Genomic survey and expression analysis of cellulose synthase superfamily and COBRA-like gene family in < em > Zanthoxylum bungeanum < /em > stipule thorns
Physiol Mol Biol Plants. 2024 Mar;30(3):369-382. doi: 10.1007/s12298-024-01432-x. Epub 2024 Mar 15.ABSTRACTThe Cellulose Synthase gene (CS) superfamily and COBRA-like (COBL) gene family are essential for synthesizing cellulose and hemicellulose, which play a crucial role in cell wall biosynthesis and the hardening of plant tissues. Our study identified 126 ZbCS and 31 ZbCOBL genes from the Zanthoxylum bungeanum (Zb) genome. Phylogenetic analysis and conservative domain analysis unfolded that ZbCS and ZbCOBL genes were divided into seven and two subfamilies, respectively. Gene duplication data suggested that more than 75% o...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Weilong Gao Jiangbo Nie Jia Yao Jianxin Wang Shengshu Wang Xueli Zhang Yonghong Liu Yulin Liu Source Type: research
Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans
CONCLUSIONS: Plaque EAA is a strong and independent marker of poor outcome in patients with severe atherosclerosis. Plaque EAA was linked to mesenchymal endothelial and smooth muscle cells. Endothelial-to-mesenchymal transition was associated with EAA, which was experimentally validated. Epigenetic aging mechanisms may provide new targets for treatments that reduce atherosclerosis complications.PMID:38634280 | DOI:10.1161/ATVBAHA.123.320692 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Ernest Diez Benavente Robin J G Hartman Tim R Sakkers Marian Wesseling Yannicke Sloots Lotte Slenders Arjan Boltjes Barend M Mol Gert J de Borst Dominique P V de Kleijn Koen H M Prange Menno P J de Winther Johan Kuiper Mete Civelek Sander W van der Laan S Source Type: research
Protocol for Testing the Effects of ssDNA Aptamer in HeLa and MCF-7
Methods Mol Biol. 2024 Apr 19. doi: 10.1007/7651_2024_539. Online ahead of print.ABSTRACTConventional approaches for treating tumors encompass chemotherapy, radiotherapy, and surgery. However, these methods come with their limitations when applied in clinical practice. Aptamers are often referred to as "chemical antibodies" and consist of short DNA or RNA molecules, designed to bind to a wide range of targets, including proteins or nucleic acid structures. They exhibit strong affinities and remarkable specificity for their target molecules, making them capable of functioning as therapeutic agents to directly impede tumor c...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Haregewoin Bezu Woldekidan Zandile Nxumalo Mutsa M Takundwa Adugna Abdi Woldesemayat Deepak B Thimiri Govinda Raj Source Type: research
Transcriptomics Analysis Identifies the Decline in the AT2 Stem Cell Niches in Aged Human Lungs
Am J Respir Cell Mol Biol. 2024 Apr 18. doi: 10.1165/rcmb.2023-0363OC. Online ahead of print.ABSTRACTAging poses a global public health challenge, which is linked to the rise of age-related lung diseases. The precise understanding of the molecular and genetic changes in the aging lung that elevate the risk of acute and chronic lung diseases remains incomplete. Alveolar type II (AT2) cells are stem cells that maintain epithelial homeostasis and repair the lung after injury. AT2 progenitor function decreases with aging. The maintenance of AT2 function requires niche support from other cell types, but little has been done to ...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Xue Liu Xuexi Zhang Changfu Yao Jiurong Liang Paul W Noble Dianhua Jiang Source Type: research
Asthma Pathogenesis: Phenotypes, Therapies and Gaps. Summary of the Aspen Lung Conference 2023
This report summarizes the proceedings of the 2023 Aspen Lung Conference, which was organized to review the clinical and molecular heterogeneity of asthma and to better understand the impact of genetic, environmental, cellular, and molecular influences on disease susceptibility, heterogeneity, and severity. The goals of the conference were to review new information about asthma phenotypes, cellular processes, and cellular signatures underlying disease heterogeneity and treatment response. The report concludes with ongoing gaps in our understanding of asthma pathobiology and provides some recommendations for future research...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Sunita Sharma Anthony N Gerber Monica Kraft Sally E Wenzel Source Type: research
Positive Association between Dehydroepiandrosterone (DHEA) and Gene Expression of the gamma-aminobutyric acid (GABA-A) Receptor δ Subunit
The objective of the present study was to examine associations between the levels of steroid hormones and GABA-A receptor δ subunit expression in the immune system. We focused on this subunit because GABA-A receptors that contain it become significantly more sensitive to steroid hormones. We collected 80 blood samples from reproductive age women for the purpose of analyzing dehydroepiandrosterone (DHEA), 17β-estradiol, progesterone, and allopregnanolone using liquid chromatography-mass spectrometry (LC-MS). Furthermore, we extracted peripheral blood mononuclear cells (PBMCs) for determining mRNA expression levels of GABA...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Ajna Hamidovic Soojeong Cho John Davis Source Type: research
Inflammatory breast cancer: Epidemiologic data and therapeutic results
In this study, we reviewed the literature using the Surveillance, Epidemiology, and End Results (SEER) database compared to other published series. We observed that in the high incidence areas (North of Africa) when compared to "classical" breast cancer, IBC was associated to younger age (less than 50 years) with rapid evolution of signs and symptoms (in less than 3 up to 6 months), and more aggressive clinical and histopathological-molecular parameters, due to the predominance of triple-negative and HER2+ subtypes in around 60% of cases. An epidemiologic trend was observed in both high and low incidence areas since the ei...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Hamouda Boussen Yosra Berrazaga None Sherif Kullab Maroua Manai Narjess Berrada Nesrine Mejri Ismail Siala Paul H Levine Massimo Cristofanilli Source Type: research
Inflammatory breast cancer: As surgical oncologists, what can we do?
Int Rev Cell Mol Biol. 2024;384:113-124. doi: 10.1016/bs.ircmb.2024.02.004. Epub 2024 Mar 28.ABSTRACTBreast cancer surgery is the primary treatment for early-stage breast cancer. However, inflammatory breast cancer (IBC), with its specific presentation characterized by skin invasion, is unfit for primary surgery. According to the different guidelines, the management of IBC is trimodal with the coordination of oncologists, surgeons, and radiation therapists. Advances in breast cancer imaging and the development of more targeted therapies make new challenges for this aggressive cancer. This chapter aims to provide an update ...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Hatem Bouzaiene Fatma Saadallah Hanen Bouaziz Olfa Jaidane Jamel Ben Hassouna Tarak Dhieb Khaled Rahal Source Type: research
Advances in targets in inflammatory breast cancer
Int Rev Cell Mol Biol. 2024;384:125-152. doi: 10.1016/bs.ircmb.2023.10.005. Epub 2024 Feb 5.NO ABSTRACTPMID:38637096 | DOI:10.1016/bs.ircmb.2023.10.005 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Toshiaki Iwase Xiaoping Wang Lan Thi Hanh Phi Nithya Sridhar Naoto T Ueno Jangsoon Lee Source Type: research
Inflammatory breast cancer (IBC) advocacy-Past, present and future!
In conclusion, in defining the evolving roles of Patient Advocacy in IBC over the past 25 years, we examine what has been done, along with its challenges, and what work still remains from the perspectives of different patient advocates.PMID:38637097 | DOI:10.1016/bs.ircmb.2023.11.001 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Jeannine Donahue Joshlyn Earls Valerie Fraser Ginny Mason Heather Pirowski Peggy Stephens Source Type: research
Radiation for inflammatory breast cancer: Updates
Int Rev Cell Mol Biol. 2024;384:25-46. doi: 10.1016/bs.ircmb.2023.10.004. Epub 2023 Oct 19.ABSTRACTInflammatory breast cancer (IBC) is a diagnosis based on a constellation of clinical features of edema (peau d'orange) of a third or more of the skin of the breast with a palpable border and a rapid onset of breast erythema. Incidence of IBC has increased over time, although it still makes up only 1-4% of all breast cancer diagnoses. Despite recent encouraging data on clinical outcomes, the published local-regional control rates remain consistently lower than the rates for non-IBC. In this review, we focus on radiotherapy, pr...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Michael C Stauder Source Type: research
Inflammatory breast cancer: An overview about the histo-pathological aspect and diagnosis
Int Rev Cell Mol Biol. 2024;384:47-61. doi: 10.1016/bs.ircmb.2024.02.001. Epub 2024 Mar 29.ABSTRACTInflammatory Breast Cancer (IBC) is a rare and aggressive form of locally advanced breast cancer, classified as stage T4d according to the tumor-node-metastasis staging criteria. This subtype of breast cancer is known for its rapid progression and significantly lower survival rates compared to other forms of breast cancer. Despite its distinctive clinical features outlined by the World Health Organization, the histopathological characteristics of IBC remain not fully elucidated, presenting challenges in its diagnosis and trea...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Ghada Sahraoui Nabil Rahoui Maha Driss Karima Mrad Source Type: research
Inflammatory breast cancer biomarkers and biology
Int Rev Cell Mol Biol. 2024;384:63-76. doi: 10.1016/bs.ircmb.2023.11.002. Epub 2024 Feb 5.ABSTRACTInflammatory breast cancer (IBC) is a unique breast cancer with a highly virulent course and low 5- and 10-year survival rates. Even though it only accounts for 1-5% of breast cancers it is estimated to account for 10% of breast cancer deaths annually in the United States. The accuracy of diagnosis and classification of this unique cancer is a major concern within the medical community. Early molecular and biological studies incidentally included IBC samples with other conventional breast cancers and were not informative as to...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Kenneth L van Golen Source Type: research
Deciphering the molecular biology of inflammatory breast cancer through molecular characterization of patient samples and preclinical models
Int Rev Cell Mol Biol. 2024;384:77-112. doi: 10.1016/bs.ircmb.2023.10.006. Epub 2024 Feb 10.ABSTRACTInflammatory breast cancer is an aggressive subtype of breast cancer with dismal patient prognosis and a unique clinical presentation. In the past two decades, molecular profiling technologies have been used in order to gain insight into the molecular biology of IBC and to search for possible targets for treatment. Although a gene signature that accurately discriminates between IBC and nIBC patient samples and preclinical models was identified, the overall genomic and transcriptomic differences are small and ambiguous, mainl...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Charlotte Rypens Christophe Van Berckelaer Fedor Berditchevski Peter van Dam Steven Van Laere Source Type: research
Preface
Int Rev Cell Mol Biol. 2024;384:xiii-xiv. doi: 10.1016/S1937-6448(24)00060-1.NO ABSTRACTPMID:38637102 | DOI:10.1016/S1937-6448(24)00060-1 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Maroua Manai Hamouda Boussen Massimo Cristofanilli Source Type: research
