Single-cell transcriptomics dissects the transcriptome alterations of hematopoietic stem cells in myelodysplastic neoplasms
Myelodysplastic neoplasms (MDS) are myeloid neoplasms characterized by disordered differentiation of hematopoietic stem cells and a predisposition to acute myeloid leukemia (AML). The underline pathogenesis re... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 17, 2024 Category: Research Authors: Xiangzong Zeng, Yichen Wang, Min Dai, Wei Li, Qingtian Huang, Lingsha Qin, Yuquan Li, Yanwen Yan, Xiangjun Xue, Fang Yi, Wenhao Li, Langyu He, Qifa Liu and Ling Qi Tags: Research Source Type: research
Landscapes of gut bacterial and fecal metabolic signatures and their relationship in severe preeclampsia
Preeclampsia is a pregnancy-specific disease leading to maternal and perinatal morbidity. Hypertension and inflammation are the main characteristics of preeclampsia. Many factors can lead to hypertension and i... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 17, 2024 Category: Research Authors: Xianxian Liu, Xiaoming Zeng, Xing Li, Siming Xin, Feng Zhang, Faying Liu, Yang Zeng, Jilin Wu, Yang Zou and Xinwei Xiong Tags: Research Source Type: research
Integrated lipid metabolomics and proteomics analysis reveal the pathogenesis of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder that can lead to female infertility. Lipid metabolomics and proteomics are the new disciplines in systems biology aimed to discove... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 17, 2024 Category: Research Authors: Yu Qian, Yun Tong, Yaqiong Zeng, Jingyu Huang, Kailu Liu, Ying Xie, Juan Chen, Mengya Gao, Li Liu, Juan Zhao, Yanli Hong and Xiaowei Nie Tags: Research Source Type: research
Tumor immune dysfunction and exclusion subtypes in bladder cancer and pan-cancer: a novel molecular subtyping strategy and immunotherapeutic prediction model
Molecular subtyping is expected to enable precise treatment. However, reliable subtyping strategies for clinical application remains defective and controversial. Given the significance of tumor immune dysfunct... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 17, 2024 Category: Research Authors: Kun Zheng, Youlong Hai, Hongqi Chen, Yukun Zhang, Xiaoyong Hu and Kai Ni Tags: Research Source Type: research
An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study
Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an u... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 17, 2024 Category: Research Authors: Yifei Cheng, Lang Wu, Junyi Xin, Shuai Ben, Silu Chen, Huiqin Li, Lingyan Zhao, Meilin Wang, Gong Cheng and Mulong Du Tags: Research Source Type: research
Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection
Machine learning (ML) methods are increasingly becoming crucial in genome-wide association studies for identifying key genetic variants or SNPs that statistical methods might overlook. Statistical methods pred... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 16, 2024 Category: Research Authors: Z. Alireza, M. Maleeha, M. Kaikkonen and V. Fortino Tags: Protocol Source Type: research
Desmosomes in heart and skin: friends or foes?
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 16, 2024 Category: Research Authors: Giuseppina Caiazzo, Rosa Redenta De Simone, Emanuele Monda, Ferdinando Barretta, Fabiana Uomo, Cristina Mazzaccara, Matteo Megna, Limongelli Giuseppe and Giulia Frisso Tags: Letter to the Editor Source Type: research
Machine learning and optical coherence tomography-derived radiomics analysis to predict persistent diabetic macular edema in patients undergoing anti-VEGF intravitreal therapy
This study aimed to develop and evaluate an OCT-omics prediction model for assessing anti-vascular endothelial growth f... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 16, 2024 Category: Research Authors: Zhishang Meng, Yanzhu Chen, Haoyu Li, Yue Zhang, Xiaoxi Yao, Yongan Meng, Wen Shi, Youling Liang, Yuqian Hu, Dan Liu, Manyun Xie, Bin Yan and Jing Luo Tags: Research Source Type: research
Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic
This study attempted to investigate the mechanism of QA on ather... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 15, 2024 Category: Research Authors: Qiao Jin, Chiyuan Zhang, Ran Chen, Luping Jiang, Hongli Li, Pengcui Wu and Liang Li Tags: Research Source Type: research
Architecting the metabolic reprogramming survival risk framework in LUAD through single-cell landscape analysis: three-stage ensemble learning with genetic algorithm optimization
Recent studies have increasingly revealed the connection between metabolic reprogramming and tumor progression. However, the specific impact of metabolic reprogramming on inter-patient heterogeneity and progno... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 15, 2024 Category: Research Authors: Xinti Sun, Minyu Nong, Fei Meng, Xiaojuan Sun, Lihe Jiang, Zihao Li and Peng Zhang Tags: Research Source Type: research
Application of high-precision 3D scanner in keloids evaluation to improve patients ’ compliance: a questionnaire-based study
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 15, 2024 Category: Research Authors: Huayi Wu, Zixi Jiang, Xiang Chen, Shuang Zhao and Zeyu Chen Tags: Letter to the Editor Source Type: research
Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition
Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 13, 2024 Category: Research Authors: Gilar Gorji-Bahri, B. Madhu Krishna, Catharina Hagerling, Akira Orimo, Karin Jirstr öm, Konstantinos S. Papadakos and Anna M. Blom Tags: Research Source Type: research
Immersed in a reservoir of potential: amniotic fluid-derived extracellular vesicles
This review aims to encapsulate the current knowledge in extracellular vesicles extracted from amniotic fluid and amniotic fluid derived stem/stromal cells. Amniotic fluid (AF) bathes the developing fetus, pro... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 12, 2024 Category: Research Authors: Ishara Atukorala, Natalie Hannan and Lisa Hui Tags: Review Source Type: research
Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology
Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of targeted therapy of multiple tumor-associated antigens in hepatocellular ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 12, 2024 Category: Research Authors: Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu & hellip; Tags: Research Source Type: research
Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson ’s disease
In this study, we aimed to explore the potential biomarkers and underlying molecular pathways of nicotine for the treatment of olfactory dys... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 12, 2024 Category: Research Authors: Qinglong Guo, Yi Wang, Liangchen Yu, Liao Guan, Xuefei Ji, Xiaohui Li, Gang Pang, Zhenhua Ren, Lei Ye and Hongwei Cheng Tags: Research Source Type: research
