Chemo-free treatment of adult patients with Ph-positive acute lymphoblastic leukemia: latest updates from the 2023 ASH annual meeting
The chemo-free concept represents a new direction for managing adult patients with Ph-positive acute lymphoblastic leukemia (Ph + ALL). The tyrosine kinase inhibitors (TKIs), blinatumomab and venetoclax serve ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 16, 2024 Category: Hematology Authors: Ting Shi and Hong-Hu Zhu Tags: Correspondence Source Type: research
Perioperative versus adjuvant S-1 plus oxaliplatin chemotherapy for stage II/III resectable gastric cancer (RESONANCE): a randomized, open-label, phase 3 trial
Evidence from Europe shows that perioperative chemotherapy may be beneficial for the treatment of locally advanced gastric cancer, but reliable and robust data is lacking. To rectify this, the phase 3 RESONANC... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 8, 2024 Category: Hematology Authors: Xinxin Wang, Canrong Lu, Bo Wei, Shuo Li, Ziyu Li, Yingwei Xue, Yingjiang Ye, Zhongtao Zhang, Yihong Sun, Han Liang, Kai Li, Linghua Zhu, Zhichao Zheng, Yanbing Zhou, Yulong He, Fei Li & hellip; Tags: Correspondence Source Type: research
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in the clinical delivery of immunomodulatory comp... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 2, 2024 Category: Hematology Authors: Qiang Lu, Dongquan Kou, Shenghan Lou, Milad Ashrafizadeh, Amir Reza Aref, Israel Canadas, Yu Tian, Xiaojia Niu, Yuzhuo Wang, Pedram Torabian, Lingzhi Wang, Gautam Sethi, Vinay Tergaonkar, Franklin Tay, Zhennan Yuan and Peng Han Tags: Review Source Type: research
Identification of SARS-CoV-2-specific T cell and its receptor
The T-cell receptor (TCR) repertoires exhibits distinct signatures associated with COVID-19 severity. However, the precise identification of vaccine-induced SARS-CoV-2-specific TCRs and T-cell immunity mechani... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 27, 2024 Category: Hematology Authors: Qian Zhang, Qing Liang, Rui Zhang, Nan Wang, Xu Xiao, Jiahao Shao and Kejia Wang Tags: Correspondence Source Type: research
Targeting inflammation as cancer therapy
Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 22, 2024 Category: Hematology Authors: Manni Wang, Siyuan Chen, Xuemei He, Yong Yuan and Xiawei Wei Tags: Review Source Type: research
Targeted protein degradation in hematologic malignancies: latest updates from the 2023 ASH annual meeting
Protein degraders, emerging as a novel class of therapeutic agents, have gained widespread attention due to their advantages. They have several advantages over traditional small molecule inhibitors, including ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 22, 2024 Category: Hematology Authors: Guangcai Zhong, Ran Kong, Shi Feng, Cong Wang, Qingbo Hao, Weilin Xie and Xiangxiang Zhou Tags: Correspondence Source Type: research
Decoding the glycoproteome: a new frontier for biomarker discovery in cancer
Cancer early detection and treatment response prediction continue to pose significant challenges. Cancer liquid biopsies focusing on detecting circulating tumor cells (CTCs) and DNA (ctDNA) have shown enormous... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 22, 2024 Category: Hematology Authors: Kai He, Maryam Baniasad, Hyunwoo Kwon, Tomislav Caval, Gege Xu, Carlito Lebrilla, Daniel W. Hommes and Carolyn Bertozzi Tags: Review Source Type: research
Proteomic characterization of esophageal squamous cell carcinoma response to immunotherapy reveals potential therapeutic strategy and predictive biomarkers
Immunotherapy is the first-line therapy for esophageal squamous cell carcinoma (ESCC), yet many patients do not respond due to drug resistance and the lack of reliable predictive markers. We collected 73 ESCC ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 15, 2024 Category: Hematology Authors: Fahan Ma, Yan Li, Chan Xiang, Bing Wang, Jie Lv, Jinzhi Wei, Zhaoyu Qin, Yan Pu, Kai Li, Haohua Teng, Subei Tan, Jinwen Feng, Zhanxian Shang, Yunzhi Wang, Sha Tian, Changsheng Du & hellip; Tags: Correspondence Source Type: research
Optical nanomaterial-based detection of biomarkers in liquid biopsy
Liquid biopsy, which is a minimally invasive procedure as an alternative to tissue biopsy, has been introduced as a new diagnostic/prognostic measure. By screening disease-related markers from the blood or oth... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 14, 2024 Category: Hematology Authors: Young Jun Kim, Won-Yeop Rho, Seung-min Park and Bong-Hyun Jun Tags: Review Source Type: research
FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion
Emerging evidences suggest that aberrant metabolites contributes to the immunosuppressive microenvironment that leads to cancer immune evasion. Among tumor immunosuppressive cells, myeloid-derived suppressor c... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - February 24, 2024 Category: Hematology Authors: Zeda Zhao, Juliang Qin, Ying Qian, Chenshen Huang, Xiaohong Liu, Ning Wang, Liqin Li, Yuqing Chao, Binghe Tan, Na Zhang, Min Qian, Dali Li, Mingyao Liu and Bing Du Tags: Research Source Type: research
IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts
It remains challenging to obtain positive outcomes with chimeric antigen receptor (CAR)-engineered cell therapies in solid malignancies, like colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC)... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - February 9, 2024 Category: Hematology Authors: Astrid Van den Eynde, Laura Gehrcken, Tias Verhezen, Ho Wa Lau, Christophe Hermans, Hilde Lambrechts, Tal Flieswasser, Delphine Quatannens, Gils Roex, Karen Zwaenepoel, Elly Marcq, Philippe Joye, Edgar Cardenas De La Hoz, Christophe Deben, Alessia Gaspari Tags: Research Source Type: research
METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation
While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - February 1, 2024 Category: Hematology Authors: Meilin Xue, Lei Dong, Honghai Zhang, Yangchan Li, Kangqiang Qiu, Zhicong Zhao, Min Gao, Li Han, Anthony K. N. Chan, Wei Li, Keith Leung, Kitty Wang, Sheela Pangeni Pokharel, Ying Qing, Wei Liu, Xueer Wang & hellip; Tags: Research Source Type: research
Metabolic reprogramming in the tumor microenvironment of liver cancer
The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 31, 2024 Category: Hematology Authors: Jian Lin, Dongning Rao, Mao Zhang and Qiang Gao Tags: Review Source Type: research
cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
Cancer is a complex disease resulting from abnormal cell growth that is induced by a number of genetic and environmental factors. The tumor microenvironment (TME), which involves extracellular matrix, cancer-a... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 17, 2024 Category: Hematology Authors: Hongying Zhang, Yongliang Liu, Jieya Liu, Jinzhu Chen, Jiao Wang, Hui Hua and Yangfu Jiang Tags: Review Source Type: research
The Association of Agent Orange Exposure with the progression of monoclonal gammopathy of undetermined significance to multiple myeloma: a population-based study of Vietnam War Era Veterans
Herbicide and pesticide exposure [e.g., agent orange (AO)] is associated with an increased risk of multiple myeloma (MM) due to the contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, it is unclear ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 8, 2024 Category: Hematology Authors: Lawrence W. Liu, Mei Wang, Nikhil Grandhi, Mark A. Schroeder, Theodore Thomas, Kristin Vargo, Feng Gao, Kristen M. Sanfilippo and Su-Hsin Chang Tags: Correspondence Source Type: research
