Reply to Montmeat et al.
No abstract available (Source: Pain)
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research

Sex differences in medical cannabis-related adverse effects? Do not forget the context!
No abstract available (Source: Pain)
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to Quintner
No abstract available (Source: Pain)
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research

Pain cannot be a conditioned response
No abstract available (Source: Pain)
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research

Targeting intrinsically disordered regions facilitates discovery of calcium channels 3.2 inhibitory peptides for adeno-associated virus–mediated peripheral analgesia
In this study, we report the engineering of the potent and selective iPAs of CaV3.2 from the intrinsically disordered regions (IDRs) of CaV3.2 intracellular segments. Using established prediction algorithms, we localized the IDRs in CaV3.2 protein and identified several CaV3.2iPA candidates that significantly reduced CaV3.2 current in HEK293 cells stably expressing human wide-type CaV3.2. Two prototype CaV3.2iPAs (iPA1 and iPA2) derived from the IDRs of CaV3.2 intracellular loops 2 and 3, respectively, were expressed selectively in the primary sensory neurons of dorsal root ganglia in vivo using recombinant adeno-associate...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Rethinking the definition of chronic postsurgical pain: composites of patient-reported pain-related outcomes vs pain intensities alone
This study included measures of function in a composite score of patient-reported outcomes (PROs) to investigate the incidence of CPSP. Registry data were analyzed for PROs 1 day and 12 months postoperatively. Based on pain intensity and pain-related interference with function, patients were allocated to the groups “CPSPF” (at least moderate pain with interference), “mixed” (milder symptoms), and “no CPSPF”. The incidence of CPSPF was compared with CPSP rates referring to published data. Variables associated with the PRO-12 score (composite PROs at 12 months; numeric rating scale 0-10) were analyzed by linear r...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Ketogenic diet prevents methylglyoxal-evoked nociception by scavenging methylglyoxal
Methylglyoxal (MGO) is a reactive dicarbonyl byproduct of glycolysis implicated in a growing number of neuropathic pain conditions, including chemotherapy-induced peripheral neuropathy, diabetic peripheral neuropathy, and radiculopathy with lumbar disk herniation. Recent studies show success in preclinical models treating these disorders with an interventional ketogenic diet. Here, we tested the hypothesis that a ketogenic diet modifies pathological MGO signaling as a mechanism underlying neuropathy improvement. We found that mice injected with MGO displayed nocifensive behaviors, whereas mice prefed a ketogenic diet were ...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Astrocytic phosphatase and tensin homolog deleted on chromosome 10 regulates neuropathic pain by facilitating 3-hydroxy-3-methylglutaryl-CoA reductase–dependent cholesterol biosynthesis
Recent studies have noted the role of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in developing neuropathic pain, but the underlying mechanisms are obscure. We found that PTEN was mainly expressed in astrocytes in the rat spinal cord and dramatically downregulated after chronic constriction injury (CCI). Intrathecal injection of a PTEN inhibitor induced pain-related behaviors in naive rats. By contrast, administration of a PTEN protector effectively mitigated CCI-induced pain. Adeno-associated virus–mediated overexpression of astrocytic PTEN in the spinal cord reduced glial activation and neuroinfl...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Autoantibodies from patients with complex regional pain syndrome induce pro-inflammatory effects and functional disturbances on endothelial cells in vitro
Complex regional pain syndrome (CRPS) is an inadequate local response after a limb trauma, which leads to severe pain and autonomic and trophic changes of the affected limb. Autoantibodies directed against human β2 adrenergic and muscarinic M2 receptors (hβ2AR and hM2R) have been described in CRPS patients previously. We analyzed sera from CRPS patients for autoantibodies against hβ2AR, hM2R, and endothelial cells and investigated the functional effects of purified IgG, derived from 13 patients with CRPS, on endothelial cells. Eleven healthy controls, 7 radial fracture patients without CRPS, and 10 patients with periphe...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Autobiographical memory predicts postsurgical pain up to 12 months after major surgery
This study addressed these gaps by conducting a prospective, longitudinal study of memory performance, postsurgical pain, and psychosocial factors in 97 adult participants scheduled for major surgery. Memories were evaluated using the Autobiographical Memory Test before and one month after surgery when participants were asked to recall personal events related to positive and pain-related word cues. Responses were coded for level of specificity, emotional valence, and surgery-related content. Questionnaires assessing presence/absence of pain and psychological functioning were administered before and at 1-, 3-, 6-, and 12-mo...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Cognitive functional therapy compared with core exercise and manual therapy in patients with chronic low back pain: randomised controlled trial
Cognitive functional therapy (CFT) is a physiotherapy-led intervention that has evolved from an integration of foundational behavioral psychology and neuroscience within the physiotherapist practice directed at the multidimensional nature of chronic low back pain (CLBP). The current evidence about the comparative effectiveness of CFT for CLBP is still scarce. We aimed to investigate whether CFT is more effective than core training exercise and manual therapy (CORE-MT) in pain and disability in patients with CLBP. A total of 148 adults with CLBP were randomly assigned to receive 5 one-hour individualized sessions of either ...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Pain severity ratings in the 11th revision of the International Classification of Diseases: a versatile tool for rapid assessment
This study aimed to evaluate this severity code by comparing the ratings with established psychometric measures of pain-related interference and distress. An online survey was posted to self-help groups for chronic pain, and 595 participants (88.7% women, 59.5 ± 13.5 years) rated each of the severity parameters (pain intensity, pain-related interference, and pain-related distress) on an NRS from 0 to 10 and completed the Pain Disability Index and the Pain Coping Questionnaire (FESV, 3 subscales). The participants reported a mean pain intensity of 6.4 ± 1.9, mean pain-related interference of 6.7 ± 2.1, and mean pain-rela...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Effect of prolonged experimental neck pain on exercise-induced hypoalgesia
This study investigated EIH in a healthy population during experimental neck pain. Forty participants were randomized into this double-blinded parallel-group study. On 4 separate test days (day 0, day 2, day 4, and day 15), participants completed the Neck Disability Index and scored neck pain intensity during head movements on a numerical rating scale. At the end of day 0 and day 2, nerve growth factor (NGF) or isotonic saline (control) was injected into the right splenius capitis muscle. Pressure pain thresholds (PPTs) were recorded bilaterally over splenius capitis (neck), temporalis (head), and tibialis anterior (leg) m...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Post-acute sensory neurological sequelae in patients with severe acute respiratory syndrome coronavirus 2 infection: the COVID-PN observational cohort study
This study aimed to characterize the occurrence and severity of pain and peripheral neuropathy symptoms in patients with SARS-CoV-2 infection. An observational cohort study included adults tested for a SARS-CoV-2 infection at an academic medical center (assigned as CV+ or control, based on test results). Thirty to 90 days after the index SARS-CoV-2 test, patients completed a web-based questionnaire assessing pain, peripheral neuropathy-related sensory symptoms, and symptoms in the distribution of cranial nerves (current symptoms, symptoms at testing and 2 weeks thereafter). Univariate analyses compared the outcomes between...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Drug–drug–gene interaction risk among opioid users in the U.S. Department of Veterans Affairs
Response to analgesic therapy is influenced by several factors including genetics and drug–drug interactions. Pharmacogenetic (PGx) variants in the CYP2D6 gene modify response to opioids by altering drug metabolism. We sought to determine the potential impact of PGx testing on the care of Veterans with noncancer pain prescribed opioids metabolized by CYP2D6 (codeine, hydrocodone, or tramadol). A retrospective analysis was performed within the Veterans Health Administration evaluating prescription records for pain medications metabolized by CYP2D6 and interacting drugs from 2012 to 2017. Among 2,436,654 Veterans Health Ad...
Source: Pain - November 21, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research