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Total 13932141 results found since Jan 2013.

Performance Measurement Outcomes: An Analysis of Health Care–Associated Infections in New York State
Conclusion: Identifying hospitals that are consistently performing poorly and hospitals consistently performing well will allow administrators and clinicians to focus their efforts including budgetary to where improvements are needed. Patient care and the reduction of HAIs are a priority for health care institutions. While the results are similar to those reported by NYS, this approach can be used more comprehensively and can be interpreted more easily by administrators and practitioners. Health care administrators and clinicians may find the information useful to address infection rates. Hospitals consistently perform...
Source: Quality Management in Healthcare - September 26, 2021 Category: Health Management Tags: Original Articles Source Type: research

Systematic Undercoding of Diagnostic Procedures in National Inpatient Sample (NIS): A Threat to Validity Due to Surveillance Bias
Conclusions: Our findings question the validity of using NIS and other administrative databases for health services and outcomes research that rely on certain diagnostic procedures. Unfortunately, the NIS does not provide granular data that can control for differences in diagnostic procedure use, which can lead to surveillance bias. Researchers and policy makers must understand and acknowledge the limitations inherent in these databases, when used for pay-for-performance initiatives and hospital benchmarking.
Source: Quality Management in Healthcare - September 26, 2021 Category: Health Management Tags: Original Articles Source Type: research

Improvement in the Prediction of Coronary Heart Disease Risk by Using Artificial Neural Networks
Conclusions: The findings suggest that the ANN model is a promising approach for predicting CHD risk and a good screening procedure to identify high-risk subjects.
Source: Quality Management in Healthcare - September 26, 2021 Category: Health Management Tags: Methods and Instruments Source Type: research

Supporting Discovery and Inquiry: A Canadian Hospital's Approach to Building Research and Innovation Capacity in Point-of-Care Health Professionals
Conclusions: Engaging those who provide care directly to patients and families in research and innovation is critical to ensuring high-quality health outcomes and patient experience. Creative and innovative funding models, collaborative leadership, and partnerships with key stakeholders to support research and innovation are needed to ensure sustainability.
Source: Quality Management in Healthcare - September 26, 2021 Category: Health Management Tags: Quality Management Applications Source Type: research

The diagnostic contribution of intracranial vessel wall imaging in the differentiation of primary angiitis of the central nervous system from other intracranial vasculopathies
ConclusionVWI seems a new and useful imaging method in the differential diagnosis of PACNS and might be a useful adjunct for post-treatment follow-up.
Source: Neuroradiology - September 25, 2021 Category: Radiology Source Type: research

Quantitative dynamic contrast-enhanced MRI and readout segmentation of long variable echo-trains diffusion-weighted imaging in differentiating parotid gland tumors
ConclusionThe combination of quantitative DCE-MRI and RESOLVE-DWI is beneficial for characterizing four histological types of PTs.
Source: Neuroradiology - September 25, 2021 Category: Radiology Source Type: research

Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology
AbstractPerivascular spaces (PVS) of the brain, often called Virchow-Robin spaces, comprise fluid, cells and connective tissue, and are externally limited by astrocytic endfeet. PVS are involved in clearing brain waste and belong to the “glymphatic” system and/or the “intramural periarterial drainage” pathway through the basement membranes of the arteries. Related brain waste clearance systems include the blood–brain barrier, scavenger cells, cerebrospinal fluid, perineural lymphatic drainage pathways and the newly charac terised meningeal lymphatic vessels. Any functional abnormality of PVS or related clearance ...
Source: Neuroradiology - September 25, 2021 Category: Radiology Source Type: research

A 10-year longitudinal study of deep white matter lesions on magnetic resonance imaging
ConclusionThe results of this 10-year longitudinal study imply a positive correlation between long-standing hypertension and the progression of DWMLs.
Source: Neuroradiology - September 25, 2021 Category: Radiology Source Type: research

Impaired intrinsic functional connectivity among medial temporal lobe and sub-regions related to memory deficits in intracranial dural arteriovenous fistula
ConclusionThis pilot study gives insights into significant intrinsic functional connectivity changes in the memory regions of the dAVF brain. The results may have clinical implications in the choice of interventional management of dAVF and can impact clinical decision making for realizable prevention of progressive memory impairment and irreversible brain damage in such patients.
Source: Neuroradiology - September 25, 2021 Category: Radiology Source Type: research

Characterization of Morphologic and Cytochemical Staining Properties of Exogenous Materials Mimicking Fungal Organisms Encountered in Skin Biopsies
Conclusion: We present a comprehensive characterization of the morphologic and cytochemical staining properties of multiple exogenous materials that may contaminate a skin biopsy. This characterization will aid the pathologist by providing a mechanism to identify potential contaminants in skin biopsies.
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: CME Article Source Type: research

Immunoglobulin and Complement Immunohistochemistry on Paraffin Sections in Autoimmune Bullous Diseases: A Systematic Review and Meta-analysis
Abstract: Immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded tissue has been proposed as a potential tool in the diagnosis of autoimmune bullous diseases (AIBDs) in lieu of standard direct immunofluorescence (DIF) microscopy. To comprehensively determine the diagnostic accuracy of immunoglobulin and complement IHC for diagnosis of AIBDs, we conducted a systematic review and multivariate Bayesian model-based meta-analysis of the literature. Quality and heterogeneity assessment of studies was performed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) checklist and the I2 index, respecti...
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Review Article Source Type: research

Image Morphometric Analysis of B Cells and Plasma Cells in Erythema Nodosum Leprosum With Clinicopathological Correlation
Abstract: Erythema nodosum leprosum (ENL) occurs as an immunological complication of multibacillary leprosy (MBL). The pathogenesis of ENL is long considered to be a T-cell–mediated process. The role of B cells and plasma cells in ENL is not well described in the literature. Therefore, we investigated the B-cell and plasma cell infiltrates in the skin biopsies of biopsy-proven cases of ENL by immunohistochemistry and image morphometry and compared the result with paucibacillary leprosy and MBL. Moreover, we sought a correlation of the B-cell and plasma cell infiltrates with different clinical, hematological, histopat...
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Original Study Source Type: research

Histological and Immunohistochemical Changes of Congenital Melanocytic Nevi With Age
Abstract: Clinical but not histological changes of congenital melanocytic nevi (CMN) with age are well characterized. Our objective was to analyze histological changes of CMN with age and discuss possible clinical implications of our findings. We investigated serial excisions of 21 patients with CMN and compared histological and immunohistochemical features over time. The median number of serial excisions was 6 [interquartile range (IQR) 5–7], the median age at the first excision was 12 months (IQR 5–98), and the median time between the first and last analyzed excision was 53 months (IQR 45–64). The projected adu...
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Original Study Source Type: research

Evolution of Dupilumab-Associated Cutaneous Atypical Lymphoid Infiltrates
Conclusion: These cases highlight the transformation of lymphoid infiltrates after dupilumab treatment for AD and emphasize the importance of clinical and histopathologic evaluation before and during treatment with dupilumab for treatment-refractory presumed AD.
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Original Study Source Type: research

Characteristic Clinicopathological Features of Secondary Extramammary Paget Disease With Underlying Anorectal Adenocarcinoma: Evenly Circumferential Perianal Distribution, Fibroepithelioma of Pinkus-like Changes, and Subepidermal Mucin Deposits Without Invasive Tumor Cells
This study aimed to identify the clinical and histopathological characteristics of secondary extramammary Paget disease (EMPD) with underlying anorectal adenocarcinoma so as to differentiate it from primary cutaneous EMPD. Seventeen and 8 cases of primary and secondary EMPD with anorectal adenocarcinoma, respectively, were retrieved from the pathology archive and the clinical and histopathological features reviewed. The tumor samples from 21 cases were totally resected specimens, whereas 3 and 1 of secondary and primary cases were punch biopsied, respectively. All 8 (100%) cases of secondary EMPD presented evenly distribut...
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Original Study Source Type: research

Diagnostic Utility of C4d by Direct Immunofluorescence in Bullous Pemphigoid
In conclusion, the current study shows that C4d is a more sensitive but not a 100% specific marker of BP. We conclude that C4d by DIF could be an interesting diagnostic adjunct for BP, particularly in IgG−/C3c− double negative cases.
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Brief Report Source Type: research

A Case Report of Small Lymphocytic Lymphoma Mimicking Primary Cutaneous Marginal Zone Lymphoma With Plasmacytic Differentiation
No abstract available
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Brief Report Source Type: research

Acral Calcified Vascular Leiomyoma: Report of 3 Cases and Literature Review
We report 3 examples of this unusual condition on the feet of 2 male and one female subjects (aged, 68, 69, and 80 years) and make a review of the 31 cases available in the literature. Two of our cases are associated with highly uncommon features, such as transepidermal calcium elimination and concomitant calcaneal spur.
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Combining Reflective Confocal Microscopy and Dynamic Optical Coherence Tomography to Diagnose Melanoacanthoma: Case Report
We present a case of a 38-year-old man with Fitzpatrick skin type IV with an asymmetric black papule showing clinical and dermoscopic features of both melanoma and SK. Reflectance confocal microscopy (RCM) and dynamic optical coherence tomography (d-OCT) were used for further evaluation. RCM revealed acanthotic epidermis with a mixed honeycomb and cobblestone pattern, polycyclic bulbous rete ridges, and bright plump cells within entrapped, edged, dermal papillae, compatible with pigmented SK. Also noted were a population of fairly uniform bright dendritic cells scattered quite evenly at all levels of the epidermis and the ...
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Fortuitous Eradication of an Aggressive Basal Cell Carcinoma Via Foreign Body Reaction to a Polyurethane Vacuum-Assisted Closure Sponge
Abstract: The foreign body reaction (FBR) is a well-documented immune reaction. Much of the literature on FBRs has focused on minimizing this immune response to mitigate the impact on medical implants. Here, we present a case that illustrates a serendipitous oncologic outcome from an FBR. A 54-year-old man presented with an aggressive basal cell carcinoma (BCC). At the first resection, he had broadly positive surgical margins. The surgical wound was temporized with a polyurethane wound vacuum assisted closure (VAC) device. He was lost to follow-up having retained a VAC sponge for a total of 12 weeks. A wide re-resectio...
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Papillary Dermal Elastolysis Secondary to Combination Nivolumab and Cabiralizumab Therapy: Histiocytes and Dermal Mucin as Clues to the Diagnosis
We report a third patient with distinctive, generalized atrophic macules that developed after a morbilliform eruption during a clinical trial for treatment of metastatic pancreatic adenocarcinoma. Histopathological findings demonstrated diminished elastic fibers in the papillary dermis, associated with a histiocyte-rich infiltrate and increased dermal mucin, features that should clue the dermatopathologist to this condition.
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Indolent, Painful, and Dystrophic Nail Unit Tumor in an Elderly Man: Answer
No abstract available
Source: The American Journal of Dermatopathology - September 25, 2021 Category: Pathology Tags: Clinical Pathologic Challenge Answer Source Type: research

Appropriate coding and billing in occupational health
This article explores commonly billed occupational injuries and illnesses.
Source: The Nurse Practitioner - September 25, 2021 Category: Nursing Tags: Feature: CODING & BILLING: NCPD Connection Source Type: research

Women of Influence: Fabrisia Ambrosio, University of Pittsburgh and UPMC International
Fabrisia Ambrosio is a winner of a 2021 Women of Influence award.
Source: bizjournals.com Health Care:Biotechnology headlines - September 25, 2021 Category: Biotechnology Authors: Richard Cerilli Source Type: news

Queing up against dragon: Four democracies vs China unfolds amid global crises of Covid and climate chang
US News: WASHINGTON: The United States and India, bilaterally and quadrilaterally with Japan and Australia, have committed to massively...
Source: Reuters: Health - September 25, 2021 Category: Consumer Health News Source Type: news

Safeguarding the rights and welfare of the health-care workers amid the pandemic: a social protection approach
This study applies both doctrinal and non-doctrinal research methods with the legal and authoritative approaches by integrating the three elements of social protections, which are working conditions, insurance protection and social assistance for the protection of HCWs. A pragmatic approach to the social protection system by integrating these elements can safeguard the rights and welfare of the frontline HCWs amid the pandemic. This approach should be made effective for the sustainability of the HCW and health industry in Malaysia. This paper highlights the significance of initiating and empowering ad hoc approaches ...
Source: International Journal of Human Rights in Healthcare - September 25, 2021 Category: International Medicine & Public Health Authors: Harlida Abdul Wahab Asmar Abdul Rahim Nor Anita Abdullah Source Type: research

Reconsidering the criteria of the healthy house's interior design during crises: COVID-19 pandemic as an example
This study methodology adopted both inductive approach and a Study Application Model to define the Healthy House Criteria and fulfill the study objectives. Under the inductive approach a holistic literature review was undertaken while the Study Application Model implied defining the conception of the overall Criteria of the Healthy House's interior design under the COVID-19. The finding of the study showed some areas needed to improve current healthy house's criteria in terms of its interior design that may be used to cope with potential crises such as the COVID-19. Based on the revealed findings, the researcher suggest...
Source: International Journal of Human Rights in Healthcare - September 25, 2021 Category: International Medicine & Public Health Authors: Anas Atef Shamaileh Source Type: research

How standup comedy helped me conquer anxiety, depression – and fear of public speaking
Finding a humorous angle to some of my darkest episodes – and sharing them with strangers – was strangely cathartic“Have you gone mad?” asked one friend. “You’re so brave. I could never do that. Wouldn’t meditation be wiser?” said another. For someone with a long history of depression and anxiety, plus a morbid fear of public speaking, taking up standup comedy might seem like a masochistic decision. Yet to me it makes perfect sense. Excruciating fear of failure is at the heart of most people’s aversion to attempting to make a room full of strangers laugh. But controlling that fear, and not succumbing to i...
Source: Guardian Unlimited Science - September 25, 2021 Category: Science Authors: Nick McGrath Tags: Comedy Depression Anxiety Society Culture Life and style Psychology Science Health & wellbeing Source Type: news

Women of Influence: Fabrisia Ambrosio, University of Pittsburgh and UPMC International
Fabrisia Ambrosio is a winner of a 2021 Women of Influence award.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - September 25, 2021 Category: Pharmaceuticals Authors: Richard Cerilli Source Type: news

90 Motivational Saturday Quotes for a Happy Weekend and Life
You wake up without the alarm clock going off. Without hurrying through your morning routine. It’s Saturday and your weekend has just begun. To help you to make the best of this day and your weekend I want to share 90 motivational Saturday quotes that will inspire you and give you some timeless tips from the past few thousands of years on living a happier and more fulfilling life. So let’s get going with that to give your Saturday a boost of energy, positivity and to get you started on the right foot. And if you want more tips to help you make this a happy weekend have a look at this post with inner peace quotes or th...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - September 25, 2021 Category: Consumer Health News Authors: Henrik Edberg Tags: Personal Development Source Type: blogs

Pandemic creates a cycle of decline of physical activity and mental health, study suggests
Calling it a broad-scale problem, researchers say changes are needed to make activity — and open spaces — more accessible to all.
Source: Washington Post: To Your Health - September 25, 2021 Category: Consumer Health News Authors: Erin Blakemore Source Type: news

A new pancreatic adenocarcinoma-derived organoid model of acquired chemoresistance to FOLFIRINOX: first insight of the underlying mechanisms
CONCLUSIONS: We reproductively obtained resistant organoids FoxR that significantly showed less sensitivity to FOLFORINOX treatment than the PaTa-1818x naive organoids from which they were derived. Our resistant model is representative of the sequential steps of chemoresistance observed in patients in terms of growth arrest (proliferation blockade), residual disease (cell quiescence/dormancy) and relapse.SIGNIFICANCE: To our knowledge, this is the first genuine in vitro model of resistance to the three drugs in combined therapy. This new PDO model will be a great asset for the discovery of acquired chemoresistance mechanis...
Source: Biology of the Cell - September 25, 2021 Category: Cytology Authors: Elsa Hadj Bachir Charles Poiraud Sonia Paget Nicolas Stoup Soumaya El Moghrabi Belinda Duch êne Nathalie Jouy Antonino Bongiovanni Meryem Tardivel Louis-Bastien Weiswald Marie Vandepeutte C ésar Beugniez Fabienne Escande Emmanuelle Leteurtre OrgaRES con Source Type: research

Examining the cooperativity mode of antibody and CD8 < sup > + < /sup > T cell immune responses for vaccinology
Trends Immunol. 2021 Sep 4:S1471-4906(21)00155-1. doi: 10.1016/j.it.2021.08.003. Online ahead of print.ABSTRACTA fundamental unsolved issue in vaccine design is how neutralizing antibodies and cytotoxic CD8+ T cells cooperate numerically in controlling virus infections. We hypothesize on a viewpoint for the multiplicative cooperativity between neutralizing antibodies and CD8+ T cells and propose how this might be exploited for improving vaccine-induced protective immunity.PMID:34561159 | DOI:10.1016/j.it.2021.08.003
Source: Trends in Immunology - September 25, 2021 Category: Allergy & Immunology Authors: Gennady Bocharov Dmitry Grebennikov Jordi Argilaguet Andreas Meyerhans Source Type: research

Estimating salivary carriage of severe acute respiratory syndrome coronavirus 2 in nonsymptomatic people and efficacy of mouthrinse in reducing viral load: A randomized controlled trial
CONCLUSIONS: Nonsymptomatic people can pose a risk of transmitting the virus, and mouthrinses are simple and efficacious means of reducing this risk, especially when the load is less than 104 copies per milliliter.PRACTICAL IMPLICATIONS: At a time when resources are stretched, the findings of this study contribute to evidence-based selection of personal protection equipment and simple infection-control practices to reduce contagion at source. This clinical trial was registered at ClinicalTrials.gov. The registration number is NCT04603794.PMID:34561086 | DOI:10.1016/j.adaj.2021.05.021
Source: Journal of the American Dental Association - September 25, 2021 Category: Dentistry Authors: PremPrashant Chaudhary Arsen Melkonyan Archana Meethil Shweta Saraswat David L Hall James Cottle Mark Wenzel Nadine Ayouty Spenser Bense Fabiola Casanova Matthew Chaney Hannah Chase Rebecca Hermel Matthew McClement Claire Sesson Bryce Woolsey Purnima Kuma Source Type: research

Synthesis of 3'- O-alkyl homologues and a biotin probe of isorhamnetin and evaluation of cytotoxic efficacy on cancer cells
Chem Biodivers. 2021 Sep 24. doi: 10.1002/cbdv.202100301. Online ahead of print.ABSTRACTIsorhamnetin is a natural flavonoid which shows a variety of biological activities such as antioxidant, anti-inflammation and antitumor. In order to identify the cellular binding protein of isorhamnetin as potential anti-cancer target, we first synthesized 3'- O -substituted quercetin as isorhamnetin analogues and evaluated the growth inhibitory activity of these derivatives on breast, colon and prostate cancer cell lines. The preliminary results showed that the 3'- O modification did not affect the cytotoxic activity of the scaffold. A...
Source: Chemistry and Biodiversity - September 25, 2021 Category: Biochemistry Authors: Mingyan Zhu Zhuojin Yang Yi Zheng Nafisa Tursumamat Source Type: research

Peer-Led, Remote Intervention to Improve Mental Health Outcomes Using a Holistic, Spirituality-Based Approach: Results from a Pilot Study
Community Ment Health J. 2021 Sep 24. doi: 10.1007/s10597-021-00893-8. Online ahead of print.ABSTRACTIn the United States, Black communities face a complex mental health burden, with growing attention on addressing these disparities through the lens of holistic wellbeing. Given the dearth of research on faith-based interventions focused on mental health through the lens of holistic wellbeing, this study evaluates the impact of a spirituality-based, peer-led one-group pre-test post-test pilot intervention in a sample of Black individuals in the Bronx, New York City. The eight-session creating healthy culture curriculum, foc...
Source: Community Mental Health Journal - September 25, 2021 Category: Psychiatry Authors: Shahmir H Ali Farhan M Mohsin Addie Banks Philip Lynn Sahnah Lim Source Type: research

Repair pathways for radiation DNA damage under normoxic and hypoxic conditions: Assessment with a panel of repair-deficient human TK6 cells
J Radiat Res. 2021 Sep 25:rrab084. doi: 10.1093/jrr/rrab084. Online ahead of print.ABSTRACTVarious types of DNA lesions are produced when cells are exposed to ionizing radiation (IR). The type and yield of IR-induced DNA damage is influenced by the oxygen concentration. Thus, different DNA repair mechanisms may be involved in the response of normoxic and hypoxic cells to irradiation with IR. However, differences between the repair mechanisms of IR-induced DNA damage under normoxic versus hypoxic conditions have not been clarified. Elucidating the relative contribution of individual repair factors to cell survival would giv...
Source: Cell Research - September 25, 2021 Category: Cytology Authors: Masataka Tsuda Naoto Shimizu Hinako Tomikawa Ryosuke Morozumi Hiroshi Ide Source Type: research

Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function
Cell Res. 2021 Sep 24. doi: 10.1038/s41422-021-00565-y. Online ahead of print.ABSTRACTThe AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis. Although much has been learned on how low energy status and glucose starvation activate AMPK, how AMPK activity is properly controlled in vivo is still poorly understood. Here we report that UHRF1, an epigenetic regulator highly expressed in proliferating and cancer cells, interacts with AMPK and serves to suppress AMPK activity under both basal and stressed conditions. As a nuclear protein, UHRF1 promotes AMPK nuclear retention and strongly suppresses n...
Source: Cell Research - September 25, 2021 Category: Cytology Authors: Xiang Xu Guangjin Ding Caizhi Liu Yuhan Ding Xiaoxin Chen Xiaoli Huang Chen-Song Zhang Shanxin Lu Yunpeng Zhang Yuanyong Huang Zhaosu Chen Wei Wei Lujian Liao Shu-Hai Lin Jingya Li Wei Liu Jiwen Li Sheng-Cai Lin Xinran Ma Jiemin Wong Source Type: research

A prospective observational study of persistent opioid use after complex foot and ankle surgery
CONCLUSION: The probability of using opioid analgesia six months after complex foot and ankle surgery was significantly higher in patients who used opioids preoperatively. Regular preoperative opioid use was associated with a greater risk of PPOU compared with occasional or "as required" opioid use prior to surgery.PMID:34561837 | DOI:10.1007/s12630-021-02104-0
Source: Canadian Journal of Anaesthesia - September 25, 2021 Category: Anesthesiology Authors: Michelle Verrier Shuang Niu Kimberly Kroetch Karen Buro Chris Douglas James Green Mary E Pedersen Derek Dillane Source Type: research

Intravenous immunoglobulin and the current risk of moderate and severe anaphylactic events, a cohort study
Clin Exp Immunol. 2021 Sep 25. doi: 10.1111/cei.13665. Online ahead of print.ABSTRACTThis large cohort study from the US Premier Healthcare Database evaluated the risk and predictors of anaphylaxis in association with intravenous immunoglobulin (IVIg) therapy in the inpatient and outpatient setting. Data were collected retrospectively (01/2009-12/2018) from 24,919 patients administered IgPro10 IVIg, median age 54 years. Immunoglobulins of interest were IgPro10 and other IVIg given before or after IgPro10. Moderate and severe anaphylaxis was identified from same-day parenteral epinephrine and IVIg use and reviews of patient...
Source: Clinical and Developmental Immunology - September 25, 2021 Category: Allergy & Immunology Authors: Carlos Martinez Christopher Wallenhorst Sheryl van Nunen Source Type: research

Neutrophil-mediated mechanisms of damage and in vitro protective effect of colchicine in non-vascular Beh çet's syndrome
Clin Exp Immunol. 2021 Sep 25. doi: 10.1111/cei.13664. Online ahead of print.ABSTRACTBehçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations. Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive oxygen species (ROS) production and neutrophil extracellular traps (NETs) release. Here, we investigated neutrophil-mediated mechanisms of damage in non-vascular BS manifestations and explored the in vitro effects of colchicine in counteracting these mechanisms. NETs and intracellular ROS production was assessed in blood samples from 80 BS patients (46 with active n...
Source: Clinical and Developmental Immunology - September 25, 2021 Category: Allergy & Immunology Authors: Alessandra Bettiol Matteo Becatti Elena Silvestri Flavia Rita Argento Eleonora Fini Amanda Mannucci Silvia Galora Irene Mattioli Maria Letizia Urban Danilo Malandrino Adalgisa Palermo Niccol ò Taddei Giacomo Emmi Domenico Prisco Claudia Fiorillo Source Type: research

The impact of interpersonal relationships on rural doctors' clinical courage
CONCLUSION: As a collective, rural doctors can learn, use and strengthen clinical courage and support its development in new members of the discipline. Relationships with rural communities, rural patients and urban colleagues can support the clinical courage of rural doctors. When detractors challenge the value of clinical courage, it requires individual rural doctors and their community of practice to champion rural doctors' way of working.PMID:34560821 | DOI:10.22605/RRH6668
Source: Rural and Remote Health - September 25, 2021 Category: Rural Health Authors: Lucie Walters Ian Couper Ruth A Stewart David G Campbell Jill Konkin Source Type: research

Pediatric cataract: Epidemiological, etiological, clinical and therapeutic features at the Yaounde gyneco-obstetrics and pediatric hospital
CONCLUSION: Pediatric cataracts are relatively rare. Identification of risk factors may help decrease their incidence.PMID:34561092 | DOI:10.1016/j.jfo.2021.08.001
Source: Journal Francais d Ophtalmologie - September 25, 2021 Category: Opthalmology Authors: V Takou Tsapmene C Nanfack Ngoune O Abdouramani A Omgbwa Eballe L Bella Assumpta Source Type: research

Pharmacist-led interventions for people living with severe and persistent mental illness: A systematic review
CONCLUSION: There is evidence that pharmacist-led interventions improve consumer-reported and clinical outcomes for people living with severe and persistent mental illness. Pharmacists are capable and have a role in supporting people living with severe and persistent mental illness, either individually or as interprofessional collaborators with other healthcare professionals. Future research should attempt to better understand which particular intervention components have the greatest impact and also evaluate the implementation and long-term sustainability of such interventions.PMID:34560826 | DOI:10.1177/00048674211048410
Source: The Australian and New Zealand Journal of Psychiatry - September 25, 2021 Category: Psychiatry Authors: Ricki Ng Sarira El-Den Victoria Stewart Jack C Collins Helena Roennfeldt Sara S McMillan Amanda J Wheeler Claire L O'Reilly Source Type: research

Correction: Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12
J Immunol. 2021 Sep 24:ji2100809. doi: 10.4049/jimmunol.2100809. Online ahead of print.NO ABSTRACTPMID:34561231 | DOI:10.4049/jimmunol.2100809
Source: Journal of Immunology - September 25, 2021 Category: Allergy & Immunology Authors: Genevi ève Paulissen Mehdi El Hour Natacha Rocks Maud M Gu éders Fabrice Bureau Jean-Michel Foidart Carlos Lopez-Otin Agn ès Noel Didier D Cataldo Source Type: research

Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics Is Mediated by cIAP-2 and RIPK-1/3 through the Activation of mTORC
In this study, we investigated the mechanism governing SM-induced cell death during differentiation into M1 macrophages and in polarized M1 macrophages. IFN-γ stimulation conferred on M0 macrophages the sensitivity to SM-induced cell death through the Jak/STAT, IFN regulatory factor-1, and mammalian target of rapamycin complex-1 (mTORC-1)/ribosomal protein S6 kinase pathways. Interestingly, mTORC-1 regulated SM-induced cell death independent of M1 differentiation. In contrast, SM-induced cell death in polarized M1 macrophages is regulated by the mTORC-2 pathway. Moreover, SM-induced cell death is regulated by cellular IAP...
Source: Journal of Immunology - September 25, 2021 Category: Allergy & Immunology Authors: Hamza Ali Simon Xin Min Dong Niranjala Gajnayaka Edana Cassol Jonathan B Angel Ashok Kumar Source Type: research

Exposure to Systemic Immunosuppressive Ultraviolet Radiation Alters T Cell Recirculation through Sphingosine-1-Phosphate
J Immunol. 2021 Sep 24:ji2001261. doi: 10.4049/jimmunol.2001261. Online ahead of print.ABSTRACTSystemic suppression of adaptive immune responses is a major way in which UV radiation contributes to skin cancer development. Immune suppression is also likely to explain how UV protects from some autoimmune diseases, such as multiple sclerosis. However, the mechanisms underlying UV-mediated systemic immune suppression are not well understood. Exposure of C57BL/6 mice to doses of UV known to suppress systemic autoimmunity led to the accumulation of cells within the skin-draining lymph nodes and away from non-skin-draining lymph ...
Source: Journal of Immunology - September 25, 2021 Category: Allergy & Immunology Authors: Benita C Y Tse Rachael A Ireland Jun Yup Lee Felix Marsh-Wakefield Lai Fong Kok Anthony S Don Scott N Byrne Source Type: research

Overexpression of Transmembrane TNF Drives Development of Ectopic Lymphoid Structures in the Bone Marrow and B Cell Lineage Alterations in Experimental Spondyloarthritis
J Immunol. 2021 Sep 24:ji2100512. doi: 10.4049/jimmunol.2100512. Online ahead of print.ABSTRACTTNF is important in immune-mediated inflammatory diseases, including spondyloarthritis (SpA). Transgenic (tg) mice overexpressing transmembrane TNF (tmTNF) develop features resembling human SpA. Furthermore, both tmTNF tg mice and SpA patients develop ectopic lymphoid aggregates, but it is unclear whether these contribute to pathology. Therefore, we characterized the lymphoid aggregates in detail and studied potential alterations in the B and T cell lineage in tmTNF tg mice. Lymphoid aggregates developed in bone marrow (BM) of ve...
Source: Journal of Immunology - September 25, 2021 Category: Allergy & Immunology Authors: Merlijn H Kaaij Jasper Rip Kim C M Jeucken Yik Y Kan Charlotte C N van Rooijen Job Saris Desiree Pots Silke Frey Joep Grootjans Georg Schett Leonie M van Duivenvoorde Martijn A Nolte Rudi W Hendriks Odilia B J Corneth Jan Piet van Hamburg Dominique L P Ba Source Type: research

Regulation and Role of αE Integrin and Gut Homing Integrins in Migration and Retention of Intestinal Lymphocytes during Inflammatory Bowel Disease
J Immunol. 2021 Sep 24:ji2100220. doi: 10.4049/jimmunol.2100220. Online ahead of print.ABSTRACTTargeting interactions between α4β7 integrin and endothelial adhesion molecule MAdCAM-1 to inhibit lymphocyte migration to the gastrointestinal tract is an effective therapy in inflammatory bowel disease (IBD). Following lymphocyte entry into the mucosa, a subset of these cells expresses αEβ7 integrin, which is expressed on proinflammatory lymphocytes, to increase cell retention. The factors governing lymphocyte migration into the intestinal mucosa and αE integrin expression in healthy subjects and IBD patients remain incomp...
Source: Journal of Immunology - September 25, 2021 Category: Allergy & Immunology Authors: Mary E Keir Franklin Fuh Ryan Ichikawa Meghan Acres Jason A Hackney Gillian Hulme Christopher D Carey Jeremy Palmer Claire J Jones Anna K Long Jenny Jiang Sha Klabunde John C Mansfield Cary M Looney William A Faubion Andrew Filby John A Kirby Jacqueline M Source Type: research

Warm-water footbath improves dysmenorrhoea and heart rate variability in college students: a randomised controlled trial
In conclusion, a warm-water footbath is beneficial in improving the pain severity among college students with dysmenorrhoea.Impact StatementWhat is already known on this subject? Dysmenorrhoea is the most common gynaecological condition affecting 34-94% of young women. The existing conventional therapeutic strategies for dysmenorrhoea have potential adverse events. Among the complementary therapies for pain, the warm-water footbath is a widely used thermal therapy in improving peripheral neuropathy symptoms and improving patients' quality of life. The subjects with dysmenorrhoea associate with significantly altered autonom...
Source: Journal of Obstetrics and Gynaecology - September 25, 2021 Category: OBGYN Authors: Shih-Ju Wu Wei-Chih Kan Chih-Chung Shiao Source Type: research