Inhibition of miR ‐124 improves neonatal necrotizing enterocolitis via an MYPT1 and TLR9 signal regulation mechanism
ConclusionmiR ‐124 was a promoter of NEC, which promotes the intestine cell apoptosis and inflammatory cell infiltration through the inhibition of TLR9 expression by targeting ROCK1. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Yiyu Yin, Zhenfang Qin, Xiaobing Xu, Xu Liu, Huaxin Zou, Xiaole Wu, Junhua Cao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

MicroRNA ‐99b suppresses human cervical cancer cell activity by inhibiting the PI3K/AKT/mTOR signaling pathway
This study aimed to explore the effect of miR ‐99b‐5p (miR‐99b) on invasion and migration in cervical cancer through the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway. The microarray‐based analysis was used to screen out differentially expressed miRNAs. Expression of miR‐99b, PI3K, AKT, mTOR, and ribosomal protein S6 kinase (p70S6K) was determined in both cervical cancer tissues and paracancerous tissues. Next, alteration of miR‐99b expression in cervical cancer was conducted to evaluate levels of PI3K, AKT, mTOR, p70S6K matrix metallopept...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Yong ‐Jie Li, Yue Wang, Yi‐Ying Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Altered plasma proteins released from platelets and endothelial cells are associated with human patent ductus arteriosus
Ductus arteriosus closure involves functional and structural remodeling, controlled by many factors and we for the first time demonstrate six key differential plasma proteins in human patent ductus arteriosus patients using proteomic technology and present a model to illustrate the constriction and closure of ductus arteriosus. Those proteins are closely related to platelet activation and coagulation cascades, complement mannan ‐binding‐lectin, and other systemic signaling pathways. Our findings for the first time indicate that the differential proteins involved in different pathways may play key roles in the nonclosur...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Hai ‐Tao Hou, Xi‐Zhang, Jun Wang, Li‐Xin Liu, Jian‐Feng Zhang, Qin Yang, Guo‐Wei He Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome
Irritable bowel syndrome (IBS) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of 18% in the world. The pathophysiology of the IBS is hardly understood, whereas several possible mechanisms, such as visceral hypersensitivity, irregular gut motility, abnormal brain –gut relations, and the role of infectious agents, are implicated in initiation and development this syndrome. It appears that the main obligatory pathogens correspond with the IBS disease. AbstractIrritable bowel syndrome (IBS) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of ...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Aref Shariati, Fateme Fallah, Ali Pormohammad, Ali Taghipour, Hossein Safari, Alireza salami chirani, Sahar Sabour, Mahmood Alizadeh ‐Sani, Taher Azimi Tags: REVIEW ARTICLE Source Type: research

Cell fate regulation by reticulon ‐4 in human prostate cancers
Our results showed that reticulon ‐4 (RTN4) was downregulated and targeted by miR‐148a‐3p, and inhibited prostate cancer cell proliferation by inducing cell cycle arrest and senescence, suggesting that RTN4 may be an important molecular event linked to prostate cancer. AbstractReticulon ‐4 (RTN4), a reticulon family protein localized in the endoplasmic reticulum, is reported to be involved in multiple physiological processes like neuroendocrine secretion and membrane trafficking in neuroendocrine cells. Previous studies have presented a great potential of RTN4 for the treatment o f autoimmune‐mediated demyelinati...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Hu Zhao, Weipeng Su, Changyan Zhu, Tengyue Zeng, Shunliang Yang, Weizhen Wu, Dong Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Effects of nebulized N ­‐acetylcystein on the expression of HMGB1 and RAGE in rats with hyperoxia‐­induced lung injury
ConclusionHMGB1 and RAGE were involved in the pathogenesis of hyperoxia ‐induced lung injury, inhalation of NAC might alleviate hyperoxia‐induced lung injury by regulating the expression of HMGB1 and RAGE. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Junying Qiao, Lixia Chen, Xianjie Huang, Feifei Guo Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Cholinergic activity regulates the secretome of epicardial adipose tissue: Association with atrial fibrillation
Muscarinic receptor type 3 is upregulated after adipogenesis.Epicardial fat from atrium or ventricles express this receptor and contain cholinergic activity.Epicardial fat ‐released proteins after cholinergic activity as possible predictors of postoperative AF AbstractBotulinum toxin injection on epicardial fat, which inhibits acetylcholine (ACh) release, reduced the presence of atrial fibrillation (AF) in patients after heart surgery. Thus, we wanted to study the profile of the released proteins of epicardial adipose tissue (EAT) under cholinergic activity (ACh treatment) and their value as AF predictors. Biopsies, expl...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Marinela Couselo ‐Seijas, Jose N. López‐Canoa, Rosa M. Agra‐Bermejo, Esther Díaz‐Rodriguez, Angel L. Fernandez, Jose M. Martinez‐Cereijo, Dario Durán‐Muñoz, Susana B. Bravo, Alba Velo, Laila González‐Melchor, Xesus A. Fernánd Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Knockdown of NEAT1 repressed the malignant progression of glioma through sponging miR ‐107 and inhibiting CDK14
We found that inhibition of nuclear paraspeckle assembly transcript 1 (NEAT1) repressed glioma development via sponging miR ‐107. The correlation between NEAT1 and miR‐107 was validated in our study, and cyclin dependent kinase 14 (CDK14) was targeted by miR‐107 by using bioinformatics analysis. All these data revealed that NEAT1/miR‐107/CDK14 axis was involved in glioma development AbstractAberrant expressions of long noncoding RNAs (lncRNAs) contribute to carcinogenesis via regulating tumor suppressors or oncogenes. LncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been recognized as an oncogene to pro...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Yingwei Zhen, Yang Nan, Shewei Guo, Longzhou Zhang, Ge Li, Saichao Yue, Xianzhi Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

c ‐Met inhibition is required for the celecoxib‐attenuated stemness property of human colorectal cancer cells
In this study, we found that among these NSAIDs, celecoxib has t he most potency for CSC inhibition of CRC cells, largely correlating to inhibition of c‐Met, not COX‐2. Further analysis reveals that c‐Met activity was required for basal CSC property. Silence of c‐Met blocked whereas overexpression of c‐Met enhanced the celecoxib‐inhibited CSC propert y. Collectively, these results not only first elucidate the mechanism underlying celecoxib‐inhibited CSC but also indicate c‐Met as a critical factor for the CSC property of CRC cells. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Yueh ‐Ming Lin, Chien‐Chang Lu, Yi‐Ping Hsiang, Shu‐Chuan Pi, Chih‐I Chen, Kung‐Chuan Cheng, Hsiao‐Lin Pan, Pei‐Hsuan Chien, Yun‐Ju Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Preparation of adriamycin gelatin microsphere ‐loaded decellularized periosteum that is cytotoxic to human osteosarcoma cells
The effectiveness of these two scaffolds in killing human osteosarcoma cells was tested by evaluating cell viability overtime of the cancer cells cultured with the scaffolds. In summary, a gelatin/decellularized periosteum ‐based biologic scaffold material was designed aiming for local delivery of chemotherapy drugs for osteosarcoma, with the results showing ability of the scaffolds in sustaining release of the cancer drug and in suppressing growth of the cancer cells in vitro AbstractThe purpose of this study was to develop a novel approach to treat bone osteosarcoma using a multipurpose scaffold aiming for local drug d...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Chuan Chen, Jianghui Dong, Hong Chen, Xin Wang, Jin Mei, Liping Wang, Cory J Xian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Redefining the signaling pathways from pluripotency to pancreas development: In vitro β‐cell differentiation
We summarized the current knowledge on the developmental biology of the pancreas to understand the mechanism underlying the insulin ‐producing cell (IPC) protocols, and discussed the appropriate signaling involved in the early body axes and endoderm patterning up to endocrine precursor (EP) and β‐cell specification. In addition, we showed that transplantation of differentiated embryonic stem (dES) cells in early differentia tion stage, leads to a better outcome, compared with full differentiation of mature β‐cells’ graft. AbstractPancreatic β‐cells are destroyed by the immune system, in type 1 diabetes (T1D) a...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Mahmoud Hashemitabar, Elham Heidari Tags: MINI ‐REVIEW Source Type: research

Embryo quality, and not chromosome nondiploidy, affects mitochondrial DNA content in mouse blastocysts
This study constructed haploid, diploid, triploid, and tetraploid blastocysts by parthenogenetic activation, intracytoplasmic sperm injection with one or two sperm heads, blastomere electrofusion, respectively, and generated reduced cytoplasm quality embryos from diabetic mouse and in vitro fertilization of aged oocytes, and examined whether nondiploidy or reduced cytoplasm quality causes premature mitochondrial biosynthesis. MtDNA numbers of each blastocyst from different models were tested by absolute quantitative real ‐time polymerase chain reaction. It was found that mtDNA content in preimplantation embryos was not a...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Ying Jing, Li Li, Yuan ‐Yuan Li, Ying‐Chun Ouyang, Qing‐Yuan Sun, Cui‐Lian Zhang, Rong Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

miR ‐142‐3p as tumor suppressor miRNA in the regulation of tumorigenicity, invasion and migration of human breast cancer by targeting Bach‐1 expression
ConclusionFor the first time, our results revealed that miR ‐142‐3p could target Bach‐1in breast cancer cells leading to the reduction of EMT‐related proteins and reduced cell proliferation, invasion, and migration. The results also demonstrated that miR‐142‐3p could regulate important tumor suppressor miRNAs in breast cancer cells. In conclusion , our results suggest that miR‐142‐3p could be a good candidate for the targeted therapy of breast cancer, especially for the invasive type. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Behzad Mansoori, Ali Mohammadi, Mehri Ghasabi, Solmaz Shirjang, Razeieh Dehghan, Vahid Montazeri, Uffe Holmskov, Tohid Kazemi, Pascal Duijf, Morten Gjerstorff, Behzad Baradaran Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A novel multidimensional signature predicts prognosis in hepatocellular carcinoma patients
In conclusion, we found a signature that can predict survival of HCC patients and serve as a prognostic marker for HCC. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Song Wang, Jian ‐Hua Zhang, Huan Wang, Lu Yang, Shuai Hong, Bo Yu, Jin‐Cheng Guo, Jing Liu, Yan‐Bing Zhu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Long noncoding RNA NEAT1 promotes the growth of human retinoblastoma cells via regulation of miR ‐204/CXCR4 axis
In conclusion, NEAT1 promotes the development of RB via miR‐204/CXCR4 axis, which provides a new target for the treatment of RB disease. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Wei Zhong, Jingpu Yang, Miyang Li, Lin Li, Aipeng Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research