Topoisomerase III (TOP3) Inhibitors and Antiviral Compounds based on Cyanine Dyes
Topoisomerase 3B (TOP3B) is the only topoisomerase that can act on RNA as well as DNA, and thus has been a target of interest for the development of cancer therapies and RNA viral infection therapies. In the context of cancer, TOP3B is not an essential gene, but a subset of cancer cells with pre-existing genome instability are particularly vulnerable to the inactivation of TOP3B. While inhibitors for other topoisomerases are among the most potent and widely used anticancer agents, there are no known inhibitors of TOP3B. In the context of RNA viral infections, TOP3B has been implicated as a host factor for the replication o...
Source: NIH OTT Licensing Opportunities - July 5, 2023 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NIA NCI Source Type: research
Combined RNA and DNA Vaccination Strategy for Improving the Vaccine Immune Response
The development of an effective HIV vaccine has been an ongoing area of research. HIV sequence diversity and immunodominance are major obstacles in the design of an effective vaccine against HIV. Researchers at the National Cancer Institute (NCI) have developed a novel vaccine strategy that combines both DNA and mRNA vaccination to induce an effective immune response. This combination strategy could also be used to develop vaccines against cancer or other infectious diseases (ex. SARS-CoV-2). Previous studies by NCI determined that regions of the polypeptides Gag and Env are both essential to the core structure and env...
Source: NIH OTT Licensing Opportunities - July 5, 2023 Category: Research Authors: ott8admin Tags: Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
High-Throughput Assay for Detection and Monitoring of Endocrine Disrupting Chemicals in Water Sources
There is growing awareness that a wide variety of synthetic and natural compounds that may be present in water sources, such as streams, wells, and ground water, may lead to adverse health effects, including increased cancer risk. Even low concentrations of these compounds are of concern, as they may have biological effects at concentrations of parts per billion or less. In particular, the presence of endocrine disrupting chemicals (EDCs) in the environment is under examination for potential adverse effects on human health, such as immune suppression, impaired fertility, and increased incidence of cancer, diabetes, and obe...
Source: NIH OTT Licensing Opportunities - June 29, 2023 Category: Research Authors: ott8admin Tags: Diagnostics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
Camel VHH Nanobodies Bind the S2 Subunit of SARS-CoV-2 and Broadly Neutralize Variants including Omicron
Since its emergence in 2019, COVID-19 infected over 600 million people and over 6 million people have died from the disease. COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Neutralizing antibodies have been developed to bind to the receptor binding domain (RBD) on the spike (S) protein. Blocking the interaction of the RBD and the ACE2 receptor, is critical in neutralizing the virus. However, the S2 subunit, is also critical for viral infection and entry into human cells. The S2 subunit is highly conserved across many coronaviruses, however, there are currently no effective antibodies targeting this S2 sub...
Source: NIH OTT Licensing Opportunities - June 29, 2023 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
Topoisomerase III (TOP3) Inhibitors as Antiviral and Anticancer Compounds based on Bisacridines
Topoisomerase 3B (TOP3B) is the only topoisomerase that can act on RNA as well as DNA. Thus, it is a target of interest for the development of cancer therapies and RNA viral infection therapies. TOP3B is not an essential gene for carcinogenesis, but a subset of cancer cells with pre-existing genome instability are particularly vulnerable to the inactivation of TOP3B. While inhibitors for other topoisomerases are among the most potent and widely used anticancer agents, there are no known inhibitors of TOP3B. In RNA viral infections, TOP3B has been implicated as a host factor for the replication of positive strand RNA viruse...
Source: NIH OTT Licensing Opportunities - June 28, 2023 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
Methods of Predicting Patient Treatment Response and Resistance via Single-Cell Transcriptomics of Their Tumors
Tailoring the best treatments to cancer patients remains a highly important endeavor in the oncology field. However, personalized treatment courses are challenging to determine, and technologies or methods that can successfully be employed for precision oncology are lacking.Researchers at the NCI have built a new method for guiding cancer patient therapy based on single cell transcriptomics data of their tumors. This precision oncology data science and software framework is termed PERsonalized single-Cell Expression-based Planning for Treatments In ONcology (PERCEPTION). It capitalizes on recent, matched bulk and single-ce...
Source: NIH OTT Licensing Opportunities - June 27, 2023 Category: Research Authors: ott8admin Tags: Software / Apps Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
National Cancer Institute dosimetry system for Nuclear Medicine (NCINM) Computer Program
Nuclear medicine is the second largest source of medical radiation exposure to the general population after computed tomography imaging. Imaging modalities utilizing nuclear medicine produce a more detailed view of internal structure and function and are most commonly used to diagnose diseases such as heart disease, Alzheimer ’s and brain disorders. They are used to visualize tumors, abscesses due to infection or abnormalities in abdominal organs. When using radionuclides for diagnosis or therapy in nuclear medicine, it is critical to accurately estimate unintended dose to organs at risk surrounding tumors or of therap e...
Source: NIH OTT Licensing Opportunities - May 15, 2023 Category: Research Authors: ott8admin Tags: Software / Apps Licensing Desired NCI Source Type: research
National Cancer Institute dosimetry system for Computed Tomography (NCICT) Computer Program
About half of the per capita dose of radiation due to medical exposures is provided by computed tomography (CT) examinations. Approximately 80 million CTs are performed annually in the United States. CT scans most commonly look for internal bleeding or clots, abscesses due to infection, tumors and internal structures. Although CT provides great patient benefit, concerns exist about potential associated risks from radiation doses – especially in pediatric patients more sensitive to radiation. Better understanding of the magnitude of radiation dose delivered during CT examinations is crucial to estimate risks and make an i...
Source: NIH OTT Licensing Opportunities - May 15, 2023 Category: Research Authors: ott8admin Tags: Software / Apps Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
Lentiviral Vectors with Dual Fluorescence/Luminescence Reporters
The National Cancer Institute ’sProtein Expression Laboratory seeks parties to co-develop dual luminescent/fluorescent cancer biomarkers.In research settings, visualization of tumors or tumor cells is often done using either bioluminescence or fluorescence. However, both of these methods have shortcomings: bioluminescence is not sensitive enough to sort individual tumor cells, and fluorescence cannot be used effectively to view internal tumors and is best used with su rface tumors.Researchers at NCI developed twelve lentiviral vectors that express both fluorescent and luminescent markers as a single fusion protein un...
Source: NIH OTT Licensing Opportunities - May 1, 2023 Category: Research Authors: ott8admin Tags: Research Materials Licensing Desired NCI Source Type: research
Novel Human Islet Amyloid Polypeptides as Alzheimer ’s Disease Biomarkers and Inhibitors of Amyloid Formation
Over 34 million Americans are living with diabetes. An estimated 6.5 million Americans are living with Alzheimer ’s disease (AD) and type 2 diabetes mellites (T2DM). Amyloidosis due to aggregation of amyloid-β is key pathogenic event in AD, whereas aggregation of mature islet amyloid polypeptide (IAPP37) in human islet leads to β-cell dysfunction. A hallmark feature of T2DM is the accumulation of islet amy loid polypeptide fibrils in pancreatic islets. Such accumulations form amyloid plaques and cause apoptosis of -cells of islets. Researchers at NIA used a bioinformatic and molecular biological approaches to ident...
Source: NIH OTT Licensing Opportunities - April 28, 2023 Category: Research Authors: ott8admin Source Type: research
T Cell Receptor Targeting CD22 for the Treatment of Lymphomas and Leukemias
CD22 is a protein expressed by normal B cells and B-lymphoid malignancies. Its limited tissue expression pattern makes it a safe antigen for targeted therapies, such as T-cell Receptor (TCR)-T cell therapy. CD22-targeting therapies already on the market, mainly antibody-immunotoxin conjugates and chimeric antigen receptors (CAR)-T cells, have limitations such as resistance to treatment and/or side effects. Resistance mechanisms to the current CD22 therapies involve loss or modulation of target antigen on the cell surface. TCRs are expected to overcome these resistance mechanisms as they use distinct target recognition mech...
Source: NIH OTT Licensing Opportunities - April 5, 2023 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
: Single Domain Antibodies targeting HPV E6/E7 Oncogenic Peptide/MHC complexes
Human papillomavirus (HPV) has been linked to many cancers including cervix, uterine, anus, vulva, vagina, and penis. Although HPV vaccines exist to prevent HPV-associated cancers, there are still more than 5,000 deaths caused by HPV-associated cancers each year in the US and cervical cancer continues to be the second leading cause of cancer death in women ages 20 to 39. Engineered T cell receptor (TCR) therapy has been effective in some patients with HPV16 E6 expressing cancers, however, there continues to be a need for more therapies targeting HPV16 E6, when current treatment options fail. NCI inventors have identified...
Source: NIH OTT Licensing Opportunities - April 4, 2023 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
High-Throughput Assay for Detection and Monitoring of Endocrine Disrupting Chemicals in Water Sources
There is growing awareness that a wide variety of synthetic and natural compounds that may be present in water sources, such as streams, wells, and ground water, may lead to adverse health effects, including increased cancer risk. Even low concentrations of these compounds are of concern, as they may have biological effects at concentrations of parts per billion or less. In particular, the presence of endocrine disrupting chemicals (EDCs) in the environment is under examination for potential adverse effects on human health, such as immune suppression, impaired fertility, and increased incidence of cancer, diabetes, and obe...
Source: NIH OTT Licensing Opportunities - March 8, 2023 Category: Research Authors: ott8admin Tags: Diagnostics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
Method for HLA LOH Detection in Liquid Biopsies
Human leukocyte antigen (HLA) LOH (LOH) is a known resistance mechanism by which cancers evade T cell receptor-(TCR-)based immunotherapies. This class of therapies includes immune checkpoint inhibition (ICI, e.g., Pembrolizumab), engineered TCR (T cell receptor)-T cell adoptive transfer, tumor infiltrating lymphocytes (TIL), T-cell engagers, and other modalities. Dozens of therapies in this category were developed with many in clinical trials. The resistance mechanism noted here, HLA LOH, causes these therapies to fail. Therefore, it is beneficial to know before treating a patient whether their cancer ’s genome has under...
Source: NIH OTT Licensing Opportunities - March 2, 2023 Category: Research Authors: ott8admin Tags: Diagnostics Licensing Desired & Collaboration Desired Collaboration Sought NIDCD NCI Source Type: research
A Human Monoclonal Antibody Against Deacetylated PNAG for Use as an Antimicrobial Agent
Biofilms are complex microbial communities, surface attached and held together by self-produced polymer matrices. These matrices are mainly composed of polysaccharides, secreted proteins and nucleic acids. Poly-N-acetyl glucosamine (PNAG) is a highly conserved surface polysaccharide expressed by a range of bacterial, fungal and protozoan microorganisms. It is associated with microbial biofilm formation. Partial deacetylation of PNAG (dPNAG) is critical for the function of PNAG in biofilm formation and required for the structural development and integrity of biofilm. Antibodies to PNAG and/or dPNAG have significant...
Source: NIH OTT Licensing Opportunities - March 2, 2023 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
