Serum long non-coding Ribonucleic Acid H19 serves as a biomarker for systemic lupus erythematosus and participates in the disease progression
CONCLUSIONS: The expression of H19 is upregulated in patients with SLE and plays a role in cell function and inflammation by targeting miR-19b in PBMCs, which may be one of the pathological mechanisms of SLE.PMID:38634475 | DOI:10.1177/09612033241243175 (Source: Lupus)
Source: Lupus - April 18, 2024 Category: Rheumatology Authors: Hongyu Yang Shuping Wang Fei Wang Xuemei Bai Juan Ren Source Type: research
Receipt of rheumatology care and lupus-specific labs among young adults with systemic lupus erythematosus: A US Medicare retention in care cohort study
CONCLUSION: Disparities in care, measured by rheumatology visits and serology testing, exist by neighborhood disadvantage, race and ethnicity, and region among young adults with lupus, despite uniform Medicare coverage. Findings support evaluating lupus care quality measures and their impact on US lupus outcomes.PMID:38631342 | DOI:10.1177/09612033241247905 (Source: Lupus)
Source: Lupus - April 17, 2024 Category: Rheumatology Authors: Maria Schletzbaum W Ryan Powell Shivani Garg Joseph Kramer Brad C Astor Andrea Gilmore-Bykovskyi Amy J Kind Christie M Bartels Source Type: research
Upregulation of PD-1 and its ligands and expansion of T peripheral helper cells in the nephritic kidneys of lupus-prone BXSB- < em > Yaa < /em > mice
CONCLUSION: The results of this study suggest that kidney-infiltrating PD-1+ Tph cells expanded concomitantly with the upregulation of PD-L1 and PD-L2 in the kidneys and the progression of lupus nephritis.PMID:38622764 | DOI:10.1177/09612033241247908 (Source: Lupus)
Source: Lupus - April 16, 2024 Category: Rheumatology Authors: Rina Moriyama Yasuhiro Katsumata Yuko Okamoto Masayoshi Harigai Source Type: research
Upregulation of PD-1 and its ligands and expansion of T peripheral helper cells in the nephritic kidneys of lupus-prone BXSB- < em > Yaa < /em > mice
CONCLUSION: The results of this study suggest that kidney-infiltrating PD-1+ Tph cells expanded concomitantly with the upregulation of PD-L1 and PD-L2 in the kidneys and the progression of lupus nephritis.PMID:38622764 | DOI:10.1177/09612033241247908 (Source: Lupus)
Source: Lupus - April 16, 2024 Category: Rheumatology Authors: Rina Moriyama Yasuhiro Katsumata Yuko Okamoto Masayoshi Harigai Source Type: research
Predictors of damage accrual and its impact on health-related quality of life of thrombotic antiphospholipid syndrome: Independent validation of the damage index for antiphospholipid syndrome (DIAPS)
CONCLUSION: This external validation of DIAPS reinforces the ability of the score to correlate with HR-QoL while also highlighting risk factors for HR-QoL impairment other than damage accrual.PMID:38616341 | DOI:10.1177/09612033241246360 (Source: Lupus)
Source: Lupus - April 15, 2024 Category: Rheumatology Authors: Pedro Gaspar Ana Sofia M Fernandes Ana Mafalda Abrantes In ês Parreira In ês Silva Ryan C Silva Mariana B Nobre Joana R Martins Catarina Mota Source Type: research
Extracellular mitochondrial components as new biomarkers for lupus nephritis
This study has evaluated extracellular mitochondrial components, including cell-free mitochondria, and cell-free mitochondrial DNA as probable biomarkers of the degree of nephritis. Both showed a significant correlation with proteinuria and protein-creatinine ratio. Our study substantiates their usage as clinical biomarkers of nephritis upon their validation in a larger cohort of lupus nephritis patients and other forms of nephritis. Although the current data suggest using cell-free mitochondria as a biomarker of lupus nephritis is better than the cell-free mitochondrial DNA.PMID:38621786 | DOI:10.1177/09612033241247622 (Source: Lupus)
Source: Lupus - April 15, 2024 Category: Rheumatology Authors: Sharath Gowda Khushboo Rana Ankit Kumar Pradip Kumar Prajapati Namisha Patel Sapan Pandya Ratika Srivastava Source Type: research
Idiopathic intracranial hypertension as the initial presenting manifestation of systemic lupus erythematosus in a child
We report a 12-year-old girl presented with chronic holocranial headache and occasional episodes of projectile vomiting for the last 6 months and then developed blurring of vision for the last month. She fulfilled the criteria for IIH. Subsequent evaluation revealed a diagnosis of SLE. The occurrence of IIH in SLE is not coincidental and is reported in 1%-5.4% of patients with SLE. Though corticosteroids have not been widely used in IIH, underlying SLE warranted administering corticosteroids with subsequent complete resolution of IIH. Pediatricians, neurologists, intensivists, and ophthalmologists should consider SLE as a ...
Source: Lupus - April 12, 2024 Category: Rheumatology Authors: Murugan Sudhakar Anu P Kocheril Anish S George George I Vettiyil Anitha Jasper Sathish Kumar Source Type: research
Idiopathic intracranial hypertension as the initial presenting manifestation of systemic lupus erythematosus in a child
We report a 12-year-old girl presented with chronic holocranial headache and occasional episodes of projectile vomiting for the last 6 months and then developed blurring of vision for the last month. She fulfilled the criteria for IIH. Subsequent evaluation revealed a diagnosis of SLE. The occurrence of IIH in SLE is not coincidental and is reported in 1%-5.4% of patients with SLE. Though corticosteroids have not been widely used in IIH, underlying SLE warranted administering corticosteroids with subsequent complete resolution of IIH. Pediatricians, neurologists, intensivists, and ophthalmologists should consider SLE as a ...
Source: Lupus - April 12, 2024 Category: Rheumatology Authors: Murugan Sudhakar Anu P Kocheril Anish S George George I Vettiyil Anitha Jasper Sathish Kumar Source Type: research
Considering belimumab during pregnancy: A more viable option over time
CONCLUSIONS: Belimumab may be an option for pregnant women with difficult-to-control lupus. Further research is needed to confirm the absence of association between belimumab and foetal harm.PMID:38594808 | DOI:10.1177/09612033241245549 (Source: Lupus)
Source: Lupus - April 10, 2024 Category: Rheumatology Authors: Paloma Vela-Casasempere Roc ío Caño Alameda Silvia G ómez Sabater Silvia Cortell Aznar Encarnaci ón Pérez Pascual Source Type: research
Considering belimumab during pregnancy: A more viable option over time
CONCLUSIONS: Belimumab may be an option for pregnant women with difficult-to-control lupus. Further research is needed to confirm the absence of association between belimumab and foetal harm.PMID:38594808 | DOI:10.1177/09612033241245549 (Source: Lupus)
Source: Lupus - April 10, 2024 Category: Rheumatology Authors: Paloma Vela-Casasempere Roc ío Caño Alameda Silvia G ómez Sabater Silvia Cortell Aznar Encarnaci ón Pérez Pascual Source Type: research
Maternal and fetal outcomes in pregnancy complicated by pre-existing lupus nephritis: Insights from a developing country Pakistan
CONCLUSION: The maternal and fetal outcomes in pre-existing LN depend on the disease activity at the time of conception. No correlation was found between International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of LN and adverse disease and pregnancy outcomes.PMID:38594605 | DOI:10.1177/09612033241246642 (Source: Lupus)
Source: Lupus - April 9, 2024 Category: Rheumatology Authors: Tabassum Elahi Saima Ahmed Muhammed Mubarak Ejaz Ahmed Source Type: research
Maternal and fetal outcomes in pregnancy complicated by pre-existing lupus nephritis: Insights from a developing country Pakistan
CONCLUSION: The maternal and fetal outcomes in pre-existing LN depend on the disease activity at the time of conception. No correlation was found between International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of LN and adverse disease and pregnancy outcomes.PMID:38594605 | DOI:10.1177/09612033241246642 (Source: Lupus)
Source: Lupus - April 9, 2024 Category: Rheumatology Authors: Tabassum Elahi Saima Ahmed Muhammed Mubarak Ejaz Ahmed Source Type: research
Enrolment of the first paediatric cohort into the Australian lupus registry and biobank: A single-centre experience
CONCLUSION: We have established our centre as the first paediatric participating site of the ALRB, providing contemporary data on the clinical characteristics, serological profile and health-related quality of life outcomes of Australian children with SLE. Paediatric involvement with this national registry will provide a unique perspective for future clinical and scientific research. Collection of Australian-specific paediatric longitudinal data will also enable a broader understanding of SLE within a multicultural Australian population.PMID:38587355 | DOI:10.1177/09612033241244879 (Source: Lupus)
Source: Lupus - April 8, 2024 Category: Rheumatology Authors: Bronwyn D Power Rangi Kandane-Rathnayake Georgina Tiller William D Renton Angela Cox Lilian Johnstone Alberta Hoi Peter Gowdie Source Type: research
Enrolment of the first paediatric cohort into the Australian lupus registry and biobank: A single-centre experience
CONCLUSION: We have established our centre as the first paediatric participating site of the ALRB, providing contemporary data on the clinical characteristics, serological profile and health-related quality of life outcomes of Australian children with SLE. Paediatric involvement with this national registry will provide a unique perspective for future clinical and scientific research. Collection of Australian-specific paediatric longitudinal data will also enable a broader understanding of SLE within a multicultural Australian population.PMID:38587355 | DOI:10.1177/09612033241244879 (Source: Lupus)
Source: Lupus - April 8, 2024 Category: Rheumatology Authors: Bronwyn D Power Rangi Kandane-Rathnayake Georgina Tiller William D Renton Angela Cox Lilian Johnstone Alberta Hoi Peter Gowdie Source Type: research
Lack of awareness of systemic lupus erythematosus and its consequences in a cohort of moderate and severe patients in Spain: The LupusVoice study
CONCLUSION: This study highlights the need to increase SLE awareness among patients, HCPs, and the broader public in order to improve patient QoL. Being aware of the clinical and emotional impact of such lack of awareness, as well as the role played by context on the patient experience of SLE, is a crucial step towards achieving this goal.PMID:38577967 | DOI:10.1177/09612033241242886 (Source: Lupus)
Source: Lupus - April 5, 2024 Category: Rheumatology Authors: Maria Galindo Izquierdo Joaqu ín Borrás Blasco Silvia P érez Ortega Tarek Carlos Salman-Monte Paloma Vela-Casasempere Esther Rodr íguez Almaraz Jaime Calvo-Alen Jos é María Álvaro-Gracia Álvaro M Julia Barbado Ajo Ra ül Rubio Renau Marta Galvez-F Source Type: research
