Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis
Conclusion: The presented data suggest that pregabalin primarily acts on neuronal Ca2+ channel trafficking thereby reducing Ca2+-mediated cytotoxicity and neuronal damage in an animal model of MS. Future clinical trials need to assess the benefit for neuronal survival by expanding the indication for pregabalin administration to MS patients in further disease phases.Neurosignals 2018;26:77 –93 (Source: Neurosignals)
Source: Neurosignals - November 27, 2018 Category: Neurology Source Type: research
The Critical Role of Intrinsic Membrane Oscillations
Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Because cortical circuits are incapable of maintaining high frequency activity in the gamma range for prolonged periods, those processes dependent on co...
Source: Neurosignals - October 5, 2018 Category: Neurology Source Type: research
Ethylenediaminetetraacetic Acid Inhibits < b > < i > Vibrio Vulnificus < /i > < /b > -Induced Dendritic Cell Apoptosis by Lowering [Ca < sup > 2+ < /sup > ] < sub > i < /sub >
Conclusions: EDTA inhibitsV. Vulnificus-induced DC apoptosis by lowering [Ca2+]i via m-Tor-STAT3-Bcl-2 signaling pathway.Neurosignals 2018;26:58 –65 (Source: Neurosignals)
Source: Neurosignals - May 29, 2018 Category: Neurology Source Type: research
Endomorphin-2 Inhibits the Activity of the Spinoparabrachial Projection Neuron through Presynaptic Mechanisms in the Spinal Dorsal Horn in Rats
Conclusion: Applying EM2 to the SDH could produce analgesia through inhibiting the activities of the spinoparabrachial PNs in lamina I by reducing presynaptic neurotransmitters release from the primary afferent terminals.Neurosignals 2018;26:43 –57 (Source: Neurosignals)
Source: Neurosignals - March 19, 2018 Category: Neurology Source Type: research
Brain Beta-Catenin Signalling During Stress and Depression
Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway. In the canonical Wnt signalling pathway, beta-catenin again plays multiple roles. In the embryonic stage, the regulation of beta-catenin levels activates genes that govern cell proliferation and differentiation. In an adult organism, beta-catenin continues to regulate the cell cycle – as a result over-expression of beta-catenin may lead to cancer. In the brain, dysfunctions in Wnt signalling related to beta-catenin levels may also cause various pa...
Source: Neurosignals - February 28, 2018 Category: Neurology Source Type: research
The Myth of Blunted Gamers: No Evidence for Desensitization in Empathy for Pain after a Violent Video Game Intervention in a Longitudinal fMRI Study on Non-Gamers
Conclusions: The present results provide strong evidence against the frequently proclaimed negative effects of playing violent video games and will therefore help to communicate a more realistic scientific perspective of the effects of violent video gaming in real life.Neurosignals 2018;26:22 –30 (Source: Neurosignals)
Source: Neurosignals - February 8, 2018 Category: Neurology Source Type: research
Association between COMT Polymorphism Val158Met and Opioid Consumption in Patients with Postoperative Pain: A Meta-Analysis
Conclusion: Patients with Val/Met but not Met/Met allele variant consumed less opioid, though larger and better-designed studies are required to obtain an exclusive conclusion about the correlation between postoperative pain and COMT Val158Met polymorphism.Neurosignals 2018;26:11 –21 (Source: Neurosignals)
Source: Neurosignals - January 31, 2018 Category: Neurology Source Type: research
Introducing a Virtual Lesion Model of Dysphagia Resulting from Pharyngeal Sensory Impairment
Conclusions: Withdrawal of sensory afferent information by topical anesthesia leads to reduced response to pneumatic pharyngeal stimulation in a distributed cortical sensorimotor network in healthy subjects. The proposed paradigm may serve to investigate the effect of neuromodulatory treatments specifically on pharyngeal sensory impairment as relevant cause of neurogenic dysphagia.Neurosignals 2018;26:1 –10 (Source: Neurosignals)
Source: Neurosignals - January 31, 2018 Category: Neurology Source Type: research
The Myth of Blunted Gamers: No Evidence for Desensitization in Empathy for Pain after a Violent Video Game Intervention in a Longitudinal fMRI Study on Non-Gamers
Conclusions: The present results provide strong evidence against the frequently proclaimed negative effects of playing violent video games and will therefore help to communicate a more realistic scientific perspective of the effects of violent video gaming in real life.Neurosignals 2018;26:22 –30 (Source: Neurosignals)
Source: Neurosignals - January 30, 2018 Category: Neurology Source Type: research
Association between COMT Polymorphism Val158Met and Opioid Consumption in Patients with Postoperative Pain: A Meta-Analysis
Conclusion: Patients with Val/Met but not Met/Met allele variant consumed less opioid, though larger and better-designed studies are required to obtain an exclusive conclusion about the correlation between postoperative pain and COMT Val158Met polymorphism.Neurosignals 2018;26:11 –21 (Source: Neurosignals)
Source: Neurosignals - January 24, 2018 Category: Neurology Source Type: research
