó rki uk ł adu odporno ś ciowego. Ze wzgl ę du na jej istotn ą rol ę w regulac...
Source: Postepy higieny i medycyny doswiadczalnej - August 28, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:788-796 "Analysis of the relationship between single nucleotide polymorphism of the CD209, IL-10, IL-28 and CCR5 D32 genes with the human predisposition to developing tick-borne encephalitis"
Conclusions: SNP rs2287886 CD 209 AG heterozygotes predispose humans to develop TBE. Single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and CCR5 D32 genes does not correlate with the severity of TBE. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - August 28, 2017 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2017; 71:773-787 "The pathophysiological basis of the protective effects of metformin in heart failure"
Metformin, currently recommended as the drug of first choice in type 2 diabetes mellitus (T2DM), is one of the few antihiperglycemic drugs to reduce cardiovascular risk. Nonetheless, due to the risk of lactic acidosis during metformin therapy, its usage in patients with diabetes and heart failure (HF) is still a matter of debate. The aim of this review is to present data supporting the possibility of using metformin in the treatment of diabetic patients with concomitant heart failure. In the failing heart, metformin through the mechanism related to AMP-activated protein kinase (AMPK) activity, improves free fatty acids (FF...
Source: Postepy higieny i medycyny doswiadczalnej - August 25, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:761-772 "Compounds of psoriasis with obesity and overweight"
Many epidemiological studies have confirmed the relationship of obesity and psoriasis, and it is believed that obesity is an independent risk factor for its development and is associated with a worse prognosis. Furthermore, the reduction of body weight, using low-calorie diet combined with exercise, reduces the severity of psoriasis.
Visceral adipose tissue is the largest endocrine organ, producing proinflammatory cytokines (TNF- α , IL-6, IL-17) and adipokines (adiponectin, omentin, chemerin). They participate in the development of dyslipidemia, insulin resistance, diabetes, and consequently of the cardiovascular diseas...
Source: Postepy higieny i medycyny doswiadczalnej - August 25, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:747-760 "The role of vitamin C in epigenetic regulation"
Vitamin C (L-ascorbic acid) is a micronutrient best known for its anti-scurvy activity in humans. Vitamin C is involved in many biological processes involving enzymatic reactions that are catalyzed by members of dioxygenases which use Fe(II) and 2-oxoglutarate as a co-substrate.
The article reviews recent data that suggest the involvement of ascorbate in dioxygenases catalyzed chromatin and DNA modifications which thereby contribute to epigenetic regulation. Concerning chromatin modification, the dioxygenases are involved in distinct demethylation reactions with varying specificity for the position of the lysine on the ta...
Source: Postepy higieny i medycyny doswiadczalnej - August 24, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:737-746 "The role of bile acids in the pathogenesis of bowel diseases"
Bile acids not only play a cardinal role in the digestion and absorption of fat and fat-soluble vitamins, but also significantly affect gastrointestinal motor, sensory and secretory functions, intestinal barrier permeability and the regulation of the inflammatory response. The results of recent studies have revealed complex interactions between bile acids and the gut microbiota. In addition, bile acids also play a role of signaling molecules regulating the activity of lipid and glucose metabolic pathways, as well as a role of ligands for transcription factors. Genetic factors associated with the regulation of bile acid syn...
Source: Postepy higieny i medycyny doswiadczalnej - August 24, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:727-736 "Neopterin as a marker of cellular immunological response"
Neopterin is a pyrazino-pyrimidine compound that belongs to the pteridine group. It is known to be a biochemical marker associated with cell-mediated immunity. It is produced by human monocytes/macrophages and dendritic cells from guanosine triphosphate (GTP) upon stimulation with interferon gamma (IFN γ ), which is released by activated limphocytes Th. Neopterin is a very important clinic parameter, though the physiological role has not been exactly definited thus far. The level of neopterin reflects the stage of activation of the cellular immune system, which is important in the pathogenesis and progression of various d...
Source: Postepy higieny i medycyny doswiadczalnej - August 24, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:713-726 "The role of trophic factors and inflammatory processes in physical activity-induced neuroprotection in Parkinson ’ s disease"
Glial cells and neurotrophins play an important role in maintaining homeostasis of the CNS. Disturbances of their function can lead to a number of nervous system diseases, including Parkinson ’ s disease (PD). Current clinical studies provide evidence that moderate physical activity adapted to the health status of PD patients can support pharmacological treatment, slow down the onset of motor impairments, and extend the patients period of independence. Physical activity, by stimulating the production and release of endogenous trophic factors, prevents the neurodegeneration of dopaminergic neurons via inhibition of inflam...
Source: Postepy higieny i medycyny doswiadczalnej - August 22, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:703-712 "Immune disorders in sepsis and their treatment as a significant problem of modern intensive care"
Despite the great advances in the treatment of sepsis over the past 20 years, sepsis remains the main cause of death in intensive care units. In the context of new possibilities of treating sepsis, a comprehensive response of the immune system to the infection, immunosuppression, in particular, has in recent years gained considerable interest. There is vast evidence pointing to the correlation between comorbid immunosuppression and an increased risk of recurrent infections and death. Immune disorders may impact the clinical course of sepsis. This applies in particular to patients with deteriorated clinical response to infe...
Source: Postepy higieny i medycyny doswiadczalnej - August 22, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:690-702 "Mitochondrial functionality in female reproduction"
This article addresses issues of mitochondrial role and function in mammalian oocyte and presents new approaches in studies of mitochondrial function in female germ cells. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - August 14, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:681-689 "The role of the BLCA-4 nuclear matrix protein
in bladder cancer"
Bladder cancer (BC) affects usually older people. According to information provided by the National Cancer Registry in 2012. BC was the 4th, in terms of illness, cancer in men and 11th in women. Early diagnosis of bladder cancer is important because detected later has worse prognosis.
Diagnosis of bladder cancer is not simple and it is still very invasive. Usually the cystoscopy or endoscopic bladder biopsy with histopathological evaluation and cytology of urine sediment is used. This prompted researchers to look for alternative noninvasive methods of diagnosis of bladder cancer. Recently, it was described the group of si...
Source: Postepy higieny i medycyny doswiadczalnej - August 14, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:662-680 "Role of copper in the process of spermatogenesis"
Copper (Cu) is an essential trace element required for the normal development of living organisms. Due to its redox potential, copper is a cofactor in many enzymes responsible for important processes in cells. Copper deficiency has a significant influence on the reduction or the total eradication of copper-dependent enzymes in the body, thereby inhibiting cell life processes. On the other hand, copper is a very reactive element and in its free state, it can trigger the production of large amounts of free radicals, which will consequently lead to the damage of proteins and DNA. Because of those reasons, living organisms hav...
Source: Postepy higieny i medycyny doswiadczalnej - August 10, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:649-661 "Circulating miRNAs as non-invasive biomarkers
for non-small cell lung cancer diagnosis, prognosis and prediction of treatment response"
The discovery of a new class of molecules, the 22-24 nucleotides long RNA, has initiated a new chapter in genetic information regulation studies. These molecules have a significant impact on the functioning of cells by means of negative regulation of expression of targeted mRNA. Special attention is given to exogenous, circulating miRNAs, whose levels of expression in different body fluids varies and can be deregulated by pathological, as well as physiological conditions. Extensive studies on the diagnostic potential of miRNAs are currently conducted. Attempts are made to determine specific profiles of miRNAs that will cor...
Source: Postepy higieny i medycyny doswiadczalnej - August 10, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:663-683 "Role of copper in the process of spermatogenesis"
Copper (Cu) is an essential trace element required for the normal development of living organisms. Due to its redox potential, copper is a cofactor in many enzymes responsible for important processes in cells. Copper deficiency has a significant influence on the reduction or the total eradication of copper-dependent enzymes in the body, thereby inhibiting cell life processes. On the other hand, copper is a very reactive element and in its free state, it can trigger the production of large amounts of free radicals, which will consequently lead to the damage of proteins and DNA. Because of those reasons, living organisms hav...
Source: Postepy higieny i medycyny doswiadczalnej - August 9, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:649-662 "Circulating miRNAs as non-invasive biomarkers
for non-small cell lung cancer diagnosis, prognosis and prediction of treatment response"
The discovery of a new class of molecules, the 22-24 nucleotides long RNA, has initiated a new chapter in genetic information regulation studies. These molecules have a significant impact on the functioning of cells by means of negative regulation of expression of targeted mRNA. Special attention is given to exogenous, circulating miRNAs, whose levels of expression in different body fluids varies and can be deregulated by pathological, as well as physiological conditions. Extensive studies on the diagnostic potential of miRNAs are currently conducted. Attempts are made to determine specific profiles of miRNAs that will cor...
Source: Postepy higieny i medycyny doswiadczalnej - August 9, 2017 Category: Research Tags: Review article Source Type: research
