Newer Treatments for Mood and Anxiety Disorders
For more than 20 years, the mainstay of pharmacologic treatment for depression and anxiety disorders has been serotonin reuptake inhibitors and selective serotonin and norepinephrine reuptake inhibitors. There are newer medications, many with novel mechanisms of action, that have come to market; however, first-lin e treatments remain the same. There are now more robust data on the use of various augmentation agents in the treatment of major depressive disorder providing better recommendations for use by the primary care provider. Data to support the use of psychedelic-assisted psychotherapy in the treatment o f mood and ...
Source: Medical Clinics of North America - April 21, 2024 Category: Primary Care Authors: Jesse Markman, Heidi Combs Source Type: research
Novel Therapies for the Treatment of Cardiovascular Disease
Over the last decade, randomized clinical trials of several pharmacologic agents have demonstrated a reduction in cardiovascular mortality and other important secondary outcomes. Angiotensin-Neprilysin Inhibitors and Sodium-Glucose Co-transporter 2 inhibitors have now become pillars in the treatment of heart failure. Ivabradine is a negative chronotropic agent used as an adjunctive therapy in patients with heart failure. Two new hypertension therapies, zilebresiran and aprocitentan, are currently in investigational stages. Finally, mavacamten has emerged as a pharmacologic treatment for hypertrophic obstructive cardiomyopa...
Source: Medical Clinics of North America - April 12, 2024 Category: Primary Care Authors: Abdul Aziz A. Asbeutah, Zachary D. Goldberger Source Type: research
What Are the New Therapeutic Options in the Outpatient World?
In 2023, the FDA approved 55 new drugs. The average number of new drug approvals over the last decade has been about 45 per year. This is a remarkable number of medications for physicians to keep track of, and it is easy to miss important therapies that become available. Beyond knowing all the new available therapies, understanding the role of these therapies and when they are actually worth the very high prices of newly released drugs is a very important part of being a good health care professional in 2024. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - April 12, 2024 Category: Primary Care Authors: Douglas Paauw Tags: Preface Source Type: research
Newer Therapies in Rheumatology
Seven of the 11 newer medications recently or soon to be approved to treat rheumatologic diseases discussed in this article are biologic agents and reflect the current ability of science to target specific components of the immune system. The other agents are molecules that are directed against specific immune pathway targets as well. All have shown superiority to placebo and in some cases have been compared to currently accepted therapies. Safety issues are generally centered around infections due to the immune-interrupting nature of these therapies. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - April 8, 2024 Category: Primary Care Authors: Alison Bays, Gregory C. Gardner Source Type: research
Biologics, Single Maintenance and Reliever Therapy, Oral Immunotherapy, and More: Updates from the World of Allergy, Asthma, and Immunology
Atopic conditions are common complaints in a primary care office. From atopic dermatitis to severe asthma and complicated food allergy, primary care physicians are the first stop for most allergic conditions. The past decade has seen significant advancements in the treatment of atopic conditions with the development of biologics and the evolution of different types of immunotherapies, with a particular nod to advancements in oral immunotherapy for treatment of food allergy. These advancements served as the inspiration for this issue of Medical Clinics of North America. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - April 6, 2024 Category: Primary Care Authors: Andrew Lutzkanin, Kristen M. Lutzkanin Tags: Preface Source Type: research
Infectious Disease Updates for Primary Care
This article summarizes the situation with public health threats for primary care patients as of early 2024 and provides updates on strategies for the prevention, diagnosis, and treatment of common infections where new treatments and vaccines are available. For flu and COVID, an update on treatment is also provided —along with pearls useful for the busy primary care provider. The authors also discuss a new treatment option for drug-resistant vulvovaginal candidiasis and provide a balanced view of the increasingly popular technique of preventing bacterial sexually transmitted infections using doxycycline afte r condomless...
Source: Medical Clinics of North America - March 28, 2024 Category: Primary Care Authors: Denise J. McCulloch, Paul S. Pottinger Source Type: research
CME Accreditation Page
(Source: Medical Clinics of North America)
Source: Medical Clinics of North America - March 27, 2024 Category: Primary Care Source Type: research
Patient Management with Stable Ischemic Heart Disease
MEDICAL CLINICS OF NORTH AMERICA (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - March 27, 2024 Category: Primary Care Authors: Alexander C. Fanaroff, John W. Hirshfeld Source Type: research
Copyright
ELSEVIER (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - March 27, 2024 Category: Primary Care Source Type: research
Forthcoming Issues
Allergy and Immunology (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - March 27, 2024 Category: Primary Care Source Type: research
Contributors
JACK ENDE, MD, MACP (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - March 27, 2024 Category: Primary Care Source Type: research
Contents
Jack Ende (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - March 27, 2024 Category: Primary Care Source Type: research
Immunology and Allergy Medicine Takes Center Stage
In this issue of Medical Clinics of North America, Guest Editors Andrew Lutzkanin III, MD, FAAFP and Kristen M Lutzkanin, MD offer a spectacular compilation of immunologic and allergic challenges in clinical care, and they provide clinicians with the latest updates for the optimal and practical management of patients with common and uncommon immune-mediated clinical conditions. I ’ll highlight a few of the very common clinical conditions and encourage readers to take advantage of all that this issue has to offer. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - March 21, 2024 Category: Primary Care Authors: Daniel D. Dressler Tags: Foreword Source Type: research
CME Accreditation Page
(Source: Medical Clinics of North America)
Source: Medical Clinics of North America - February 7, 2024 Category: Primary Care Source Type: research
Sexually Transmitted Infections
MEDICAL CLINICS OF NORTH AMERICA (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - February 7, 2024 Category: Primary Care Authors: Susan Tuddenham Source Type: research
