Azilsartan improves doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, proinflammatory pathway, and apoptosis
This study investigated whether azilsartan could mitigate doxorubicin-induced cardiotoxicity. We divided 28 male rats into four groups: the control group receiving a standard diet and water, the vehicle group given DMSO orally for two weeks, doxorubicin group receiving 2.5 mg/kg of doxorubicin three times a week for two weeks, and azilsartan group treated with 5 mg/kg/day of azilsartan orally and doxorubicin. Doxorubicin-induced cardiotoxicity was evidenced by a significant increase in TNF-α, IL-1β, MDA, and caspase-3 levels and significantly decreased TAC and Bcl-2 levels in the cardiac tissues of treated rats compared ...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mohammed Al-Chlaihawi Ali Janabi Source Type: research
Add-on treatment with Cerebrolysin improves clinical symptoms in patients with ALS: results from a prospective, single-center, placebo-controlled, randomized, double-blind, phase II study
J Med Life. 2023 Dec;16(12):1750-1755. doi: 10.25122/jml-2023-0459.ABSTRACTAmyotrophic lateral sclerosis (ALS) is a devastating and progressive neurodegenerative disease with limited treatment options available. Cerebrolysin is a drug candidate for the treatment of ALS because of its neuroprotective and neuroregenerative effects. We initiated a pilot clinical study of a combination of Cerebrolysin and riluzole to assess the therapeutic benefit of Cerebrolysin as an add-on treatment on clinical signs and symptoms in outpatients with ALS. Twenty patients with a clinically definitive diagnosis of ALS were enrolled and randoml...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Alfredo Jos é Firstenfeld Jorge Listorti Nasser Jalaff Claudia Patricia Loaiza Orozco Francisco Navarrete Gosdenovich Timo Schurr Source Type: research
Unveiling the Future of Neurorehabilitation: Insights from the 18 < sup > th < /sup > Congress from the Society for the Study of Neuroprotection and Neuroplasticity (SSNN) in Conjunction with the WFNR-EFNR Central Asia Regional Meeting
J Med Life. 2023 Dec;16(12):1717-1722. doi: 10.25122/jml-2023-1033.NO ABSTRACTPMID:38585518 | PMC:PMC10994616 | DOI:10.25122/jml-2023-1033 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Stefana-Andrada Dobran Alexandra Gherman Dafin Mure şanu Source Type: research
Insights into Swallowing Disorders: the Dysphagia Course Series
J Med Life. 2023 Dec;16(12):1714-1716. doi: 10.25122/jml-2023-1032.NO ABSTRACTPMID:38585519 | PMC:PMC10994618 | DOI:10.25122/jml-2023-1032 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Stefana-Andrada Dobran Alexandra Gherman Dafin Muresanu Source Type: research
Disability inclusion assessment in primary healthcare centers in Eastern Saudi Arabia: a way forward
This study aimed to identify challenges related to accessibility in infrastructure, services, equipment, processes, and training in primary healthcare settings. The study was conducted in Dammam, AlKhobar, and AlQatif in August 2022, using an analytical, quantitative cross-sectional approach. A total of 56 primary healthcare centers (PHCs) were assessed across multiple domains. Government-built PHCs had an average accessibility rate of 83.2%, while those located in rented buildings scored an average of 67.1%. One domain that scored highly among both building types was the clinic rooms domain, with an average score of 90%. ...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Lamees Yousef Norah Almatroodi Dannah AlAngari Rahaf AlShehri Shahad Alshammari Source Type: research
Immediate and localized effect of Kinesio tape on the hand grip strength of sedentary female adults
J Med Life. 2023 Dec;16(12):1776-1782. doi: 10.25122/jml-2023-0333.ABSTRACTThe current study aimed to assess the immediate and localized effect of Kinesio Taping (KT) on hand grip strength. A cross-sectional study was conducted on 60 sedentary female university students (aged 18-23) divided into two groups of 30 subjects each. The experimental group received KT with 50% tension of the tape on the forearm and 100% tension on the hand, and the control group received a placebo application of KT (KT without tension on the hand and forearm). Hand grip strength was assessed before and immediately after applying KT using a hand-h...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mariam Ameer Ammar Al Abbad Arun Vijay Subbarayalu Areej Alsharari Rawan AlRuwaili Saylah AlFuhigi Nadia Hmdan Amjad Alshammari Ghala Alhuthayl Source Type: research
Analysis of road traffic injuries presented to the emergency department in the Eastern Province of Saudi Arabia: a hospital-based study
J Med Life. 2023 Dec;16(12):1825-1838. doi: 10.25122/jml-2023-0316.ABSTRACTThe increasing incidence of road traffic injuries (RTIs) has contributed to the disability and death of millions of people on both a national and global level. This retrospective study was conducted at King Fahad University Hospital (KFUH), Khobar, Saudi Arabia, and included all patients who presented at the emergency department due to road traffic accidents (RTAs) between January 1st, 2022, and December 31st, 2022. Patient data was retrieved from the health information system at KFUH. Descriptive and inferential analysis were performed with several...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Amaar Amir Baraa Amir Asim Alghannam Tareq Abdeen Abdullah Al-Howaish Rayan Alsheniber Abdullah Al-Mulhim Dunya Alfaraj Source Type: research
Dentists' attitudes and prescription practices for analgesics and antibiotics in Kirkuk Governorate, Iraq
This study aimed to assess the prescribing patterns of analgesics and antibiotics by dentists in Kirkuk City, Iraq, focusing on their attitudes, knowledge levels, and practices regarding these medications. A cross-sectional survey was conducted among 280 dentists in Kirkuk City. The dentists were contacted via their work email addresses, and they responded to a survey. Descriptive statistics, including frequency analysis, were employed to evaluate the appropriateness of analgesic and antibiotic prescriptions for different dental conditions. The first-choice analgesic for 44.6% of dentists was mefenamic acid, followed by pa...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Zainab Azal Mahdi Jihan Abdulhussein Ibrahim Source Type: research
Comparison of immediate versus post-stenting ureteroscopy for ureteral stones treatment
J Med Life. 2023 Dec;16(12):1745-1749. doi: 10.25122/jml-2023-0199.ABSTRACTUreteroscopy is a highly effective treatment for ureteral stones, characterized by a high stone-free rate and a low need for re-treatment. Ureteral stent placement can improve the insertion of the ureteral access sheath and ureteroscope but may be associated with higher morbidity prior to and after ureteroscopy. The study aimed to compare immediate versus post-stenting ureteroscopy for ureteral stone treatment in terms of operative time, intra- and post-operative complications, length of hospital stay, and stone-free rate. This prospective study inv...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Ali Hadi Sabhan Source Type: research
Improving caregiver preparedness in the care transition of stroke patients: a scoping review
J Med Life. 2023 Dec;16(12):1723-1731. doi: 10.25122/jml-2023-0142.ABSTRACTStroke is a life-threatening condition caused by the rupture of a brain blood vessel, potentially causing brain damage within minutes, severe disability, and even death. After initial hospitalization and rehabilitation, most stroke survivors return home, relying on their family members as caregivers for activities of daily living and treatments. This scoping review aimed to evaluate caregivers' readiness for transitioning stroke patient care to a home environment. We conducted a comprehensive search on Scopus, PubMed, ScienceDirect, and Google Schol...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mukhripah Damaiyanti Haeril Amir Desy Dwi Cahyani Nurun Salaman Alhidayat Novi Afrianti Cut Rahmiati Hera Hastuti Apriani Susmita Sari Rahmat Hidayat Source Type: research
Cardamonin mitigates kidney injury by modulating inflammation, oxidative stress, and apoptotic signaling in rats subjected to renal ischemia and reperfusion
J Med Life. 2023 Dec;16(12):1852-1856. doi: 10.25122/jml-2023-0093.ABSTRACTRenal ischemia-reperfusion injury (IRI) is a critical health concern that aggravates the pathophysiology of acute kidney injury (AKI), leading to high mortality rates in intensive care units. Cardamonin is a natural compound with anti-inflammatory and antioxidant properties. The current study aimed to evaluate the renoprotective impact of cardamonin against AKI induced by renal IRI. Male rats (n=5 per group) were divided into four groups: the sham group underwent anesthesia and abdominal incision only; the control group experienced bilateral renal a...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Haidar Hameed Ali Al-Sultany Murooj Altimimi Heider Qassam Najah Rayish Hadi Source Type: research
Assessment of dietary magnesium intake in the Eastern Province of Saudi Arabia
J Med Life. 2023 Dec;16(12):1789-1795. doi: 10.25122/jml-2023-0279.ABSTRACTMagnesium is an essential element and the most abundant intracellular cation after potassium. This cross-sectional study assessed the average dietary magnesium intake among residents of the Eastern Province of Saudi Arabia. Data was collected using a self-reported validated electronic questionnaire between April 2022 and July 2023. The first part of the survey included demographic data, and the second section comprised 33 items, including a semi-quantitative tool specifically designed to evaluate magnesium intake over the last three months. We inclu...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Ali Mohsen Abualrahi Fatimah Habib Alhanabi Rahaf Saeed Alalloush Zainab Hashim Alsalman Waleed Ibrahim Albaker Mona Hmoud AlSheikh Fatimah Abdulwahed Almuzain Mohammed Taha Al-Hariri Source Type: research
In silico study, synthesis, and antineoplastic evaluation of thiazole-based sulfonamide derivatives and their silver complexes with expected carbonic anhydrase inhibitory activity
This study aimed to design, synthesize, and evaluate the cytotoxic activity of novel thiazole-sulfanilamide derivatives, specifically compounds M3, M4, and M5, through molecular docking and biological assays. The synthesis utilized essential chemical compounds, including sulfanilamide, chloro-acetyl chloride, thiourea, derivatives of benzaldehyde, and silver nitrate. The docking study was carried out using Molecular Operating Environment (MOE) software, and cytotoxic activity was predicted by MTT assay. The synthesized compounds demonstrated a reduction in the viability of cancer cells. Compound M5 had an IC50 of 18.53 µg...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Esraa Mahdi Naji Noor Hatef Naser Sahar Aqeel Hussein Source Type: research
Clinical and radiological outcomes of open reduction alone versus open reduction with pelvic osteotomy for developmental dysplasia of the hip in children over 1.5 years of age
J Med Life. 2023 Dec;16(12):1839-1843. doi: 10.25122/jml-2023-0212.ABSTRACTDevelopmental dysplasia of the hip (DDH) is commonly addressed through surgical intervention, usually performed in a specialized tertiary care facility. The purpose of this study was to evaluate the surgical outcomes in patients with DDH who had open reduction alone or in conjunction with bone surgery at our facility. We retrospectively reviewed the medical records of patients with DDH, categorizing them into two groups: Group OR underwent open reduction (OR) alone, and group ORBO underwent OR in conjunction with femoral or pelvic osteotomies. The m...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Ali Saleh Aljanabi Wissam Saleh Hakim Source Type: research
Functional capacity in smoking patients after coronary artery bypass grafting surgery: a quasi-experimental study
J Med Life. 2023 Dec;16(12):1760-1768. doi: 10.25122/jml-2023-0282.ABSTRACTCoronary artery bypass grafting surgery (CABG) is an important approach to treating coronary heart disease. However, patients undergoing open heart surgery are at risk of postoperative complications. Cigarette smoking is one of the preoperative risk factors that may increase postoperative complications. Studies show that early mobilization intervention may reduce these complications and improve functional capacity, but the impact of smoking on early outcomes after CABG has been controversial for the past two decades. This quasi-experimental study ex...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mohammed Essa Alsubaiei Wadha Althukair Hind Almutairi Source Type: research
