International Journal of Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Promising predictive molecular biomarkers for cervical cancer (Review)
Int J Mol Med. 2024 Jun;53(6):50. doi: 10.3892/ijmm.2024.5374. Epub 2024 Apr 12.ABSTRACTCervical cancer (CC) constitutes a serious public health problem. Vaccination and screening programs have notably reduced the incidence of CC worldwide by >80%; however, the mortality rate in low‑income countries remains high. The staging of CC is a determining factor in therapeutic strategies: The clinical management of early stages of CC includes surgery and/or radiotherapy, whereas radiotherapy and/or concurrent chemotherapy are the recommended therapeutic strategies for locally advanced CC. The histopathological characteristics...
Source: International Journal of Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Marcela Lizano Adela Carrillo-Garc ía Erick De La Cruz-Hern ández Leonardo Josu é Castro-Muñoz Adriana Contreras-Paredes Source Type: research

[Retracted] MicroRNA ‑202 inhibits endometrial stromal cell migration and invasion by suppressing the K‑Ras/Raf1/MEK/ERK signaling pathway
Int J Mol Med. 2024 Jun;53(6):51. doi: 10.3892/ijmm.2024.5375. Epub 2024 Apr 12.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell invasion assay data shown in Figs. 2C and 4B were strikingly similar to data appearing in different form in a paper by different authors at a different research institute that had already been submitted for publication. Owing to the fact that the contentious data in the above article had already been submitted for publication prior to its submission to International Journal of Molecular Medicine, the Editor...
Source: International Journal of Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Di Zhang Ling Wang Hua-Lei Guo Zi-Wei Zhang Chong Wang Ri-Cheng Chian Zhi-Fen Zhang Source Type: research

Stem cell ‑mediated modulation of pyroptosis contributes to tissue repair in noninfective inflammatory‑related diseases (Review)
Int J Mol Med. 2024 May;53(5):46. doi: 10.3892/ijmm.2024.5370. Epub 2024 Apr 5.ABSTRACTPyroptosis, a programmed cell death marked by lytic and inflammatory characteristics, plays a crucial role in non‑infectious inflammation‑related diseases but can lead to detrimental outcomes when dysregulated. Stem cells have emerged as key players in modulating pyroptosis through paracrine signaling, offering a novel avenue for tissue repair and regeneration. The present review delved into previous studies elucidating the intricate interplay between stem cells and pyroptosis, emphasizing the potential of stem cell‑based therapies...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Yi Wei Li Li Yiping Wang Yan Chen Zhengyang Li Chufei Huang Yangchen Wei Chiyu Jia Zuo Wang Junlin Liao Source Type: research

Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)
Int J Mol Med. 2024 May;53(5):48. doi: 10.3892/ijmm.2024.5372. Epub 2024 Apr 5.ABSTRACTHistone chaperones serve a pivotal role in maintaining human physiological processes. They interact with histones in a stable manner, ensuring the accurate and efficient execution of DNA replication, repair and transcription. Retinoblastoma binding protein (RBBP)4 and RBBP7 represent a crucial pair of histone chaperones, which not only govern the molecular behavior of histones H3 and H4, but also participate in the functions of several protein complexes, such as polycomb repressive complex 2 and nucleosome remodeling and deacetylase, the...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Yajing Zhan Ankang Yin Xiyang Su Nan Tang Zebin Zhang Yi Chen Wei Wang Juan Wang Source Type: research

Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research

Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway
Int J Mol Med. 2024 May;53(5):49. doi: 10.3892/ijmm.2024.5373. Epub 2024 Apr 5.ABSTRACTSeveral studies have shown that berberine (BBR) is effective in protecting against myocardial ischemia‑reperfusion injury (MI/RI). However, the precise molecular mechanism remains elusive. The present study observed the mechanism and the safeguarding effect of BBR against hypoxia/reoxygenation (H/R) myocardial injury in H9c2 cells. BBR pretreatment significantly improved the decrease of cell viability, P62 protein, Rho Family GTPase 3 (RhoE) protein, ubiquinone subunit B8 protein, ubiquinol‑cytochrome c reductase core protein U, the ...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Fajia Hu Tie Hu Yamei Qiao Huang Huang Zeyu Zhang Wenxiong Huang Jichun Liu Songqing Lai Source Type: research