International Journal of Phytomedicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Comparison Between Topical Sucralfate, Topical Platelet-Rich Plasma and Topical Ozonated Virgin Coconut Oil to Enhance Wound Healing in Diabetic Ulcer Mice model
Conclusions: Topical ozonated VCO can potentially accelerate wound healing in diabetic ulcers better than topical sucralfate and topical PRP.  (Source: International Journal of Phytomedicine)
Source: International Journal of Phytomedicine - July 10, 2021 Category: Science Authors: Renni Yuniati Source Type: research

Biocompatibility assessment and antiproliferative activity of Detarium microcarpum Guill. and Perr. fruit pulp extracts.
This study was designed to assess de biocompatibility ofDetarium microcarpumfruit extract on normal fibroblasts and its antiproliferative potentiality on human osteosarcoma MG-63 cells. Primary dermal fibroblasts and human osteosarcoma MG-63 cells were treated with different concentrations of hexane, chloroform, ethyl acetate and methanol extracts ofD. microcarpumfruit pulp for 24h, 48h and 72h. The biocompatibility property of extracts on the normal fibroblasts and its antiproliferative activity on the human osteosarcoma cells were evaluated by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenytetrazolium bromide (MTT) assay....
Source: International Journal of Phytomedicine - July 10, 2021 Category: Science Authors: Rouamba Ablass é Source Type: research

Screening of secondary metabolites and immunostimulation potential of poly herbal formoulation (Asparagus racemosus, Mucuna pruriens, Anacyclus pyrethrum and Tribulus terristeris) in Wistar Albino rats
In this study, Immunomodulatory activity of Polyherbal formulation was determined. First of all, plants methanolic extracts ofAsparagus racemosus, Mucuna pruriens, Anacyclus pyrethrum, Tribulus terrestris were prepared. The methanolic extracts of each plant were taken separately in equal amount and mixed to prepare the Polyherbal formulation (PHF). Screening test was applied on PHF for quantitative analysis. Hemolytic activity, thrombolytic activity and antioxidant activity were determined on experimental animals. To demonstrate the effect of standard Immunol drug, CCl4 and polyherbal formulation extract on hematological p...
Source: International Journal of Phytomedicine - July 10, 2021 Category: Science Authors: shifa shaffique Source Type: research

Tulbaghia violacea Harv. Extracts Affect Key Intermediates of the Cryptococcus neoformans Ergosterol Biosynthetic Pathway
This study investigated the mechanism of inhibition ofCryptococcus neoformans byTulbaghia violacea plant extract.C. neoformans cultures were treated with sub-inhibitory concentrations ofT. violacea extract and the effect of the exposure on the production of various sterol intermediates was analyzed by high performance reverse phase liquid chromatography. Plant extract treatedC. neoformans cultures exhibited reductions in ergosterol production after 48 hrs of exposure in a dose dependent manner. HPLC analysis overall revealed an accumulation in squalene, 2,3-oxidosqualene and lanosterol intermediates after extract treatment...
Source: International Journal of Phytomedicine - July 10, 2021 Category: Science Authors: Benesh Munilal Somai Source Type: research

Antioxidant activity evaluated in vitro of endophytic fungi isolated from Talinum triangulare leaves
Endophytic fungi are microbes that reside in the tissues of living plants without causing any apparent damage. They are very diverse microorganisms that synthesize compounds of various classes within their host plants. The aim of this work is to evaluate the total phenol content and antioxidant capacity of endophytic fungal extracts isolated from the leaves ofTalinum triangulare. For this purpose, the extraction of metabolites was carried out using ethyl acetate. The total phenols of the fungal extracts were determined by the classical colorimetric method of Folin-Ciocalteu and the antioxidant capacity was evaluated by the...
Source: International Journal of Phytomedicine - July 10, 2021 Category: Science Authors: GONO Kpan Nestor Source Type: research

Curcumin loaded Solid lipid nanoparticles enhanced efficacy in vascular dementia against Homocysteine induced toxicity
Vascular dementia (VaD), a diverse group of brain disorders with cognitive decline is attributable to cerebrovascular pathologies. Recent studies have shown that mitochondrial dysfunctions and oxidative stress are involved in cognitive decline. The aim of the present study was designed to evaluate the effects of Curcumin loaded solid lipid nanoparticles (Cur-SLNP) in vascular dementia (VaD) against homocystiene (HCY) induced toxicity by behavioral and biochemical assessment in different regions of the brain. The sign of VaD i.e., learning and memory levels were evaluated with different behavioural assessment like plus maze...
Source: International Journal of Phytomedicine - May 20, 2021 Category: Science Authors: Bhagyasree Prathipati Source Type: research

Potential antioxidant and hypoglycaemic effect of the flower extract of < em > Bougainvillea spectabilis < /em > Willd. (Nyctaginaceae)
The study evaluated the antioxidant and hypoglycaemic potentials of the ethanol flower extract ofBougainvillea spectabilis. Flower extract ofBougainvillea spectabilis were obtained by cold maceration method. The preliminary phytochemical screening and hypoglycaemic effect were carried out using standard methods. Antioxidant screening was carried out using DPPH antioxidant assay test. Five rats were used for each group; normal control, standard control, 100, 200 and 400 mg/kg b.w. doses of the crude ethanol flower extract ofB. spectabilis to test the hypoglycaemic effect in alloxan-induced diabetic rats. Blood glucose level...
Source: International Journal of Phytomedicine - May 20, 2021 Category: Science Authors: Fave Yohanna Tata Source Type: research

Formulation, Characterisation and Preclinical evaluation of Antidiabetic activity of Polyherbal tablet
Diabetes mellitus is a complex and a diverse group of disorders that disturbs the metabolism of carbohydrate, fat and protein. The number of diabetes mellitus cases has been increasing worldwide in recent years. In 2000, the WHO estimated a total of 171 million people with diabetes mellitus from the global population, and this report projected to increase to 366 million by 2030.Now a days polyherbal formulations made by a different herbal pharmaceutical company is very much popular and acceptable for chronic use in case of diabetes, hypertension, bronchial asthma, hyperlipidemia, rheumatoid arthritis, etc. As the incidence...
Source: International Journal of Phytomedicine - May 20, 2021 Category: Science Authors: B Ray Source Type: research

Herbal Medicines in management and prevention of COVID-19
Traditional herbal medicines are widely accepted in the world. Certain countries and WHO have research investment in traditional herbal medicines. COVID-19 came as a major Health care challenge for human in 2019. 480 deaths have been recorded till 18th of April 2020 in India. No pharmaceutical products have yet been shown to be safe and effective for the treatment of COVID-19. Major 3 types of targets of COVID-19 were identified by researches, which are as follow – 1) Inhibit coronavirus at structural level, 2) Inhibit coronavirus RNA synthesis and replication and 3) Inhibit virulence factor of Coronavirus. Certain Herba...
Source: International Journal of Phytomedicine - May 20, 2021 Category: Science Authors: Ritav Viralbhai Brahmbhatt Source Type: research

Formulation and Development of Spirulina ( < em > Athrospira plantasis < /em > ) Loaded Chocolatesas Immunity Boosters
Adults, as well as children, have a great need for nutrients such as Calcium, Iron, Zinc, Protein, and Vitamin B12. Spirulina is very rich in protein, omega 3 and omega 6 oils, vitamin, and mineral, and its incorporation into chocolates will enrich their nutritional values. Spirulina satisfies the nutritional needs by providing all these nutrients, as well as all the essential amino acids. Spirulina is unique and 100% safe. In fact, Spirulina is the only natural food that contains GLA (gamma linoleic acid) an essential fatty acid that is found only in mother ’s milk. This GLA plays a very vital in balancing the hormonal ...
Source: International Journal of Phytomedicine - January 17, 2021 Category: Science Authors: Shweta Prashant Ghode Source Type: research

Immune stimulating and galectin-3 inhibitory effects of a hydrophilic polysaccharide nutraceutical from Tinospora cordifolia
Tinospora cordifoliais an important ayurvedic herb known for its immune stimulating effect. In this investigation, we describe the galectin-3 inhibitory and immune stimulating properties of a novel water-soluble nutraceutical made fromTinospora cordifolia stem. This proprietary extract (T2CA) had a total yield of 6% and contained 86.9% carbohydrates with a high proportion of patented (1,4)- α-D-glucan in it. The T2CA activated T-cytotoxic and NK cells significantly contributing to its immune stimulating effect. Moreover, T2CA induced the activation of functional NK cells in human lymphocyte cultures that in turn contribut...
Source: International Journal of Phytomedicine - January 17, 2021 Category: Science Authors: Cheppail Ramachandran Source Type: research

Prevention of β-amyloid-induced toxicity in a differentiated neuronal (IMR32) cell line by Khaya grandifololia (Welw) C. DC.
Alzheimer ’s disease (AD) belongs to the class of neurodegenerative disorder and is biochemically characterized by amyloid-β (Aβ) plaques deposition, accumulation of neurofibrillary tangles (NFTs) accumulation and ultimately neuronal loss. Even though, the progress made in developing efficient AD therapy, there is no effective drug capable to stop and/or slow down AD progression. In the current article, we investigated the neuroprotective effect ofKhaya grandifololia crude extract and fraction 2 against A β42-induced cytotoxicity and hyperphosphorylation of tau protein in differentiated neuronal cells (IMR32).Reactive...
Source: International Journal of Phytomedicine - January 17, 2021 Category: Science Authors: Ella Fils Armand Source Type: research

Acute toxicity, anti-inflammatory and antinociceptive investigations of extracts from < em > Ampelocissus africana < /em > (Lour) Merr (Vitaceae) rhizomes
This study focused on pharmacological investigations effects of methanolic and aqueous extracts fromAmpelocissus africana (Lour) Merr rhizomes.The acute toxicity of the extracts fromAmpelocissus africana was performed under OECD 423 guidelines. The anti-inflammatory activity was evaluatedin vivo using carrageenan-induced paw edemaof mice at the doses to 50, 100, 200, 400, 600 mg/kg body weight (bw).   The antinociceptive activity of the extracts was determined using acetic acid, formalin nociception models in mice at the doses to 50, 100, 200, 400 and 600 mg/kg bw. The involvement of ATP-sensitive K+ channel pathway and o...
Source: International Journal of Phytomedicine - January 17, 2021 Category: Science Authors: Wendkouni Leila Marie Esther Belem-Kabr é Source Type: research

< em > Zygophyllum album < /em > aqueous extract reduces oxidative damage in red blood cells and attenuates pro-inflammatory plasma markers in hypercholesterolemic-diabetic rats
In conclusion,Z. album reduces radical attack and improves the anti-inflammatory proprieties in hypercholesterolemic-diabetic rats. (Source: International Journal of Phytomedicine)
Source: International Journal of Phytomedicine - January 17, 2021 Category: Science Authors: Yasmina BAHLIL Source Type: research

< em > Isodon rugosus < /em > as potential source of phytopharmacological agents: A review
This piece of writing is aimed to attract the concern of readers and researchers toward the natural bioactive compounds hidden in the depth of natural life. Plant based bioactive compounds have become first choice as a potential source of pharmacological agents. Families of bioactive compounds such as flavonoids, polyphenols, carotenoids, diterpenes, sterols and vitamins enlist the class of naturally occurring families of organic compounds that are widely utilized for the maintenance of natural life.Isodon rugosus is one of the richest plants ofLamiaceaefamily which contain plenty of biological active compounds. In this re...
Source: International Journal of Phytomedicine - January 17, 2021 Category: Science Authors: Muhammad Muneeb Ahmad Source Type: research