Neuronal activity drives glymphatic waste clearance
Nature Reviews Neurology, Published online: 15 April 2024; doi:10.1038/s41582-024-00963-xTwo new studies show that clearance of waste, including pathogenic amyloid, through the glymphatic system is driven by synchronized neuronal activity. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 15, 2024 Category: Neurology Authors: Lisa Kiani Source Type: research
Neurofilaments as biomarkers in neurological disorders — towards clinical application
Nature Reviews Neurology, Published online: 12 April 2024; doi:10.1038/s41582-024-00955-xNeurofilaments have been validated as specific body fluid biomarkers of neuro-axonal injury. In this Review, Khalil and colleagues provide an update on the structure and function of neurofilaments, analytical approaches and challenges in different clinical contexts, and progress towards clinical application of neurofilaments as a biomarker in various neurological disorders. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 12, 2024 Category: Neurology Authors: Michael Khalil Charlotte E. Teunissen Sylvain Lehmann Markus Otto Fredrik Piehl Tjalf Ziemssen Stefan Bittner Maria Pia Sormani Thomas Gattringer Samir Abu-Rumeileh Simon Thebault Ahmed Abdelhak Ari Green Pascal Benkert Ludwig Kappos Manuel Comabella Hayr Source Type: research
Addressing disparities in neurology by identifying gaps in hospital care
Nature Reviews Neurology, Published online: 12 April 2024; doi:10.1038/s41582-024-00960-0Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a broad spectrum of diversity, equity and inclusion initiatives. We spoke with neurosurgeon Sonia Mejía Pérez from Mexico about her work to address gaps in hospital care for individuals from minority groups, such as LGBT+ people. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 12, 2024 Category: Neurology Authors: Lisa Kiani Source Type: research
EBV-specific T cells in multiple sclerosis
Nature Reviews Neurology, Published online: 10 April 2024; doi:10.1038/s41582-024-00959-7New data recently reported at the ACTRIMS Forum add to growing evidence of an aetiological role for Epstein–Barr virus infection in multiple sclerosis. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 10, 2024 Category: Neurology Authors: Heather Wood Source Type: research
BTK inhibitor falters in multiple sclerosis trials
Nature Reviews Neurology, Published online: 10 April 2024; doi:10.1038/s41582-024-00958-8Findings of phase III trials of the Bruton’s tyrosine kinase inhibitor evobrutinib in patients with relapsing multiple sclerosis were recently presented at the ACTRIMS Forum. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 10, 2024 Category: Neurology Authors: Heather Wood Source Type: research
Support for network theories of schizophrenia
Nature Reviews Neurology, Published online: 05 April 2024; doi:10.1038/s41582-024-00956-wA computational neuroimaging study has shed new light on the relationship between morphological changes in the brain in schizophrenia and the network architecture of the brain, providing evidence to support two network theories of the disorder. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 5, 2024 Category: Neurology Authors: Martijn P. van den Heuvel Sara L. Seoane Source Type: research
Addressing disparities in neurology by building the workforce in LMICs
Nature Reviews Neurology, Published online: 04 April 2024; doi:10.1038/s41582-024-00952-0Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a broad spectrum of diversity, equity and inclusion initiatives. We spoke with stroke neurologist Nirali Vora from the USA about her work to build neurology capacity in low and middle-income countries. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 4, 2024 Category: Neurology Authors: Lisa Kiani Source Type: research
Diversity, equity and inclusion in neurology
Nature Reviews Neurology, Published online: 04 April 2024; doi:10.1038/s41582-024-00951-1This month, Nature Reviews Neurology launches a Series to highlight the importance of diversity, equity and inclusion in the neurology community and in neurological care to address health disparities and thereby to improve global brain health. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 4, 2024 Category: Neurology Source Type: research
Neurostimulation for treatment of post-stroke impairments
Nature Reviews Neurology, Published online: 03 April 2024; doi:10.1038/s41582-024-00953-zVarious neurostimulation techniques are being explored for the treatment of physical impairments in people with stroke. This Review summarizes our current knowledge of the techniques that are now in clinical use or have reached the stage of pivotal trials alongside emerging techniques and highlights the need for further studies. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 3, 2024 Category: Neurology Authors: Jesse Dawson Azmil H. Abdul-Rahim Teresa J. Kimberley Source Type: research
Insights into epileptogenesis from post-traumatic epilepsy
This article reviews the epidemiology and clinical features of post-traumatic epilepsy and discusses how an understanding of the underlying epileptogenic mechanisms might inform the development of anti-epileptogenic medications. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 3, 2024 Category: Neurology Authors: Matthew Pease Kunal Gupta Solomon L. Mosh é Daniel J. Correa Aristea S. Galanopoulou David O. Okonkwo Jorge Gonzalez-Martinez Lori Shutter Ramon Diaz-Arrastia James F. Castellano Source Type: research
Approval of omaveloxolone for Friedreich ataxia
Nature Reviews Neurology, Published online: 03 April 2024; doi:10.1038/s41582-024-00957-9The recent approval of omaveloxolone for the treatment of Friedreich ataxia in the USA and Europe represents an important milestone in the field of rare neurological diseases. However, many challenges lie ahead, including the translation of trial results into clinical practice, and the management of patients’ expectations. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 3, 2024 Category: Neurology Authors: Sylvia Boesch Elisabetta Indelicato Source Type: research
Neurological care for LGBT+ people
Nature Reviews Neurology, Published online: 18 March 2024; doi:10.1038/s41582-024-00944-0In this Review, the authors discuss the unique neurological health disparities faced by sexual and gender minority (LGBT+) people. The Review presents clinical considerations alongside language and practice recommendations to promote inclusive care, and highlights the gaps in need of further research. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 18, 2024 Category: Neurology Authors: Salvatore Giovanni Volpe Joya Ahmad Roshni Abee Patel Nicole Rosendale Source Type: research
Towards the era of biological biomarkers for Parkinson disease
Nature Reviews Neurology, Published online: 07 March 2024; doi:10.1038/s41582-024-00950-2Since its instigation in cancer research in the 1930s, the disease-staging concept has become a crucial tool in clinical research and medical practice. Two new papers have proposed biological staging and classification systems based on α-synuclein pathology for Parkinson disease and related conditions. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 7, 2024 Category: Neurology Authors: Nobutaka Hattori Source Type: research
Mitochondrial DNA marks multiple sclerosis
Nature Reviews Neurology, Published online: 05 March 2024; doi:10.1038/s41582-024-00948-wMitochondrial DNA has been identified as a potential biomarker of multiple sclerosis disease activity and treatment response. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 5, 2024 Category: Neurology Authors: Ian Fyfe Source Type: research
Parkinson disease pathology in inflammatory bowel disease
Nature Reviews Neurology, Published online: 05 March 2024; doi:10.1038/s41582-024-00945-zA new study has found evidence of α-synuclein aggregates — a key pathological hallmark of Parkinson disease — in the gut and brain in people and animals with inflammatory bowel disease. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 5, 2024 Category: Neurology Authors: Heather Wood Source Type: research
