Issue Information
No abstract is available for this article. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - November 26, 2018 Category: Radiology Tags: ISSUE INFORMATION Source Type: research
Probing carbohydrate metabolism using hyperpolarized 13C ‐labeled molecules
Glycolysis and the related pentose phosphate pathway can be monitored in real time with hyperpolarized,13C ‐labeled metabolic substrates such as13C ‐labeled, deuterated D‐glucose derivatives, [2‐13C] ‐D‐fructose, [2‐13C] dihydroxyacetone, [1 ‐13C] ‐D‐glycerate, [1‐13C] ‐D‐glucono‐δ‐lactone and [1‐13C] pyruvate in healthy and diseased tissues. Glycolysis is a fundamental metabolic process in all organisms. Anomalies in glucose metabolism are linked to various pathological conditions. In particular, elevated aerobic glycolysis is a characteristic feature of rapidly growing cells. Glycolysis a...
Source: NMR in Biomedicine - November 26, 2018 Category: Radiology Authors: Jaspal Singh,
Eul Hyun Suh,
Gaurav Sharma,
Chalermchai Khemtong,
A. Dean Sherry,
Zoltan Kovacs Tags: SPECIAL ISSUE RESEARCH ARTICLE Source Type: research
Mapping tissue water T1 in the liver using the MOLLI T1 method in the presence of fat, iron and B0 inhomogeneity
This article proposes an algorithm that provides an independent water MOLLIT1 (referred to as on ‐resonance waterT1) that would have been measured if a subject had no fat and normal iron, and imaging had been done on resonance. Fifteen NiCl2‐doped agar phantoms with different peanut oil concentrations and 30 adults with various liver diseases, nineteen (63.3%) with liver steatosis, were scanned at 3 T using the shortened MOLLI (shMOLLI)T1 mapping, multiple ‐echo spoiled gradient‐recalled echo and1H MR spectroscopy sequences. An algorithm based on Bloch equations was built in MATLAB, and water shMOLLIT1 values of b...
Source: NMR in Biomedicine - November 21, 2018 Category: Radiology Authors: Ferenc E. Mozes,
Elizabeth M. Tunnicliffe,
Ahmad Moolla,
Thomas Marjot,
Christina K. Levick,
Michael Pavlides,
Matthew D. Robson Tags: RESEARCH ARTICLE Source Type: research
Evaluation of normal cadaveric Achilles tendon and enthesis with ultrashort echo time (UTE) magnetic resonance imaging and indentation testing
In this study we examined the normal MR morphology of the cadaveric Achilles tendon and enthesis at 3 T using novel three‐dimensional ultrashort echo time (3D UTE) Cones sequences, and at 11.7 T using conventional MRI sequences. We also studied the MR properties of the Achilles tendon and enthesis includingT2*,T1, and magnetization transfer ratio (MTR). In addition, MT modeling of macromolecular proton fractions was investigated using 3D UTE Cones sequences at 3 T. Indentation testing was performed to investigate the mechanical properties of the tendons and entheses, and this was followed by histological examination...
Source: NMR in Biomedicine - November 20, 2018 Category: Radiology Authors: Bimin Chen,
Xin Cheng,
Erik W. Dorthe,
Yinghua Zhao,
Darryl D'Lima,
Graeme M. Bydder,
Sirun Liu,
Jiang Du,
Ya ‐Jun Ma Tags: RESEARCH ARTICLE Source Type: research
Fitting algorithms and baseline correction influence the results of non ‐invasive in vivo quantitation of 2‐hydroxyglutarate with 1H‐MRS
Quantitation of 2 ‐HG levels showed similar mean tissue concentrations for IDH mutated tumors (2.65mM, range 3.06 – 2.20) for all methods. Bland Altman plots did not reveal a systematic bias for any of the algorithms tested. We showed a significant correlation regarding 2‐HG concentration with few statistical o utliers. However, evaluation of outliers suggested that in vivo quantitation of 2‐HG is not only affected by analysis domains, but also by baseline correction being a major contributing factor to 2‐HG fit. 1H ‐MRS enables non‐invasive detection of 2‐hydroxyglutarate (2‐HG), an oncometabolite accumu...
Source: NMR in Biomedicine - November 20, 2018 Category: Radiology Authors: Katharina J. Wenger,
Elke Hattingen,
Patrick N. Harter,
Christian Richter,
Kea Franz,
Joachim P. Steinbach,
Oliver B ähr,
Ulrich Pilatus Tags: RESEARCH ARTICLE Source Type: research
A protocol for quantifying cardiogenic oscillations in dynamic 129Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis
This study sought to evaluate whether the dynamics of129Xe spectroscopy provide additional insight, with particular focus on quantifying cardiogenic oscillations in the RBC resonance.129Xe spectra were dynamically acquired in eight healthy volunteers and nine subjects with idiopathic pulmonary fibrosis (IPF).129Xe FIDs were collected every 20 ms (TE = 0.932 ms, 512 points, dwell time = 32 μs, flip angle ≈ 20°) during a 16 s breathing maneuver. The FIDs were pre‐processed using the spectral improvement by Fourier thresholding technique (SIFT) and fit in the time domain to determine the airspace, interstitial ...
Source: NMR in Biomedicine - November 20, 2018 Category: Radiology Authors: Elianna A. Bier,
Scott H. Robertson,
Geoffry M. Schrank,
Craig Rackley,
Joseph G. Mammarappallil,
Sudarshan Rajagopal,
H. Page McAdams,
Bastiaan Driehuys Tags: RESEARCH ARTICLE Source Type: research
Levels of choline ‐containing compounds in normal liver and liver metastases of colorectal cancer as recorded by 1H MRS
ConclusionAn increased tCho content was not observed in1H MR spectra of liver metastasis of colorectal cancer, compared with normal liver. This may be due to the background of a high tCho signal in spectra of normal liver or to an intrinsic lower tCho content in these tumors, but is most likely the result of necrosis in metastatic tumor tissue. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - November 20, 2018 Category: Radiology Authors: Edwin E.G.W. Voert,
Linda Heijmen,
Jack J.A. Asten,
Alan J. Wright,
Iris D. Nagtegaal,
Cornelis J.A. Punt,
Johannes H.W. Wilt,
Hanneke W.M. Laarhoven,
Arend Heerschap Tags: RESEARCH ARTICLE Source Type: research
Application of in vivo MR methods in the study of breast cancer metabolism
Metabolism is altered during cell proliferation. Methods like MRI, diffusion and perfusion MRI, dynamic contrast enhanced MRI, MR elastography, in vivo MR spectroscopy and hyperpolarized MR have been evaluated for their potential to study breast tumor metabolism. This review discusses the changes in tumor microstructure, microenvironment, abnormal vasculature permeability etc. due to alterations in tumor metabolism monitored by various MRI methodologies. In addition, changes in metabolic pathways due to altered choline, phospholipid and energy metabolism can be detected using MR spectroscopy. In the last two decades, vario...
Source: NMR in Biomedicine - November 20, 2018 Category: Radiology Authors: Naranamangalam R. Jagannathan Tags: SPECIAL ISSUE REVIEW ARTICLE Source Type: research
MRI evaluation of vulvar squamous ‐cell carcinoma in fresh radical local excision specimens for cancer localization and prediction of surgical tumor‐free margins
This study assessed the feasibility of 7 T ex vivo MRI in localizing vulvar squamous‐cell carcinoma (VSCC) and assessing tumor‐free margins in fresh radical local excision specimens to guide the surgeon. Annotations of VSCC and tumor‐free margins on ex vivo MRI were directly compared with histology. The results demonstrated high di agnostic performance in VSCC localization and identification of margins less than 8 mm as well as high correlation and agreement between ex vivo MRI and histology which suggest clinical applicability. In the surgical treatment of vulvar squamous ‐cell carcinoma (VSCC), tumor‐free ma...
Source: NMR in Biomedicine - November 15, 2018 Category: Radiology Authors: Jan Heidkamp,
Petra L.M. Zusterzeel,
Adriana C.H. Engen ‐van Grunsven,
Christiaan G. Overduin,
Andor Veltien,
Arie Maat,
Maroeska M. Rovers,
Jurgen J. Fütterer Tags: RESEARCH ARTICLE Source Type: research
Three ‐dimensional NMR microscopy of zebrafish specimens
High resolution MRM was used to image formalin ‐fixed and formalin‐fixed paraffin embedded zebrafish specimens to study morphology of the mutants. It is demonstrated that 3D images with resolution up to 25 μm/pixel with strong contrast (T1W, T2W, MT, DWI or their combinations) could be obtained. That enables (semi)automatic organ segmentati on. While zebrafish embryos in the first five days after fertilization are clear and amenable to optical analysis, older juveniles and adults are not, due to pigmentation development and tissue growth. Thus other imaging methods are needed to image adult specimens. NMR is a versati...
Source: NMR in Biomedicine - November 15, 2018 Category: Radiology Authors: Timothy L. Kline,
Caroline R. Sussman,
Maria V. Irazabal,
Prasanna K. Mishra,
Elisabeth A. Pearson,
Vicente E. Torres,
Slobodan I. Macura Tags: RESEARCH ARTICLE Source Type: research
Glucagon infusion alters the hyperpolarized 13C ‐urea renal hemodynamic signature
This study demonstrate that hyperpo larized13C ‐urea enables monitoring of renal urinary excretion effectsin vivo. Renal urea handling is central to the urine concentrating mechanism, and as such the ability to image urea transport in the kidney is an important potential imaging biomarker for renal functional assessment. Glucagon levels associated with changes in dietary protein intake have been shown to influence renal urea handling; however, the exact mechanism has still to be fully understood. Here we investigate renal function and osmolite distribution using [13C,15N] urea dynamics and23Na distribution before and 60 ...
Source: NMR in Biomedicine - November 14, 2018 Category: Radiology Authors: Haiyun Qi,
Christian Østergaard Mariager,
Per Mose Nielsen,
Marie Schroeder,
Jakob Lindhardt,
Rikke Nørregaard,
Janet D. Klein,
Jeff M. Sands,
Christoffer Laustsen Tags: RESEARCH ARTICLE Source Type: research
Left ventricular blood flow patterns at rest and under dobutamine stress in healthy pigs
In this study the feasibility of 4D flow MRI during dobutamine ‐induced stress was assessed, and changes in intraventricular blood flow patterns are reported for the porcine heart. A decrease in cardiac volume, antero‐septally oriented diastolic inflow and high velocity flow was found, providing unfavorable conditions for diastolic vortex development compar ed with the rest condition. Intracardiac blood flow patterns are affected by the morphology of cardiac structures and are set up to support the heart's pump function. Exercise affects contractility and chamber size as well as pre ‐ and afterload. The aim of this s...
Source: NMR in Biomedicine - November 7, 2018 Category: Radiology Authors: Nikola Cesarovic,
Julia Busch,
Miriam Lipiski,
Maximilian Fuetterer,
Thea Fleischmann,
Silvia Born,
Constantin Deuster,
Mareike Sauer,
Francesco Maisano,
Sebastian Kozerke,
Christian T. Stoeck Tags: RESEARCH ARTICLE Source Type: research
Erratum
NMR in Biomedicine, EarlyView. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - November 6, 2018 Category: Radiology Tags: ERRATUM Source Type: research
A multi ‐parametric PET/MRI study of breast cancer: Evaluation of DCE‐MRI pharmacokinetic models and correlation with diffusion and functional parameters
NMR in Biomedicine, EarlyView. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - October 31, 2018 Category: Radiology Authors: Marianna Inglese,
Carlo Cavaliere,
Serena Monti,
Ernesto Forte,
Mariarosaria Incoronato,
Emanuele Nicolai,
Marco Salvatore,
Marco Aiello Source Type: research
VERDICT ‐AMICO: Ultrafast fitting algorithm for non‐invasive prostate microstructure characterization
NMR in Biomedicine, EarlyView. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - October 31, 2018 Category: Radiology Authors: Elisenda Bonet ‐Carne,
Edward Johnston,
Alessandro Daducci,
Joseph G. Jacobs,
Alex Freeman,
David Atkinson,
David J. Hawkes,
Shonit Punwani,
Daniel C. Alexander,
Eleftheria Panagiotaki Source Type: research
