Calf rEF: Impact of Calf Muscle Pump Dysfunction With Reduced Ejection Fraction on All-Cause Mortality
To evaluate mortality outcomes by varying degrees of reduced calf muscle pump (CMP) ejection fraction (EF). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 24, 2024 Category: Internal Medicine Authors: Robert D. McBane, David Liedl, Waldemar Wysokinski, Paul W. Wennberg, Ana I. Casanegra, Atefeh Ghorbanzadeh, Adelaide Arruda-Olson, Christopher G. Scott, Alex T. Lee, Azza Ahmed, Thom W. Rooke, Damon E. Houghton Tags: Original article Source Type: research
CoaguChek and Coag-Sense PT2 Meter Point of Care INR Device Validation
To standardize international normalized ratio (INR) measurements and improve data integrity by enabling electronic result transmission for warfarin monitoring, two point-of-care (POC) devices were evaluated against an internal plasma INR reference method. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 24, 2024 Category: Internal Medicine Authors: Robert D. McBane, Carlee O ’Connor, Jennifer Lutz, Jennifer Blanco, Levi A. Hartman, Anna Kramer, Josephine Uy, Traci Schumann, Katherine Hartung, Michael Luker, David Hodge, Paula Santrach, Brad S. Karon Tags: Original Article Source Type: research
Carpal Tunnel Syndrome and Transthyretin Amyloidosis in the All of Us Research Program
To evaluate the association of carpal tunnel syndrome (CTS) with incident heart failure and incident amyloidosis and to assess the risk of CTS in pathogenic TTR genetic variant carriers. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 24, 2024 Category: Internal Medicine Authors: Naman S. Shetty, Akhil Pampana, Nirav Patel, Mathew S. Maurer, Parag Goyal, Peng Li, Garima Arora, Pankaj Arora Tags: Original article Source Type: research
Cardiorespiratory Fitness as a Predictor of Non –Cardiovascular Disease and Non-Cancer Mortality in Men
To evaluate the association of 5 major cause-specific non –cardiovascular disease (CVD) and non-cancer deaths with cardiorespiratory fitness (CRF). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 24, 2024 Category: Internal Medicine Authors: Joshua R. Sparks, Xuewen Wang, Carl J. Lavie, Jiajia Zhang, Xuemei Sui Tags: Original article Source Type: research
Surgical Coronary Revascularization in Patients With Underlying Atrial Fibrillation: State-of-the-Art Review
The number of individuals referred for coronary artery bypass grafting (CABG) with preoperative atrial fibrillation (AF) is reported to be 8% to 20%. Atrial fibrillation is a known marker of high-risk patients as it was repeatedly found to negatively influence survival. Therefore, when performing surgical revascularization, consideration should be given to the concomitant treatment of the arrhythmia, the clinical consequences of the arrhythmia itself, and the selection of adequate surgical techniques. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 24, 2024 Category: Internal Medicine Authors: Emil J. D ąbrowski, Anna Kurasz, Michał Pasierski, Luigi Pannone, Michalina M. Kołodziejczak, Giuseppe M. Raffa, Matteo Matteucci, Silvia Mariani, Maria E. de Piero, Mark La Meir, Bart Maessen, Paolo Meani, Patrick McCarthy, James L. Cox, Roberto Lorus Tags: Review Source Type: research
Food and Drug Omnibus Reform Act: A Critical Course Correction
On December 29, 2022, the Consolidated Appropriations Act, 2023 (Public Law No. 117-328) was signed into law, containing the Food and Drug Omnibus Reform Act of 2022 (FDORA), which introduces significant reforms to the US Food and Drug Administration (FDA).1 This paper highlights select provisions of FDORA that, in our view, have broad implications for the clinical and pharmaceutical sectors, such as promoting clinical trial diversity, revising the accelerated approval process, modernizing clinical trial operations, updating marketing exclusivities, expanding cosmetics regulation, and fortifying infant formula oversight. (...
Source: Mayo Clinic Proceedings - April 24, 2024 Category: Internal Medicine Authors: Aditya Narayan, I. Glenn Cohen, Eli Y. Adashi Tags: Perspectives and controversies Source Type: research
Blood Calcium, Genetic Risk, and Risk of Incident Kidney Stone: A Population-Based Cohort Study
To investigate the association between blood calcium concentration and incident kidney stone as well as to assess the role played by genetic susceptibility. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 16, 2024 Category: Internal Medicine Authors: Xi Cao, Si Li, Yunlong Guan, Zhonghe Shao, Minghui Jiang, Miao Wang, Xingjie Hao Tags: Original Article Source Type: research
Incident Diuretic Use and Subsequent Risk of Bone Fractures
To investigate the association of incident use of diuretics with subsequent risk of incident bone fractures. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 3, 2024 Category: Internal Medicine Authors: Keiichi Sumida, Prabin Shrestha, Yamini Mallisetty, Satya Surbhi, Fridtjof Thomas, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy Tags: Original article Source Type: research
Predicting Primary Care Physician Burnout From Electronic Health Record Use Measures
To evaluate the ability of routinely collected electronic health record (EHR) use measures to predict clinical work units at increased risk of burnout and potentially most in need of targeted interventions. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 3, 2024 Category: Internal Medicine Authors: Daniel Tawfik, Mohsen Bayati, Jessica Liu, Liem Nguyen, Amrita Sinha, Thomas Kannampallil, Tait Shanafelt, Jochen Profit Tags: Original article Source Type: research
Advancing Translation of Clinical Research Into Practice and Population Health Impact Through Implementation Science
Translational and implementation sciences aim to prioritize and guide efforts to create greater efficiency and speed of scientific innovation across the translational science continuum to improve patient and population health. Key principles and practices rooted in translational and implementation science may be incorporated into clinical trials research, particularly pragmatic trials, to improve the relevance and impact of scientific innovation. This thematic review intends to raise awareness on the value of translational and implementation science in clinical research and to encourage its use in designing and implementin...
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Lila J. Finney Rutten, Jennifer L. Ridgeway, Joan M. Griffin Tags: Thematic Review on Forward Thinking on Clinical Trials in Clinical Practice Source Type: research
State of Gene Therapy for Monogenic Cardiovascular Diseases
Over the past 2 decades, significant efforts have been made to advance gene therapy into clinical practice. Although successful examples exist in other fields, gene therapy for the treatment of monogenic cardiovascular diseases lags behind. In this review, we (1) highlight a brief history of gene therapy, (2) distinguish between gene silencing, gene replacement, and gene editing technologies, (3) discuss vector modalities used in the field with a special focus on adeno-associated viruses, (4) provide examples of gene therapy approaches in cardiomyopathies, channelopathies, and familial hypercholesterolemia, and (5) present...
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Sahej Bains, John R. Giudicessi, Katja E. Odening, Michael J. Ackerman Tags: Review Source Type: research
Pemphigus Vulgaris
A man in his mid-40s was referred with a 2-week history of painful erosions in his mouth followed by spontaneous fragile blisters on his trunk and extremities, resulting in painful erosions. Physical examination demonstrated oral lesions, widespread skin erosions, crusted lesions, and flaccid bullae over his body (Figure 1). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Nika Kianfar, Maryam Daneshpazhooh, Julia S. Lehman Tags: Medical image Source Type: research
Breast Cancer Screening Recommendations for Transgender Patients: A Review
Shifting societal attitudes trending toward increased acceptance of transgender people has contributed to a growth in the population of individuals who openly identify as transgender as well as an increase in utilization of gender-affirming surgeries. Therefore, health care providers should work toward increasing their knowledge with respect to the health care needs of the transgender population, particularly given that these individuals often face discrimination in the health care system. Moreover, transgender breast cancer screening rates lag behind breast cancer screening rates for cisgender individuals. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Alex Suarez, Julia Bisschops, Katharine Lampen-Sachar Tags: Review Source Type: research
A Cross-Sectional Survey Study of Cannabis Use for Fibromyalgia Symptom Management
To assess the use of cannabis as a symptom management strategy for patients with fibromyalgia. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Abhinav Singla, Christopher V. Anstine, Linda Huang, Jordan K. Rosedahl, Arya B. Mohabbat, Lindsey M. Philpot Tags: Original article Source Type: research
Vitamin D Supplementation: To D or Not to D?
Vitamin D was once considered a panacea for a variety of ailments but now is considered by some to be unimportant. As is often the case, the pendulum swings widely from one extreme to the other. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Robert Joseph Fakheri Tags: Commentary Source Type: research
