Changes in multi-modality management of acromegaly in a tertiary centre over 2 decades
ConclusionThe vast majority of patients with acromegaly now have successful disease control with a multimodal approach. They reached biochemical control sooner in the most recent half of the study period. Future work should focus on those patients who are still uncontrolled and on the sequelae of the disease. (Source: Pituitary)
Source: Pituitary - March 23, 2024 Category: Endocrinology Source Type: research
Prolactin-secreting tumors, dopamine agonists and pregnancy: a longitudinal experience of a tertiary neuroendocrine center
ConclusionFoetal exposure to DAs during the first weeks of embryogenesis is not associated with a greater risk of complications. The transient and mild developmental disorders recorded resolved spontaneously and the prevalence was substantially overlapping with that observed in the general population. (Source: Pituitary)
Source: Pituitary - March 18, 2024 Category: Endocrinology Source Type: research
Pituitary tumours without distinct lineage differentiation express stem cell marker SOX2
ConclusionsOur study is the first to biologically characterise pituitary tumours WDLD. We demonstrate that these tumours exhibit a higher expression of the stem cell marker SOX2 compared with other lineage-differentiated tumours, suggesting possible involvement of stem cells in their development. (Source: Pituitary)
Source: Pituitary - March 14, 2024 Category: Endocrinology Source Type: research
Correction: Impulse control disorders in patients with dopamine agonist-treated pituitary adenomas: a cross-sectional multicenter study
(Source: Pituitary)
Source: Pituitary - March 13, 2024 Category: Endocrinology Source Type: research
Glucose intolerance in acromegaly is driven by low insulin secretion; results from an intravenous glucose tolerance test
ConclusionWe demonstrated that low insulin secretion is the main driver behind glucose intolerance in acromegaly. Compared to NGT and IGT controls with obesity, patients with NGT or IGT acromegaly had higher Si. Together, these findings suggest that impaired insulin secretion might be a specific mechanism for glucose intolerance in acromegaly. (Source: Pituitary)
Source: Pituitary - February 21, 2024 Category: Endocrinology Source Type: research
Impulse control disorders in patients with dopamine agonist-treated pituitary adenomas: a cross-sectional multicenter study
ConclusionICDs with a broad range of psychiatric symptoms are common in individuals with DA-treated prolactinoma and NFPAs. Endocrinologists should be aware of this potential side effect, particularly in patients and those a personal history of psychiatric disorder. (Source: Pituitary)
Source: Pituitary - February 12, 2024 Category: Endocrinology Source Type: research
Elevated risk of recurrence and retreatment for silent pituitary adenomas
ConclusionPatients undergoing resection of SPAs should be closely monitored for disease recurrence through more frequent clinical follow-up and diagnostic imaging than other adenomas, particularly among patients with STR and younger patients. Several patients can be observed after radiographic recurrence, and the decision to retreat should be individualized. Longitudinal clinical follow-up of SPAs, including an assessment of symptoms, endocrine function, and imaging remains critical. (Source: Pituitary)
Source: Pituitary - February 12, 2024 Category: Endocrinology Source Type: research
Impulse control disorders in patients with dopamine agonist-treated pituitary adenomas: a cross-sectional multicenter study
ConclusionICDs with a broad range of psychiatric symptoms are common in individuals with DA-treated prolactinoma and NFPAs. Endocrinologists should be aware of this potential side effect, particularly in patients and those a personal history of psychiatric disorder. (Source: Pituitary)
Source: Pituitary - February 12, 2024 Category: Endocrinology Source Type: research
Elevated risk of recurrence and retreatment for silent pituitary adenomas
ConclusionPatients undergoing resection of SPAs should be closely monitored for disease recurrence through more frequent clinical follow-up and diagnostic imaging than other adenomas, particularly among patients with STR and younger patients. Several patients can be observed after radiographic recurrence, and the decision to retreat should be individualized. Longitudinal clinical follow-up of SPAs, including an assessment of symptoms, endocrine function, and imaging remains critical. (Source: Pituitary)
Source: Pituitary - February 12, 2024 Category: Endocrinology Source Type: research
Different patient versus provider perspectives on living with Cushing ’s disease
ConclusionsCD patients experience long term symptoms and impaired QoL which may in part be due to a perception of lack of effective treatment options and little hope for improvement. Communicating experiences and care goals may improve long term outcomes for CD patients. (Source: Pituitary)
Source: Pituitary - February 5, 2024 Category: Endocrinology Source Type: research
