Raising the curtain on cerebral malaria ’s deadly agents
Using state-of-the-art brain imaging technology, scientists at the National Institutes of Health filmed what happens in the brains of mice that developed cerebral malaria (CM). The results, published in PLOS Pathogens, reveal the processes that lead to fatal outcomes of the disease and suggest an antibody therapy that may treat it. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - December 6, 2016 Category: Neurology Source Type: news

Untangling a cause of memory loss in neurodegenerative diseases
Tauopathies are a group of neurodegenerative disorders, including Alzheimer ’s disease that are characterized by the deposition of aggregates of the tau protein inside brain cells. A new study reveals that the cutting of tau by an enzyme called caspase-2 may play a critical role in the disordered brain circuit function that occurs in these diseases. Of interest, the culpr it tau fragment identified in this study is actually resistant to forming aggregates, and it causes a disturbance in memory function in animal models before brain cell loss occurs. (Source: NINDS Press Releases and News: National Institute of Neurologic...
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - October 11, 2016 Category: Neurology Source Type: news

Targeting cardiovascular disease risk factors may be important across a lifetime
New findings suggest that all adults, including those over 65, should be mindful of risk factors for cardiovascular disease. The results, published in the Journal of the American Geriatric Society, are part of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, which looks at stroke incidence in approximately 30,000 individuals. The REGARDS study is funded by the National Institutes of Health ’s National Institute of Neurological Disorders and Stroke (NINDS). (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - October 5, 2016 Category: Neurology Source Type: news

Researchers find a gap in the brain ’s firewall against Parkinson’s disease
In a study in mice, researchers found that they could reduce the progression of the toxic aggregates of α-synuclein that are found in the brains of Parkinson’s disease patients. The results suggest that a protein called lymphocyte-activation gene 3 (LAG3) plays a role in transmitting α-synuclein aggregates from one brain cell to another and could provide a possible target to slow the progression o f Parkinson’s disease. The study, published in Science, was partially funded by the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS). (Source: NINDS Press Releases and News: ...
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - September 30, 2016 Category: Neurology Source Type: news

“Sixth sense” may be more than just a feeling
With the help of two young patients with a unique neurological disorder, an initial study by scientists at the National Institutes of Health suggests that a gene called PIEZO2 controls specific aspects of human touch and proprioception, a “sixth sense” describing awareness of one’s body in space. Mutations in the gene caused the two to have movement and balance problems and the loss of some forms of touch. Despite their difficulties, they both appeared to cope with these challenges by relying heavily on vision and other senses. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - September 23, 2016 Category: Neurology Source Type: news

NINDS Names Dr. Clinton B. Wright as Director of the Office of Clinical Research
The National Institute of Neurological Disorders and Stroke (NINDS) has named vascular neurologist Clinton B. Wright, M.D., M.S., as director of its Office of Clinical Research (OCR) and associate director of the institute. Dr. Wright is expected to join the NINDS in November. NINDS is part of the National Institutes of Health (NIH). (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - September 15, 2016 Category: Neurology Source Type: news

New members appointed to National Advisory Neurological Disorders and Stroke Council
Four distinguished individuals from the neuroscience community have been chosen to serve on the National Advisory Neurological Disorders and Stroke Council, the principal advisory body to the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - September 15, 2016 Category: Neurology Source Type: news

Stem cell therapy heals injured mouse brain
Scientists and clinicians have long dreamed of helping the injured brain repair itself by creating new neurons, and an innovative NIH-funded study published today in Nature Medicine may bring this goal much closer to reality. A team of researchers has developed a therapeutic technique that dramatically increases the production of nerve cells in mice with stroke-induced brain damage. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - August 22, 2016 Category: Neurology Source Type: news

Researchers examine how Parkinson ’s disease alters brain activity over time
Neuroscientists peered into the brains of patients with Parkinson ’s disease and two similar conditions to see how their neural responses changed over time. The study, funded by the NIH’s Parkinson’s Disease Biomarkers Program and published today in Neurology, may provide a new tool for testing experimental medications aimed at alleviating symptoms and slowi ng the rate at which the diseases damage the brain. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - August 15, 2016 Category: Neurology Source Type: news

NIH-funded study supports surgery as treatment for myasthenia gravis
In a global study of myasthenia gravis, an autoimmune disease that causes muscle weakness and fatigue, researchers found that surgical removal of an organ called the thymus reduced patients ’ weakness, and their need for immunosuppressive drugs. The study, published in the New England Journal of Medicine, was partially funded by the National Institutes of Health. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - August 10, 2016 Category: Neurology Source Type: news

Novel genetic mutation may lead to the progressive loss of motor function
Researchers from the National Institutes of Health and their colleagues identified the genetic cause and a possible therapeutic target for a rare form of pediatric progressive neuropathy. Neuropathy, damage or disease affecting the peripheral nervous system, can range from rare conditions linked to a patient ’s exome to more common causes like diabetes and viral infections. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - August 3, 2016 Category: Neurology Source Type: news

New imaging method may predict risk of post-treatment brain bleeding after stroke
In a study of stroke patients, investigators confirmed through MRI brain scans that there was an association between the extent of disruption to the brain’s protective blood-brain barrier and the severity of bleeding following invasive stroke therapy. The results of the National Institutes of Health-funded study were published in Neurology. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - June 17, 2016 Category: Neurology Source Type: news

Standard blood pressure target is sufficient for treating some strokes
An international stroke study found that standard and intensive blood pressure treatments were equally effective in the emergency treatment of acute intracerebral hemorrhage, a type of stroke caused by bleeding into the brain. Patients whose systolic blood pressure was reduced rapidly in emergency rooms to standard levels used to treat acute stroke (140-179 mm Hg) did as well as patients whose pressure was reduced to intensive levels (110-139 mm Hg). The study, published in the New England Journal of Medicine, was funded by the NIH’s National Institute of Neurological Disorders and Stroke (NINDS). (Source: NINDS Press Re...
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - June 8, 2016 Category: Neurology Source Type: news