Evaluation and comparison of thirty noninvasive models for diagnosing liver fibrosis in chinese hepatitis B patients
In conclusion, in Chinese CHB patients, the 30 existing noninvasive models were not suitable for assessing each stage of fibrosis except cirrhosis before and after antiviral therapy, especially in gauging progression and regression of liver fibrosis following therapy. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 28, 2018 Category: Infectious Diseases Authors: Xiao ‐Qin Dong, Zhao Wu, Hong Zhao, Gui‐Qiang Wang, China HepB‐Related Fibrosis Assessment Research Group Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
Journal of Viral Hepatitis, Volume 25, Issue 12, Page 1403-1405, December 2018. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 26, 2018 Category: Infectious Diseases Tags: ISSUE INFORMATION Source Type: research

Incidence and determinants of spontaneous hepatitis B surface antigen seroclearance and seroconversion in hepatitis B e antigen ‐negative chronic infection patients: A population‐based prospective cohort
This study reveals HBsAg seroconversion rates and HBV DNA undetectability epidemiological characteristics of patients with HBsAg seroclearance and suggests that monitoring HBV DNA is needed when managing HBeAg ‐negative chronic patients, even after clearing HBsAg. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 26, 2018 Category: Infectious Diseases Authors: Liguo Zhu, Xiangjun Zhai, Qungang Wang, Jie Jiang, Hong Peng, Ci Song, Zijun Ge, Jiao Qian, MingHao Zhou, Yan Zhou, Jianfang Xu, Hongjian Liu, Dong Hang, Zhibin Hu, Hongbin Shen, Fengcai Zhu Tags: ORIGINAL ARTICLE Source Type: research

Variants of hepatitis B virus surface antigen observed during therapy with nucleic acid polymer REP 2139 ‐Ca have no influence on treatment outcome and its detection by diagnostic assays
This article is protected by copyright. All rights reserved. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 19, 2018 Category: Infectious Diseases Authors: Hrvoje Mijo čević, Hadi Karimzadeh, Judith Seebach, Zainab Usman, Al‐Mahtab Mamun, Michel Bazinet, Andrew Vaillant, Michael Roggendorf Tags: Original Paper Source Type: research

Dynamic Changes in Innate Immune Responses During Direct Acting Antiviral Therapy for HCV Infection
In conclusion, PrOD+R for 12 weeks was well‐tolerated with no VF. Our data demonstrate dynamic alterations in innate immune profiles during highly‐potent IFN‐free DAA therapy. The downregulation of ISG post‐therapy s uggests reversal of the “exhausted” ISG phenotype following SVR, and the rise in ISGs and IFNα/IFN‐responsive chemokines late during therapy suggests resetting of IFN responsiveness that may be relevant in determining duration of or immunological sequelae from DAA therapy, including HBV react ivation.This article is protected by copyright. All rights reserved. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 19, 2018 Category: Infectious Diseases Authors: Jacinta A. Holmes, Charles Carlton ‐Smith, Arthur Y. Kim, Emily O. Dumas, Joelle Brown, Jenna L. Gustafson, Georg M. Lauer, Sakuni T. Silva, Maxwell Robidoux, Daniel Kvistad, Nadia Alatrakchi, Pierre Tonnerre, Daniel E. Cohen, Hongtao Zhang Tags: Original Paper Source Type: research

Polarization of granulocytic myeloid ‐derived suppressor cells by hepatitis C core protein is mediated via IL‐10/STAT3 signalling
SummaryMyeloid ‐derived suppressor cells (MDSCs) have been described as suppressors of T‐cell function in many malignancies. Impaired T‐cell responses have been observed in patients with chronic hepatitis C virus infection (CHC), which is reportedly associated with the establishment of persistent HCV infecti on. Therefore, we hypothesized that MDSCs also play a role in chronic HCV infection. MDSCs in the peripheral blood of 206 patients with CHC and 20 healthy donors were analyzed by flow cytometry. Peripheral blood mononuclear cells (PBMCs) of healthy donors cultured with hepatitis C virus core protein (HCVc) were s...
Source: Journal of Viral Hepatitis - November 19, 2018 Category: Infectious Diseases Authors: Meng Wang, Yu Ping, Zhiqin Li, Jieyao Li, Zhen Zhang, Dongli Yue, Xinfeng Chen, Liping Wang, Lan Huang, Jianmin Huang, Li Yang, Xuan Zhao, Shuangning Yang, Hong Li, Jijing Shi, Jiansheng Li, Yi Zhang Tags: ORIGINAL ARTICLE Source Type: research

Transplantation of kidneys from HCV viremic donors to HCV viremic recipients followed by early direct acting anti ‐viral therapy without ribavirin
ConclusionWe observed that HCV viremic recipients undergoing KT from a viremic donor followed by the initiation of DAA therapy without ribavirin was safe and efficacious. In the DAA era, the utilization of HCV positive organs has the potential to decrease waitlist times, expand the donor pool, and improve survival.This article is protected by copyright. All rights reserved. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 18, 2018 Category: Infectious Diseases Authors: Nikhil Kapila, Gianina Flocco, Kawtar Al Khalloufi, Xaralambos B. Zervos Tags: Short Communication Source Type: research

Applying core theory and spatial analysis to identify Hepatitis C Virus infection ‘core areas’ in British Columbia, Canada
This article is protected by copyright. All rights reserved. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 17, 2018 Category: Infectious Diseases Authors: Zahid Ahmad Butt, Sunny Mak, Dionne Gesink, Mark Gilbert, Jason Wong, Amanda Yu, Stanley Wong, Maria Alvarez, Mei Chong, Jane Buxton, Mark Tyndall, Mel Krajden, Naveed Zafar Janjua Tags: Original Paper Source Type: research

Sex hormone levels by presence and severity of cirrhosis in women with chronic hepatitis C virus infection
SummaryCirrhosis is associated with hormonal dysregulation, as evidenced by secondary amenorrhoea in reproductive ‐aged women, and feminization of cirrhotic men. Whether hormone levels vary by severity of cirrhosis in women is not known. If identified, such changes may have important clinical relevance, particularly, as low sex hormone binding globulin (SHBG) and follicle stimulating hormone (FSH) are known t o promote metabolic and cardiovascular disease in women. In a cohort of post‐menopausal women with chronic hepatitis C virus (HCV) infection, we compared comprehensive sex hormone levels by presence of cirrhosis, ...
Source: Journal of Viral Hepatitis - November 14, 2018 Category: Infectious Diseases Authors: Monika Sarkar, Jennifer C. Lai, Deirdre Sawinski, Toni E. Zeigler, Marcelle Cedars, Kimberly A. Forde Tags: ORIGINAL ARTICLE Source Type: research

Liver transplant listing for hepatitis C ‐associated cirrhosis and hepatocellular carcinoma has fallen in the United Kingdom since the introduction of direct‐acting antiviral therapy
In this study, we assessed the impact of DAA on liver transplant indications in the UK and waiting list outcomes for patients with HCV. We as sessed UK adult elective liver transplant registrants between 2006 and 2017. The aetiology of liver disease at registration was reclassified using an accepted hierarchical system and changes were assessed over time and compared before and after the introduction of DAA. Registration UKELD scores and 1‐year waiting list outcomes were also compared. The proportion of waiting list patients registered with HCV‐related cirrhosis reduced after the introduction of DAA from 10.5% in 2013 ...
Source: Journal of Viral Hepatitis - November 14, 2018 Category: Infectious Diseases Authors: Arash Vaziri, Alexander Gimson, Kosh Agarwal, Mark Aldersley, Andrew Bathgate, Douglas MacDonald, Stuart McPherson, David Mutimer, William Gelson Tags: ORIGINAL ARTICLE Source Type: research

High response and re ‐infection rates among people who inject drugs treated for hepatitis C in a community needle and syringe programme
This article is protected by copyright. All rights reserved. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 13, 2018 Category: Infectious Diseases Authors: Jasmine Schulkind, Brian Stephens, Farsana Ahmad, Linda Johnston, Sharon Hutchinson, Donna Thain, Zoe Ward, Peter Vickerman, Matt Hickman, John F Dillon Tags: Original Paper Source Type: research

Glecaprevir/Pibrentasvir in Patients with Chronic HCV Genotype 3 Infection: An Integrated Phase 2/3 Analysis
This article is protected by copyright. All rights reserved. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 12, 2018 Category: Infectious Diseases Authors: Steven Flamm, David Mutimer, Armen Asatryan, Stanley Wang, Jurgen Rockstroh, Yves Horsmans, Paul Y Kwo, Ola Weiland, Erica Villa, Jeong Heo, Edward Gane, Stephen D. Ryder, Tania M. Welzel, Peter J Ruane, Kosh Agarwal, Teresa I Ng, Zhenyi X Tags: Original Article Source Type: research

Efficacy and safety of antiviral treatment on blocking the mother ‐to‐child transmission of hepatitis B virus: a meta‐analysis
ConclusionsLamivudine, telbivudine, and tenofovir disoproxil fumarate are equally effective in blocking HBV MTCT. Antiviral treatment can be applied from the second trimester, without obvious safety concerns.This article is protected by copyright. All rights reserved. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 11, 2018 Category: Infectious Diseases Authors: Jiahui Song, Fan Yang, Shuo Wang, Sakinatou Tikande, Yang Deng, Weina Tang, Guangwen Cao Tags: Original Paper Source Type: research

The impact of currently licensed therapies on viral and immune responses in Chronic Hepatitis B: considerations for future novel therapeutics
This article is protected by copyright. All rights reserved. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 11, 2018 Category: Infectious Diseases Authors: Upkar S. Gill, Patrick T.F. Kennedy Tags: Commissioned Review Source Type: research

The accuracy of baseline viral load for predicting the efficacy of elbasvir/grazoprevir in participants with hepatitis C virus genotype 1a infection: an integrated analysis
This article is protected by copyright. All rights reserved. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - November 9, 2018 Category: Infectious Diseases Authors: Lawrence Serfaty, Ira Jacobson, J ürgen Rockstroh, Frederick L. Altice, Peggy Hwang, Eliav Barr, Michael Robertson, Barbara Haber Tags: Original Paper Source Type: research