Anti-N-methyl-d-aspartate Receptor Encephalitis in People Living with HIV: Case Report and Literature Review
AbstractWith the increase in the number of cases of autoimmune encephalitis (AE), the cerebrospinal fluid (CSF) of people living with HIV (PLWH) showing abnormal behavior, cognitive impairment or abnormal movements should be actively screened for the antibody panel of AE. Early recognition and treatment can prevent severe seizures or coma and markedly improve the prognosis of patients. The first-line immunotherapy for AE includes intravenous methylprednisolone and immunoglobulin. However, whether long-time immunosuppressive maintenance therapy is needed is debated. For PLWH, immunosuppressive therapy and even steroids coul...
Source: Neurology and Therapy - March 26, 2024 Category: Neurology Source Type: research

REBISTART: Adherence of Patients with Multiple Sclerosis to Treatment with Subcutaneous Interferon Beta in the Context of a Patient Support Program
ConclusionsVery high adherence rates independent of the PSP nursing service over 1  year of treatment indicate that IFN beta-1a sc is an easy-to-use and well-tolerated disease-modifying drug.Trial Registration NumberVfa.de: No. 892.https://www.vfa.de/de/arzneimittel-forschung/datenbanken-zu-arzneimitteln/nisdb/nis-details/_892. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 26, 2024 Category: Neurology Source Type: research

Impact of Baseline Neuropathy Severity on Vutrisiran Treatment Response in the Phase 3 HELIOS-A Study
ConclusionsVutrisiran demonstrated benefit in neurologic function and other key efficacy measures versus external placebo across all four baseline neuropathy severity quartiles. Patients initiating vutrisiran earlier in their disease course retained the highest neurologic function level after 18  months, highlighting the importance of early diagnosis and treatment.Trial Registration NumberClinicalTrials.gov: NCT03759379. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 21, 2024 Category: Neurology Source Type: research

Publisher Correction: Summary of Research: What Is the True Impact of Cognitive Impairment for People Living with Multiple Sclerosis? A Commentary of Symposium Discussions at the 2020 European Charcot Foundation
(Source: Neurology and Therapy)
Source: Neurology and Therapy - March 19, 2024 Category: Neurology Source Type: research

Correction: Neurofilament Light Chain in Adult and Pediatric Multiple Sclerosis: A Promising Biomarker to Better Characterize Disease Activity and Personalize MS Treatment
(Source: Neurology and Therapy)
Source: Neurology and Therapy - March 18, 2024 Category: Neurology Source Type: research

Holistic, Long-Term Management of People with Relapsing Multiple Sclerosis with Cladribine Tablets: Expert Opinion from France
AbstractCladribine tablets (CladT) has been available for therapeutic use in France since March 2021 for the management of highly active relapsing multiple sclerosis (RMS). This high-efficacy disease-modifying therapy (DMT) acts as an immune reconstitution therapy. In contrast to most high-efficacy DMTs, which act via continuous immunosuppression, two short courses of oral treatment with CladT at the beginning of years 1 and 2 of treatment provide long-term control of MS disease activity in responders to treatment, without the need for any further pharmacological treatment for several years. Although the labelling for Clad...
Source: Neurology and Therapy - March 15, 2024 Category: Neurology Source Type: research

Assessing the Long-Term (48-Week) Effectiveness, Safety, and Tolerability of Fremanezumab in Migraine in Real Life: Insights from the Multicenter, Prospective, FRIEND3 Study
ConclusionThis RWE study documents that long-term fremanezumab treatment is highly effective and remarkably well tolerated in subjects with HFEM or CM with multiple (>  3) therapeutic failures, even in the presence of concomitant medication overuse, psychiatric comorbidities, or both. The effectiveness-to-tolerability ratio appears to be better in RWE than in RCTs. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 7, 2024 Category: Neurology Source Type: research

Impact of Immune Cells on Stroke Limited to Specific Subtypes: Evidence from Mendelian Randomization Study
ConclusionOur study reveals several causal links between immune phenotypes and stroke and its different subtypes, highlighting the complex interactions between the immune system and stroke. These findings provide new directions for further uncovering the biological basis of stroke and assist in advancing research on early interventions and treatment strategies. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 6, 2024 Category: Neurology Source Type: research

Assessment of Barriers to Referral and Appointment Wait Times for the Evaluation of Spinal Muscular Atrophy (SMA): Findings from a Web-Based Physician Survey
ConclusionsInfants directly referred to a SMA care center versus a general sample practice were more likely to experience shorter SMA diagnostic journeys and appointment wait times. Triage guidelines for referrals specific to “hypotonia and motor delay” including use of “key emergency words” may shorten wait times and support early diagnosis and treatment of SMA. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 2, 2024 Category: Neurology Source Type: research

The Association Between National Institutes of Health Stroke Scale Score and Clinical Outcome in Patients with Large Core Infarctions Undergoing Endovascular Treatment
ConclusionsThe findings indicate that higher baseline NIHSS scores correlate with poorer outcomes and increased mortality, particularly when scores exceed 20. Moreover, age and sex indirectly influence favorable outcomes through their association with baseline NIHSS scores. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 1, 2024 Category: Neurology Source Type: research

Constructing and Validating a Nomogram Model for Short-Term Prognosis of Patients with AChR-Ab+ GMG
ConclusionThe constructed nomogram, based on key patient indicators, shows promise as a clinically useful tool for predicting the short-term efficacy of treatment of AChR-Ab+ GMG. Validation in larger, multicenter cohorts is needed to further substantiate its applicability. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 1, 2024 Category: Neurology Source Type: research

Summary of Research: What Is the True Impact of Cognitive Impairment for People Living with Multiple Sclerosis? A Commentary of Symposium Discussions at the 2020 European Charcot Foundation
AbstractCognitive symptoms affect disease management and activities of daily living for people living with multiple sclerosis (MS). This summary of research article summarises previously published discussions  (‘What is the true impact of cognitive impairment for people living with multiple sclerosis? A commentary of symposium discussions at the 2020 European Charcot Foundation’) from the 2020 European Charcot Foundation meeting between a patient expert living with MS, a neuropsychologist and a neu rologist about the impact of cognitive impairment on people living with MS. These discussions highlighted that cognitive...
Source: Neurology and Therapy - February 20, 2024 Category: Neurology Source Type: research

Monitoring of Perioperative Microcirculation Dysfunction by Near-Infrared Spectroscopy for Neurological Deterioration and Prognosis of Aneurysmal Subarachnoid Hemorrhage: An Observational, Longitudinal Cohort Study
ConclusionsThe rSO2 concentration in patients with neurological deterioration is generally lower than that in patients without neurological deterioration, and at least one time point in the population with neurological deterioration can be significantly monitored via NIRS. However, further studies are needed to determine the role of microcirculation and other predictive factors in the neurocritical management of EBI after aSAH, as these factors can reduce the incidence of adverse outcomes and mortality during hospitalization. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 17, 2024 Category: Neurology Source Type: research

Safety and Tolerability of Combining CGRP Monoclonal Antibodies with Gepants in Patients with Migraine: A Retrospective Study
ConclusionThe findings of this study demonstrate that combining CGRP mAbs with gepants is a safe and well-tolerated treatment approach for migraine. Future studies are warranted to further validate these findings and explore long-term outcomes. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 15, 2024 Category: Neurology Source Type: research

Understanding the Symptoms and Impacts Experienced by People with Relapsing –Remitting MS: A Qualitative Investigation Using Semi-Structured Interviews
ConclusionThere was a high frequency of concepts associated with physical function, fatigue, and sensory-motor actions. A conceptual model was developed that captures the disease symptoms, impairments, and impacts identified in the interviews as well as known processes and symptoms identified in the literature search. This model underpins the appropriateness of PRO instruments, such as the PROMIS Fatigue (MS) 8a and PROMIS Physical Function (MS) 15a, which evaluate symptoms and impacts that matter most to people with MS. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 12, 2024 Category: Neurology Source Type: research