Activation of AMPK in platelets promotes the production of offspring
Platelets. 2024 Dec;35(1):2334701. doi: 10.1080/09537104.2024.2334701. Epub 2024 Apr 17.ABSTRACTPlatelets are terminally differentiated anucleated cells, but they still have cell-like functions and can even produce progeny platelets. However, the mechanism of platelet sprouting has not been elucidated so far. Here, we show that when platelet-rich plasma(PRP) was cultured at 37°C, platelets showed a spore phenomenon. The number of platelets increased when given a specific shear force. It is found that AMP-related signaling pathways, such as PKA and AMPK are activated in platelets in the spore state. Meanwhile, the mRNA exp...
Source: Platelets - April 17, 2024 Category: Hematology Authors: Tong Zhang Mengnan Yang Shujun Li Rong Yan Kesheng Dai Source Type: research
Storage of plasma-derived exosomes: evaluation of anticoagulant use and preserving temperatures
In conclusion, plasma-dervied exosome characteristics strictly depend on the anticoagulants and storage temperature and duration.PMID:38630028 | DOI:10.1080/09537104.2024.2337255 (Source: Platelets)
Source: Platelets - April 17, 2024 Category: Hematology Authors: Caiting Yang Jie Han Hai Liu Yuyu He Zhenhua Zhang Xiaochun Liu Farooq Waqas Lizhong Zhang Huiping Duan Jing He Li Dong Source Type: research
Activation of AMPK in platelets promotes the production of offspring
Platelets. 2024 Dec;35(1):2334701. doi: 10.1080/09537104.2024.2334701. Epub 2024 Apr 17.ABSTRACTPlatelets are terminally differentiated anucleated cells, but they still have cell-like functions and can even produce progeny platelets. However, the mechanism of platelet sprouting has not been elucidated so far. Here, we show that when platelet-rich plasma(PRP) was cultured at 37°C, platelets showed a spore phenomenon. The number of platelets increased when given a specific shear force. It is found that AMP-related signaling pathways, such as PKA and AMPK are activated in platelets in the spore state. Meanwhile, the mRNA exp...
Source: Platelets - April 17, 2024 Category: Hematology Authors: Tong Zhang Mengnan Yang Shujun Li Rong Yan Kesheng Dai Source Type: research
Storage of plasma-derived exosomes: evaluation of anticoagulant use and preserving temperatures
In conclusion, plasma-dervied exosome characteristics strictly depend on the anticoagulants and storage temperature and duration.PMID:38630028 | DOI:10.1080/09537104.2024.2337255 (Source: Platelets)
Source: Platelets - April 17, 2024 Category: Hematology Authors: Caiting Yang Jie Han Hai Liu Yuyu He Zhenhua Zhang Xiaochun Liu Farooq Waqas Lizhong Zhang Huiping Duan Jing He Li Dong Source Type: research
The natural anticoagulant protein S; hemostatic functions and deficiency
Platelets. 2024 Dec;35(1):2337907. doi: 10.1080/09537104.2024.2337907. Epub 2024 Apr 11.ABSTRACTProtein S (PS) is a vital endogenous anticoagulant. It plays a crucial role in regulating coagulation by acting as a cofactor for the activated protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. Additionally, it possesses direct anticoagulant properties by impeding the intrinsic tenase and prothrombinase complexes. Protein S oversees the coagulation process in both the initiation and propagation stages through these roles. The significance of protein S in regulating blood clotting can be inferred from the signi...
Source: Platelets - April 11, 2024 Category: Hematology Authors: Fahad S Alshehri Abdullah A Bashmeil Ibrahim A Alamar Sarah K Alouda Source Type: research
Correlations among different platelet aggregation pathways in a group of healthy volunteers
Platelets. 2024 Dec;35(1):2336093. doi: 10.1080/09537104.2024.2336093. Epub 2024 Apr 11.ABSTRACTPlatelet aggregation is a complicated process mediated by different signaling pathways. As the process is highly complex and apparently redundant, the relationships between these pathways are not yet fully known. The aim of this project was to study the interconnections among seven different aggregation pathways in a group of 53 generally healthy volunteers aged 20 to 66 years. Platelet aggregation was induced with thrombin receptor activating peptide 6 (TRAP), arachidonic acid (AA), platelet activating factor 16 (PAF), ADP, col...
Source: Platelets - April 11, 2024 Category: Hematology Authors: Alejandro Carazo Marcel Hrub ša Luk áš Konečný Catherine Gunaseelan Jaka Fadraersada Pavel Sko řepa Mark éta Paclíková Franti šek Musil Jana Karl íčková Lenka Javorsk á Kate řina Matoušová Lenka Kujovsk á Krčmová Alena Šmahelová Vlad Source Type: research
The natural anticoagulant protein S; hemostatic functions and deficiency
Platelets. 2024 Dec;35(1):2337907. doi: 10.1080/09537104.2024.2337907. Epub 2024 Apr 11.ABSTRACTProtein S (PS) is a vital endogenous anticoagulant. It plays a crucial role in regulating coagulation by acting as a cofactor for the activated protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. Additionally, it possesses direct anticoagulant properties by impeding the intrinsic tenase and prothrombinase complexes. Protein S oversees the coagulation process in both the initiation and propagation stages through these roles. The significance of protein S in regulating blood clotting can be inferred from the signi...
Source: Platelets - April 11, 2024 Category: Hematology Authors: Fahad S Alshehri Abdullah A Bashmeil Ibrahim A Alamar Sarah K Alouda Source Type: research
Correlations among different platelet aggregation pathways in a group of healthy volunteers
Platelets. 2024 Dec;35(1):2336093. doi: 10.1080/09537104.2024.2336093. Epub 2024 Apr 11.ABSTRACTPlatelet aggregation is a complicated process mediated by different signaling pathways. As the process is highly complex and apparently redundant, the relationships between these pathways are not yet fully known. The aim of this project was to study the interconnections among seven different aggregation pathways in a group of 53 generally healthy volunteers aged 20 to 66 years. Platelet aggregation was induced with thrombin receptor activating peptide 6 (TRAP), arachidonic acid (AA), platelet activating factor 16 (PAF), ADP, col...
Source: Platelets - April 11, 2024 Category: Hematology Authors: Alejandro Carazo Marcel Hrub ša Luk áš Konečný Catherine Gunaseelan Jaka Fadraersada Pavel Sko řepa Mark éta Paclíková Franti šek Musil Jana Karl íčková Lenka Javorsk á Kate řina Matoušová Lenka Kujovsk á Krčmová Alena Šmahelová Vlad Source Type: research
The natural anticoagulant protein S; hemostatic functions and deficiency
Platelets. 2024 Dec;35(1):2337907. doi: 10.1080/09537104.2024.2337907. Epub 2024 Apr 11.ABSTRACTProtein S (PS) is a vital endogenous anticoagulant. It plays a crucial role in regulating coagulation by acting as a cofactor for the activated protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. Additionally, it possesses direct anticoagulant properties by impeding the intrinsic tenase and prothrombinase complexes. Protein S oversees the coagulation process in both the initiation and propagation stages through these roles. The significance of protein S in regulating blood clotting can be inferred from the signi...
Source: Platelets - April 11, 2024 Category: Hematology Authors: Fahad S Alshehri Abdullah A Bashmeil Ibrahim A Alamar Sarah K Alouda Source Type: research
Correlations among different platelet aggregation pathways in a group of healthy volunteers
Platelets. 2024 Dec;35(1):2336093. doi: 10.1080/09537104.2024.2336093. Epub 2024 Apr 11.ABSTRACTPlatelet aggregation is a complicated process mediated by different signaling pathways. As the process is highly complex and apparently redundant, the relationships between these pathways are not yet fully known. The aim of this project was to study the interconnections among seven different aggregation pathways in a group of 53 generally healthy volunteers aged 20 to 66 years. Platelet aggregation was induced with thrombin receptor activating peptide 6 (TRAP), arachidonic acid (AA), platelet activating factor 16 (PAF), ADP, col...
Source: Platelets - April 11, 2024 Category: Hematology Authors: Alejandro Carazo Marcel Hrub ša Luk áš Konečný Catherine Gunaseelan Jaka Fadraersada Pavel Sko řepa Mark éta Paclíková Franti šek Musil Jana Karl íčková Lenka Javorsk á Kate řina Matoušová Lenka Kujovsk á Krčmová Alena Šmahelová Vlad Source Type: research
The natural anticoagulant protein S; hemostatic functions and deficiency
Platelets. 2024 Dec;35(1):2337907. doi: 10.1080/09537104.2024.2337907. Epub 2024 Apr 11.ABSTRACTProtein S (PS) is a vital endogenous anticoagulant. It plays a crucial role in regulating coagulation by acting as a cofactor for the activated protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. Additionally, it possesses direct anticoagulant properties by impeding the intrinsic tenase and prothrombinase complexes. Protein S oversees the coagulation process in both the initiation and propagation stages through these roles. The significance of protein S in regulating blood clotting can be inferred from the signi...
Source: Platelets - April 11, 2024 Category: Hematology Authors: Fahad S Alshehri Abdullah A Bashmeil Ibrahim A Alamar Sarah K Alouda Source Type: research
Correlations among different platelet aggregation pathways in a group of healthy volunteers
Platelets. 2024 Dec;35(1):2336093. doi: 10.1080/09537104.2024.2336093. Epub 2024 Apr 11.ABSTRACTPlatelet aggregation is a complicated process mediated by different signaling pathways. As the process is highly complex and apparently redundant, the relationships between these pathways are not yet fully known. The aim of this project was to study the interconnections among seven different aggregation pathways in a group of 53 generally healthy volunteers aged 20 to 66 years. Platelet aggregation was induced with thrombin receptor activating peptide 6 (TRAP), arachidonic acid (AA), platelet activating factor 16 (PAF), ADP, col...
Source: Platelets - April 11, 2024 Category: Hematology Authors: Alejandro Carazo Marcel Hrub ša Luk áš Konečný Catherine Gunaseelan Jaka Fadraersada Pavel Sko řepa Mark éta Paclíková Franti šek Musil Jana Karl íčková Lenka Javorsk á Kate řina Matoušová Lenka Kujovsk á Krčmová Alena Šmahelová Vlad Source Type: research
Platelet rich fibrin as a bioactive matrix with proosteogenic and proangiogenic properties on human healthy primary cells in vitro
In conclusion, PRF possess proosteogenic, potentially osteoconductive as well as proangiogenic properties, making it a beneficial tool for bone tissue regeneration.PMID:38390838 | DOI:10.1080/09537104.2024.2316744 (Source: Platelets)
Source: Platelets - February 23, 2024 Category: Hematology Authors: Eva Dohle Lena Schmeinck Kamelia Parkhoo Robert Sader Shahram Ghanaati Source Type: research
Recent advances in microfluidic technology of arterial thrombosis investigations
In conclusion, microfluidic technology has revolutionized the study of arterial thrombosis by enabling the construction of artificial blood vessels and accurately reproducing hemodynamics. In the future, microfluidics will place greater emphasis on versatility and automation, holding great promise for advancing antithrombotic therapeutic and prophylactic measures.PMID:38390892 | DOI:10.1080/09537104.2024.2316743 (Source: Platelets)
Source: Platelets - February 23, 2024 Category: Hematology Authors: Jingying Lin Si Chen Chunying Zhang Juan Liao Yuemei Chen Shanying Deng Zhigang Mao Tonghao Zhang Na Tian Yali Song Tingting Zeng Source Type: research
Platelet rich fibrin as a bioactive matrix with proosteogenic and proangiogenic properties on human healthy primary cells in vitro
In conclusion, PRF possess proosteogenic, potentially osteoconductive as well as proangiogenic properties, making it a beneficial tool for bone tissue regeneration.PMID:38390838 | DOI:10.1080/09537104.2024.2316744 (Source: Platelets)
Source: Platelets - February 23, 2024 Category: Hematology Authors: Eva Dohle Lena Schmeinck Kamelia Parkhoo Robert Sader Shahram Ghanaati Source Type: research
