Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT < sub > 2C < /sub > receptor in the mouse brain
CONCLUSIONS: Our findings reveal differential effects of 5-HT depletion and ethanol cessation on 5-HT2C receptor editing. Central 5-HT depletion attenuated editing in the prefrontal cortex and the hippocampus, whereas ethanol deprivation, coinciding with reduced Tph2 expression in the hippocampus, enhanced receptor editing efficiency specifically in this brain region. This study highlights the interplay between 5-HT synthesis, ethanol cessation, and 5-HT2C receptor editing, providing potential mechanism underlying increased ethanol consumption and deprivation.PMID:37923824 | DOI:10.1007/s43440-023-00545-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 4, 2023 Category: Drugs & Pharmacology Authors: Magdalena Zaniewska Natalia Alenina Sebastian Fr öhler Wei Chen Michael Bader Source Type: research
Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism
CONCLUSION: Findings from this work reveal that a smaller dose of MIT (1 mg/kg) poses no risk to hippocampal synaptic transmission. Alteration in neuroplasticity-associated proteins may be a molecular mechanism for MIT (5 and 10 mg/kg)-induced LTP disruption and cognitive impairments. Data from this work posit that MIT acted differently from MOR on neuroplasticity and its underlying mechanisms.PMID:37924443 | DOI:10.1007/s43440-023-00541-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 4, 2023 Category: Drugs & Pharmacology Authors: Suleiman Yunusa Zurina Hassan Christian P M üller Source Type: research
Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT < sub > 2C < /sub > receptor in the mouse brain
CONCLUSIONS: Our findings reveal differential effects of 5-HT depletion and ethanol cessation on 5-HT2C receptor editing. Central 5-HT depletion attenuated editing in the prefrontal cortex and the hippocampus, whereas ethanol deprivation, coinciding with reduced Tph2 expression in the hippocampus, enhanced receptor editing efficiency specifically in this brain region. This study highlights the interplay between 5-HT synthesis, ethanol cessation, and 5-HT2C receptor editing, providing potential mechanism underlying increased ethanol consumption and deprivation.PMID:37923824 | DOI:10.1007/s43440-023-00545-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 4, 2023 Category: Drugs & Pharmacology Authors: Magdalena Zaniewska Natalia Alenina Sebastian Fr öhler Wei Chen Michael Bader Source Type: research
Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism
CONCLUSION: Findings from this work reveal that a smaller dose of MIT (1 mg/kg) poses no risk to hippocampal synaptic transmission. Alteration in neuroplasticity-associated proteins may be a molecular mechanism for MIT (5 and 10 mg/kg)-induced LTP disruption and cognitive impairments. Data from this work posit that MIT acted differently from MOR on neuroplasticity and its underlying mechanisms.PMID:37924443 | DOI:10.1007/s43440-023-00541-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 4, 2023 Category: Drugs & Pharmacology Authors: Suleiman Yunusa Zurina Hassan Christian P M üller Source Type: research
Serum levels of biomarkers that may link chronic obstructive pulmonary disease and depressive disorder
CONCLUSIONS: Higher levels of IL-18, TGF-β, RANTES, and uPAR in patients with COPD might indicate the presence of depressive disorder and suggest the need for further evaluation of the mental state of these patients.PMID:37921965 | DOI:10.1007/s43440-023-00548-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 3, 2023 Category: Drugs & Pharmacology Authors: El żbieta Małujło-Balcerska Tadeusz Pietras Witold Śmigielski Source Type: research
Therapeutic, diagnostic and prognostic values of TRIM proteins in prostate cancer
Pharmacol Rep. 2023 Nov 3. doi: 10.1007/s43440-023-00534-9. Online ahead of print.ABSTRACTProstate cancer is the second most prevalent cancer in men worldwide. The TRIM (tripartite motif) family of proteins is involved in the regulation of various cellular processes, including antiviral immunity, apoptosis, and cancer progression. In recent years, several TRIM proteins have been found to play important roles in prostate cancer initiation and progression. TRIM proteins have indicated oncogenic activity in prostate cancer by enhancing androgen or estrogen receptor signaling and promoting cancer cell growth. Inhibition of TRI...
Source: Pharmacological Reports - November 3, 2023 Category: Drugs & Pharmacology Authors: Xiaojiang Li Yuzhuo Bai Ke Feng Zhendong Chu Haijun Li Zhicheng Lin Lin Tian Source Type: research
Introduction to the thematic collection "Psychedelic Medicine: Therapeutic Applications and Implications for Future Research"
Pharmacol Rep. 2023 Oct 31. doi: 10.1007/s43440-023-00549-2. Online ahead of print.NO ABSTRACTPMID:37904067 | DOI:10.1007/s43440-023-00549-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 31, 2023 Category: Drugs & Pharmacology Authors: Krystyna Go łembiowska Source Type: research
Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review
Pharmacol Rep. 2023 Oct 31. doi: 10.1007/s43440-023-00544-7. Online ahead of print.ABSTRACTCannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes involved in the biosynthesis and degradation of the endocannabinoids make up the endocannabinoid system (ECS). The components of the ECS are proven to modulate a vast bulk of various physiological and pathological processes due to their abundance throughout the human body. Such discoveries have attracted the researchers' attention and emerged as a potential therapeutical target for the treatment of various diseases. In the present article, we reviewed ...
Source: Pharmacological Reports - October 31, 2023 Category: Drugs & Pharmacology Authors: Gidion Wilson Lingling Yang Xiaojuan Su Shuqin Ding Liuyan Li Youyue Yang Xiaoying Wang Weibiao Wang Yuping Sa Yue Zhang Jianyu Chen Xueqin Ma Source Type: research
Introduction to the thematic collection "Psychedelic Medicine: Therapeutic Applications and Implications for Future Research"
Pharmacol Rep. 2023 Oct 31. doi: 10.1007/s43440-023-00549-2. Online ahead of print.NO ABSTRACTPMID:37904067 | DOI:10.1007/s43440-023-00549-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 31, 2023 Category: Drugs & Pharmacology Authors: Krystyna Go łembiowska Source Type: research
Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review
Pharmacol Rep. 2023 Oct 31. doi: 10.1007/s43440-023-00544-7. Online ahead of print.ABSTRACTCannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes involved in the biosynthesis and degradation of the endocannabinoids make up the endocannabinoid system (ECS). The components of the ECS are proven to modulate a vast bulk of various physiological and pathological processes due to their abundance throughout the human body. Such discoveries have attracted the researchers' attention and emerged as a potential therapeutical target for the treatment of various diseases. In the present article, we reviewed ...
Source: Pharmacological Reports - October 31, 2023 Category: Drugs & Pharmacology Authors: Gidion Wilson Lingling Yang Xiaojuan Su Shuqin Ding Liuyan Li Youyue Yang Xiaoying Wang Weibiao Wang Yuping Sa Yue Zhang Jianyu Chen Xueqin Ma Source Type: research
Introduction to the thematic collection "Psychedelic Medicine: Therapeutic Applications and Implications for Future Research"
Pharmacol Rep. 2023 Oct 31. doi: 10.1007/s43440-023-00549-2. Online ahead of print.NO ABSTRACTPMID:37904067 | DOI:10.1007/s43440-023-00549-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 31, 2023 Category: Drugs & Pharmacology Authors: Krystyna Go łembiowska Source Type: research
Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review
Pharmacol Rep. 2023 Oct 31. doi: 10.1007/s43440-023-00544-7. Online ahead of print.ABSTRACTCannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes involved in the biosynthesis and degradation of the endocannabinoids make up the endocannabinoid system (ECS). The components of the ECS are proven to modulate a vast bulk of various physiological and pathological processes due to their abundance throughout the human body. Such discoveries have attracted the researchers' attention and emerged as a potential therapeutical target for the treatment of various diseases. In the present article, we reviewed ...
Source: Pharmacological Reports - October 31, 2023 Category: Drugs & Pharmacology Authors: Gidion Wilson Lingling Yang Xiaojuan Su Shuqin Ding Liuyan Li Youyue Yang Xiaoying Wang Weibiao Wang Yuping Sa Yue Zhang Jianyu Chen Xueqin Ma Source Type: research
Introduction to the thematic collection "Psychedelic Medicine: Therapeutic Applications and Implications for Future Research"
Pharmacol Rep. 2023 Oct 31. doi: 10.1007/s43440-023-00549-2. Online ahead of print.NO ABSTRACTPMID:37904067 | DOI:10.1007/s43440-023-00549-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 31, 2023 Category: Drugs & Pharmacology Authors: Krystyna Go łembiowska Source Type: research
Psychedelics action and schizophrenia
Pharmacol Rep. 2023 Oct 30. doi: 10.1007/s43440-023-00546-5. Online ahead of print.ABSTRACTPsychedelics are compounds acting by serotonin 5-hydroxytryptamine (5-HT)2A receptor activation and induce several behavioral responses. They are of special interest because of their positive effects on neuropsychiatric disorders (depression and posttraumatic stress disorder). However, several findings revealed that some psychedelic actions are similar to symptoms observed in schizophrenia (psychosis, sensorimotor gating impairments, attention, and working memory deficits) which might limit their clinical applications. Psychedelics a...
Source: Pharmacological Reports - October 30, 2023 Category: Drugs & Pharmacology Authors: Marzena Ma ćkowiak Source Type: research
Preclinical models of treatment-resistant depression: challenges and perspectives
Pharmacol Rep. 2023 Oct 26. doi: 10.1007/s43440-023-00542-9. Online ahead of print.ABSTRACTTreatment-resistant depression (TRD) is a subgroup of major depressive disorder in which the use of classical antidepressant treatments fails to achieve satisfactory treatment results. Although there are various definitions and grading models for TRD, common criteria for assessing TRD have still not been established. However, a common feature of any TRD model is the lack of response to at least two attempts at antidepressant pharmacotherapy. The causes of TRD are not known; nevertheless, it is estimated that even 60% of TRD patients ...
Source: Pharmacological Reports - October 26, 2023 Category: Drugs & Pharmacology Authors: Magdalena Kolasa Agata Faron-G órecka Source Type: research
