Could CAR-T cell therapy improve kidney transplants?
Chimeric antigen receptor-T cell therapy (CAR-T cell therapy) could provide a revolutionary approach to organ transplantation for patients who are hard to match and susceptible to rejection, Mayo Clinic researchers discovered. Their pioneering research focuses on using CAR-T cells derived from the patient's own immune system to prevent rejection of donated organs. Sensitized patients are those who have high levels of antibodies that cause their immune systems to react negatively to potential donor organs. These… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 2, 2024 Category: Research Source Type: news
New study finds triple-negative breast cancer tumors with an increase in immune cells have lower risk of recurrence after surgery
ROCHESTER, Minn. — A new multicenter, international study suggests that people who have early-stage triple-negative breast cancer (TNBC) and high levels of immune cells within their tumors may have a lower risk of recurrence and better survival rates even when not treated with chemotherapy. The study was published today in the Journal of American Medical Association (JAMA). TNBC is a breast cancer subtype that does not respond to drugs that target the estrogen receptor or… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 2, 2024 Category: Research Source Type: news
Study documents safety, improvements from stem cell therapy after spinal cord injury
ROCHESTER, Minn. — A Mayo Clinic study shows stem cells derived from patients' own fat are safe and may improve sensation and movement after traumatic spinal cord injuries. The findings from the phase 1 clinical trial appear in Nature Communications. The results of this early research offer insights on the potenti al of cell therapy for people living with spinal cord injuries and paralysis for whom options to improve function are extremely limited. In the study… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 1, 2024 Category: Research Source Type: news
Mayo Clinic, Terasaki Institute launch collaboration for transplant innovation
JACKSONVILLE, Fla. — Mayo Clinic and Terasaki Institute for Biomedical Innovation announced today a research collaboration centered on improving organ transplant outcomes. Beginning in April, Mayo Clinic biomedical researchers and Terasaki Institute scientists will work together on two core areas: real-time monitori ng of donated organ health from procurement to transplant surgery and developing predictive technologies to determine which transplant recipients have a higher likelihood of rejection. That will be done by creating prognostic signatures and… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 1, 2024 Category: Research Source Type: news
Growing mini-organs to find new treatments for complex disease
Microscopic view of an intestinal organoid Mayo Clinic investigators are growing three-dimensional human intestines in a dish to track disease and find new cures for complex conditions such as inflammatory bowel disease. These mini organs function like human intestines with the ability to process metabolites that convert food into energy on a cellular level and secrete mucus that protects against bacteria. These 3D mini intestines in a dish, known as "organoids," provide a unique platform… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 31, 2024 Category: Research Source Type: news
A year of advancing novel regenerative biotherapeutics toward patient care
Mayo Clinic's Center for Regenerative Biotherapeutics has advanced the development and biomanufacturing of novel therapeutics, called biologics, for cancer and inflammatory conditions into clinical trials. "My dream has been to develop innovative technologies that go beyond treating symptoms to curing diseases. The ultimate aim is to ensure that these advancements are accessible to all patients in need," says Julie Allickson, Ph.D., the Michael S. and Mary Sue Shannon Director of the Mayo Clinic Center for Regenerative Biotherapeutics. Dr.… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 23, 2023 Category: Research Source Type: news
Mayo Clinic Comprehensive Cancer Center highlights research advances in 2023
ROCHESTER, Minn. — Mayo Clinic researchers make new discoveries, develop first-of-its-kind tools and technologies and constantly improve upon existing ones with the goal to provide the best in healthcare. The following five stories are a round-up of some of the most significant medical research advances at Mayo Cl inic Comprehensive Cancer Center over the past year. Discoveries range from harnessing artificial intelligence (AI) to detect disease sooner to advancing treatments for rare and complex diseases. Advancing… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 21, 2023 Category: Research Source Type: news
Minnesota Partnership awards five collaborative research grants for 2023
The Minnesota Partnership for Biotechnology and Medical Genomics (MNP) has announced its five research awardees for 2023. MNP is funded by the State of Minnesota and provides support for innovative research conducted by collaborative teams from the University of Minnesota and Mayo Clinic. Totaling $6.75 million, this year ’s awards support innovative projects on cancer, rare genetic diseases, neurodegenerative diseases, cognitive aging and new health models to study diseases. The award-winning projects are: Minnesota Functional Omics… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 21, 2023 Category: Research Source Type: news
Researchers map how measles virus spreads in human brain
ROCHESTER, Minn. — Mayo Clinic researchers mapped how the measles virus mutated and spread in the brain of a person who succumbed to a rare, lethal brain disease. New cases of this disease, which is a complication of the measles virus, may occur as measles reemerges among the unvaccinated, say researchers. Roberto Cattaneo, Ph.D. Using the latest tools in genetic sequencing, researchers at Mayo Clinic reconstructed how a collective of viral genomes colonized a human… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 21, 2023 Category: Research Source Type: news
A new smartphone application aims to predict the safety of liver surgery
ROCHESTER, Minn. — An international research team led by Dr. Patrick Starlinger, a hepatobiliary and pancreas surgeon from Mayo Clinic Comprehensive Cancer Center, developed a risk prediction model that can be calculated with a smartphone app. It provides an individualized risk assessment for patients before liver resection to evaluate the safety of liver surgery. Compared to standard preoperative tests, the research suggests the model offers a predictive model for postoperative liver failure. The model's effectiveness… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 8, 2023 Category: Research Source Type: news
17-gene signature linked to remission after triple-negative breast cancer treatment
Mayo Clinic researchers have discovered a distinctive pattern in a specific set of 17 genes that may be associated with remission after treatment for triple-negative breast cancer. The multi-omics study, published in Breast Cancer Research, highlights the potential for further investigating this signature as a target for individualized medicine. Approximately 10-15% of breast cancers fall into the category of "triple-negative," indicating that their growth is not driven through the hormone receptors for estrogen or progesterone, nor by… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 21, 2023 Category: Research Source Type: news
Mayo Clinic selects Owen Garrick, M.D., as dean of Clinical Trials
Mayo Clinic Research leaders are excited to announce the arrival of Owen Garrick, M.D., as the dean of Clinical Trials. Dr. Garrick will start in his new position on Oct. 30. The dean of Clinical Trials is tasked with strengthening Mayo Clinic's standing as a national leader of innovative, demand-generating clinical trials for patients everywhere. Dr. Garrick will lead the transformation of Mayo Clinic ’s clinical trials, including developing digital capabilities, accelerating the volume of remote… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 20, 2023 Category: Research Source Type: news
Mayo Clinic and Oxford Nanopore announce collaboration to advance precision medicine for cancer and genetic disorders
Joint development collaboration to bring leading-edge nanopore sequencing into clinical laboratories at Mayo Clinic to increase understanding and improve treatment of cancer and genetic disorders ROCHESTER, Minn., and OXFORD, UK — Mayo Clinic and Oxford Nanopore Technologies, the company delivering a new generation of nanopore-based molecular sensing technology, today unveiled a multi-year joint development collaboration to develop new clinical tests for diseases and improve patient care. Mayo Clinic and Oxford Nanopore h ave identified several areas… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 19, 2023 Category: Research Source Type: news
Mayo Clinic Proceedings, Kidney International publish consensus statement on new approach to identifying kidney disorder
Forty-eight international experts on membranous nephropathy have co-authored a consensus report that calls for a new method of classifying diagnoses of the syndrome. They say the change would result in greater accuracy in diagnoses, which would open the door to improved patient care and targeted treatment. To call attention to the report, Mayo Clinic Proceedings and Kidney International have published the report simultaneously. Membranous nephropathy is a kidney disorder that involves immunologic attack on structures… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 17, 2023 Category: Research Source Type: news
Mayo Clinic study sheds light on rare genetic disorder and blood cancers
In a recent study, Mayo Clinic researchers examined telomere biology disorders, a group of rare genetic disorders characterized by short telomeres. Telomeres are long segments at the end of chromosomes that protect the DNA from unraveling, similar to the small plastic sheath at the end of a shoelace. Telomeres shorten naturally with age but become abnormally shorter in telomere biology disorders. People with these disorders often have bone marrow failure and, for unknown reasons, a high… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 11, 2023 Category: Research Source Type: news
