Journal of Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations
J Oncol. 2024 Mar 18;2024:1529449. doi: 10.1155/2024/1529449. eCollection 2024.ABSTRACTAberrant glycosylation in tumor cells is a hallmark during carcinogenesis. KRAS gene mutations are the most well-known oncogenic abnormalities but their association with glycan alterations in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. We employed patient-derived 3D organoids to culture pure live PDAC cells, excluding contamination by fibroblasts and immune cells, to gasp the comprehensive cancer cell surface glycan expression profile using lectin microarray and transcriptomic analyses. Surgical specimens from 24 PDAC pat...
Source: Journal of Oncology - March 26, 2024 Category: Cancer & Oncology Authors: Hiromitsu Nakahashi Tatsuya Oda Osamu Shimomura Yoshimasa Akashi Kazuhiro Takahashi Yoshihiro Miyazaki Tomoaki Furuta Yukihito Kuroda Pakavarin Louphrasitthiphol Bryan J Mathis Hiroaki Tateno Source Type: research