Reaching consensus on drug resistance conferring mutations (Part 2)
Publication date: December 2016 Source:International Journal of Mycobacteriology, Volume 5, Supplement 1 Author(s): D.M. Cirillo, P. Miotto, E. Tagliani (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - January 11, 2017 Category: Infectious Diseases Source Type: research

Reaching consensus on drug resistance conferring mutations (Part 1)
Conclusions ReSeqTB serves as a single repository for the compilation, curation, and validation of existing and newly created sequences and metadata on M. tuberculosis strains and will use the currently reviewed data set, validated by international experts, as a starting point until sufficient new sequence data are accumulated. This initiative is supported by a global partnership of academic institutions, public health agencies, and nongovernmental organizations including the Critical Path Institute, FIND, the World Health Organization, the New Diagnostics Working Group, the U.S. Centers for Disease Control and Prevention,...
Source: International Journal of Mycobacteriology - January 11, 2017 Category: Infectious Diseases Source Type: research

Evaluation the virulence of Mycobacterium bovis isolated from milk samples through histopathological study in laboratory animals
Conclusion Our study conclude the presence of M. bovis isolates in milk in high percentage pause important source of tuberculosis infection for human being. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - December 16, 2016 Category: Infectious Diseases Source Type: research

Pathogenesis of multi drug-resistant and extensively drug-resistant tuberculosis as a determinant of future treatment success
Publication date: Available online 25 November 2016 Source:International Journal of Mycobacteriology Author(s): Faramarz Valafar (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - December 7, 2016 Category: Infectious Diseases Source Type: research

Diagnosing tuberculosis in the 21st century – Dawn of a genomics revolution?
Publication date: December 2016 Source:International Journal of Mycobacteriology, Volume 5, Issue 4 Author(s): Christopher Jeanes, Justin O’Grady Tuberculosis (TB) ranks alongside HIV as the leading cause of death worldwide, killing 1.5million people in 2014. Traditional laboratory techniques do not provide sufficiently rapid results to inform clinicians on appropriate treatment, especially in the face of increasingly prevalent drug-resistant TB. Rapid molecular methods such as PCR and LAMP are vital tools in the fight against TB, however, rapid advances in next generation sequencing (NGS) technology are allowing inc...
Source: International Journal of Mycobacteriology - December 5, 2016 Category: Infectious Diseases Source Type: research

Challenging dogma and stagnation in TB research
Publication date: December 2016 Source:International Journal of Mycobacteriology, Volume 5, Issue 4 Author(s): Matthew Bates, Rumina Hassan, Ben Marais, Francine Ntoumi, Dorothy Yeboah-Manu (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - December 5, 2016 Category: Infectious Diseases Source Type: research

Radiographic manifestations of Tuberculosis in HIV positive patients: Correlation with CD4+ T-cell count
Conclusion In CD4+ cell count <500, the dominant radiographic pattern of Tuberculosis is atypical presentation. At this level of immunity, CD4+ T cell dysfunction may play a deterministic role in TB radiographic manifestation. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - December 4, 2016 Category: Infectious Diseases Source Type: research

Development of rapid immuno-diagnostic test for the early detection of tuberculosis
Conclusion The combination of targeted antigens and developed mAbs could be used as novel biomarker for detection of active TB directly from patient sera. We are trying to uncover the best antigen and mAbs recipe for the development of point of care diagnosis of active tuberculosis. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - December 2, 2016 Category: Infectious Diseases Source Type: research

Childhood tuberculosis in Qatar
Publication date: Available online 1 December 2016 Source:International Journal of Mycobacteriology Author(s): J.P.N. Singh, Reem Mohammed, Thanveer Thayyullathil, Abdullatif Al-Khal, Zubaida Al- Suwaidi Childhood tuberculosis (TB) has been long neglected but has gained attention in recent years. In 2012, the World Health Organization annual report included an estimate for childhood TB for the first time, and in the following year, the TB Alliance received a grant from UNITAID to develop pediatric TB formulations. Qatar is a low-incidence country. In this observational study, laboratory-confirmed cases of TB were an...
Source: International Journal of Mycobacteriology - December 1, 2016 Category: Infectious Diseases Source Type: research

Effectiveness of a novel cellular therapy to treat multidrug-resistant tuberculosis
Conclusion MSC treatment could vastly improve treatment outcomes for MDR-TB patients. Our findings could revolutionize therapy options and have strong implications for future directions of MDR-TB therapy research (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 28, 2016 Category: Infectious Diseases Source Type: research

Antimycobacterial ingredients from plants used in traditional medicine to treat Buruli ulcer
Conclusions The results completed support the use these plants in the indigenous knowledge against BU. Further analyses of active principles might lead to new drug toe fight against BU. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 28, 2016 Category: Infectious Diseases Source Type: research

The difficulties of childhood tuberculosis diagnosis
Conclusions Tuberculosis in children is often undiagnosed or difficult to diagnose, most developing countries still using ancient methods which can recognize only the developed tuberculosis. It’s necessary to evaluate the issue’s importance in order to improve the diagnosis conditions (systematic culture and susceptibility test in children), and to ensure the availability of the effective treatment (the pediatric formulation of the essential drugs). (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 26, 2016 Category: Infectious Diseases Source Type: research

The prevalence of tuberculosis among Iranian elderly patients admitted to the infectious ward of hospital: A systematic review and meta-analysis
Conclusion The prevalence of tuberculosis among Iranian elderly patients admitted to the Infectious ward of hospital is high and it is recommended considering tuberculosis as differential diagnosis in elderly patients with infectious symptoms. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 26, 2016 Category: Infectious Diseases Source Type: research

Thoracic surgical interventions for DR-TB and their results
Conclusions In conclusion, surgical intervention should be offered and made available for greater number of DR-TB patients. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 26, 2016 Category: Infectious Diseases Source Type: research

Rehabilitation of treated TB patients: Social, psychological and economic aspects
Conclusion Therefore despite having completed treatment, many people continue to suffer. Hence it is necessary that robust systems for post-treatment rehabilitation are put in place, and are designed based on the needs of those affected. Peer to peer counselling can be a low-cost high-impact strategy to address some of these issues. Institutional provisions, under the national response in each country, must be put in place if individuals are to successfully complete treatment, and return to their normal lives. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 26, 2016 Category: Infectious Diseases Source Type: research