Enhancement of Skin Barrier Function and Augmentation of Epidermal Cell-Cell Interactions by Galactomyces Ferment Filtrate
Dear Editor: (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 29, 2024 Category: Dermatology Authors: Satoshi Nakamizo, Xianghong Yan, Kenji Kabashima Source Type: research
Lack of cutis verticis gyrata is associated with c.1279_1290del12 of SLCO2A1 in 43 Japanese patients with pachydermoperiostosis
Pachydermoperiostosis (PDP), also known as primary hypertrophic osteoarthropathy (PHO), is a rare hereditary condition mainly characterized by clubbing of the digits, periostosis of long bones, pachydermia, and cutis verticis gyrata (CVG) [1]. Biallelic mutations in HPGD and SLCO2A1 disturb prostaglandin E2 (PGE2) catabolism, leading to increased circulating PGE2 levels and causing PHO autosomal recessive 1 (PHOAR1) and PHO autosomal recessive 2 (PHOAR2), respectively [2,3]. The two major clinical subtypes of PDP include a complete-form-type (Complete-PDP), characterized by the presence of CVG along with the three main fea...
Source: Journal of Dermatological Science - March 23, 2024 Category: Dermatology Authors: H Niizeki, R Tanaka, T Nomura, A Seki, M Miyasaka, Y Matsumoto, M Ishibashi, S Narumi, K Nakabayashi, K Yoshida Source Type: research
Visualization of intradermal blood vessel structures by dual-wavelength photoacoustic microscopy and characterization of three-dimensional construction of livedo-racemosa in cutaneous polyarteritis nodosa
Photoacoustic microscopy is expected to have clinical applications as a noninvasive and three-dimensional (3D) method of observing intradermal structures. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 23, 2024 Category: Dermatology Authors: Kazuyo Sujino, Keiji Tanese, Yasuko Saito, Junko Kuramoto, Hideaki Iwazaki, Taiichiro Ida, Sadakazu Aiso, Nobuaki Imanishi, Hiroki Kajita, Keitaro Fukuda, Masayuki Amagai, Akiko Tanikawa Tags: Original Article Source Type: research
Proteome characterization of XPC-deficient melanocytes generated by CRISPR-Cas9 technology reveals alteration in the expression of several hundred of proteins
Dear Editor: (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 23, 2024 Category: Dermatology Authors: Muriel Cario, Julie Scalia, Walid Mahfouf, Elodie Muzotte, Vincent Michaud, Claudio Plaisant, Jean-William Dupuy, Thierry Douki, Fanny Morice-Picard, J érôme Rambert, Eric Perrier, Sandra Trompezinski, Hamid-Reza Rezvani Source Type: research
IL-4-induced decrease in both the number and CTLA-4 expression of Treg impairs suppression of Th2 type inflammation in severe atopic dermatitis
Treg plays a pivotal role in the suppression of Th2 cell and the maintenance of immune homeostasis. The precise molecular mechanism underlying the disruption of Treg suppression of Th2 cell and the promotion of Th2 type inflammation in allergic diseases remains elusive. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 23, 2024 Category: Dermatology Authors: Bocheng Wang, Zhiying Yu, Jiao Liu, Yuyang Tian, Yijia Ruan, Tinghui Kong, Mingjun Hou, Bihui Yu, Shiqi Ling, Di Wang, Yishan Chen, Yingping Xu, Weiwei Deng, Yunsheng Liang Source Type: research
Anti-BP230 IgE autoantibodies in bullous pemphigoid intraindividually correlate with disease activity
Bullous pemphigoid (BP), the most common subepidermal autoimmune blistering disease, is classically defined by the presence of IgG autoantibodies directed against the hemidesmosomal proteins BP180 (type XVII collagen) and BP230 and the predominance of skin lesions. Several studies have addressed the role of anti-BP180 IgE in patients and experimental models, while data on anti-BP230 IgE are scarce. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 22, 2024 Category: Dermatology Authors: Shirin Emtenani, Beke E. Linnemann, Andreas Recke, Anabelle von Georg, Stephanie Goltez, Enno Schmidt, Nina van Beek Source Type: research
Maximizing the Potential of Biobanks in Dermatology Research
Letter to the Editor, (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 21, 2024 Category: Dermatology Authors: Alison M Treichel, Jacky HK Chen, Samantha Epstein, Thomas S McCormick, Jeremy S Bordeaux, David J Alouani, Kevin D Cooper Source Type: research
JSID ’s Fellowship Shiseido Research Grant
The Japanese Society for Investigative Dermatology (JSID) is seeking candidates for JSID ’s Fellowship Shiseido Research Grant. This research grant is intended to promote innovative research that will contribute to the progress of cutaneous biology. This research grant is aimed at researchers working in the following fields: (1) skin aging, (2) keratinocyte biology, (3) pigment cell b iology, (4) hair biology, (5) cosmeceuticals, and (6) all the basic research areas related to (1)-(5), e.g. immunology. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 13, 2024 Category: Dermatology Authors: Manabu Ohyama Source Type: research
LEKTI domain 6 displays anti-inflammatory action in vitro and in a murine atopic dermatitis model
Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a serine protease inhibitor consisting of multiple domains. A loss of function mutation is described in Netherton patients that show severe symptoms of atopic lesions and itch. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 12, 2024 Category: Dermatology Authors: Pascal Canbolat, Jenny Wilzopolski, Sabine Kaessmeyer, Viviane Filor, Jonathan Vidak, Marc R üger, Hans-Jürgen Mägert, Wolf-Georg Forssmann, Wolfgang Bäumer Source Type: research
RAS-activated PI3K/AKT signaling sustains cellular senescence via P53/P21 axis in experimental models of psoriasis
Psoriasis is a chronic immune-mediated skin disease in which upper epidermal keratinocytes exhibit a senescent-like phenotype. In psoriatic skin, a variety of inflammatory cytokines can activate intracellular pathways including phosphatidylinositol 3-kinase (PI3K)/AKT signaling and RAS effectors. AKT and RAS participate to cellular senescence, but currently their role in senescence responses occurring in psoriasis have not yet been investigated. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 7, 2024 Category: Dermatology Authors: Laura Mercurio, Jacob Bailey, Adam Bleier Glick, Elena Dellambra, Claudia Scarponi, Sabatino Pallotta, Cristina Albanesi, Stefania Madonna Tags: Original Article Source Type: research
Targeting antibody-mediated complement-independent mechanism in bullous pemphigoid with diacerein
Bullous pemphigoid (BP) is an antibody-mediated blistering disease predominantly affecting the elderly. The pathogenesis involves both complement-dependent and complement-independent mechanisms. The therapeutic potential of targeting complement-independent mechanism has not yet been determined. The mainstay of treatment, corticosteroid, has many side effects, indicating the needs of better treatments. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 5, 2024 Category: Dermatology Authors: Yung-Tsu Cho, Chih-Hung Lee, Jing-Yi Lee, Chia-Yu Chu Tags: Original Article Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 1, 2024 Category: Dermatology Source Type: research
Editor's Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 1, 2024 Category: Dermatology Source Type: research
High α-diversity of skin microbiome and mycobiome in Japanese patients with vitiligo
Vitiligo is an acquired pigmentary disorder characterized by depigmented patches on the skin that majorly impact patients' quality of life. Although its etiology involves genetic and environmental factors, the role of microorganisms as environmental factors in vitiligo pathology remains under-researched. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 29, 2024 Category: Dermatology Authors: Yasutaka Kuroda, Lingli Yang, Takakazu Shibata, Masahiro Hayashi, Yuta Araki, Makiko Nishida, Takeshi Namiki, Teruhiko Makino, Tadamichi Shimizu, Tamio Suzuki, Tetsuya Sayo, Yoshito Takahashi, Daisuke Tsuruta, Ichiro Katayama Tags: Original Article Source Type: research
Rh family C glycoprotein contributes to psoriatic inflammation through regulating the dysdifferentiation and cytokine secretion of keratinocytes
Keratinocyte dysdifferentiation and proinflammatory cytokine production play a central role in psoriatic inflammation. According to recent studies, the Rh family C glycoprotein (RHCG) enhances cell proliferation and disrupts cell differentiation. However, the specific role of RHCG psoriasis development remains unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 29, 2024 Category: Dermatology Authors: Wei Liu, Yaqi Wang, Yitian Zhang, Mingzhu Zhou, Hanjiang Gu, Mei Lu, Yumin Xia Tags: Original Article Source Type: research
