Comparing closure compliance and ease of use for consumer product packs designed to reduce access to children
by Annalise Richmond, David C. Schwebel, Clara Ng Pak Leung, Elke Vallez, Heidi Lesage, Raf Degeyter, Zhiwu Liang, Gerard Stijntjes
Child impeding packs are difficult for children to open so protect them from unintended access to hazardous contents inside the pack. However, if packs are difficult for adults to open, in normal usage scenarios, this may result in a higher occurrence of packs being left open. This research explor es differences in ease of usage and closure compliance between two types of child impeding packs of liquid laundry detergent capsules. The two packs, “Pinch& Lift ” and “Press& Lift ”, had d...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Annalise Richmond Source Type: research
Assessing the causal associations of different types of statins use and knee/hip osteoarthritis: A Mendelian randomization study
This study comprehensively evaluated the causal relationship between different types of statins use and knee/hip osteoarthritis (OA) using a two-sample and multivariate Mendelian randomization (MR) method. MethodsMR analysis was conducted using publicly available summary statistics data from genome-wide association studies (GWAS) to assess the causal associations between total statins use (including specific types) and knee/hip OA. The primary analysis utilized the inverse variance-weighted (IVW) method, with sensitivity analysis conducted to assess robustness. Multivariable MR (MVMR) analysis adjusted for low-density lipo...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Xin Chen Source Type: research
Serum brain-derived neurotrophic factor levels in type 2 diabetes mellitus patients and its association with cognitive impairment: A meta-analysis
by Wan-li He, Fei-xia Chang, Tao Wang, Bi-xia Sun, Rui-rong Chen, Lian-ping Zhao
ObjectiveTo compare the serum levels of brain-derived neurotrophic factor (BDNF) in type 2 diabetes mellitus (T2DM) patients with healthy controls (HC) and evaluate the BDNF levels in T2DM patients with/without cognitive impairment. MethodsPubMed, EMBASE, and the Cochrane Library databases were searched for the published English literature on BDNF in T2DM patients from inception to December 2022. The BDNF data in the T2DM and HC groups were extracted, and the study quality was evaluated using the Agency for Healthcare Research and Quality. A m...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Wan-li He Source Type: research
Shroud waving self-determination: A qualitative analysis of the moral and epistemic dimensions of obstetric violence in the Netherlands
The objective of this qualitative research is to gain insight into the working and normalization of obstetric violence by focusing on the moral and epistemic injustices that both facilitate obstetric violence and make it look acceptable. Following the study design of Responsive Evaluation, interviews, homogenous, and heterogenous focus groups were done in three phases, with thirty-one participants, consisting of ten mothers, eleven midwives, five doulas and five midwives in training. All participants were already critically engaged with the topic, which was a selection criterion to b e able to bring the existing depth of k...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Rodante van der Waal Source Type: research
Prevalence and factors associated with burnout among health professionals of a public hospital network during the COVID-19 pandemic
by Patricia Martins, Richardson Warley Siqueira Luzia, Jair Alves Pereira Filho, Kelly Silva Welsh, C íntia Fuzikawa, Rodrigo Nicolato, Márcia Mascarenhas Alemão, Márcio Augusto Gonçalves, José Carlos Cavalheiro, Ianny Dumont Ávila, Ricardo Teixeira Veiga
Burnout is most commonly defined as a syndrome characterized by emotional exhaustion, cynicism, and ineffectiveness, which occurs in response to chronic stressors at work. It can adversely affect health workers’ physical and mental health, and the quality of care provided. The COVID-19 pandemic increased stressors and could impact burnout prevalence in this grou...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Patricia Martins Source Type: research
Modeling the shared risks of malaria and anemia in Rwanda
by Pacifique Karekezi, Jean Damascene Nzabakiriraho, Ezra Gayawan
In sub-Saharan Africa, malaria and anemia contribute substantially to the high burden of morbidity and mortality among under-five children. In Rwanda, both diseases have remained public health challenge over the years in spite of the numerous intervention programs and policies put in place. This s tudy aimed at understanding the geographical variations between the joint and specific risks of both diseases in the country while quantifying the effects of some socio-demographic and climatic factors. Using data extracted from Rwanda Demographic and Health Surve...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Pacifique Karekezi Source Type: research
Echogenic intracardiac foci detection and location in the second-trimester ultrasound and association with fetal outcomes: A systematic literature review
ConclusionEIF alone was not associated with adverse outcomes for the infant. Only persistent EIF on the right side showed evidence of carrying a higher risk of cardiac abnormality and would warrant further follow-up. (Source: PLoS One)
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Hope Eleri Jones Source Type: research
Language abilities and associated risk factors of school-aged children with cleft lip and palate
by Lim Hui Hui, Eh Yee Ling, Yazmin Ahmad Rusli, Goh Bee See, Hasherah Mohd Ibrahim
Previous research on children with cleft lip and palate (CLP) reported unequivocal findings with regard to language skills, with the majority suggesting persistent difficulties in early childhood. While expressive language deficits improved with age, receptive language skills were consistently low er than peers. Further study investigating the long term and persistent impact of language deficits amongst school-aged children with CLP is warranted. This was a cross-sectional study, aimed to determine the language abilities and explore the as...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Lim Hui Hui Source Type: research
Effects of brief mindfulness training on smoking cue-reactivity in tobacco use disorder: Study protocol for a randomized controlled trial
The objective of the present study is to investigate the impact of BMT intervention on smoking cue-reactivity among Chinese college students with TUD, to uncover the dynamic models of brain function involved in this process. MethodA randomized control trial (RCT) based on electroencephalography (EEG) was designed. We aim to recruit 90 participants and randomly assign to the BMT and control group (CON) with 1:1 ratio. A brief mindfulness training will be administered to experimental group. After the intervention, data collection will be conducted in the follow-up stage with 5 timepoints of assessments. EEG data will be reco...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Linlin Cheng Source Type: research
The student-teacher framework guided by self-training and consistency regularization for semi-supervised medical image segmentation
by Boliang Li, Yaming Xu, Yan Wang, Luxiu Li, Bo Zhang
Due to the high suitability of semi-supervised learning for medical image segmentation, a plethora of valuable research has been conducted and has achieved noteworthy success in this field. However, many approaches tend to confine their focus to a singular semi-supervised framework, thereby overlo oking the potential enhancements in segmentation performance offered by integrating several frameworks. In this paper, we propose a novel semi-supervised framework named Pesudo-Label Mean Teacher (PLMT), which synergizes the self-training pipeline with pseudo-labeling and co...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Boliang Li Source Type: research
Bioinformatics and system biology approaches to determine the connection of SARS-CoV-2 infection and intrahepatic cholangiocarcinoma
ConclusionThis study is expected to provide valuable references and potential drugs for future research and treatment of COVID-19 and ICC. (Source: PLoS One)
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Xinyi Zhou Source Type: research
Doxorubicin causes cachexia, sarcopenia, and frailty characteristics in mice
by Paola Sanches Cella, Ricardo Lu ís Nascimento de Matos, Poliana Camila Marinello, Júlio Cesar da Costa, Felipe Arruda Moura, Ana Paula Frederico Rodrigues Loureiro Bracarense, Patricia Chimin, Rafael Deminice
While chemotherapy treatment can be lifesaving, it also has adverse effects that negatively impact the quality of life. To investigate the effects of doxorubicin chemotherapy on body weight loss, strength and muscle mass loss, and physical function impairments, all key markers of cachexia, sarcope nia, and frailty. Seventeen C57/BL/6 mice were allocated into groups. 1) Control (n = 7): mice were exposed to intra...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Paola Sanches Cella Source Type: research
Enhancing early autism diagnosis through machine learning: Exploring raw motion data for classification
by Maria Luongo, Roberta Simeoli, Davide Marocco, Nicola Milano, Michela Ponticorvo
In recent years, research has been demonstrating that movement analysis, utilizing machine learning methods, can be a promising aid for clinicians in supporting autism diagnostic process. Within this field of research, we aim to explore new models and delve into the detailed observation of certain features that previous literature has identified as prominent in the classification process. Our study employs a game-based tablet application to collect motor data. We use artificial neural networks to analyze raw trajectories in a "drag and dro...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Maria Luongo Source Type: research
The association between < i > Dioscorea sansibarensis < /i > and < i > Orrella dioscoreae < /i > as a model for hereditary leaf symbiosis
by Tessa Acar, Sandra Moreau, Marie-Fran çoise Jardinaud, Gabriella Houdinet, Felicia Maviane-Macia, Frédéric De Meyer, Bart Hoste, Olivier Leroux, Olivier Coen, Aurélie Le Ru, Nemo Peeters, Aurelien Carlier
Hereditary, or vertically-transmitted, symbioses affect a large number of animal species and some plants. The precise mechanisms underlying transmission of functions of these associations are often difficult to describe, due to the difficulty in separating the symbiotic partners. This is especiall y the case for plant-bacteria hereditary symbioses, which lack experimentally tractable model systems. Here, we demons...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Tessa Acar Source Type: research
Untargeted metabolomics reveals that declined PE and PC in obesity may be associated with prostate hyperplasia
ConclusionsIn conclusion, obese patients with BPH had a unique metabolic profile, and alterations in PE and PC in these patients be associated with the development and progression of BPH. (Source: PLoS One)
Source: PLoS One - April 19, 2024 Category: Biomedical Science Authors: Guorui Fan Source Type: research
