Erratum
Kidney Blood Press Res 2023;48:260 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 28, 2023 Category: Urology & Nephrology Source Type: research
Unveiling the Unexpected: Why Doctors Should Look Beyond the Lungs When Predicting COVID-19 Mortality
Introduction: The main objective of this study was to identify the best combination of admission day parameters for predicting COVID-19 mortality in hospitalized patients. Furthermore, we sought to compare the predictive capacity of pulmonary parameters to that of renal parameters for mortality from COVID-19.
Methods: In this retrospective study, all patients admitted to a tertiary hospital between September 1st, 2020 and December 31st, 2020, who were clinically symptomatic and tested positive for COVID-19, were included.
We gathered extensive data on patient admissions, including laboratory results, comorbidities, chest...
Source: Kidney and Blood Pressure Research - April 25, 2023 Category: Urology & Nephrology Source Type: research
Relationship between serial serum neutrophil-lymphocyte ratio, cardiovascular mortality, and all-cause mortality in Chinese peritoneal dialysis patients
Conclusions
While baseline NLR was an independent predictor of all-cause mortality in PD patients, persistent elevation in NLR appeared to further amplify the risk. Regular monitoring of serial serum NLR may enable early identification of patients who are at risk of advers e outcome. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 25, 2023 Category: Urology & Nephrology Source Type: research
Green dialysis – let us talk about dialysis fluid.
Background: Hemodialysis is one of the most resources consuming medical intervention. Due to its concept, the proper amount of dialysis fluid passed through dialyser is crucial to obtain the expected outcomes. The most frequent source of dialysis fluid is production from liquid concentrate (delivered in containers or plastic bags) in dialysis machine. Alternatively, concentrates for dialysis may be produced in dialysis center by dilution in mixing devices dry or semi-dry pre-mixed compounds connected with system of central dialysis fluid delivery system. Dialysate consumption depends on various factors like type of hemodia...
Source: Kidney and Blood Pressure Research - April 25, 2023 Category: Urology & Nephrology Source Type: research
Clinicopathological Characteristics and Outcomes of Immunoglobulin A Nephropathy with Different Types of Dyslipidemia: A Retrospective Single-Center Study
Conclusions: IgAN patients with dyslipidemia presented more severe clinicopathological characteristics. Male gender and proteinuria are significantly associated with the occurrence of dyslipidemia in IgAN patients. Patients in the dyslipidemia group had a worse prognosis than those in the non-dyslipidemia group, which may be essential for the disease management of IgAN and help identify the high-risk patients.Kidney Blood Press Res 2023;48:186 –193 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 14, 2023 Category: Urology & Nephrology Source Type: research
Polymorphisms of CARD9 Gene Predict Disease Progression and Renal Survival of Immunoglobulin A Nephropathy
Conclusion: CARD9 variants are associated with disease severity and rapid disease progression for IgAN in a Chinese Han population. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 14, 2023 Category: Urology & Nephrology Source Type: research
Single-cell transcriptome sequencing reveals molecular mechanisms of renal injury in essential hypertension
Conclusion: Exploring the changes of gene expression in hypertension-injured kidneys may be helpful to identify the early biomarkers and signal pathways of this disease. Our data provide rich resources for understanding the pathogenesis of hypertensive renal injury and formulating effective treatment strategies. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 14, 2023 Category: Urology & Nephrology Source Type: research
Vitamin D ameliorates podocyte injury by enhancing autophagy activity in diabetic kidney disease
Conclusion: Vitamin D ameliorates podocyte injury of DKD by enhancing podocyte autophagy activity, which may become a potential candidate autophagy activator for the therapeutic interventions for DKD. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 13, 2023 Category: Urology & Nephrology Source Type: research
The long-term survival outcome in older patients with different pathological types of chronic kidney disease
Introduction: Chronic kidney diseases (CKD) are prevalent in older people and renal pathological manifestations are important for diagnosis, treatment and prognosis. However, the long-term survival outcome and risk factors for older CKD patients with different pathological types are not fully understood and need to be further investigated.
Methods: Medical data were recorded and all-cause mortality were followed up in patients underwent renal biopsy diagnosed in Guangdong Provincial people hospital from 2005 to 2015. Kaplan-Meier analysis were used to identify the incidence of survival outcomes. Multivariate Cox regressio...
Source: Kidney and Blood Pressure Research - April 11, 2023 Category: Urology & Nephrology Source Type: research
Identification the genetic influence of SARS-CoV-2 infections on IgA nephropathy based on bioinformatics method.
Conclusion: We successfully identified hub genes that may act as biomarkers of COVID-19 and IgAN and also screened out some potential drugs to provide new ideas for COVID-19 and IgAN treatment. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 11, 2023 Category: Urology & Nephrology Source Type: research
Novel metabolites to improve glomerular filtration rate estimation
Conclusion: We screened out the metabolites that increased or decreased with mGFR decline in CKD patients from the Chinese population, and 10 of them were highly correlated. They are potential novel metabolites to improve GFR estimation. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 10, 2023 Category: Urology & Nephrology Source Type: research
Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney.
Introduction: While recent investigations show that klotho exerts reno-protective actions, it has not been fully addressed whether klotho protein supplementation reverses renal damage.
Methods: The impacts of subcutaneous klotho supplementation on rats with subtotal nephrectomy were examined. Animals were divided into 3 groups: group1 (short remnant, SR): remnant kidney for 4 weeks, group 2 (long remnant, LR): remnant kidney for 12 weeks and group 3 (klotho supplementation: KL): klotho protein (20 μg/kg/day) supplementation on the remnant kidney. Blood pressure, blood and urine compositions with conventional methods such...
Source: Kidney and Blood Pressure Research - April 5, 2023 Category: Urology & Nephrology Source Type: research
International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe
Conclusion: Our findings show how the longitudinal outcome of patients with type 2 diabetes varies significantly across European countries even after accounting for the distribution of underlying risk factors.Kidney Blood Press Res 2023;48:165 –174 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 4, 2023 Category: Urology & Nephrology Source Type: research
Methodology and Baseline Data of a Comparative Exploratory Double-Blinded Randomized Study of Intravenous Iron on Fibroblast Growth Factor 23 and Phosphate in Chronic Kidney Disease
Modern intravenous iron compounds (e.g., ferric carboxymaltose [FCM] and ferric derisomaltose [FDI]) are utilized in the treatment of iron deficiency anemia in non-dialysis-dependent chronic kidney disease (ND-CKD). Product-specific alterations in the metabolism of fibroblast growth factor 23 (FGF-23) leading to hypophosphatemia have been described for certain intravenous iron compounds, such as FCM, with potential effects on bone and cardiovascular health and quality of life. No prior head-to-head comparison between FCM and FDI exists in ND-CKD. This single-center exploratory double-blind randomized controlled trial prima...
Source: Kidney and Blood Pressure Research - April 4, 2023 Category: Urology & Nephrology Source Type: research
Increased plasma homocysteine levels are associated with left ventricular hypertrophy in hypertensive patients with normal renal function.
This study aimed to investigate relationships among left ventricular mass index (LVMI), plasma homocysteine levels and renal function in a population from southern China. Methods: A cross-sectional study was performed in 2464 patients from June 2016 to July 2021. Patients were divided into three groups based on gender-specific tertiles of homocysteine levels. LVMI ≥ 115 g/m2 for man, or ≥ 95 g/m2 for woman was defined as LVH. Results: LVMI and the percentage of LVH were increased, while estimated glomerular filtration rate (eGFR) was decreased with the increase in homocysteine levels, both significantly. Multivariate s...
Source: Kidney and Blood Pressure Research - March 30, 2023 Category: Urology & Nephrology Source Type: research
