Neurokinin-1 Receptor Antagonist-Based Triple Regimens in Preventing Chemotherapy-Induced Nausea and Vomiting: A Network Meta-Analysis
Conclusions: Different NK-1RAs-based triple regimens shared equivalent effect on CINV control. Various triple regimens had superior antiemetic effect than duplex regimen in patients with HEC. Only aprepitant-based triple regimen showed better CINV control compared with duplex regimen in patients receiving MEC. Palonosetron and first-generation 5HT3RAs might share equivalent CINV control in the combination of NK-1RAs and dexamethasone. Lower doses of dexamethasone might be applied when used with NK-1RAs and 5HT3RAs. (Source: JNCI)
Source: JNCI - October 29, 2016 Category: Cancer & Oncology Authors: Zhang, Y., Yang, Y., Zhang, Z., Fang, W., Kang, S., Luo, Y., Sheng, J., Zhan, J., Hong, S., Huang, Y., Zhou, N., Zhao, H., Zhang, L. Tags: Review Source Type: research
Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis
Conclusions: Epidemiological evidence supports the potential of vitamin B6 as a cancer risk reduction agent and the role of PLP as a cancer screening biomarker, especially for gastrointestinal tumors. However, inconsistent findings from total intake and intervention studies suggest that vitamin B6 might also be an indicator of other dietary protective micronutrients. (Source: JNCI)
Source: JNCI - October 29, 2016 Category: Cancer & Oncology Authors: Mocellin, S., Briarava, M., Pilati, P. Tags: Review Source Type: research
Prediction of Trastuzumab Benefit in HER2-Positive Breast Cancers: Is It in the Intrinsic Subtype?
(Source: JNCI)
Source: JNCI - October 27, 2016 Category: Cancer & Oncology Authors: Kim, J., Pareja, F., Weigelt, B., Reis-Filho, J. S. Tags: Editorial Source Type: research
Fit for Chemo: Nerves May Thank You
(Source: JNCI)
Source: JNCI - October 27, 2016 Category: Cancer & Oncology Authors: Leon-Ferre, R., Ruddy, K. J., Staff, N. P., Loprinzi, C. L. Tags: Editorial Source Type: research
Intrinsic Subtype and Therapeutic Response Among HER2-Positive Breaty st Tumors from the NCCTG (Alliance) N9831 Trial
Conclusions: The majority of clinically defined HER2-positive tumors were classified as HER2-enriched or luminal using the Prosigna algorithm. Intrinsic subtype alone cannot replace conventional histopathological evaluation of HER2 status because many tumors that are classified as luminal A or luminal B will benefit from adjuvant trastuzumab if that subtype is accompanied by HER2 overexpression. However, among tumors that overexpress HER2, we speculate that assessment of intrinsic subtype may influence treatment, particularly with respect to evaluating alternative therapeutic approaches for that subset of HER2-positive tum...
Source: JNCI - October 27, 2016 Category: Cancer & Oncology Authors: Perez, E. A., Ballman, K. V., Mashadi-Hossein, A., Tenner, K. S., Kachergus, J. M., Norton, N., Necela, B. M., Carr, J. M., Ferree, S., Perou, C. M., Baehner, F., Cheang, M. C. U., Thompson, E. A. Tags: Article Source Type: research
BMI, Lifestyle Factors and Taxane-Induced Neuropathy in Breast Cancer Patients: The Pathways Study
Conclusions: Obesity and low MVPA were associated with CIPN in breast cancer patients who received taxane treatment. (Source: JNCI)
Source: JNCI - October 27, 2016 Category: Cancer & Oncology Authors: Greenlee, H., Hershman, D. L., Shi, Z., Kwan, M. L., Ergas, I. J., Roh, J. M., Kushi, L. H. Tags: Article Source Type: research
Linguistic Strategies for Improving Informed Consent in Clinical Trials Among Low Health Literacy Patients
Conclusions: The effectiveness of metaphors for explaining randomization depends on health literacy, with a benign metaphor being particularly effective for patients at the lower end of the health literacy spectrum. The theoretical model demonstrates the cognitive and affective predictors of behavioral intention to participate in cancer RCTs and offers guidance on how future research should employ communication strategies to improve the informed consent processes. (Source: JNCI)
Source: JNCI - October 27, 2016 Category: Cancer & Oncology Authors: Krieger, J. L., Neil, J. M., Strekalova, Y. A., Sarge, M. A. Tags: Article Source Type: research
Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer
Conclusions: These results highlight NEDD8-pathway inhibition by pevonedistat as a potentially effective treatment for poorly differentiated, clinically aggressive CRC. (Source: JNCI)
Source: JNCI - October 21, 2016 Category: Cancer & Oncology Authors: Picco, G., Petti, C., Sassi, F., Grillone, K., Migliardi, G., Rossi, T., Isella, C., Di Nicolantonio, F., Sarotto, I., Sapino, A., Bardelli, A., Trusolino, L., Bertotti, A., Medico, E. Tags: Article Source Type: research
A USE1ful Biomarker and Molecular Target in Lung Cancer?
(Source: JNCI)
Source: JNCI - October 20, 2016 Category: Cancer & Oncology Authors: Xu, W., Neckers, L. Tags: Solicited Editorial Source Type: research
Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis
Conclusions: USE1 proteins are frequently overexpressed in lung cancer, and missense mutations in USE1 prolong the half-life of the protein, promoting tumor formation. Our findings reveal novel roles for USE1 in lung cancer and the possible use of USE1 as a novel biomarker and therapeutic target for lung cancer treatment. (Source: JNCI)
Source: JNCI - October 20, 2016 Category: Cancer & Oncology Authors: Kim, S.-J., Hyeong Lee, T., Hee Nam, S., Kim, J.-H., Oh, S., Sook Cho, Y., Sup Lee, M., Choi, S., Lee, P. C. W. Tags: Article Source Type: research
Financial Hardships Experienced by Cancer Survivors: A Systematic Review
Conclusions: Financial hardship is common among cancer survivors, although we found substantial heterogeneity in its prevalence. Our findings highlight the need for consistent use of definitions, terms, and measures to determine the best intervention targets and inform intervention development in order to prevent and minimize the impact of financial hardship experienced by cancer survivors. (Source: JNCI)
Source: JNCI - October 19, 2016 Category: Cancer & Oncology Authors: Altice, C. K., Banegas, M. P., Tucker-Seeley, R. D., Yabroff, K. R. Tags: Review Source Type: research
Urinary Cadmium and Breast Cancer: A Prospective Danish Cohort Study
Conclusions: This large prospective study showed no association between urinary concentration of cadmium and subsequent risk for development of postmenopausal breast cancer. (Source: JNCI)
Source: JNCI - October 19, 2016 Category: Cancer & Oncology Authors: Eriksen, K. T., McElroy, J. A., Harrington, J. M., Levine, K. E., Pedersen, C., Sorensen, M., Tjonneland, A., Meliker, J. R., Raaschou-Nielsen, O. Tags: Article Source Type: research
The Association of Dyslipidemia With Chronic Lymphocytic Leukemia: A Population-Based Study
Conclusions: We demonstrate a higher prevalence of dyslipidemia preceding a diagnosis of CLL compared with control subjects, supporting preclinical data. Lipid-lowering medications appear to confer a survival advantage in CLL. Prospective studies are needed to confirm these results and test their potential as therapeutic applications. (Source: JNCI)
Source: JNCI - October 19, 2016 Category: Cancer & Oncology Authors: Mozessohn, L., Earle, C., Spaner, D., Cheng, S. Y., Kumar, M., Buckstein, R. Tags: Article Source Type: research
Prediagnostic Body Mass Index Trajectories in Relation to Prostate Cancer Incidence and Mortality in the PLCO Cancer Screening Trial
Conclusions: Our results suggest that BMI trajectories during adulthood that result in obesity lead to an elevated risk of fatal prostate cancer. (Source: JNCI)
Source: JNCI - October 19, 2016 Category: Cancer & Oncology Authors: Kelly, S. P., Graubard, B. I., Andreotti, G., Younes, N., Cleary, S. D., Cook, M. B. Tags: Article Source Type: research
When Less is More
(Source: JNCI)
Source: JNCI - October 17, 2016 Category: Cancer & Oncology Authors: Castle, P. E. Tags: Editorial Source Type: research
