Journal of the American Society of Nephrology : JASN This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Authors Reply: Serum Protein-induced Tubular Injury
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Lidberg, K., Himmelfarb, J., Kelly, E., Akilesh, S. Tags: Letter to the Editor Source Type: research

Serum Protein-Induced Tubular Injury
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: ONeill, W. C. Tags: Letter to the Editor Source Type: research

Authors Reply: "On the Importance of Considering Glycosylation when Evaluating Biologic Therapies"
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Angeletti, A., Ravani, P., Bruschi, M., Ghiggeri, G. M. Tags: Letter to the Editor Source Type: research

On the Importance of Considering Glycosylation When Evaluating Biologic Therapies
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Lemaire, M. Tags: Letter to the Editor Source Type: research

A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients Five-Tier Rating System
Conclusions This proof-of-concept study suggests that a composite end point incorporating allograft function may improve the post-transplant component of the five-tier system by better differentiating between transplant programs with respect to long-term graft outcomes. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Wang, K., Deng, Y., Stewart, D., Formica, R. N. Tags: Transplantation Source Type: research

The Relationship between Cerebrovascular Reactivity and Cerebral Oxygenation during Hemodialysis
Conclusions We found significant relationships between regional rsCVR measured in the brain and decline in intradialytic ScO2. Our results warrant further exploration of using CVR in determining a patient’s risk of cerebral ischemic injury during HD. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Richerson, W. T., Schmit, B. D., Wolfgram, D. F. Tags: Dialysis Source Type: research

Coronary Artery Calcification Score and the Progression of Chronic Kidney Disease
Conclusion Our findings suggest that a high CACS is associated with significantly increased risk of adverse kidney outcomes and CKD progression. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Yun, H.-R., Joo, Y. S., Kim, H. W., Park, J. T., Chang, T. I., Son, N.-H., Yoo, T.-H., Kang, S.-W., Sung, S., Lee, K.-B., Lee, J., Oh, K.-H., Han, S. H., on behalf of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) Tags: Chronic Kidney Disease Source Type: research

A Deep Learning Approach for Automated Segmentation of Kidneys and Exophytic Cysts in Individuals with Autosomal Dominant Polycystic Kidney Disease
Conclusions We developed a fully automated segmentation method to measure TKV that excludes exophytic cysts and has an accuracy similar to that of a human expert. This technique may be useful in clinical studies that require automated computation of TKV to evaluate progression of ADPKD and response to treatment. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Kim, Y., Tao, C., Kim, H., Oh, G.-Y., Ko, J., Bae, K. T. Tags: Chronic Kidney Disease Source Type: research

Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and Their Combination in Patients with Chronic Kidney Disease: A Randomized Crossover Clinical Trial
Conclusions Albuminuria changes in response to dapagliflozin and eplerenone did not correlate, supporting systematic rotation of these therapies to optimize treatment. Combining dapagliflozin with eplerenone resulted in a robust additive UACR-lowering effect. A larger trial in this population is required to confirm long-term efficacy and safety of combined SGLT2 inhibitor and MRA treatment. Clinical Trial registry name and registration number: European Union Clinical Trials Register, EU 2017–004641–25. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Provenzano, M., Puchades, M. J., Garofalo, C., Jongs, N., DMarco, L., Andreucci, M., De Nicola, L., Gorriz, J. L., Heerspink, H. J. L., on behalf of the ROTATE-3 study group, ROTATE-3 study group members, Pennino, De Gregorio, Polese, Caturano, Minutolo, Tags: Chronic Kidney Disease Source Type: research

Complementary Nck1/2 Signaling in Podocytes Controls {alpha} Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition
Conclusion These findings reveal distinct, yet complementary, roles for Nck proteins in regulating podocyte adhesion, controlling GBM composition, and sustaining filtration barrier integrity. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Martin, C. E., Phippen, N. J., Keyvani Chahi, A., Tilak, M., Banerjee, S. L., Lu, P., New, L. A., Williamson, C. R., Platt, M. J., Simpson, J. A., Krendel, M., Bisson, N., Gingras, A.-C., Jones, N. Tags: Normal Kidney Structure and Function Source Type: research

Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy
Conclusions VRAC/LRRC8 channels are crucial for the function and integrity of proximal tubules, but not for more distal nephron segments despite their larger need for volume regulation. LRRC8A/D channels may be required for the basolateral exit of many organic compounds, including cellular metabolites, in proximal tubules. Proximal tubular injury likely results from combined accumulation of several transported molecules in the absence of VRAC channels. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Lopez-Cayuqueo, K. I., Planells-Cases, R., Pietzke, M., Oliveras, A., Kempa, S., Bachmann, S., Jentsch, T. J. Tags: Normal Kidney Structure and Function Source Type: research

Immunological Interaction of HLA-DPB1 and Proteinase 3 in ANCA Vasculitis is Associated with Clinical Disease Activity
Conclusions The risk allele HLA-DPB1*04:01 has been associated with PR3-ANCA, but its immunopathologic role was unclear. These studies demonstrate that HLA-DPB1*04:01 and PR3225–239 initiate an immune response. Autoreactive T cells specifically recognized PR3225–239 presented by HLA-DPB1*04:01. Although larger studies should validate these findings, the pathobiology may explain the observed increased risk of relapse in our cohort. Moreover, lack of HLA and autoantigen interaction observed during long-term remission signals immunologic nonresponsiveness. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Chen, D. P., McInnis, E. A., Wu, E. Y., Stember, K. G., Hogan, S. L., Hu, Y., Henderson, C. D., Blazek, L. N., Mallal, S., Karosiene, E., Peters, B., Sidney, J., James, E. A., Kwok, W. W., Jennette, J. C., Ciavatta, D. J., Falk, R. J., Free, M. E. Tags: Glomerulonephritis and Interstitial Nephritis Source Type: research

Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease
Conclusions Polycystin-2 in the ER appears to be critical for anticystogenesis and likely functions as a potassium ion channel to facilitate potassium–calcium counterion exchange for inositol trisphosphate–mediated calcium release. The results advance the understanding of ADPKD pathogenesis and provides proof of principle for pharmacotherapy by TRIC-B activators. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Padhy, B., Xie, J., Wang, R., Lin, F., Huang, C.-L. Tags: Genetic Disease of the Kidney Source Type: research

Myeloid CCR2 Promotes Atherosclerosis after AKI
Conclusions Our data introduce an experimental model of remote proatherogenic effects of renal IR and delineate myeloid CCR2 signaling as a mechanistic requirement. Monocytes should be considered as mobile mediators when addressing systemic vascular sequelae of kidney injury. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Hüsing, A. M., Wulfmeyer, V. C., Gaedcke, S., Fleig, S. V., Rong, S., DeLuca, D., Haller, H., Schmitt, R., von Vietinghoff, S. Tags: Acute Kidney Injury Source Type: research

Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification
Conclusions TMEM174 is a novel regulator of Pi homeostasis that interacts with NPT2A. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Miyazaki-Anzai, S., Keenan, A. L., Blaine, J., Miyazaki, M. Tags: Chronic Kidney Disease Source Type: research