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Promoter of lncRNA MORT is aberrantly methylated in colorectal cancer
In conclusion, based on our results, promoter hypermethylation of MORT might be considered as a potential biomarker for CRC detection.PMID:38619194 | DOI:10.1080/15257770.2024.2328732 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Aylar Nazari Tayyebeh Ghasemi Mohammad Khalaj-Kondori Ramin Fathi Source Type: research

Correlation of BARD1 gene polymorphisms with risk of neuroblastoma: a meta-analysis
Nucleosides Nucleotides Nucleic Acids. 2024 Apr 15:1-19. doi: 10.1080/15257770.2024.2336215. Online ahead of print.ABSTRACTBRCA1-associated RING domain protein 1 (BARD1) gene polymorphisms may be associated with neuroblastoma (NB) susceptibility. However, the results remain controversial. Relevant studies were identified by searching PubMed, Web of Science, Embase, China National Knowledge Infrastructure databases up to March 5, 2023. The strength of the association between BARD1 polymorphisms and susceptibility of NB was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) through the fixed- or...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Shan Chen Di Xu Rongdong Huang Yang Lin Lizhi Li Source Type: research

Effects of nucleoside analogues, lipophilic prodrugs and elaidic acids on core signaling pathways in cancer cells
CONCLUSIONS: The findings suggest that both parent drugs, prodrugs, and the EA chain influence cell survival and signaling pathways.PMID:38619266 | DOI:10.1080/15257770.2024.2339952 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Marika A Fra ńczak Claudine van der Sande Elisa Giovannetti Godefridus J Peters Source Type: research

Difluoroacetic acid: an alternative acid in the detritylation reaction for the solid-phase synthesis of oligonucleotides
Nucleosides Nucleotides Nucleic Acids. 2024 Apr 11:1-9. doi: 10.1080/15257770.2024.2337145. Online ahead of print.ABSTRACTDichloroacetic acid or trichloroacetic acid are commonly used in the detritylation reaction of the automated solid-phase synthesis of oligonucleotides. Dichloroacetic acid, however, is often contaminated with trichloroacetaldehyde (chloral), leading to the formation of inseparable impurities in the final oligonucleotide product. In this work, three different sequences, namely T18, d(TAA)6, and an 18-mer mixed sequence, were used as models to compare the deprotection efficiency of three acids: trichloroa...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 11, 2024 Category: Biochemistry Authors: Quanjian Li Dhruval Joshi Yogesh S Sanghvi Hongbin Yan Source Type: research

Evaluation of miR-130b-3p and miR-375 levels and telomere length with telomerase activity in prostate cancer
Nucleosides Nucleotides Nucleic Acids. 2024 Apr 9:1-12. doi: 10.1080/15257770.2024.2334896. Online ahead of print.ABSTRACTProstate cancer (PC) is the most frequent cancer in males, as well as the second highest cause of cancer-related deaths in men. Differences in expression levels of miRNAs were linked with prostat cancer pathogenesis. qPCR was used to evaluate the expression of miR-130b-3p and miR-375 in Benign Prostate Hyperplasia (BPH (n = 20) and PC (n = 22, pre- and post-operative) patients plasma. Relative telomere lengths (RLTs) in genomic DNA isolated from plasma were measured with qPCR, and telomerase activity an...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 9, 2024 Category: Biochemistry Authors: Abdullah Karada ğ Ebubekir Dirican Çağdaş Gökhun Özmerdiven Ata Özen Semih Ayan Selda Kabadere Source Type: research

Association of rs11081062 polymorphism of DLGAP1 gene and levels of SLC1A1 protein with obsessive-compulsive disorder
This study suggests that rs11081062 in DLGAP1 may be associated with OCD and that SLC1A1 protein levels may be involved in the occurrence of OCD. We believe that our research can contribute to the understanding of the importance of glutamate in OCD.PMID:38593060 | DOI:10.1080/15257770.2024.2336213 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 9, 2024 Category: Biochemistry Authors: Efruz İrem Akkuş Burcu Bayo ğlu Ne şe Kocabaşoğlu Jansed Berfin Y ıldız M üjgan Cengiz Source Type: research