Superior oblique palsy as the initial manifestation of anti-contactin-1 IgG4 autoimmune nodopathy: A case report
We report a case of anti-contactin-1 neuropathy initially manifesting as isolated superior oblique palsy, aiming to broaden the clinical spectrum of the disease. A 68-year-old male with well-controlled diabetes, hypertension, and hyperlipidemia developed acute binocular vertical diplopia, progressing over two months to include distal paresthesia, sensory ataxia, ageusia, and dysarthria. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 22, 2024 Category: Allergy & Immunology Authors: Young Gi Min, Woohee Ju, Jung-Joon Sung Tags: Short Communication Source Type: research
Atractylodin ameliorates lipopolysaccharide-induced depressive-like behaviors in mice through reducing neuroinflammation and neuronal damage
In this study, the lipopolysaccharide (LPS)-induced mouse model was used to explore the antidepressant effects and molecular mechanisms of atractylodin. The results showed that atractylodin increased sugar preference, also reduced immobility time in FST and TST. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 22, 2024 Category: Allergy & Immunology Authors: Feng Liu, Yaping Wang, Dongbo Li, Tao Yang Source Type: research
Antigen-specific immunotherapy via delivery of tolerogenic dendritic cells for multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system resulting from loss of immune tolerance. Many disease-modifying therapies for MS have broad immunosuppressive effects on peripheral immune cells, but this can increase risks of infection and attenuate vaccine-elicited immunity. A more targeted approach is to re-establish immune tolerance in an autoantigen-specific manner. This review discusses methods to achieve this, focusing on tolerogenic dendritic cells. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 19, 2024 Category: Allergy & Immunology Authors: Vivien Li, Michele Binder, Anthony W. Purcell, Trevor J. Kilpatrick Tags: Review Article Source Type: research
V-set and immunoglobulin domain containing 4 inhibits oxidative stress, mitochondrial dysfunction, and inflammation to attenuate Parkinson's disease progression by activating the JAK2/STAT3 pathway
V-set and immunoglobulin domain containing 4 (VSIG4) inhibits neurological dysfunction, microglial M1 polarization, and inflammation to participate in the progression of neurological disorders, but evidence regarding Parkinson's disease (PD) is scarce. The present study intended to investigate the engagement of VSIG4 in PD progression, and the potential mechanism. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 17, 2024 Category: Allergy & Immunology Authors: Pingping Cai, Junmei Wang, Jiangtao Xu, Min Zhang, Xinxin Yin, Shengquan He, Jingcong Zhuang Source Type: research
Corticospinal tract hyperintensity in patients with LGI1-antibody encephalitis and other central nervous system disorders with neuroglial antibodies
The frequency of corticospinal tract (CST) T2/FLAIR hyperintensity in disorders with neuroglial antibodies is unclear. Herein, we retrospectively reviewed brain MRIs of 101 LGI1-antibody encephalitis patients, and observed CST hyperintensity in 30/101(30%). It was mostly bilateral (93%), not associated with upper motor neuron signs/symptoms (7%), and frequently decreased over time (39%). In a systematic review including patients with other neuroglial antibodies, CST hyperintensity was reported in 110 with neuromyelitis optica (94%), myelin oligodendrocyte glycoprotein-associated disease (2%), Ma2-antibody (3%) and GAD65-an...
Source: Journal of Neuroimmunology - April 17, 2024 Category: Allergy & Immunology Authors: Lucia Campetella, Macarena Villagran Garc ía, Antonio Farina, Marie Benaiteau, Raffaele Iorio, Paolo Calabresi, Alberto Vogrig, Salvatore Versace, Nicolás Lundahl Ciano-Petersen, Elodie Bicilli Brotelle, Pierre Branger, Clotilde Verlut, Sophie Langner-L Tags: Short Communication Source Type: research
MiR-24-3p enhances the Treg/Th17 balance to improve cerebral ischemic injury by suppressing acetyl-CoA carboxylase 1 expression
We examined the roles of potential miRNAs in regulating ACC1 expression in Tregs and treating ischemic stroke. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 11, 2024 Category: Allergy & Immunology Authors: Yong Wang, Yan Yang, Lijun Xie, Xiaona An, Lu Zhang Source Type: research
Offspring behavioral outcomes following maternal allergic asthma in the IL-4-deficient mouse
Maternal allergic asthma (MAA) during pregnancy has been associated with increased risk of neurodevelopmental disorders in humans, and rodent studies have demonstrated that inducing a T helper-2-mediated allergic response during pregnancy leads to an offspring behavioral phenotype characterized by decreased social interaction and increased stereotypies. The interleukin (IL)-4 cytokine is hypothesized to mediate the neurobehavioral impact of MAA on offspring. Utilizing IL-4 knockout mice, this study assessed whether MAA without IL-4 signaling would still impart behavioral deficits. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 8, 2024 Category: Allergy & Immunology Authors: Jared J. Schwartzer, Jamie S. Church, Jenna N. Russo, Shanthini Ragoonaden Source Type: research
Altered EBV specific immune control in multiple sclerosis
Since the 1980s it is known that immune responses to the Epstein-Barr virus (EBV) are elevated in multiple sclerosis (MS) patients. Recent seroepidemiologial data have shown that this alteration after primary EBV infection identifies individuals with a more than 30-fold increased risk to develop MS. The mechanisms by which EBV infection might erode tolerance for the central nervous system (CNS) in these individuals, years prior to clinical MS onset, remain unclear. In this review I will discuss altered frequencies of EBV life cycle stages and their tissue distribution, EBV with CNS autoantigen cross-reactive immune respons...
Source: Journal of Neuroimmunology - April 5, 2024 Category: Allergy & Immunology Authors: Christian M ünz Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 4, 2024 Category: Allergy & Immunology Source Type: research
Microglia and amyloid plaque formation in Alzheimer's disease – Evidence, possible mechanisms, and future challenges
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline that severely affects patients and their families. Genetic and environmental risk factors, such as viral infections, synergize to accelerate the aging-associated neurodegeneration. Genetic risk factors for late-onset AD (LOAD), which accounts for most AD cases, are predominantly implicated in microglial and immune cell functions. As such, microglia play a major role in amyloid beta (A β) plaque (the major pathological hallmark of AD) formation. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 4, 2024 Category: Allergy & Immunology Authors: Stefanie Fruhw ürth, Henrik Zetterberg, Søren R. Paludan Source Type: research
Enrichment of liver MAIT cells in a mouse model of Alzheimer's disease
Emerging evidence has supported a role for the immune system and liver in Alzheimer's disease (AD). However, our understanding of how hepatic immune cells are altered in AD is limited. We previously found that brain mucosal-associated invariant T (MAIT) cell numbers are increased in AD. Furthermore, loss of MAIT cells and their antigen-presenting molecule, MR1, reduced amyloid- β accumulation in the brain. MAIT cells are also significantly present in the liver. Therefore, we sought to analyze MAIT and other immune cells in the AD liver. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 21, 2024 Category: Allergy & Immunology Authors: Season K. Wyatt-Johnson, Holly N. Kersey, Randy R. Brutkiewicz Tags: Short Communication Source Type: research
Three-year follow-up of rheumatoid meningitis with matrix metalloprotease-9 levels in the serum and cerebrospinal fluid as indicators of disease activity: A case report
Rheumatoid meningitis (RM) is an extra-articular complication of rheumatoid arthritis (RA). Although reports of RM sine arthritis exist, most patients with this presentation were diagnosed with RA within one year of RM onset. There are no established biomarkers reflecting the disease activity of RM. This case report highlights the elevation of matrix metalloprotease (MMP)-9 levels during the acute phase of RM and decline during remission. Additionally, this is the first case report of RA diagnosed three years after the onset of RM. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 16, 2024 Category: Allergy & Immunology Authors: Keishu Murakami, Katsuichi Miyamoto, Jinsoo Koh, Yoshinori Kajimoto, Hidefumi Ito Tags: Short Communication Source Type: research
Peripheral oedema as an adverse effect of treatment of secondary progressive multiple sclerosis with siponimod: A case series
We report 3 SPMS patients treated with siponimod who developed new or worsening peripheral oedema soon after commencing treatment. In one case, peripheral oedema resulted in immobility. Siponimod-related peripheral oedema deserves wider recognition due to the potential for morbidity and over-investigation. Clinicians should assess for pre-existing oedema and coexisting conditions that may predispose to developing peripheral oedema prior to commencing siponimod. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 13, 2024 Category: Allergy & Immunology Authors: Edward H. Chang, Todd A. Hardy Tags: Short Communication Source Type: research
Peripheral oedema as an adverse effect of treatment of secondary progressive MS with siponimod: A case series
We report 3 SPMS patients treated with siponimod who developed new or worsening peripheral oedema soon after commencing treatment. In one case, peripheral oedema resulted in immobility. Siponimod-related peripheral oedema deserves wider recognition due to the potential for morbidity and over-investigation. Clinicians should assess for pre-existing oedema and coexisting conditions that may predispose to developing peripheral oedema prior to commencing siponimod. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 13, 2024 Category: Allergy & Immunology Authors: Edward H. Chang, Todd A. Hardy Tags: Short Communication Source Type: research
Mycobacterial spindle cell pseudotumor of the spinal cord: Case report and literature review
We report the first description of spinal cord mycobacterial spindle cell pseudotumor. A patient with newly diagnosed advanced HIV presented with recent-onset bilateral leg weakness and was found to have a hypermetabolic spinal cord mass on structural and molecular imaging. Biopsy and cultures from blood and cerebrospinal fluid confirmed spindle cell pseudotumor due to Mycobacterium avium-intracellulare. Despite control of HIV and initial reduction in pseudotumor volume on antiretrovirals and antimycobacterials (azithromycin, ethambutol, rifampin/rifabutin), he ultimately experienced progressive leg weakness due to pseudot...
Source: Journal of Neuroimmunology - March 11, 2024 Category: Allergy & Immunology Authors: Michael Tran Duong, Adam Ungemach, Faizan Malik, Melissa T. Duong, Noah Wasserman, Kumarasen Cooper, Austin R. Pantel, Jessica O'Neil, Zsofia Szep Source Type: research
