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Augmentation of Docetaxel-Induced Cytotoxicity in Human PC-3 Androgen-Independent Prostate Cancer Cells by Combination With Four Natural Apoptosis-Inducing Anticancer Compounds
In conclusion, the combination of DTX with the four test compounds could effectively enhance the anti-prostate cancer activity of DTX. This combination has the added value of reducing the DTX effective concentration. We surmise that calebin A, 3'-hydroxypterostilbene, hispolon, and tetrahydrocurcumin were all excellent drug candidates that produced significant antiproliferative activity when used alone and synergistically enhanced the anticancer effect of DTX. Further in vivo studies using animal models of prostate cancer are needed to confirm our in vitro findings.PMID:37292146 | PMC:PMC10249917 | DOI:10.1177/1934578x2311...
Source: Natural Product Communications - June 9, 2023 Category: Biochemistry Authors: Inass A Ahmed Saly Hafiz Sabrina van Ginkel Satyanarayana R Pondugula Azza S Abdelhaffez Hayam G Sayyed Ebtihal A Abd El-Aziz Mahmoud M Mansour Source Type: research