Real-world Evidence from a Narrow Therapeutic Index Product (Levothyroxine) Reflects the Therapeutic Equivalence of Generic Drug Products
It appears that some prescribers are not aware that FDA bioequivalence standards ensure that generic products do not differ in safety, efficacy, or quality (including potency) from regulatory standards that govern brand-name products. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 12, 2024 Category: Drugs & Pharmacology Authors: FDA Source Type: news

No Benefit of Levothyroxine in Heart Donors No Benefit of Levothyroxine in Heart Donors
New data challenge the common practice of levothyroxine administration in potential heart donors after brain death to preserve heart function and make more hearts available for transplantation.Medscape Medical News (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - December 4, 2023 Category: Transplant Surgery Tags: Cardiology News Source Type: news

Rude Awakening on Trying to Keep Donor Hearts Usable With Common Hormone Infusions
(MedPage Today) -- Giving unstable brain-dead heart donors intravenous levothyroxine did not lead to more hearts being transplanted, a randomized trial showed. In hemodynamically unstable potential donors, administering the thyroid hormone supplement... (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - December 1, 2023 Category: Cardiology Source Type: news

Levothyroxine Infusion Does Not Increase Heart Transplants Versus Saline Infusion
THURSDAY, Nov. 30, 2023 -- Intravenous levothyroxine infusion does not result in more hearts being transplanted than saline infusion among hemodynamically unstable brain-dead potential heart donors, according to a study published in the Nov. 30... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 30, 2023 Category: Pharmaceuticals Source Type: news

T3 in Hypothyroidism Gets Extra Recommendation, With Caveats T3 in Hypothyroidism Gets Extra Recommendation, With Caveats
UK thyroid societies say the combination of LT3 with levothyroxine (LT4) may be warranted when symptoms persist after monotherapy, but only under key conditions.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - July 20, 2023 Category: Allergy & Immunology Tags: Diabetes & Endocrinology News Source Type: news

Surge in Desiccated Thyroid Extract Use for Hypothyroidism Surge in Desiccated Thyroid Extract Use for Hypothyroidism
Prescriptions for desiccated thyroid hormone for newly diagnosed hypothyroidism nearly doubled, while scripts for first-line levothyroxine monotherapy dropped, to the surprise of the researchers.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - June 21, 2023 Category: Drugs & Pharmacology Tags: Diabetes & Endocrinology News Source Type: news

Suicide attempt with levothyroxine overdose - Gill AS, Rai HK, Karunakaran A, Chaudhuri A.
Symptoms of levothyroxine overdose may vary depending on age, metabolism, etc. There are no specific guidelines for treating levothyroxine poisoning. Here, we present the case of a 69-year-old man with a history of panhypopituitarism, hypertension, and end... (Source: SafetyLit)
Source: SafetyLit - April 19, 2023 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

21 million Americans may take a hypothyroidism drug they don ’t need
A Yale researcher says that the season during which patients are diagnosed could be to blame for potentially deadly over-treatment with the drug levothyroxine. (Source: Yale Science and Health News)
Source: Yale Science and Health News - April 5, 2023 Category: Universities & Medical Training Source Type: news

Parathyroid Drug on Hold; FreeStyle Libre Safety Note; Levothyroxine Overprescribed?
(MedPage Today) -- The FDA "identified deficiencies" in Ascendis Pharma's new drug application for its hypoparathyroidism drug palopegteriparatide (TransCon PTH), putting new labeling and post-marketing discussions on hold for now, the developer... (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - April 5, 2023 Category: Endocrinology Source Type: news

Thyroid Drug on Hold; FreeStyle Libre Safety Note; Levothyroxine Overprescribed?
(MedPage Today) -- The FDA "identified deficiencies" in Ascendis Pharma's new drug application for its hypoparathyroidism drug palopegteriparatide (TransCon PTH), putting new labeling and post-marketing discussions on hold for now, the developer... (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - April 5, 2023 Category: Endocrinology Source Type: news

Zydus Lifesciences gets USFDA nod to market generic drug
The company has received the final approval for Levothyroxine Sodium for Injection in strength of 100 mcg/vial, 200 mcg/vial, and 500 mcg/vial from the US Food and Drug Administration (USFDA), the drug firm said in a statement. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - March 28, 2023 Category: Pharmaceuticals Source Type: news

Levothyroxine Recall; Klotho & Osteoporosis Protection; Marriage for a Lower HbA1c?
(MedPage Today) -- The FDA announced a nationwide recall of 27 lots of IBSA Pharma's levothyroxine sodium oral solution (Tirosint-SOL) due to subpotency. Children conceived using assisted reproductive technology (ART) had no significant differences... (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - February 7, 2023 Category: Endocrinology Source Type: news

IBSA Pharma Inc. Issues Voluntary Nationwide Recall of Select Lots of TIROSINT ®-SOL (levothyroxine sodium) Oral Solution Due to Subpotency
IBSA Pharma Inc. is voluntarily recalling 27 lots of TIROSINT ®-SOL (levothyroxine sodium) Oral Solution to the consumer level. This voluntary recall has been initiated because these lots may be subpotent. The company’s analyses show a slight decrease below 95.0% of its labeled amount in levothyroxin (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 1, 2023 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Treat Subclinical Hypothyroidism in Pregnant Women: Study Treat Subclinical Hypothyroidism in Pregnant Women: Study
Pregnant women with subclinical hypothyroidism and no thyroid peroxidase antibodies who received levothyroxine had similar gestational diabetes and preeclampsia rates as others with normal thyroid.First Look (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - January 10, 2023 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

TSH Levels and Levothyroxine Compliance in DTC Patients TSH Levels and Levothyroxine Compliance in DTC Patients
Learn more about levothyroxine suppression treatment adherence and the frequency of TSH target achievement among patients with differentiated thyroid cancer.Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 29, 2022 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news