Considerations of sex as a binary variable in clinical algorithms
Nature Reviews Nephrology, Published online: 23 April 2024; doi:10.1038/s41581-024-00840-2Clinical algorithms that are used to guide medical decision-making often include sex as a variable. However, binary considerations of sex and/or gender might introduce bias due to potentially inaccurate assumptions about sex and gender-specific physiology, hormones and exposures. An equity-focused approach to sex and gender is essential when using clinical algorithms to ensure health equity across populations. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 23, 2024 Category: Urology & Nephrology Authors: Dinushika Mohottige Samira Farouk Tonia Poteat Asa Radix Selma Feldman Witchel Source Type: research
Calcium signalling and transport in the kidney
Nature Reviews Nephrology, Published online: 19 April 2024; doi:10.1038/s41581-024-00835-zCalcium reabsorption along the nephron is essential for calcium homeostasis and whole-body electrolyte balance. Here, Staruschenko et al. highlight signalling pathways and molecules involved in renal calcium handling in health and disease, and discuss progress in the integration of systems-level and molecular understanding of calcium transport and regulation. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 19, 2024 Category: Urology & Nephrology Authors: Alexander Staruschenko R. Todd Alexander Michael J. Caplan Daria V. Ilatovskaya Source Type: research
Thiazides in kidney transplant recipients: skin in the game
Nature Reviews Nephrology, Published online: 17 April 2024; doi:10.1038/s41581-024-00839-9Clinical trial data suggest that thiazides and thiazide-like drugs could be beneficial for blood-pressure lowering in patients with severe chronic kidney disease. However, prolonged exposure to these photosensitizing drugs could translate into increased risk of squamous cell carcinoma and post-transplant diabetes in the already extremely vulnerable kidney transplant population. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Steven Van Laecke Source Type: research
Epithelial cell states associated with kidney and allograft injury
Nature Reviews Nephrology, Published online: 17 April 2024; doi:10.1038/s41581-024-00834-0This Review describes parallels in the injury mechanisms that underlie acute kidney injury, chronic kidney disease and allograft injury, and explains how our understanding of the molecular changes that occur in epithelia in the context of kidney disease may contribute to the therapeutic targeting of specific epithelial cell phenotypes for the treatment of transplantation complications. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Christian Hinze Svjetlana Lovric Philip F. Halloran Jonathan Barasch Kai M. Schmidt-Ott Source Type: research
A new era in the science and care of kidney diseases
Nature Reviews Nephrology, Published online: 04 April 2024; doi:10.1038/s41581-024-00828-yDespite notable progress in basic, clinical and translational nephrology research in the past 50 years, many challenges remain. In this Review, the authors provide an overview of the current status and future directions in nephrology research and patient care. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 4, 2024 Category: Urology & Nephrology Authors: Carmine Zoccali Francesca Mallamaci Liz Lightstone Vivek Jha Carol Pollock Katherine Tuttle Peter Kotanko Andrzej Wiecek Hans Joachim Anders Giuseppe Remuzzi Kamyar Kalantar-Zadeh Adeera Levin Raymond Vanholder Source Type: research
Chronic kidney disease and the global public health agenda: an international consensus
Nature Reviews Nephrology, Published online: 03 April 2024; doi:10.1038/s41581-024-00820-6Addressing the burden of non-communicable diseases is a global public health priority. In this joint Consensus Statement, the American Society of Nephrology, the European Renal Association and the International Society of Nephrology highlight the need to recognize kidney disease as a key driver of premature mortality, in addition to other non-communicable diseases already prioritized by the World Health Organization. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 3, 2024 Category: Urology & Nephrology Authors: Anna Francis Meera N. Harhay Albert C. M. Ong Sri Lekha Tummalapalli Alberto Ortiz Agnes B. Fogo Danilo Fliser Prabir Roy-Chaudhury Monica Fontana Masaomi Nangaku Christoph Wanner Charu Malik Anne Hradsky Dwomoa Adu Sunita Bavanandan Ana Cusumano Laura So Source Type: research
Combination therapy for kidney disease in people with diabetes mellitus
Nature Reviews Nephrology, Published online: 03 April 2024; doi:10.1038/s41581-024-00827-zSeveral new drug classes have been demonstrated to improve kidney outcomes in people with diabetes mellitus. Here, the authors examine the evidence for the efficacy and safety of combination treatment to reduce the progression of diabetic kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 3, 2024 Category: Urology & Nephrology Authors: Dani ël H. van Raalte Petter Bjornstad David Z. I. Cherney Ian H. de Boer Paola Fioretto Daniel Gordin Frederik Persson Sylvia E. Rosas Peter Rossing Jennifer A. Schaub Katherine Tuttle Sushrut S. Waikar Hiddo J. L. Heerspink Source Type: research
Kidney disease: a global health priority
Nature Reviews Nephrology, Published online: 03 April 2024; doi:10.1038/s41581-024-00829-xThe prevalence of kidney disease and its associated morbidity and mortality continue to rise. This crisis cannot be tackled unless kidney disease is made a global public health priority. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 3, 2024 Category: Urology & Nephrology Source Type: research
The global landscape of kidney registries: immense challenges and unique opportunities
Nature Reviews Nephrology, Published online: 02 April 2024; doi:10.1038/s41581-024-00833-1Kidney registries are essential to understanding the burden of kidney disease and facilitating the development of sustainable and effective programs for kidney disease prevention and care. Key barriers to implementation of registries at a global scale include funding and data quality. These issues warrant the attention of the global nephrology community. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 2, 2024 Category: Urology & Nephrology Authors: Christopher H. Grant Fergus J. Caskey M. Razeen Davids Manisha Sahay Aminu K. Bello Dorothea Nitsch Samira Bell Source Type: research
Sex differences in kidney metabolism and DKD
Nature Reviews Nephrology, Published online: 28 March 2024; doi:10.1038/s41581-024-00832-2Sex differences in kidney metabolism and DKD (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 28, 2024 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Switching off SOX9 for epithelial recovery after AKI
Nature Reviews Nephrology, Published online: 26 March 2024; doi:10.1038/s41581-024-00830-4Switching off SOX9 for epithelial recovery after AKI (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Clonal haematopoiesis and AKI
Nature Reviews Nephrology, Published online: 26 March 2024; doi:10.1038/s41581-024-00831-3Clonal haematopoiesis and AKI (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Drug stewardship in chronic kidney disease to achieve effective and safe medication use
Nature Reviews Nephrology, Published online: 15 March 2024; doi:10.1038/s41581-024-00823-3Patients with chronic kidney disease often require complex polypharmacy, require dose adjustments or discontinuation with changes in kidney function, and can be susceptible to the adverse effects of medications. This Review discusses the principles of drug stewardship — that is, the effective, safe and sustainable use of medications — for people with chronic kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 15, 2024 Category: Urology & Nephrology Authors: Rasheeda K. Hall R ümeyza Kazancıoğlu Teerawat Thanachayanont Germaine Wong Dharshana Sabanayagam Marisa Battistella Sofia B. Ahmed Lesley A. Inker Erin F. Barreto Edouard L. Fu Catherine M. Clase Juan J. Carrero Source Type: research
Role of biophysics and mechanobiology in podocyte physiology
Nature Reviews Nephrology, Published online: 05 March 2024; doi:10.1038/s41581-024-00815-3In this Review, the authors examine the biophysical and biomechanical properties that influence podocyte physiology as they integrate and adapt to stimuli from their dynamic environment within the glomerular capillaries. The authors also discuss how dysregulation and loss of biomechanical resilience in podocytes can contribute to kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2024 Category: Urology & Nephrology Authors: Jonathan Haydak Evren U. Azeloglu Source Type: research
Clinical practice recommendations for kidney involvement in tuberous sclerosis complex: a consensus statement by the ERKNet Working Group for Autosomal Dominant Structural Kidney Disorders and the ERA Genes & Kidney Working Group
Nature Reviews Nephrology, Published online: 05 March 2024; doi:10.1038/s41581-024-00818-0Care for patients with tuberous sclerosis complex (TSC) should be coordinated by a multidisciplinary team. This Consensus Statement, which involved input from nephrologists, urologists, geneticists, radiologists, interventional radiologists and pathologists as well as patient representatives, provides an overview of TSC-associated kidney manifestations and outlines current recommendations for the management of kidney involvement in TSC. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2024 Category: Urology & Nephrology Authors: Djalila Mekahli Roman-Ulrich M üller Matko Marlais Tanja Wlodkowski Stefanie Haeberle Marta L ópez de Argumedo Carsten Bergmann Luc Breysem Carla Fladrowski Elizabeth P. Henske Peter Janssens Fran çois Jouret John Christopher Kingswood Jean-Baptiste La Source Type: research
