Cardiovascular safety of psychedelic medicine: current status and future directions
Pharmacol Rep. 2023 Oct 24. doi: 10.1007/s43440-023-00539-4. Online ahead of print.ABSTRACTPsychedelics are powerful psychoactive substances that alter perception and mood processes. Their effectiveness in the treatment of psychiatric diseases was known before their prohibition. An increasing number of recent studies, due to the indisputable resurgence of serotonergic hallucinogens, have shown their efficacy in alleviating depression, anxiety, substance abuse therapies, and existential distress treatment in patients facing life-threatening illness. Psychedelics are generally considered to be physiologically safe with low t...
Source: Pharmacological Reports - October 24, 2023 Category: Drugs & Pharmacology Authors: Agnieszka Ws ół Source Type: research
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum
CONCLUSIONS: Modulatory effect of olanzapine on cellular mechanisms of gasotransmitter synthesis may be an alternative way of their pharmacological action.PMID:37874531 | DOI:10.1007/s43440-023-00538-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 24, 2023 Category: Drugs & Pharmacology Authors: Artur Pa łasz Julia Kistowska Aleksandra Suszka- Świtek Marek Krzystanek Iwona B łaszczyk Itiana Castro Menezes Łukasz Filipczyk Katarzyna Bogus Source Type: research
Development and application of a systematic and quantitative weighting framework to evaluate the quality and relevance of relative potency estimates for dioxin-like compounds (DLCs) for human health risk assessment
Regul Toxicol Pharmacol. 2023 Oct 20:105500. doi: 10.1016/j.yrtph.2023.105500. Online ahead of print.ABSTRACTThe toxic equivalency factors (TEFs) approach for dioxin-like chemicals (DLCs) is currently based on a qualitative assessment of a heterogeneous data set of relative estimates of potency (REPs) spanning several orders of magnitude with highly variable study quality and relevance. An effort was undertaken to develop a weighting framework to systematically evaluate and quantitatively integrate the quality and relevance for development of more robust TEFs. Six main-study characteristics were identified as most importan...
Source: Pharmacological Reports - October 22, 2023 Category: Drugs & Pharmacology Authors: Daniele Wikoff Caroline Ring Michael DeVito Nigel Walker Linda Birnbaum Laurie Haws Source Type: research
Development and application of a systematic and quantitative weighting framework to evaluate the quality and relevance of relative potency estimates for dioxin-like compounds (DLCs) for human health risk assessment
Regul Toxicol Pharmacol. 2023 Oct 20:105500. doi: 10.1016/j.yrtph.2023.105500. Online ahead of print.ABSTRACTThe toxic equivalency factors (TEFs) approach for dioxin-like chemicals (DLCs) is currently based on a qualitative assessment of a heterogeneous data set of relative estimates of potency (REPs) spanning several orders of magnitude with highly variable study quality and relevance. An effort was undertaken to develop a weighting framework to systematically evaluate and quantitatively integrate the quality and relevance for development of more robust TEFs. Six main-study characteristics were identified as most importan...
Source: Pharmacological Reports - October 22, 2023 Category: Drugs & Pharmacology Authors: Daniele Wikoff Caroline Ring Michael DeVito Nigel Walker Linda Birnbaum Laurie Haws Source Type: research
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
CONCLUSIONS: Overall, data underline the role of miR-378a in maintaining basal cardiac structural integrity while pointing to miR-378a-independent hyperglycemia-driven cardiac hypertrophy and associated dysfunction.PMID:37851320 | DOI:10.1007/s43440-023-00535-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 18, 2023 Category: Drugs & Pharmacology Authors: Urszula Florczyk-Soluch Katarzyna Polak Reece Sabo Alicja Martyniak Jacek St ępniewski J ózef Dulak Source Type: research
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
CONCLUSIONS: Overall, data underline the role of miR-378a in maintaining basal cardiac structural integrity while pointing to miR-378a-independent hyperglycemia-driven cardiac hypertrophy and associated dysfunction.PMID:37851320 | DOI:10.1007/s43440-023-00535-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 18, 2023 Category: Drugs & Pharmacology Authors: Urszula Florczyk-Soluch Katarzyna Polak Reece Sabo Alicja Martyniak Jacek St ępniewski J ózef Dulak Source Type: research
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
CONCLUSIONS: Overall, data underline the role of miR-378a in maintaining basal cardiac structural integrity while pointing to miR-378a-independent hyperglycemia-driven cardiac hypertrophy and associated dysfunction.PMID:37851320 | DOI:10.1007/s43440-023-00535-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 18, 2023 Category: Drugs & Pharmacology Authors: Urszula Florczyk-Soluch Katarzyna Polak Reece Sabo Alicja Martyniak Jacek St ępniewski J ózef Dulak Source Type: research
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
CONCLUSIONS: Overall, data underline the role of miR-378a in maintaining basal cardiac structural integrity while pointing to miR-378a-independent hyperglycemia-driven cardiac hypertrophy and associated dysfunction.PMID:37851320 | DOI:10.1007/s43440-023-00535-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 18, 2023 Category: Drugs & Pharmacology Authors: Urszula Florczyk-Soluch Katarzyna Polak Reece Sabo Alicja Martyniak Jacek St ępniewski J ózef Dulak Source Type: research
The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats
CONCLUSIONS: Rat liver cytochrome P450 functions deteriorate with age, which may impair drug metabolism. The TPH2 knockout, which deprives brain serotonin, affects cytochrome P450 expression and activity differently in mature and senescent male rats.PMID:37848703 | DOI:10.1007/s43440-023-00540-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 17, 2023 Category: Drugs & Pharmacology Authors: Anna Haduch Ewa Bromek Wojciech Kuban Agnieszka Basi ńska-Ziobroń Przemys ław J Danek Natalia Alenina Michael Bader W ładysława A Daniel Source Type: research
Development and characterization of a temozolomide-loaded nanoemulsion and the effect of ferrocene pre and co-treatments in glioblastoma cell models
CONCLUSIONS: Altogether, our results indicate that using nanoemulsion containing temozolomide in combination with ferrocene is an effective approach to improve glioblastoma therapy outcomes.PMID:37837521 | DOI:10.1007/s43440-023-00537-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 14, 2023 Category: Drugs & Pharmacology Authors: Jeferson Gustavo Henn Matheus Bernardes Ferro Gabriel Antonio Lopes Alves Fl ávia Pires Peña Jo ão Vitor Raupp de Oliveira B árbara Müller de Souza Leonardo Fonseca da Silva Vict ória Rapack Jacinto Silva Ana Carolina Silva Pinheiro Luiza Steffens R Source Type: research
Development and characterization of a temozolomide-loaded nanoemulsion and the effect of ferrocene pre and co-treatments in glioblastoma cell models
CONCLUSIONS: Altogether, our results indicate that using nanoemulsion containing temozolomide in combination with ferrocene is an effective approach to improve glioblastoma therapy outcomes.PMID:37837521 | DOI:10.1007/s43440-023-00537-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 14, 2023 Category: Drugs & Pharmacology Authors: Jeferson Gustavo Henn Matheus Bernardes Ferro Gabriel Antonio Lopes Alves Fl ávia Pires Peña Jo ão Vitor Raupp de Oliveira B árbara Müller de Souza Leonardo Fonseca da Silva Vict ória Rapack Jacinto Silva Ana Carolina Silva Pinheiro Luiza Steffens R Source Type: research
Development and characterization of a temozolomide-loaded nanoemulsion and the effect of ferrocene pre and co-treatments in glioblastoma cell models
CONCLUSIONS: Altogether, our results indicate that using nanoemulsion containing temozolomide in combination with ferrocene is an effective approach to improve glioblastoma therapy outcomes.PMID:37837521 | DOI:10.1007/s43440-023-00537-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 14, 2023 Category: Drugs & Pharmacology Authors: Jeferson Gustavo Henn Matheus Bernardes Ferro Gabriel Antonio Lopes Alves Fl ávia Pires Peña Jo ão Vitor Raupp de Oliveira B árbara Müller de Souza Leonardo Fonseca da Silva Vict ória Rapack Jacinto Silva Ana Carolina Silva Pinheiro Luiza Steffens R Source Type: research
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation
CONCLUSIONS: The most intriguing interaction was that for ISOP + VPA, for which the addition of BOR evoked a transition from antagonism to synergy in the mouse MES model.PMID:37821793 | DOI:10.1007/s43440-023-00532-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 11, 2023 Category: Drugs & Pharmacology Authors: Jarogniew J Łuszczki Hubert Bojar Katarzyna Jankiewicz Magdalena Florek- Łuszczki Jaros ław Chmielewski Krystyna Skalicka-Wo źniak Source Type: research
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation
CONCLUSIONS: The most intriguing interaction was that for ISOP + VPA, for which the addition of BOR evoked a transition from antagonism to synergy in the mouse MES model.PMID:37821793 | DOI:10.1007/s43440-023-00532-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 11, 2023 Category: Drugs & Pharmacology Authors: Jarogniew J Łuszczki Hubert Bojar Katarzyna Jankiewicz Magdalena Florek- Łuszczki Jaros ław Chmielewski Krystyna Skalicka-Wo źniak Source Type: research
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation
CONCLUSIONS: The most intriguing interaction was that for ISOP + VPA, for which the addition of BOR evoked a transition from antagonism to synergy in the mouse MES model.PMID:37821793 | DOI:10.1007/s43440-023-00532-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 11, 2023 Category: Drugs & Pharmacology Authors: Jarogniew J Łuszczki Hubert Bojar Katarzyna Jankiewicz Magdalena Florek- Łuszczki Jaros ław Chmielewski Krystyna Skalicka-Wo źniak Source Type: research
