Potential role of genetic polymorphisms in neoadjuvant chemotherapy response in breast cancer
J Chemother. 2024 Mar 21:1-15. doi: 10.1080/1120009X.2024.2330241. Online ahead of print.ABSTRACTChemoresistance leads to treatment failure, which can arise through different mechanisms including patients' characteristics. Searching for genetic profiles as a predictor for drug response and toxicity has been extensively studied in pharmacogenomics, thus contributing to personalized medicine and providing alternative treatments. Numerous studies have demonstrated significant evidence of association between genetic polymorphisms and response to neoadjuvant chemotherapy (NAC) in breast cancer. In this review, we explored the p...
Source: Journal of Chemotherapy - March 21, 2024 Category: Cancer & Oncology Authors: Om Elez Bouhniz Abderraouf Kenani Source Type: research

Efficacy of first-line CDK 4-6 inhibitors in premenopausal patients with metastatic breast cancer and the effect of dose reduction due to treatment-related neutropenia on efficacy: a Turkish Oncology Group (TOG) study
J Chemother. 2024 Mar 18:1-7. doi: 10.1080/1120009X.2024.2330835. Online ahead of print.ABSTRACTThe only phase 3 study on the effectiveness of CDK 4-6 inhibitors in first-line treatment in premenopausal patients with hormone receptor (HR) positive, HER2 negative metastatic breast cancer is the MONALEESA-7 study, and data on the effectiveness of palbociclib is limited. Data are also limited regarding the effectiveness of CDK 4-6 inhibitors in patients whose dose was reduced due to neutropenia, the most common side effect of CDK 4-6 inhibitors. In our study, we aimed to evaluate the effectiveness of palbociclib and ribocicli...
Source: Journal of Chemotherapy - March 18, 2024 Category: Cancer & Oncology Authors: Hasan Cagri Yildirim Caner Kapar Baris Koksal Mustafa Seyyar Pervin Can Sanci Murad Guliyev Perihan Perkin Mustafa Buyukkor Sendag Yaslikaya Nargiz Majidova Merve Keskinkilic Duygu Ozaskin Tugay Avci Tugce Kubra Gunes Murat Arcagok Alper Topal Gul Sema Yi Source Type: research

Comparative effectiveness of chemotherapy in different histological types of pancreatic cancer: a PSM-based study using the SEER database
This study aimed to compare the effectiveness of chemotherapy in different histological types of pancreatic cancer using data collected from the Surveillance, Epidemiology, and End Results (SEER) database. Patients who were diagnosed with pancreatic cancer between 2004 and 2015 were selected from the SEER database. Propensity score matching (PSM) was employed to minimize the selection bias. The Kaplan-Meier survival curves and the log-rank test were utilized to compare the overall survival (OS) and cancer-specific survival (CSS) among different groups. Of the 7,653 pancreatic cancer patients, both OS and CSS were higher in...
Source: Journal of Chemotherapy - March 14, 2024 Category: Cancer & Oncology Authors: Canhua Luo Linfeng Fan Weijian Lun Miaomiao Ma Leshi Liang Changhui Yu Source Type: research

Evaluation of predictors of third-generation cephalosporin non-susceptibility and factors affecting recurrence or death in bacteremia caused by < em > Citrobacter freundii < /em > complex < em > , Enterobacter cloacae < /em > complex, and < em > Klebsiella aerogenes < /em >
J Chemother. 2024 Mar 7:1-11. doi: 10.1080/1120009X.2024.2323326. Online ahead of print.ABSTRACTFactors involved in the susceptibility of third-generation cephalosporins (3GCs) to bacteremia caused by Citrobacter freundii complex, Enterobacter cloacae complex, and Klebsiella aerogenes were investigated based on a case-case-control design. Antimicrobial therapy administered 30 days prior to bacteremia and hospitalization within 90 days were common risk factors for the 3GC susceptible and 3GC non-susceptible groups, while hospitalization from an institution or another hospital was a specific risk factor for the 3GC non-susce...
Source: Journal of Chemotherapy - March 7, 2024 Category: Cancer & Oncology Authors: Kazuhiro Kobayashi Atsuko Hata Waki Imoto Shigeki Kakuno Wataru Shibata Koichi Yamada Hiroshi Kawaguchi Norihiro Sakurai Toshikazu Ito Kazuya Uenoyama Tamotsu Takahashi Satoru Ueda Toshiro Katayama Masahide Onoue Hiroshi Kakeya Source Type: research