Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review)
Mol Med Rep. 2024 Jun;29(6):103. doi: 10.3892/mmr.2024.13227. Epub 2024 Apr 19.ABSTRACTMacrophage‑inducible C‑type lectin receptor (Mincle) is predominantly found on antigen‑presenting cells. It can recognize specific ligands when stimulated by certain pathogens such as fungi and Mycobacterium tuberculosis. This recognition triggers the activation of the nuclear factor‑κB pathway, leading to the production of inflammatory factors and contributing to the innate immune response of the host. Moreover, Mincle identifies lipid damage‑related molecules discharged by injured cells, such as Sin3‑associated protein 130...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Yuanxia Zou Jianchun Li Hongwei Su Nathupakorn Dechsupa Jian Liu Li Wang Source Type: research
Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis
In conclusion, the present findings demonstrated that dicoumarol could impede the progression of KOA by inhibiting NLRP3 activation, providing a potential treatment strategy for KOA.PMID:38639180 | DOI:10.3892/mmr.2024.13224 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Wenjie Ge Xian Zhang Qing Wang Jianjie Mao Pengfei Jia Jianping Cai Source Type: research
[Retracted] MicroRNA ‑671‑5p inhibits cell proliferation, migration and invasion in non‑small cell lung cancer by targeting MFAP3L
Mol Med Rep. 2024 Jun;29(6):101. doi: 10.3892/mmr.2024.13225. Epub 2024 Apr 19.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 4B and the Transwell cell invasion data shown in Figs. 2D and 4E were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had already been published elsewhere prior to the submission of this paper to Molecular Medicine Reports (one of which has been retracted). Moreover, there appeared to be inappropriately...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Junhui Ye Wujun Luo Lingling Luo Limin Zhai Pingping Huang Source Type: research
Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis
Mol Med Rep. 2024 Jun;29(6):102. doi: 10.3892/mmr.2024.13226. Epub 2024 Apr 19.ABSTRACTKnee osteoarthritis (KOA) is a chronic degenerative disease that affects the quality of life of middle‑aged and elderly individuals, and is one of the major factors leading to disability. Rongjin Niantong Fang (RJNTF) can alleviate the clinical symptoms of patients with KOA, but the molecular mechanism underlying its beneficial effects on KOA remains unknown. Using pharmacological analysis and in vitro experiments, the active components of RJNTF were analyzed to explore their potential therapeutic targets and mechanisms in KOA. The pot...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Jun Chen Ting Zhang Qingqing Luo Ruyi Wang Yuting Dai Zhenyuan Chen Chutian Zhang Xuzheng Chen Guangwen Wu Source Type: research
Deciphering microglial activation and neuronal apoptosis post ‑traumatic brain injury: The role of TYROBP in inflammation regulation networks
Mol Med Rep. 2024 Jun;29(6):104. doi: 10.3892/mmr.2024.13228. Epub 2024 Apr 19.ABSTRACTTraumatic Brain Injury (TBI) represents a significant public health challenge. Recovery from brain injury necessitates the collaborative efforts of various resident neural cells, predominantly microglia. The present study analyzed rat and mouse RNA expression micro‑arrays, high‑throughput RNA sequencing and single‑cell sequencing data sourced from public databases. To construct an inflammation regulation network around TYRO protein tyrosine kinase‑binding protein (TYROBP), to evaluate the role of TYROBP in cell death after TBI. T...
Source: Molecular Medicine Reports - April 19, 2024 Category: Molecular Biology Authors: Xudong Zhou Huiping Song Jingjing He Wei Han Qin Li Source Type: research
Advances in microRNA regulation of deep vein thrombosis through venous vascular endothelial cells (Review)
Mol Med Rep. 2024 Jun;29(6):96. doi: 10.3892/mmr.2024.13220. Epub 2024 Apr 12.ABSTRACTDeep vein thrombosis (DVT) is a prevalent clinical venous thrombotic condition that often manifests independently or in conjunction with other ailments. Thrombi have the propensity to dislodge into the circulatory system, giving rise to complications such as pulmonary embolism, thereby posing a significant risk to the patient. Virchow proposed that blood stagnation, alterations in the vessel wall and hypercoagulation are primary factors contributing to the development of venous thrombosis. Vascular endothelial cells (VECs) constitute the ...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Chucun Fang Feng Huang Mengting Yao Zilong Wang Jiacheng Ma Dongwen Wu Tianting Guo Fei Zhang Jianwen Mo Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Chromatin looping links gene expression to the assembly of transcription factories (Review)
Mol Med Rep. 2024 Jun;29(6):97. doi: 10.3892/mmr.2024.13221. Epub 2024 Apr 12.ABSTRACTGenes are not randomly dispersed within the nuclear space, instead they occupy precise sites either with respect to the nuclear lamina as well as to each other. This observation stands at the basis of the today well accepted concept of nuclear territories where any chromosome shows reproducible spatial connections with a selection of others in a general picture that meets a functional criterion where genes that answer the same stimuli are grouped in the same sites. In fact, transcription is not visible widely dispersed throughout the nucl...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Bruno Perillo Antimo Migliaccio Gabriella Castoria Source Type: research
MicroRNA ‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)
In conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios.PMID:38606516 | DOI:10.3892/mmr.2024....
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Woohyeong Jung Uijin Juang Suhwan Gwon Hounggiang Nguyen Qingzhi Huang Soohyeon Lee Beomwoo Lee So-Hee Kwon Seon-Hwan Kim Jongsun Park Source Type: research
[Retracted] Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR ‑145‑5p/TOP2A axis
Mol Med Rep. 2024 Jun;29(6):94. doi: 10.3892/mmr.2024.13218. Epub 2024 Apr 12.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the tumour images shown in Fig. 6B on p. 8 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were under consideration for publication at around the same time. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Mol...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Yi Du Xudong Zhang Hongwei Zhang Yiding Chen Shuying Zhu Jinjun Shu Hui Pan Source Type: research
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Advances in microRNA regulation of deep vein thrombosis through venous vascular endothelial cells (Review)
Mol Med Rep. 2024 Jun;29(6):96. doi: 10.3892/mmr.2024.13220. Epub 2024 Apr 12.ABSTRACTDeep vein thrombosis (DVT) is a prevalent clinical venous thrombotic condition that often manifests independently or in conjunction with other ailments. Thrombi have the propensity to dislodge into the circulatory system, giving rise to complications such as pulmonary embolism, thereby posing a significant risk to the patient. Virchow proposed that blood stagnation, alterations in the vessel wall and hypercoagulation are primary factors contributing to the development of venous thrombosis. Vascular endothelial cells (VECs) constitute the ...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Chucun Fang Feng Huang Mengting Yao Zilong Wang Jiacheng Ma Dongwen Wu Tianting Guo Fei Zhang Jianwen Mo Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Chromatin looping links gene expression to the assembly of transcription factories (Review)
Mol Med Rep. 2024 Jun;29(6):97. doi: 10.3892/mmr.2024.13221. Epub 2024 Apr 12.ABSTRACTGenes are not randomly dispersed within the nuclear space, instead they occupy precise sites either with respect to the nuclear lamina as well as to each other. This observation stands at the basis of the today well accepted concept of nuclear territories where any chromosome shows reproducible spatial connections with a selection of others in a general picture that meets a functional criterion where genes that answer the same stimuli are grouped in the same sites. In fact, transcription is not visible widely dispersed throughout the nucl...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Bruno Perillo Antimo Migliaccio Gabriella Castoria Source Type: research
MicroRNA ‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)
In conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios.PMID:38606516 | DOI:10.3892/mmr.2024....
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Woohyeong Jung Uijin Juang Suhwan Gwon Hounggiang Nguyen Qingzhi Huang Soohyeon Lee Beomwoo Lee So-Hee Kwon Seon-Hwan Kim Jongsun Park Source Type: research
