Cyclopeptide alkaloids from the Greek shrub < em > Paliurus spina < /em > - < em > christi < /em > and their < em > in silico < /em > binding affinity to Dipeptidyl Peptidase IV
Nat Prod Res. 2024 Apr 17:1-11. doi: 10.1080/14786419.2024.2340755. Online ahead of print.ABSTRACTA new cyclopeptide alkaloid, spinachristene A (1), along with two previously described, sanjoinenine (2) and oxyphylline C (3), were isolated from the fruits of Paliurus spina-christi Mill. All three metabolites are being isolated for the first time from the genus Paliurus. A model for the in silico binding affinity of compounds 1-3 to Dipeptidyl Peptidase IV (DPP4), which is related to type 2 diabetes (T2D), was developed. According to our model, compounds 1-3 were ranked in positions 9/12, 11/12 and 8/12, respectively and ar...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Vaios Amountzias Dennis Abatis Antonios Drakopoulos Grigoris Zoidis Nektarios Aligiannis Source Type: research
Efficient preparation of icariin from epimedin C by recyclable biphasic enzymatic hydrolysis
This study aimed to develop a sustainable and effective biphasic enzymatic hydrolysis system for the efficient conversion of epimedin C to icariin. The biphasic system was created using butyl acetate and phosphate buffer (pH 4.5) at a ratio of 3:1 (V/V) along with α-L-rhamnosidase/epimedin C (2 U/1 mg) at 50 °C for 12 h. Consequently, 98.21% of epimedin C was hydrolysed to icariin, with 95.62% of the product being transferred to the organic phase. Even after four cycles of use, the conversion ratio remained high at 75.28%. Furthermore, this novel strategy was also used for the conversion of Epimedium brevicornu Maxim. ex...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Wang Chen Yue Zhang Yuhang Zhang Zili Feng Xu He Source Type: research
Two new chemical constituents from the aerial parts of < em > Tripterygium wilfordii < /em >
Nat Prod Res. 2024 Apr 17:1-8. doi: 10.1080/14786419.2024.2342000. Online ahead of print.ABSTRACTTripterygium wilfordii has been historically employed as a conventional botanical insecticide and a plant of medicinal significance. A new dihydroagarofuran sesquiterpene (1) and a new acyclic compound (2), along with seven known compounds (3-9), have been isolated from the aerial parts of Tripterygium wilfordii. The identification of the structures of novel compounds were accomplished through comprehensive spectroscopic analyses, encompassing HRESIMS, NMR, UV, IR, and a comparative analysis with spectroscopic data from compoun...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Xia Zhang Lei Huang Yu-Jun Tang Ya-Lin Hu Wei Xu Hong-Yu Li Yu-Bo Zhang Xiao-Qi Zhang Guang-Xiong Zhou Source Type: research
Dihydrostilbenes from < em > Macaranga javanica < /em > (Blume) M üll. Arg. and their antiplasmodial activity
Nat Prod Res. 2024 Apr 17:1-7. doi: 10.1080/14786419.2024.2342555. Online ahead of print.ABSTRACTAn undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC50 value of 0.85 and 1.03 µg/mL, respectively.PMID:38629185 | DOI:10.1080/14786419.2024.2342555 (S...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Tjitjik Srie Tjahjandarie Muhammad Fajar Aldin Ratih Dewi Saputri Mulyadi Tanjung Source Type: research
Gigantol, a promising natural drug for inflammation: a literature review and computational based study
Nat Prod Res. 2024 Apr 16:1-17. doi: 10.1080/14786419.2024.2340042. Online ahead of print.ABSTRACTGigantol, a bibenzyl compound extracted from various medicinal plants, has shown a number of biological activities, making it an attractive candidate for potential medical applications. This systematic review aims to shed light on gigantol's promising role in inflammation treatment and its underlying mechanisms. Gigantol exhibits potential anti-inflammatory properties in pre-clinical pharmacological test systems. It effectively reduced the levels of pro-inflammatory markers and arachidonic acid metabolites through various path...
Source: Natural Product Research - April 16, 2024 Category: Biochemistry Authors: Raihan Chowdhury Shimul Bhuia Asraful Islam Rakib Sakib Al Hasan Manik Chandra Shill Heba A S El-Nashar Mohamed El-Shazly Muhammad Torequl Islam Source Type: research
The chemical composition of the aerial parts' essential oil of < em > Limonium lobatum < /em > (L.f.) Chaz. growing wild in Algeria
Nat Prod Res. 2024 Apr 16:1-8. doi: 10.1080/14786419.2024.2342001. Online ahead of print.ABSTRACTThe Limonium genus (Plumbaginaceae) includes several species of perennial herbs and shrubs belonging to a particular type of halophytes, known as 'recretohalophytes'. Limonium species are widely distributed in the Mediterranean region, mainly in the North-Eastern and Southern countries and several bioactivities have been well documented. In the present study, the chemical composition of the essential oil (EO) of the aerial parts of Limonium lobatum (L.f.) Chaz., a species never chemically previously studied and collected in Alg...
Source: Natural Product Research - April 16, 2024 Category: Biochemistry Authors: Larbi Derbak Natale Badalamenti Khellaf Rebbas Bendif Hamdi Maurizio Bruno Source Type: research
Study on the potential hypoglycemic flavonoids in < em > Abrus precatorius < /em > leaves: purification process, quality profile and activity mechanisms by transcriptomics and network pharmacology
This study provides a solid basis for hypoglycaemic product development and in-depth research of flavonoids in APL.PMID:38623836 | DOI:10.1080/14786419.2024.2340756 (Source: Natural Product Research)
Source: Natural Product Research - April 16, 2024 Category: Biochemistry Authors: Xujiang Yuan Xianmei Xue Zhike Liang Cuimin He Source Type: research
Neolignans with anti-inflammatory activity from < em > Piper kadsura < /em > (Choisy) Ohwi
Nat Prod Res. 2024 Apr 16:1-9. doi: 10.1080/14786419.2024.2342002. Online ahead of print.ABSTRACTTwo novel neolignans, piperkadsurenin A (1) and kadsurenin N (2), along with six known neolignans (3-8) and two lignans (9-10) were isolated from the stems of Piper kadsura (Choisy) Ohwi. Extensive spectroscopic data interpretation and ECD calculations were used to identify the structures of the new compounds 1 and 2. Especially, compound 1 represents the first example of neolignan with cyclopenta[b]pyran framework. The anti-inflammatory efficacy of compounds 1-10 in vitro was systematically assessed through NO production inhib...
Source: Natural Product Research - April 16, 2024 Category: Biochemistry Authors: Xingxing Liu Yi Wen Xilei Wang Yan Qi Wenhao Zhou Yijun Tu Jiachuan Lei Hong Cheng Jianqing Yu Source Type: research
Phytochemicals analysis and aflatoxin B < sub > 1 < /sub > detoxification potential of leaves extract of < em > Moringa oleifera < /em > and < em > Calotropis procera < /em >
Nat Prod Res. 2024 Apr 16:1-9. doi: 10.1080/14786419.2024.2342003. Online ahead of print.ABSTRACTThe present study aimed to identify the presence of certain classes of phytochemicals in the leaf extract of medicinal herbs viz. Moringa oleifera and Calotropis procera, using qualitative detection tests and explored the potential of aqueous and ethanolic extract to inhibit aflatoxin production by thin layer chromatography at 25 °C and pH (7) of different incubation times i.e. 0-, 1-, 3-, 6- and 24-h. Qualitative phytochemical analysis reported that the aqueous leave extracts of M. oleifera and C. procera contained tannins, p...
Source: Natural Product Research - April 16, 2024 Category: Biochemistry Authors: Nehrish Nisar Maryam Ajmal Nafeesa Qudsia Hanif Syed Waqas Hassan Source Type: research
Phenolic constituents from the branches of < em > Viburnum chinshanense < /em > as potential < em > α < /em > -amylase and < em > α < /em > -glucosidase inhibitory agents
Nat Prod Res. 2024 Apr 15:1-7. doi: 10.1080/14786419.2024.2341306. Online ahead of print.ABSTRACTThis paper reports the isolation of two undescribed phenolic glycosides (1 and 2), together with seven known compounds (3-9) from the branches of Viburnum chinshanense. The structures of undescribed compounds were elucidated by comprehensive spectroscopic methods (1D NMR, 2D NMR, and HRESIMS). The sugar units of compounds 1 and 2 were identified by acid hydrolysis and HPLC analysis of the chiral derivatives of the monosaccharides. Furthermore, the α‑amylase and α-glucosidase inhibitory activities of all isolates were evalua...
Source: Natural Product Research - April 15, 2024 Category: Biochemistry Authors: Hong-Juan Zhou Meng-Ya Yang Jia Chen Wei Ji Jian-Hua Shao Zi-Han Wang Chun-Chao Zhao Source Type: research
Exploring the potential of semi-synthetic Swertiamarin analogues for GLUT facilitation and insulin secretion in NIT-1 cell lines: a molecular docking and < em > in-vitro < /em > study
Nat Prod Res. 2024 Apr 15:1-5. doi: 10.1080/14786419.2024.2342005. Online ahead of print.ABSTRACTSynthesis, characterisation, and anti-diabetic potential of swertiamarin analogues against DPP-4 enzymatic inhibition was done prior to this study. However, swertiamarin and its analogues inhibited DPP-4 enzyme significantly. Semisynthetic swertiamarin analogues have been studied for antidiabetic potential and mechanism of action utilising molecular docking and in-vitro techniques. The mechanism of action for swertiamarin analogues was determined by in-silico molecular docking studies using glucose-transporters, GLUT-1 (PDB ID:...
Source: Natural Product Research - April 15, 2024 Category: Biochemistry Authors: Satyender Kumar Prakash Niguram Vinod Jairaj Neelam Chauhan Seema Jinagal Sneha Sagar Rakesh Kumar Sindhu Amrish Chandra Source Type: research
Phenolic constituents from the branches of < em > Viburnum chinshanense < /em > as potential < em > α < /em > -amylase and < em > α < /em > -glucosidase inhibitory agents
Nat Prod Res. 2024 Apr 15:1-7. doi: 10.1080/14786419.2024.2341306. Online ahead of print.ABSTRACTThis paper reports the isolation of two undescribed phenolic glycosides (1 and 2), together with seven known compounds (3-9) from the branches of Viburnum chinshanense. The structures of undescribed compounds were elucidated by comprehensive spectroscopic methods (1D NMR, 2D NMR, and HRESIMS). The sugar units of compounds 1 and 2 were identified by acid hydrolysis and HPLC analysis of the chiral derivatives of the monosaccharides. Furthermore, the α‑amylase and α-glucosidase inhibitory activities of all isolates were evalua...
Source: Natural Product Research - April 15, 2024 Category: Biochemistry Authors: Hong-Juan Zhou Meng-Ya Yang Jia Chen Wei Ji Jian-Hua Shao Zi-Han Wang Chun-Chao Zhao Source Type: research
Exploring the potential of semi-synthetic Swertiamarin analogues for GLUT facilitation and insulin secretion in NIT-1 cell lines: a molecular docking and < em > in-vitro < /em > study
Nat Prod Res. 2024 Apr 15:1-5. doi: 10.1080/14786419.2024.2342005. Online ahead of print.ABSTRACTSynthesis, characterisation, and anti-diabetic potential of swertiamarin analogues against DPP-4 enzymatic inhibition was done prior to this study. However, swertiamarin and its analogues inhibited DPP-4 enzyme significantly. Semisynthetic swertiamarin analogues have been studied for antidiabetic potential and mechanism of action utilising molecular docking and in-vitro techniques. The mechanism of action for swertiamarin analogues was determined by in-silico molecular docking studies using glucose-transporters, GLUT-1 (PDB ID:...
Source: Natural Product Research - April 15, 2024 Category: Biochemistry Authors: Satyender Kumar Prakash Niguram Vinod Jairaj Neelam Chauhan Seema Jinagal Sneha Sagar Rakesh Kumar Sindhu Amrish Chandra Source Type: research
Characteristic volatile components analysis of < em > Camelina sativa (L.) Crantz < /em > by GC-MS and their antibacterial and antioxidant activities
This study used the gas chromatography-mass spectrometry (GC-MS) to examine the differences in the aroma on the basis of extraction method such as water distillation extraction (CSPW), Solid-phase microextraction (CSPM) and subcritical extraction (CSPS). Antibacterial test was evaluated by the microdilution method against Salmonella typhimurium, Streptococcus pneumoniae, Escherichia coli, Strepococcus pyogenens, Staphylococcus aureus, and antioxidant activity was determined through DPPH free radical, hydroxyl free radical, and superoxide anion radical scavenging capacity activity. The result revealed that three extraction ...
Source: Natural Product Research - April 13, 2024 Category: Biochemistry Authors: Feifei Li Yuqing Liu Jie Zhu Zhining Li Lixian Zhang Yanni Ma Liqin Yu Source Type: research
Chemical constituents of a çai berry pulp ( < em > Euterpe oleracea Mart < /em > .) by LC-UV-BPSU/NMR and LC-UV-SPE/NMR
Nat Prod Res. 2024 Apr 13:1-8. doi: 10.1080/14786419.2024.2338805. Online ahead of print.ABSTRACTThe techniques LC-UV-BPSU and LC-UV-SPE/NMR were applied for the first time in the analysis of açai berry (Euterpe oleracea Mart.) pulp extracts. Those techniques allowed the identification of twenty-three metabolites: Valine (1), citric acid (2), tachioside (3), isotachioside (4), α-guaiacylglycerol (5), syringylglycerol (6), uridine (7), adenosine (8), dimethoxy-1,4-benzoquinone (9), koaburaside (10), protocatechuic acid (11), eurycorymboside B (12), 7',8'-dihydroxy-dihydrodehydroconiferyl alcohol-9-O-β-D-glucopyranoside (...
Source: Natural Product Research - April 13, 2024 Category: Biochemistry Authors: S érgio Scherrer Thomasi Danilo Forti C de Benedicto Thayana da Concei ção Alves B árbara Sayuri Bellete Tiago Ven âncio Rafaella de Andrade Mattietto Antonio Gilberto Ferreira Source Type: research
