Electromagnetic procedures in the treatment of pancreatic cancer: eminent or resentful?
Magy Onkol. 2023 Sep 28;67(3):194-201. Epub 2023 Sep 10.ABSTRACTThe treatment of advanced-stage pancreatic cancers is limited. Previous studies have found that the use of modulated electro-hyperthermia (mEHT) is beneficial in this patient population. However, there is no data on the optimal treatment number and initiation period. Therefore, a retrospective study was conducted with the inclusion of 96 mEHT-treated and 86 age- and sex-matched control pancreatic cancer patients. 76, 57, 38 and 33 patient pairs were enrolled into propensity score matched cohorts, whether they received at least 10, 20, 30 and 40 mEHT treatments...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Magdolna Dank Magdolna Herold M árton Tamás Garay J ózsef Gajdácsi Zolt án Herold Marcell Attila Sz ász Source Type: research
Farnesyltransferase inhibitors have antitumoral effects in mutant KRAS containing cancer cells in preclinical models
Magy Onkol. 2023 Sep 28;67(3):223-235. Epub 2023 Aug 21.ABSTRACTIn silico studies raised the possibility that farnesyltransferase inhibitors (FTIs) may have antitumoral effects on KRAS mutant cancer cells. Accordingly, we have tested FTIs (tipifarnib and lonafarnib) in G12C mutant human cancer cell lines in vitro and in vivo. We have discovered that the combination of the two drugs has a synergistic antitumoral effect. Next, we have tested FTIs on G12D mutant human cancer cell lines and found that the combination has antitumoral effect in various preclinical cancer models. At last, we have also tested FTIs on G12V mutant h...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Marcell Baranyi Bal ázs Hegedűs Eszter Moln ár J ózsef Tóvári Ivan Ran đelović Andr ás Perczel L ászló Buday Gy örgy Keserű J ózsef Tímár Source Type: research
Intra- and perioperative imaging options in neurosurgery
Magy Onkol. 2024 Mar 14;68(1):5-12. Epub 2024 Jan 12.ABSTRACTThe treatment of central nervous system tumors is still a major challenge for the oncological and neurosurgical teams. Due to the heterogeneous histological and topological characteristics of these neoplasms, every case requires individual evaluation. In addition to histology and stage, survival is largely determined by the extent of resection, which can be severely limited by the proximity of eloquent brain regions. A key component of current modern neuro-oncological care is the planning and execution of surgical intervention to ensure the longest possible progr...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Lor ánd Erőss L ászló Halász Gabriella Mikl ós Source Type: research
Brain tumor surgery in adults.
Magy Onkol. 2024 Mar 14;68(1):13-25. Epub 2023 Nov 12.ABSTRACTDespite the advanced medical and radiation therapy, the role of surgical resection of brain neoplasms still remains indisputable. The maximal safe resection of benign brain tumors may result in complete recovery of the patient. Surgery of malignant tumors can resolve mass effect, improve the neurological condition of the patient providing the possibility for further complex oncotherapy based on molecular level histopathology results. The advances in technical and multidisciplinary environment of brain tumor surgery facilitate more radical and safer resection res...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Gy örgy Attila Bagó Gerg ő Dávid Nagy Source Type: research
Neurosurgical treatment of tumors of the pineal region - literature review and overview of cases at OMIII
Magy Onkol. 2024 Mar 14;68(1):27-35. Epub 2023 Nov 23.ABSTRACTPineal region tumors account for less than 1% of adult supratentorial tumors. Their treatment requires a multimodality approach. Previously, the treatment of choice was direct surgery, which is associated with high surgical risk. Advances in minimally invasive techniques and onco-radiotherapy offer a safe and multimodal personalized therapy. The aim of our study was to describe the practice of our Institute based on combined endoscopic and radiotherapy techniques. We performed a retrospective clinical study. We processed data from 23 adult patients who underwent...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Tam ás Mezei J ános Báskay P éter Pollner Vikt ória Kovács Bal ázs Markia G ábor Nagy Andr ás Bajcsay L ászló Sipos Source Type: research
External radiation therapy of primary central nervous system tumors - current trends and practice
Magy Onkol. 2024 Mar 14;68(1):37-50. Epub 2023 Oct 22.ABSTRACTThe family of primary central nervous system (CNS) tumors is a highly heterogeneous group of diseases. In the complex care of CNS tumors, in addition to surgical and systemic treatments, modern external beam radiation therapy (EBRT) plays a prominent role. This summary article provides an overview of the current indications related to EBRT, diagnostic procedures, contouring, planning, and radiation therapy techniques and applications that can be used in daily routine for adults' most common primary CNS tumors.PMID:38484374 (Source: Magyar Onkologia)
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Árpád Kovács Source Type: research
Stereotactic radiosurgery of brain tumors
Magy Onkol. 2024 Mar 14;68(1):53-59. Epub 2023 Nov 2.ABSTRACTStereotactic radiosurgery is today a well-established treatment modality for various intracranial pathologies. The principle of high dose focused intracranial radiation guided by stereotactic technique ("Gamma Knife") was introduced by the Swedish neurosurgeon Prof. Lars Leksell in 1968. After the advent of CT and later MR imaging, stereotactic radiosurgery evolved rapidly regarding indications, and new technical solutions made it possible for linear accelerator systems to perform radiosurgery. A huge number of patients are treated yearly worldwide with this tech...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Imre Fedorcs ák Andr ás Bajcsay Levente J ánváry Source Type: research
The role of whole brain irradiation nowadays: more or less or different?
Magy Onkol. 2024 Mar 14;68(1):60-65. Epub 2023 Oct 8.ABSTRACTIn patients with poor performance status (KPS<50), ineligibility for effective systemic treatment and multiple brain metastases (BM) best supportive care is the preferred treatment over whole brain radiotherapy (WBRT). WBRT should be considered for the treatment of non-limited number (>4) brain metastases, depending on the patient's life expectancy, neurological symptoms, size, number and location of brain metastases, indication, type and availability of systemic therapy. In these patients if life expectancy is >4 months without small cell histology and ...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Ferenc Lakosi Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
The importance and areas of modern supportive and early integrated palliative care in the treatment of brain tumor patients
Magy Onkol. 2024 Mar 14;68(1):77-85. Epub 2023 Oct 22.ABSTRACTDuring the care of brain tumor patients, supportive care and palliation are carried out in an individualized manner, accompanied by adequate communication, in a multidisciplinary professional environment. In the case of brain tumor patients, the burden of symptoms resulting from the progression of the disease and the complications of treatments occur in a particularly high proportion. The supportive care of patients in a modern approach covers the targeted treatment of physical and psychosocial problems and also includes integrated palliation. Palliative care is...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Orsolya Horv áth P éter Kovács Source Type: research
Local treatment of ipsilateral breast cancer recurrences: comparison of alternative therapeutic options
Magy Onkol. 2024 Mar 14;68(1):86-88. Epub 2024 Jan 30.ABSTRACTWe compared the clinical outcomes of second breast conserving therapy (2ndBCT) versus salvage mastectomy (sMT) for the treatment of ipsilateral breast tumour recurrences (IBTR). 195 patients who presented with an IBTR after previous breast conserving treatment were salvaged either with re-excision and perioperative interstitial brachytherapy (n=39) or sMT (n=156). A total dose of 5×4.4Gy was delivered to the tumour bed, on 3 consecutive days. The median follow-up time was 59 and 56 months. During follow-up 4 (10.2%) and 28 (17.9%) second local recurrences occur...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Viktor Smanyk ó Source Type: research
Electromagnetic procedures in the treatment of pancreatic cancer: eminent or resentful?
Magy Onkol. 2023 Sep 28;67(3):194-201. Epub 2023 Sep 10.ABSTRACTThe treatment of advanced-stage pancreatic cancers is limited. Previous studies have found that the use of modulated electro-hyperthermia (mEHT) is beneficial in this patient population. However, there is no data on the optimal treatment number and initiation period. Therefore, a retrospective study was conducted with the inclusion of 96 mEHT-treated and 86 age- and sex-matched control pancreatic cancer patients. 76, 57, 38 and 33 patient pairs were enrolled into propensity score matched cohorts, whether they received at least 10, 20, 30 and 40 mEHT treatments...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Magdolna Dank Magdolna Herold M árton Tamás Garay J ózsef Gajdácsi Zolt án Herold Marcell Attila Sz ász Source Type: research
Farnesyltransferase inhibitors have antitumoral effects in mutant KRAS containing cancer cells in preclinical models
Magy Onkol. 2023 Sep 28;67(3):223-235. Epub 2023 Aug 21.ABSTRACTIn silico studies raised the possibility that farnesyltransferase inhibitors (FTIs) may have antitumoral effects on KRAS mutant cancer cells. Accordingly, we have tested FTIs (tipifarnib and lonafarnib) in G12C mutant human cancer cell lines in vitro and in vivo. We have discovered that the combination of the two drugs has a synergistic antitumoral effect. Next, we have tested FTIs on G12D mutant human cancer cell lines and found that the combination has antitumoral effect in various preclinical cancer models. At last, we have also tested FTIs on G12V mutant h...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Marcell Baranyi Bal ázs Hegedűs Eszter Moln ár J ózsef Tóvári Ivan Ran đelović Andr ás Perczel L ászló Buday Gy örgy Keserű J ózsef Tímár Source Type: research
Intra- and perioperative imaging options in neurosurgery
Magy Onkol. 2024 Mar 14;68(1):5-12. Epub 2024 Jan 12.ABSTRACTThe treatment of central nervous system tumors is still a major challenge for the oncological and neurosurgical teams. Due to the heterogeneous histological and topological characteristics of these neoplasms, every case requires individual evaluation. In addition to histology and stage, survival is largely determined by the extent of resection, which can be severely limited by the proximity of eloquent brain regions. A key component of current modern neuro-oncological care is the planning and execution of surgical intervention to ensure the longest possible progr...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Lor ánd Erőss L ászló Halász Gabriella Mikl ós Source Type: research
Brain tumor surgery in adults.
Magy Onkol. 2024 Mar 14;68(1):13-25. Epub 2023 Nov 12.ABSTRACTDespite the advanced medical and radiation therapy, the role of surgical resection of brain neoplasms still remains indisputable. The maximal safe resection of benign brain tumors may result in complete recovery of the patient. Surgery of malignant tumors can resolve mass effect, improve the neurological condition of the patient providing the possibility for further complex oncotherapy based on molecular level histopathology results. The advances in technical and multidisciplinary environment of brain tumor surgery facilitate more radical and safer resection res...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Gy örgy Attila Bagó Gerg ő Dávid Nagy Source Type: research
