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The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.01. Epub 2024 Apr 3.ABSTRACTIn this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agen...
Source: Journal of Physiology and Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: L Romano L Napolitano F Crocetto C Sciorio K Priadko M Fonticelli A Federico M Romano A G Gravina Source Type: research

Tonic action of endothelin type B and dopamine D3 receptors in spontaneously hypertensive and deoxycorticosterone acetate-salt hypertensive rats: effects of intrarenally applied selective antagonists
J Physiol Pharmacol. 2023 Feb;75(1). doi: 10.26402/jpp.2024.1.02. Epub 2024 Apr 3.ABSTRACTEndothelins and renal dopamine contribute to control of renal function and arterial pressure in health and various forms of experimental hypertension, the action is mediated by tonic activity of specific receptors. We determined the action mediated by endothelin type B and by dopamine D3 receptors (ETB-R, D3-R) in anaesthetized spontaneously hypertensive (SHR) and in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. In rats of both hypertension models infused during 60 min into the interstitium of in situ kidney were either E...
Source: Journal of Physiology and Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: B Badzynska I Baranowska J Sadowski Source Type: research

Curcumin alleviates myocardial inflammation, apoptosis, and oxidative stress induced by acute pulmonary embolism by regulating microRNA-145-5P/insulin receptor substrate 1 axis
In conclusion, curcumin alleviates myocardial inflammation, apoptosis, and oxidative stress induced by APE by regulating microRNA-145-5p/IRS1 axis.PMID:38583436 | DOI:10.26402/jpp.2024.1.03 (Source: Journal of Physiology and Pharmacology)
Source: Journal of Physiology and Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: L Jiang W Li X L Gong G Y Wang F Zhao L Han Source Type: research

Correlation between iron metabolism indicators and programmed death ligand 1 expression in advanced non-small cell lung cancer
This study aimed to explore the association between iron metabolism indicators (serum iron, transferrin, ferritin) and the expression level of programmed death factor ligand 1 in primary lesions of advanced non-small cell lung cancer. A cohort of 62 patients, including 42 men and 20 women, was recruited from October 2022 to July 2023, all diagnosed with advanced non-small cell lung cancer, confirmed through radiographic imaging and histopathological analysis. Comprehensive clinical data (such as gender, age, familial lung cancer history, smoking history, pathological classification, clinical stage, etc.) and concentrations...
Source: Journal of Physiology and Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: Y Wang G Ding Source Type: research

Kinetochore scaffold 1 downregulation suppressed the development of non-small cell lung cancer by inactivating the phosphatidylinositol 3 kinase/protein kinase B (AKT)/nuclear factor-kappa B pathway
J Physiol Pharmacol. 2023 Feb;75(1). doi: 10.26402/jpp.2024.1.05. Epub 2024 Apr 3.ABSTRACTKinetochore scaffold 1 (KNL1) is indispensable for generating motile micro-tubule attachments and isolating chromosomes. KNL1 is highly expressed in multiple middle-route tissues and promotes tumor development. However, how it functions in non-small cell lung cancer (NSCLC) is unclear. Real-time quantitative PCR (RT-qPCR) and Western blotting (WB) were used to determine KNL1 expression in NSCLC tissues and cells. The sh-KNL1 or oe-KNL1 was transfected into NSCLC cells. The colony formation assay, cell counting kit-8 (CCK-8) assay, and...
Source: Journal of Physiology and Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: L Wu G Zhang Q Zhu Y Huang Source Type: research

Osteoprotegerin and receptor activator of the nuclear factor kappa B ligand (RANKL) in healthy pubertal girls - relationships with physical growth and classical bone turnover markers
J Physiol Pharmacol. 2023 Feb;75(1). doi: 10.26402/jpp.2024.1.06. Epub 2024 Apr 3.ABSTRACTOsteoprotegerin (OPG) is a trap receptor for the receptor activator of the nuclear factor kappa B ligand (RANKL). We aimed to determine the OPG and free soluble RANKL (sRANKL) concentrations in girls during puberty and their relationships with pubertal stage, growth rate and serum concentrations of estradiol, as well as classical bone formation (N-terminal propeptide of type I collagen (PINP), bone-specific alkaline phosphatase (BALP), osteocalcin (OC)) and bone resorption (C-terminal telopeptide of type I collagen (CTX)) markers. The...
Source: Journal of Physiology and Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: B Kulik-Rechberger M Koz łowska Source Type: research

Antioxidant effect of dimethyl fumarate in pentylenetetrazole-kindled epilepsy mice and is activated by nuclear factor erythroid 2-related factor 2 pathway
This study was designed to examine the anti-oxidative stress effect of dimethyl fumarate (DMF) on pentylenetetrazole (PTZ)-induced epileptic mice, and to evaluate the correlation of its mechanism with the nuclear factor E2-related factor 2 (Nrf2)-mediated signaling pathway. The experimental mice were separated into three groups: control, model, and DMF groups. Mice in the model group were administered PTZ to establish an epilepsy model, mice in the DMF group were administered DMF concurrently when modeling, and mice in the control group were administered a 0.9% NaCl solution. The latency, severity, and frequency of epilept...
Source: Journal of Physiology and Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: Y Chang M Zhou R-Y Zhang Source Type: research

Assessment of interleukin 17A and 23 in the course of bladder cancer and selected benign urological diseases
J Physiol Pharmacol. 2023 Feb;75(1). doi: 10.26402/jpp.2024.1.08. Epub 2024 Apr 3.ABSTRACTSeveral cytokines have been indicated to be significantly involved in urological diseases. Interleukin 17A (IL-17A) and interleukin 23 (IL-23) have recently received attention for their involvement in inflammatory diseases and cancers. The aim of the study was to show changes in the level of pro-inflammatory interleukins IL-17A and IL-23 in patients with bladder cancer (BC) and selected urological diseases. An important cognitive aspect was to study the interdependencies between the studied interleukins and to assess their diagnostic ...
Source: Journal of Physiology and Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: B Szymanska J Debowski B Malkiewicz A Piwowar Source Type: research

Diodenocolic fistula healing by pentadecapeptide BPC 157 in rats. A cytoprotection viewpoint
J Physiol Pharmacol. 2023 Feb;75(1). doi: 10.26402/jpp.2024.1.09. Epub 2024 Apr 3.ABSTRACTUsing duodenocolic fistula in rats, this study attempts to highlight the particular cytoprotection aspects of the healing of fistulas and therapy potential of the stable gastric pentadecapeptide BPC 157, a cytoprotection mediator (i.e. upgrading minor vessels to induce healing at both fistula's sides). Upon duodenocolic fistula creation (two 'perforated' lesions put together) (assessed at 3, 6, 9, 12, and 15 min), BPC 157, given locally at the fistula, or intragastrically (10 μg/kg, 10 ng/kg), rapidly induces vessel 'recruitment', 'r...
Source: Journal of Physiology and Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: D Vukusic A Zenko Sever M Sever D Drmic M Milavic S Sikiric D Rasic I Krezic S Gojkovic A Prtoric P Bubalo L Coric I Dobric A Boban Blagaic Z Rasic A Skrtic S Seiwerth P Sikiric Source Type: research