Comparison of [18F]FDG and [68 Ga]pentixafor PET/CT in Nasopharyngeal Carcinoma
Conclusions[68 Ga]pentixafor is a promising imaging tracer for detecting primary and metastatic NPC. [68 Ga]pentixafor PET/CT is comparable to [18F]FDG PET/CT in the detection rate of primary tumors and metastatic cervical lymph nodes in nasopharyngeal carcinoma, but [68 Ga]pentixafor uptake was heterogeneous. [68 Ga]pentixafor PET/CT may help select patients most likely to benefit from CXCR4-directed endoradiotherapy.Clinical trial registration No.: ChiCTR2200065902 (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 16, 2024 Category: Molecular Biology Source Type: research
In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38
ConclusionsThis work shows the feasibility of labeling CTCsin vivo with OTL38 and detection with DiFC. Although further refinement of the DiFC instrument and signal processing algorithms and testing with other animal models is needed, this work may eventually pave the way for human use of DiFC. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 9, 2024 Category: Molecular Biology Source Type: research
Correction: Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 3, 2024 Category: Molecular Biology Source Type: research
Sensing and Imaging Molecular Oxygen in Mammals with Spin Lattice Relaxation Electron Paramagnetic Resonance
AbstractMolecular oxygen and its thermodynamic transformation drive nearly all life processes. Quantitative measurement and imaging of oxygen in living systems is of fundamental importance for the study of life processes and their aberrations —disease– many of which are affected by hypoxia, or low levels of oxygen. Cancer is among the disease processes profoundly affected by hypoxia. Electron paramagnetic resonance has been shown to provide remarkably accurate images of normal and cancerous tissue. In this review, we emphasize the re activity of molecular oxygen particularly highlighting the metabolic processes of livi...
Source: Molecular Imaging and Biology - March 28, 2024 Category: Molecular Biology Source Type: research
Highly Sensitive Detection of Melanin in Melanomas Using Multi-harmonic Low Frequency EPR
ConclusionsOverall, our results are paving the way for new clinical trials that will use MH clinical EPR for the characterization of pigmented skin lesions. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 22, 2024 Category: Molecular Biology Source Type: research
Passing the Molecular Imaging and Biology Torch
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 21, 2024 Category: Molecular Biology Source Type: research
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
ConclusionsThis study highlights the utility of combined functional micro-CT and FMT imaging in assessing cardiac function and detecting apoptosis, providing valuable insights into the potential of apoptosis as an early biomarker for cardiac failure. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 18, 2024 Category: Molecular Biology Source Type: research
Development of New CD38 Targeted Peptides for Cancer Imaging
ConclusionsThe novel CD38-targeted, radiolabeled bioconjugates were specific and allowed visualization of MM, providing a starting point for the clinical translation of such tracers for the detection of MM. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 13, 2024 Category: Molecular Biology Source Type: research
Test –Retest Repeatability of Patlak Slopes versus Standardized Uptake Values for Hypermetabolic Lesions and Normal Organs in an Oncologic PET/CT Population
ConclusionsAmong [18F]FDG-avid lesions, the repeatability of PS-based metrics is similar to equivalent SUV-based metrics at late post-injection time points, indicating that PS-based metrics may be suitable for tracking response to oncologic therapies. However, further validation is required in light of our study ’s limitations, including small sample size and bias toward higher retest values for some metrics. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 11, 2024 Category: Molecular Biology Source Type: research
MRI-Based Cell Tracking of OATP-Expressing Cell Transplants by Pre-Labeling with Gd-EOB-DTPA
ConclusionsOATP1B3-expressing cells can be pre-labeled with Gd-EOB-DTPA prior to injection into tissue, affording the use of clinically familiar T1-weighted MRI to robustly detect cell transplants immediately after transplant. This procedure is easily generalizable and has potential advantages over the use of iron oxide based cell labeling agents and imaging procedures. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 6, 2024 Category: Molecular Biology Source Type: research
MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates
AbstractImmunoglobulins, both full-length antibodies and smaller antibody fragments, have long been regarded as effective platforms for diagnostic and therapeutic radiopharmaceuticals. The construction of radiolabeled immunoglobulins (i.e., radioimmunoconjugates) requires the manipulation of the biomolecule through the attachment of a radiohalogenor the bioconjugation of a chelator that is subsequently used to coordinate a radiometal. Both synthetic approaches have historically relied upon the stochastic modification of amino acids within the immunoglobulin, a process which poses a risk to the structural and functional int...
Source: Molecular Imaging and Biology - March 6, 2024 Category: Molecular Biology Source Type: research
Use of Indocyanine Green Near-Infrared Imaging for Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Pilot Study
ConclusionsOur study shows that ICG-guided SLN biopsy is a feasible technique, especially in combination with conventional radioisotope method and may help for intraoperative localization of SLN. Validation studies with bigger patient cohorts are needed to prove our results. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 5, 2024 Category: Molecular Biology Source Type: research
Pre-treatment 68 Ga-PSMA-11 PET/CT Prognostic Value in Predicting Response to 177Lu-PSMA-I & amp;T Therapy and Patient Survival
ConclusionsA greater level of PSMA uptake, specifically higher tumour-to-background uptake in the hottest lesion, may hold substantial prognostic significance, considering both [177Lu]Lu-PSMA-I&T response and patient survival. These ratios may have the potential to be used for PCa patient selection for radioligand therapy. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 15, 2024 Category: Molecular Biology Source Type: research
Volumetric Parameters Derived from CXCR4-Directed PET/CT Predict Outcome in Patients with Gastrointestinal Neuroendocrine Carcinomas
ConclusionIn-vivo assessment of CXCR4 PET-derived volumetric parameters is predictive for outcome of patients with GEP-NEC and could be used as a risk stratification tool, which detects patients prone to early progression. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 8, 2024 Category: Molecular Biology Source Type: research
The Role of PET Imaging in Patients with Prion Disease: A Literature Review
AbstractPrion diseases are rare, rapidly progressive, and fatal incurable degenerative brain disorders caused by the misfolding of a normal protein called PrPC into an abnormal protein called PrPSc. Their highly variable clinical presentation mimics various degenerative and non-degenerative brain disorders, making diagnosis a significant challenge for neurologists. Currently, definitive diagnosis relies on post-mortem examination of nervous tissue to detect the pathogenic prion protein. The current diagnostic criteria are limited. While structural magnetic resonance imaging (MRI) remains the gold standard imaging modality ...
Source: Molecular Imaging and Biology - February 1, 2024 Category: Molecular Biology Source Type: research
